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Application of terlipressin in preparation of drugs for treating dynamic intestinal obstruction

A technology of terlipressin and intestinal obstruction, which is applied in the directions of drug combination, antibacterial drug, and pharmaceutical formula, can solve the problems of difficult treatment and achieve good curative effect.

Active Publication Date: 2021-04-27
THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the many complications of decompensated liver cirrhosis and the difficulty of treatment, there is an urgent need for a drug suitable for liver cirrhosis complicated by dynamic intestinal obstruction caused by various reasons.

Method used

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  • Application of terlipressin in preparation of drugs for treating dynamic intestinal obstruction
  • Application of terlipressin in preparation of drugs for treating dynamic intestinal obstruction
  • Application of terlipressin in preparation of drugs for treating dynamic intestinal obstruction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of a drug for treating concurrent dynamic intestinal obstruction

[0028] The medicine contains terlipressin and optionally one or more pharmaceutically acceptable carriers, diluents or excipients, which are added by appropriate preparation methods or steps. The term "pharmaceutically acceptable" means a compound, material, composition and / or dosage form which, within the scope of sound medical judgment, is suitable for use in contact with patient tissues without undue toxicity, irritation, allergic or other problems and complications, and is effective for its intended purpose.

[0029] The dosage forms of the above-mentioned drugs include tablets, liquids, injections or suspensions. Such formulations may be prepared by any method known in the art of pharmacy, for example by bringing into association the active ingredient with carriers or excipients.

[0030] For example, for administration in the form of injections, the active pharmaceutical ingredient (t...

Embodiment 2

[0035] Clinical data of terlipressin treatment complicated with dynamic ileus

[0036] We collected and extracted the case data of 12 patients. The details are as follows.

[0037] 1) Xu xx, male, 49 years old. Admission diagnosis: 1. Acute-on-chronic liver failure; 2. Alcoholic cirrhosis decompensation, ascites, splenomegaly; 3. Gastrointestinal bleeding: rupture and bleeding of esophageal and gastric varices; 4. Spontaneous peritonitis; 5. Lung Infection; 6. Hypoproteinemia. Treatment process: symptomatic and supportive treatment such as liver protection, jaundice reduction, albumin supplementation, diuresis, acid suppression, gastric protection and hemostasis, and anti-infection treatment with imipenem. On the 4th day of admission, the patient's abdominal pain was relieved compared with before, and he still complained of abdominal distension, abdominal pain, yellow stool color, negative occult blood, physical examination showed abdominal distension, abdominal muscle tens...

Embodiment 3

[0053] Observational comparison of patients taking terlipressin versus usual care

[0054] Table 2 Observation comparison between patients treated with terlipressin and those treated with conventional treatment

[0055]

[0056]

[0057] *Remarks: The conventional treatment here refers to the treatment of terlipressin, including fasting, enema, anti-infection, anti-virus, albumin supplementation, diuretic and other symptomatic and supportive treatment.

[0058] Summary: The use of conventional treatment methods cannot achieve good therapeutic effects, or it will be effective after many days of treatment. And adopt terlipressin treatment, generally 2-3 days just can make the patient's state of an illness be alleviated.

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Abstract

The invention relates to application of terlipressin in preparation of drugs for treating dynamic intestinal obstruction. The dynamic intestinal obstruction is complicated by middle- / late-stage hepatic diseases and can also be complicated by hepatic cirrhosis and primary peritonitis. According to the application disclosed by the invention, the technical scheme can support and supplement the existing treatment schemes to some extent and has an important clinical significance in treatment on sufferers suffering from complicated hepatic-cirrhosis-complicated dynamic intestinal obstruction.

Description

technical field [0001] The present invention relates to the technical field of new uses of medicines, in particular to the application of terlipressin in the preparation of dynamic intestinal obstruction medicines. Background technique [0002] Incomplete intestinal obstruction refers to a disease in which some intestinal contents cannot pass through the intestinal tract normally and smoothly due to various reasons, resulting in pathophysiological changes in the intestinal tract and the body. According to different causes, it can be divided into mechanical intestinal obstruction, dynamic intestinal obstruction and blood supply intestinal obstruction. Among them, the etiology of dynamic ileus is complex and diverse, and dynamic ileus can be divided into paralytic ileus and spastic ileus. The current mainstream view is that it is the intestinal wall muscle dysfunction caused by nerve reflex or toxin stimulation, which leads to the loss of intestinal peristalsis or intestinal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/095A61K45/06A61K31/407A61K31/4196A61P1/00A61P31/04A61P31/12A61P31/10A61P1/16
CPCA61K38/095A61K45/06A61K31/407A61K31/4196A61P1/00A61P31/04A61P31/12A61P31/10A61P1/16A61K2300/00Y02A50/30
Inventor 周智雷宇钟珊
Owner THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIV
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