A method for analyzing related substances of terlipressin for injection

A technology for terlipressin and related substances, which is applied in the directions of analyzing materials, material separation, measuring devices, etc., can solve the problem that the detection efficiency of terlipressin for injection has not been compared and studied, and achieve effective product quality and control. The effect of product quality and high detection efficiency
CN105301156BActive Publication Date: 2017-05-24TIANJIN CHASE SUN PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TIANJIN CHASE SUN PHARM CO LTD
Publication Date
2017-05-24

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a related substance analysis method for terlipressin for injection. The content detection method for the terlipressin for injection includes the following steps: (Step 1) preparation of test solvent: the terlipressin for injection is prepared into the test solvent; (Step 2) preparation of self-control solvent: the test solvent is diluted, so that the self-control solvent is prepared; (Step 3) related substance content calculation: the control solvent and the test solvent are respectively injected into high-performance liquid chromatographs, so that chromatograms are obtained, and the related substance content in the test solvent is obtained by calculation.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a method for analyzing related substances of terlipressin for injection. Background technique

[0002] The main active ingredient of terlipressin for injection is terlipressin (triglycine-8-lysine-vasopressin), which is a chemically synthesized polypeptide compound. The pharmacological effects of terlipressin are: reduce portal hypertension, reduce blood flow in the portal vein area, contract esophageal smooth muscle, and continuously compress esophageal varices. Terlipressin for injection is mainly used for the treatment of bleeding from esophageal varices.

[0003] Polypeptide compounds are an important class of biologically active molecules. The development of peptide and other biotechnology drug research technologies, such as peptide solid-phase synthesis technology and high-performance liquid chromatography purification and analysis technology, has made the de...

Claims

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