Formulations of terlipressin

a technology of terlipressin and terlipressin, which is applied in the field of formulations of terlipressin, can solve the problems of side effects in up to 40% of patients
US20220233634A1Pending Publication Date: 2022-07-28BIOVIE INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
BIOVIE INC
Publication Date
2022-07-28

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Abstract

The disclosure provides pharmaceutical compositions comprising terlipressin having increased concentration with long term storage stability.
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Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application claims priority to U.S. Provisional Patent Application Ser. No. 62 / 851,366, filed May 22, 2019, the contents of which is hereby incorporated by reference in its entirety.BACKGROUNDField

[0002] The disclosure is directed to stable pharmaceutical compositions of terlipressin having increased concentrations at room or ambient temperature or under refrigeration.Technical Background

[0003] Terlipressin is a synthetic vasopressin that is approved in many countries outside of the United States to treat the life-threatening complications of cirrhosis, including hepatorenal syndrome (HRS) and esophageal bleeding (EVB). Its use is limited to the hospital setting due to its short half-life (Nilsson, et al., (1990) Drugs Explt Clin. Res., XVI(6):307-314), necessitating its administration as an intravenous bolus usually every 4 to 6 hours. Additionally, terlipressin can cause side effects in up to 40% of patients. Severe side effects—incl...

Claims

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