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Preparation method of biocompatible aqueous phase quantum point

A biocompatible, quantum dot technology, applied in the field of preparation of water-phase quantum dots, can solve the problems of poor stability of quantum dots, incompatibility of oil-phase quantum dots with biological systems, etc., and achieves a simple method, easy control, and stability. Good results

Inactive Publication Date: 2009-03-11
SHANGHAI INST OF TECHNICAL PHYSICS - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to provide a simple and feasible method for preparing biocompatible water-based quantum dots by surface modification of quantum dots, which solves the problem of incompatibility between oil phase quantum dots and biological systems, and overcomes the problem of quantum dots prepared in water phase. The difficulty of poor dot stability makes the application of quantum dots in biology simpler and more convenient

Method used

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  • Preparation method of biocompatible aqueous phase quantum point
  • Preparation method of biocompatible aqueous phase quantum point

Examples

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Embodiment 1

[0030] Preparation of nuclear quantum dots: take the preparation of CdSe core as an example. Take 0.3mmol of CdO, put it in a three-necked bottle, add 0.5ml of oleic acid and 4ml of octadecene into the three-necked bottle, seal the three-necked bottle, pass argon, and after one hour, heat it to 250°C for ten minutes, then drop to At room temperature, 2.5 g of octadecylamine and 0.5 g of TOPO were added into the three-neck flask, and argon was passed through for one hour.

[0031] Take 1.8mmol of Se powder and place it in a pear-shaped bottle. The following steps are operated in a vacuum glove box. Take 1.0ml of TOP and 1.5ml of dioctylamine in a pear-shaped bottle, seal it, and take it out. After the Se powder is completely dissolved by ultrasonication, TOPSe can be obtained.

[0032] Heat the three-neck flask to 282°C, quickly inject TOPSe, take a sample in 60 seconds, inject it into a pear-shaped flask filled with acetone, and centrifuge. The precipitate is CdSe quantum do...

Embodiment 2

[0039] Preparation of nuclear quantum dots: Take the preparation of CdSe quantum dots as an example. Take 0.3mmol of CdO, put it in a three-necked bottle, add 0.8ml of oleic acid and 6ml of octadecene into the three-necked bottle, seal the three-necked bottle, pass argon, and after one hour, heat it to 250°C for ten minutes, then drop to At room temperature, 3 g of octadecylamine and 0.8 g of TOPO were added into the three-necked flask, and argon was passed through for one hour.

[0040] Take 1.0mmol of Se powder and place it in a pear-shaped bottle. The following steps are operated in a vacuum glove box. Take 0.6ml of TOP and 1.0ml of dioctylamine in a pear-shaped bottle, seal it, and take it out. After the Se powder is completely dissolved by ultrasonication, TOPSe can be obtained.

[0041] Heat the three-neck flask to 282°C, quickly inject TOPSe, take a sample in 20 seconds, and precipitate in acetone. The precipitate is CdSe quantum dots.

[0042] Fabrication of core-sh...

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Abstract

The invention discloses a method for preparing a biocompatible aqueous quantum dot. The method comprises the following steps: a high-quality quantum dot and a nucleocapsid structure thereof are prepared; a surface modification technology is combined; the nucleocapsid structure is utilized to improve the stability of the quantum dot; through mutual action of intermolecular force, an organic molecular chain on the surface of the quantum dot is changed; an organic molecule of a long chain on the surface of an oil-phase quantum dot is changed into a small molecule which contains sulfhydryl and carboxyl or amidocyanogen and has biocompatibility and is water-soluble or a derivative of a large biological molecule; and finally, the biocompatible aqueous quantum dot which can be directly dissolved in phosphate buffer and the like is obtained. The method has the advantages: the preparation and surface modification method of the quantum dot are simple and easy to control the quality, the dimension and the surface property of the quantum dot; the obtained aqueous quantum dot has the advantages of higher fluorescent efficiency, even distribution of particle diameter, strong stability and the like; and the aqueous quantum dot prepared by the method can be used for biological detection, medical diagnosis, energy transferring and the like.

Description

technical field [0001] The invention relates to the preparation technology of metal oxide quantum dots, in particular to a preparation method of biocompatible water phase quantum dots. Background technique [0002] Quantum dot nanomaterials have properties such as quantum size effect, quantum interference effect, quantum tunneling effect, Coulomb blocking effect, and nonlinear optical effect, and have shown broad application prospects in solar cells, sensors, and biomedicine. In recent years, semiconductor quantum dots (such as CdSe, PbSe, etc.) have attracted the attention of researchers. For example, studies have shown that quantum dots of different sizes and materials have unique uses in the construction of optoelectronic devices and their performance adjustment. However, considering the practical application, the application of quantum dots in the field of biomedicine is one step ahead of that in the field of optoelectronics, especially in biomedical applications such as...

Claims

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Application Information

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IPC IPC(8): C09K11/02C09K11/88
Inventor 葛美英乐阳吴杰孙艳陈鑫戴宁
Owner SHANGHAI INST OF TECHNICAL PHYSICS - CHINESE ACAD OF SCI
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