The invention discloses an aluminum alloy variable section extruded profile for spaceflight and a preparation method of the aluminum alloy variable section extruded profile. The profile consists of the following elements of, in percentage by weight, 5.0%-6.0% of Zn, 1.0%-2.0% of Cu, 0.04%-0.1% of Mn, 2.0%-3.0% of Mg, 0.15%-0.25% of Cr, 0.35%-0.42% of Fe, less than or equal to 0.25% of Si, and thebalance Al. During preparation, a finished product is obtained after being subjected to smelting, purifying, standing, casting, homogenizing treatment, ingot heating, extrusion, pre-finishing, solution treatment, straightening finishing, deep machining, aging treatment and fine adjustment treatment. According to the method, by setting specific alloy composition and the preparation process, the aluminum alloy variable section extruded profile formed by once is obtained, the strength, fatigue resistance, corrosion resistance and stress corrosion resistance of the aluminum alloy profile are greatly improved, comprehensive performance requirements of a carrier rocket launcher on the variable section aluminum alloy profile can be met, the bottleneck of extrusion forming of the variable sectionprofile at present is broken, various indexes of the aluminum alloy profile are ensured to meet standards and use requirements, and material guarantee is provided for research of new carrier rockets in China.