93 results about "De esterification" patented technology

A catalyst containing a noble metal disposed on a carrier. The noble metal is present in an amount in the range of 0.1 wt% to 10 wt% based on the total weight of the catalyst. The carrier contains at least 50 wt% of silicon carbide based on the total weight of the carrier. The silicon carbide has a surface area of at least 5 m 2 / g. A method for preparing methyl methacrylate from methacrolein and methanol using the catalyst is also disclosed.

This invention discloses a method for preparing spiramycin EP impurity G, comprising the following steps: (1) adding spiramycin I to a solvent, adding alkali and esterification reagent, and selectively esterifying at 10-30℃ to obtain a compound; (2) adding the compound to a solvent, adding alkali and esterification reagent, and selectively esterifying to obtain a compound; (3) adding the compound to an acidic solvent with pH 0.8-2.0, and selectively hydrolyzing at 0-40℃ to obtain a compound; (4) adding the compound to a solvent, adding alkali, and selectively hydrolyzing to obtain spiramycin EP impurity G. This invention uses spiramycin I as a starting point and obtains spiramycin EP impurity G through selective esterification, esterification, and two-step selective hydrolysis. The product purity can reach over 94%, which is helpful for studying the metabolic pathways and processes of spiramycin and clarifying the absorption, distribution, metabolism, and excretion characteristics of the drug.

The utility model discloses a kind of esterification with stirring ripening device. The aforementioned stirring ripening device includes reaction kettle, detachably installed at the top of reaction kettle's stirring box, stirring mechanism installed on stirring box, fixedly installed at the bottom of reaction kettle's support and fixed mechanism being set in reaction kettle and being connected with stirring mechanism. The fixed mechanism includes connecting box, reaction box, magnet piece I and magnet piece II. The reaction box is filled with macroporous adsorption resin, and lipase is adsorbed and fixed thereon. The utility model constructs composite stirring system, can produce multi-directional shear force, so that liquor is fully stirred and mixed, improves liquor ripening effect, in addition, has the adsorption and fixation function of lipase, avoids lipase loss with liquor, realizes reuse, reduces ripening cost.

This invention relates to the field of ethyl hexanoate processing technology, specifically to an automated continuous esterification equipment and method for natural ethyl hexanoate. It includes a reaction vessel, with a distillation column at the top. A primary condenser is connected to the top of the distillation column. The lower shell-side outlet of the primary condenser is connected to two parallel flow control lines. One flow control line connects to the upper end of the distillation column via a return pipe, and the other flow control line connects to a product recovery tank. The upper shell-side outlet of the primary condenser connects to a secondary condenser, and the shell-side outlet of the secondary condenser connects to a buffer tank, which is connected to a vacuum pump. A gas phase anti-impact structure is provided at the connection between the reaction vessel and the distillation column. This invention effectively improves the conversion rate and esterification quality of the ester through continuous esterification. The gas phase anti-impact structure effectively reduces the direct impact of the gas phase on the distillation column wall, significantly improving the gas phase control effect and the adaptability to the distillation process.

DEPCT64 A humectant containing oil and other components for external use on the skin. In addition, a specific characteristic of this invention is that it contains an esterification product. Component A and component B, or the esterification product containing component A and component B. And the components C and the esterification products have a pH value of 0-160. Milligrams of KOH / gram and the mass ratio of fatty acid residues obtained from component B and fatty acid residues. Fats obtained from component C in fatty acid residues which make up the esterification products. Elements A, B, and C are equal to 99.9:0.1-45:55 elements. A: Polyhydric alcohols that are dipentaerythritol, erythritol, or sorbitan; B: Components. One or more fatty acids, or equal to two, selected from straight-chain saturated fatty acids with a certain number of carbon atoms. 6-10 atoms, C composition: 1 or more fatty acids, or equal to 2 types selected from fatty acids. Containing 6-28 carbon atoms (excluding element B). -----------------------------------------------------------

This invention relates to a bioactivator based on L-proline structural modification, its synthesis method, and its application, belonging to the field of agricultural chemistry. The activator employs a biomimetic molecular design strategy, prepared through the splicing of active structural units. L-proline's unique natural source advantage and the important active unit fragment N,N-diethylethanolamine from DA-6 undergo an esterification reaction to yield 2-(diethylamino)ethyl-L-proline ester. Bioactivity experiments were conducted on wheat and soybean, respectively. The results showed that this compound can promote plant growth at low concentrations, exhibiting significantly better growth effects than the blank control in terms of germination rate, root length, and stem length. Furthermore, the preparation process of this invention is simple, low-cost, and easily scalable for industrial production, and it possesses good environmental compatibility. Its unique natural source advantage provides a new option for activator development and has significant potential for agricultural development.

This invention relates to the field of microbial fermentation technology, specifically to a Monascus purpureus strain with strong stress resistance and high esterase production, and its applications. The Monascus purpureus strain is *Monascus purpureus* (…). Monascus ruber ZH01, deposited on October 20, 2025, at the China Center for Type Culture Collection (CCTCC), accession number: CCTCC NO:M 20252263. This *Monascus purpureus* strain exhibits strong resistance to adverse conditions and can grow normally in an environment with pH 3 and 25% ethanol. Its fermentation products, after being dried at 50°C for 24 hours, still maintain a higher survival rate compared to the control. Furthermore, it can produce high levels of esterifying enzymes in mixed culture media, with an esterification power of 165.8 mg / g·100h. During the fermentation of baijiu and vinegar, esterification generates lipids, enhancing the flavor of the beverages. The production of esterified red yeast rice using *Monascus purpureus* ZH01 of this invention has advantages such as short production cycle, low cost, and high esterification power.

This invention provides a continuous preparation method for dimethyl 2-methylglutarate, carried out in a first microchannel reactor and a second microchannel reactor connected in series. The method includes: feeding 2-methylglutaronitrile and sulfuric acid solution into the first microchannel reactor for hydrolysis; and contacting them with methanol in the second microchannel reactor for esterification. The esterified material is then subjected to phase separation to obtain dimethyl 2-methylglutarate. The mass ratio of 2-methylglutaronitrile to sulfuric acid solution is 1:(5~20). The controlled temperature of the first microchannel reactor is 80~120℃; the controlled temperature of the second microchannel reactor is 65~105℃, and the controlled temperature of the second microchannel reactor is not higher than that of the first microchannel reactor; the mass ratio of 2-methylglutaronitrile to methanol is 1:(1~6). Through the synergistic operation of the microchannel reactor and multiple control parameters, the eutectic precipitation of intermediate products with ammonium sulfate can be avoided, clogging can be prevented, and efficient, high-yield continuous preparation can be achieved.

This invention provides a continuous method for preparing vitamin E succinate polyethylene glycol ester (TPGS). It uses a strongly acidic cation exchange resin (such as the Amberlyst series) or a perfluorosulfonic acid resin (such as the Nafion series) as a heterogeneous catalyst, which is packed in a fixed bed to catalyze the esterification reaction between vitamin E succinate and polyethylene glycol. This method achieves precise proportioning of reactants, instantaneous mixing, isothermal reaction, and online dehydration, reducing the reaction time from several hours required by existing batch methods to tens of minutes. It allows for long-term stable use, requires no complex post-processing, and produces products with high yield, good purity, and light color. The preparation method of this invention solves the problems of difficult catalyst recovery, excessive waste, low efficiency, and unstable product quality in existing methods, making it particularly suitable for large-scale, continuous, and green production of TPGS.

The application discloses a process for producing diacylglycerol oil by an enzyme method in a solvent-free system, and comprises the following steps: taking low-cost lipase as a catalyst, preparing lipase A by immobilization of the enzyme, preparing lipase B by an ester exchange reaction, and then taking the lipase B as a catalyst to catalyze esterification of free fatty acid and monoglyceride in a solvent-free system to prepare diacylglycerol oil.

The utility model discloses a rectifying tower externally connected with an esterification kettle, relates to the technical field of reaction kettles, and solves the problems that pipelines are connected with the esterification kettle and the rectifying tower through flanges, the disassembly is complicated, the efficiency is low, the production schedule is seriously influenced, and the actual requirements of efficient chemical production are difficult to meet. And inlet and outlet pipes communicated with the esterification kettle and one side of the rectifying tower are fixed at the bottom of the esterification kettle and one side of the rectifying tower. Through the design of the connecting assembly, the pipeline between the esterification kettle and the rectifying tower can be quickly dismounted and mounted. The pull rod is pulled to drive the moving rod to move, so that the moving rod is far away from the inlet and outlet pipe and the compression spring, and the connecting assembly can be disassembled by moving the fixed pipe downwards, thereby quickly disassembling and transversely cleaning the pipeline, effectively preventing scaling on the inner wall of the pipeline from influencing the flow rate, prolonging the service life of the pipeline, and avoiding the problem of tedious disassembly of traditional flange connection. And the production efficiency is greatly improved, and efficient chemical production requirements are met.

The application discloses an enzymatic production process of diglyceride, and comprises the following steps: using low-cost lipase as a catalyst, preparing lipase A through immobilization of the enzyme, preparing lipase B through an ester exchange reaction, and then using the lipase B as a catalyst to catalyze esterification of free fatty acid and glycerol to produce diglyceride; the method can realize efficient enzymatic production of diglyceride through a series of methods by using low-cost lipase, and the production cost is reduced. The application provides an economical and efficient method for producing diglyceride by using the enzyme method, greatly reduces the use cost of lipase in the enzymatic esterification reaction, and has certain industrialization application prospect.

The application discloses a synthesis method of 7-dehydrocholesterol and 25-hydroxy-7-dehydrocholesterol, which comprises the following steps: taking cholesterols as raw materials, and synthesizing the 7-dehydrocholesterol through oxidation, enol esterification and reduction reaction; or taking 25-hydroxycholesterols as raw materials, and synthesizing the 25-hydroxy-7-dehydrocholesterol through oxidation, enol esterification, reduction and hydrolysis reaction. The synthesis route is short, the yield is high, the industrial production is facilitated, and the method has a wide application prospect.

This invention discloses a continuous PET production system designed to address the shortcomings of traditional five-reactor processes, where insufficient precision in temperature and pressure control during the esterification stage can lead to unstable reaction rates. The invention comprises an esterification unit, a melt polycondensation unit, and a solid-phase polycondensation unit. PTA powder and EG mixed slurry first undergo esterification in the first and second esterification reactors of the esterification unit, followed by melt polycondensation in the first polycondensation reactor, the second polycondensation disc reactor, and the final polycondensation disc reactor of the melt polycondensation unit. Finally, solid-phase polycondensation is completed in the first and second solid-phase polycondensation reactors of the solid-phase polycondensation unit. This invention establishes a synergistic control architecture of "two-stage esterification – three-stage vacuum polycondensation – two-stage solid-phase polycondensation," achieving efficient and stable production at a million-ton scale. It overcomes the shortcomings of uneven material mixing and large reaction fluctuations at ultra-large scales, while also exhibiting high production efficiency and low energy consumption.

A substrate for culturing cells that comprises a modified prolamin having a net positive charge is provided. The modified prolamin may be a prolamin that has been modified through amidation or esterification, such as the addition of a methyl-ester group or an ethanolamine group. The modified prolamin is animal-free may be food-grade and / or may be free of cross-linkers. The modified prolamin may be in a coating that can be applied to a surface for culturing adherent cells, such as a microcarrier (e.g., beads) or well plates. Substrates coated with the modified prolamin are able to support cell expansion and can be used for food-grade applications such as cultured meat.

This invention discloses a flame-retardant modified polyethylene composite material and its preparation method, relating to the field of composite material technology. The composite material comprises: an α-olefin-ethylene copolymer, an EAA-grafted β-cyclodextrin multifunctional compatibility-inclusion carrier, a melamine-based flame retardant, and an antioxidant. This invention constructs an EAA-grafted β-cyclodextrin multifunctional compatibility-inclusion carrier with both inclusion-anchoring and compatibility-dispersion functions. β-cyclodextrin is stably fixed to the ethylene-acrylic acid copolymer backbone via esterification covalent bonds. Utilizing the size matching between the β-cyclodextrin cavity and melamine molecules, the melamine-based flame retardant is contained within the cavity through host-guest recognition, anchoring the flame retardant to the carrier backbone in the form of single molecules or nanoclusters. Based on the thermodynamic compatibility between the EAA backbone polyethylene segments and the α-olefin-ethylene copolymer, the flame retardant is uniformly integrated into the system through molecular chain entanglement and co-crystallization, achieving a uniform distribution of the flame-retardant units throughout the matrix.

The application belongs to the technical field of medicine, and discloses a pentacyclic triterpene derivative, a preparation method and medical application of the pentacyclic triterpene derivative, which uses alpha-hederin or oleanolic acid as raw material, and utilizes esterification reaction or amidation reaction aiming at the carboxyl of C-28 to prepare the pentacyclic triterpene derivative. The pentacyclic triterpene derivative prepared by the application has the effects of anti-inflammation, anti-oxidation and anti-apoptosis, and the synthesis method is simple, the raw material is cheap and easy to obtain, and is suitable for industrial application.

This invention discloses a 3,6-bis(4-boronic acid phenyl)carbazole compound in the field of organic chemistry, its preparation method, and its application in glucose detection. The invention efficiently synthesizes the target product through a five-step reaction involving Suzuki coupling, N-alkylation, boron esterification, and deprotection. This compound exhibits high fluorescence quantum yield, good water solubility and stability, and simple synthesis. In a DMSO / H2O mixed solvent, it can specifically bind with glucose to form a boron ester. The fluorescence intensity decreases with increasing glucose concentration through an intramolecular charge transfer effect, achieving highly sensitive, highly selective, non-enzymatic glucose detection in aqueous phase. This solves the problems of poor stability, high cost, and complex operation associated with traditional enzymatic methods, and is suitable for clinical blood glucose monitoring, food analysis, and environmental monitoring.

This invention discloses a nervonic acid-rich *Xanthoceras sorbifolium* diester oil and its preparation method, belonging to the field of oleochemical technology. The invention first removes some long-chain monounsaturated free fatty acids from *Xanthoceras sorbifolium* oil through saponification and low-temperature settling. Then, porous organic polymer materials are used to further enrich nervonic acids with higher molecular weight and larger particle size. Glycerol is added to the free fatty acids, and esterification with lipase catalyzes the synthesis of diglycerides, thus obtaining a nervonic acid-rich *Xanthoceras sorbifolium* diester oil. The addition of a compound antioxidant effectively prevents oxidative rancidity of the diester oil. The *Xanthoceras sorbifolium* diester oil prepared by this invention has a rich nervonic acid content, a high diglyceride content, and excellent thermal stability, thus showing good application prospects and value in the field of oleochemicals.

The invention provides pentaerythritol ester and a preparation method thereof. The preparation method comprises the following steps: mixing mixed fatty acid and pentaerythritol according to the molar ratio of carboxyl to hydroxyl of (1-1.5): 1, irradiating by using ultraviolet light under 0.01-0.09 MPa, and carrying out esterification reaction under the condition of ultrasonic treatment to obtain pentaerythritol ester; wherein the mixed fatty acid comprises monobasic fatty acid and dibasic fatty acid, the monobasic fatty acid is at least two of C5-C10 monobasic fatty acid, and the dibasic fatty acid is at least one of C5-C9 dibasic fatty acid. According to the preparation method, the reaction esterification rate can be remarkably increased, the reaction time is shortened, the process is simple, and the large-scale application prospect is good.

Disclosed is a bile acid-metronidazole conjugate or a stereoisomer thereof, or a salt thereof, or a solvate thereof, or a prodrug thereof, or a metabolite thereof. The bile acid-metronidazole conjugate is prepared using an esterification reaction of a bile acid compound with hydroxyl group on a metronidazole structure. The synthesis process is simple and easy for industrialization. The bile acid-metronidazole conjugate can effectively inhibit the growth of anaerobic bacteria, especially the growth of Clostridioides difficile and Helicobacter pylori, so that the bile acid-metronidazole conjugate has a significantly improved therapeutic effect in the treatment of infections caused by the anaerobic bacteria.

This invention discloses a chemical-biological fusion method for cholesterol synthesis. Using plant-derived 21-hydroxy-20-methylpregn-4-en-3-one, also known as bis(2-hydroxy-2-yl)-3-one (BA), as a raw material, cholesterol is synthesized through a four-step reaction involving sulfonation, acetylation, enzymatic hydrolysis and reduction, and Grignard coupling. Addressing the drawbacks of traditional animal-derived cholesterol, which carries unpredictable risks of pathogenic bacteria and viruses, this invention uses plant-derived steroidal raw material BA to synthesize cholesterol. This method not only offers high safety, avoiding the risk of pathogenic bacteria and viral infections, but also utilizes the tandem catalysis of esterase and carbonyl reductase during synthesis, along with coenzyme regeneration, to obtain key intermediates with high stereoselectivity and in a safe and clean manner. This significantly shortens the cholesterol synthesis route, increases efficiency, simplifies operation, minimizes solvent recycling losses, reduces waste, and allows for mild reaction conditions. This method is safe, economical, and suitable for industrial production.

The utility model relates to a rectifying device for biodiesel, including esterificator, rectifying tower and condenser, rectifying tower includes reboiler and the rectifying column of solid connection in reboiler top, first heating pipe is solidly established in reboiler, the rectifying column includes the first rectifying section, secondary heating section and second rectifying section of solid connection from below to above in proper order, second heating pipe is solidly established in secondary heating section, the outlet of esterificator communicates with the import of reboiler through first pipeline, and the top outlet of second rectifying section communicates with the import of condenser through second pipeline, and the outlet of condenser communicates with the recovery mouth of esterificator, the outlet of first heating pipe communicates with the import of second heating pipe through third pipeline, the utility model improves the rectification effect and utilization ratio to methyl alcohol, and then improves methyl alcohol purity, and the methyl alcohol purity is conveniently detected, and it is more convenient to use.

The application discloses a continuous catalytic esterification preparation method of high-purity polyglycerol fatty acid ester, which comprises the following steps: continuously feeding raw glycerol into a continuous polymerization reaction unit composed of reactors connected in multiple stages, and performing polycondensation reaction in the presence of a fixed-bed solid alkali catalyst to obtain polyglycerol; continuously feeding the obtained polyglycerol and fatty acid into a continuous esterification reaction unit composed of thin-film evaporation reactors connected in multiple stages, and performing esterification reaction under a reduced pressure condition to obtain polyglycerol fatty acid ester crude product; continuously feeding the obtained polyglycerol fatty acid ester crude product into a continuous separation and purification unit composed of molecular distillation devices connected in multiple stages, and performing fractional distillation to obtain high-purity polyglycerol fatty acid ester product; and the production efficiency is significantly improved by adopting a continuous reaction mode and a thin-film evaporation reactor with high heat and mass transfer efficiency.

This invention discloses a method for utilizing yellow water and preparing characteristic flavor esters of baijiu (Chinese liquor) based on immobilized lipase, belonging to the field of baijiu biotechnology. This invention constructs a hydrophilic-hydrophobic bifunctional microenvironment on the surface of an inorganic carrier with a mesoporous structure, and activates and immobilizes lipase under mild conditions. The resulting immobilized lipase can efficiently catalyze the esterification reaction of organic acids in yellow water of various baijiu types (light aroma, strong aroma, and sauce aroma) without the addition of external organic solvents, targeting the generation of flavor esters characteristic of baijiu. Through the synergistic effect of the bifunctional surface microenvironment and the immobilization method, the catalytic activity, stability, and reusability of the lipase in complex yellow water systems are improved. The immobilized lipase can maintain stable operation in multiple reaction cycles, significantly extending the enzyme's lifespan and reducing reaction costs. This achieves efficient conversion and high-value utilization of organic acids in yellow water, showing promising industrial application prospects.

This invention relates to the field of polymer synthesis and processing technology, and discloses a bio-based copolyester material and its preparation method and application. The bio-based copolyester material is prepared by the following method: (1) Esterification: 2,5-furandicarboxylic acid, polyol and diol are mixed evenly and subjected to esterification reaction at 200-240℃ and 0-5kPa for 4-8 hours; after the reaction, the esterification product is mixed evenly with the catalyst and then put into a polycondensation reactor; (2) Polycondensation: the esterification product is subjected to polycondensation reaction at 250-270℃ and 0.01-10kPa vacuum; after the reaction, the bio-based copolyester material is obtained by filtration, underwater pelletizing and drying. This invention can better solve the delamination problem caused by the phase interface between bio-based copolyester and PETG copolyester and further improve flexibility while satisfying the film shrinkage performance and barrier performance.

The present application relates to the technical fields of pesticide synthesis, and discloses a synthesis method of 3-amino-4-methoxydiphenyl, which takes 4-hydroxydiphenyl as a starting material, and 3-amino-4-methoxydiphenyl can be obtained through insertion carbonylation reaction, methylation esterification, amine ester exchange and rearrangement reaction.The present application has the following advantages and effects: compared with the prior art, the synthesis method of 3-amino-4-methoxydiphenyl has the advantages of green environmental protection, low cost, safety and economy, and the specific advantages are as follows: 1. the reaction condition is mild, the operation is convenient, the production equipment is simple, and the whole process is very suitable for industrialized mass production; 2. the present application avoids dangerous reactions such as nitration reaction and catalytic hydrogenation reaction, and reduces the production safety risk.