6 results about "Glutamic acid diethyl ester" patented technology

The invention belongs to the technical field of preparation of nail polish compositions, particularly relates to a bio-based perfume nail polish composition and a preparation method thereof, and provides the following scheme aiming at the problems of high emission of volatile organic compounds (VOC), serious environmental pollution, potential health risks and the like due to the fact that existing nail polish usually uses a petroleum-based solvent and synthetic resin. The invention relates to a sugarcane-fermented ethanol beverage which comprises the following raw materials in parts by weight: 30-60 parts of sugarcane-fermented ethanol, according to the invention, sugarcane fermented ethanol, acetyl tributyl citrate, diethyl lauroyl glutamate, zein, konjac glucomannan, abietic acid methacrylate, neroli oil, cananga odorata oil, sodium alginate, chitosan, mineral mica, alkannin, panthenol, organic bentonite, carnauba wax nanoparticles and a photoinitiator are used; the pollution to the environment and the dependence on non-renewable resources are effectively reduced, and the potential harm to human health is reduced.

This invention discloses a method for synthesizing p-methylaminobenzoylglutamate diethyl ester. Using p-methylaminobenzoic acid and diethyl glutamate hydrochloride as raw materials, and carbonyl diimidazole as an ester activator, the specific synthesis method involves dissolving carbonyl diimidazole in a solvent under inert gas protection, stirring, adding p-methylaminobenzoic acid to generate the active ester, then adding diethyl glutamate hydrochloride and reacting. The mixture is then concentrated, cooled, water is added dropwise, filtered, and dried to obtain p-methylaminobenzoylglutamate diethyl ester. This method is simple, convenient, low-cost, and has a high yield, showing great promise for industrialization.

The invention relates to the field of analytical chemistry, and provides a method for detecting chloroethane in L-glutamic acid diethyl ester hydrochloride by using a gas chromatography headspace method.The method comprises the following steps that 1, ethyl alcohol is used for diluting a chloroethane-methanol standard solution, and a chloroethane reference substance solution is prepared; 2) dissolving L-glutamic acid diethyl ester hydrochloride by using ethanol to prepare a test solution; and 3) detecting the chloroethane reference substance solution and the test solution by using a gas chromatography headspace method. The method is high in specificity, high in sensitivity and good in repeatability, the content of chloroethane in L-glutamic acid diethyl ester hydrochloride can be accurately and rapidly measured, dangerous reagents are not needed, harm to the human body is smaller, the detection safety is improved, and meanwhile the cost is reduced.

The invention discloses a method for detecting isomer impurities in L-glutamic acid diethyl ester hydrochloride by HPLC (High Performance Liquid Chromatography), and belongs to the technical field of chemical engineering and pharmacy. D-isomer impurities in L-glutamic acid diethyl ester hydrochloride are detected by adopting high performance liquid chromatography, a CHIRALPAK AY-H column is adopted as a chromatographic column, an ethanol solution of 0.05% diethylamine is adopted as a mobile phase, isocratic elution is carried out, and the content of the D-isomer impurities in L-glutamic acid diethyl ester hydrochloride is detected. According to the present invention, the chromatographic conditions are as follows: the chromatographic conditions are as follows: the chromatographic conditions are as follows: the chromatographic conditions are as follows: the chromatographic conditions are as follows: the chromatographic conditions are as follows: the column temperature is 35 DEG C and the detection wavelength is 220 nm, the L-glutamic acid diethyl ester hydrochloride and the D-isomer thereof can be effectively separated and the content thereof can be quantitatively detected, the method has characteristics of simple operation, strong specificity, high sensitivity, high accuracy and good linearity, and the quality of the p-fluorothiophenol product can be effectively controlled.

The invention discloses a method for separating and detecting related impurities of L-glutamic acid diethyl ester hydrochloride, which comprises the following steps: carrying out gradient elution under certain conditions by adopting a chromatographic column taking octadecylsilane chemically bonded silica as a filler and taking a mixed solution of a sodium perchlorate buffer salt solution with high concentration and low pH value and acetonitrile as a mobile phase; l-glutamic acid diethyl ester hydrochloride and five related impurities can be effectively separated. The method is good in detection result accuracy and high in sensitivity, so that a good guarantee is provided for quality control of the L-glutamic acid diethyl ester hydrochloride.

The invention relates to the technical field of medicines, in particular to a preparation method of degraded impurities in a raltitrexed preparation, which comprises 117g of aldehyde hydrate, 752 g of anhydrous Na2SO4, 70g of p-toluidine, 68ml of concentrated hydrochloric acid, 72g of hydroxylamine hydrochloride, 339ml of concentrated sulfuric acid, 125ml of methanol, 261.7 ml of H2O, 747.8 ml of NaOH solution, 20g of thioacetamide, 4785ml of absolute ethyl alcohol, 32.5 g of NaHo, 5g of activated carbon, 25.6 g of NBS, 0.32 g of toluyl peroxide, 25.6 g of NBS, 3720ml of CHCl, 441g of L-glutamic acid, 542ml of SOCl and 50g of thiophenecarboxaldehyde. According to the method, the 5-amino group of the intermediate 4 can be protected by adopting acetic anhydride, the protecting group can be removed from hydrochloric acid, the reaction condition is mild, the reagent price is low, and the toxicity is low. The method avoids the defect that a route 3 adopts Boc2O protection to remove a protecting group in a strong acid environment of trifluoroacetic acid, and particularly adopts a process of condensation, hydrolysis and acylating chlorination of an N-methylation product and NBS and condensation of the N-methylation product and L-glutamic acid diethyl ester, the next-step reaction can be carried out without purification of an intermediate, so that the post-treatment process is greatly simplified, the labor intensity is reduced, and the yield is remarkably improved.