This invention discloses a method for synthesizing p-methylaminobenzoylglutamate
diethyl ester. Using p-methylaminobenzoic acid and diethyl glutamate
hydrochloride as raw materials, and carbonyl diimidazole as an ester activator, the specific synthesis method involves dissolving carbonyl diimidazole in a
solvent under
inert gas protection, stirring, adding p-methylaminobenzoic acid to generate the active ester, then adding diethyl glutamate
hydrochloride and reacting. The mixture is then concentrated, cooled, water is added dropwise, filtered, and dried to obtain p-methylaminobenzoylglutamate
diethyl ester. This method is simple, convenient, low-cost, and has a high yield, showing great promise for industrialization.