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Preparation method of chiral MOF supermolecule composite material and application of such material in identification of penicillamine enantiomer

A composite material, supramolecular technology, applied in the fields of metal organic framework materials, electrochemical chiral sensing, and nanomaterials, which can solve the problems of sensing recognition limitations, high cost and stable availability, and inability to maintain physical and chemical properties. , to achieve the effect of simple preparation process and easy industrialization

Inactive Publication Date: 2019-11-26
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with achiral recognition, the high cost of chiral MOFs and the availability of stable MOFs have greatly limited the sensing recognition, because they are usually synthesized from expensive homochiral ligands and cannot be used after exposure to aqueous solutions. Maintain its original physical and chemical properties

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Preparation method of a chiral helical L-HDGA transparent gel

[0034] Dissolve 5 mg of L-HDGA powder in 0.5 mL of absolute ethanol and 0.5 mL of water, heat it to 70°C and place it in a -4°C refrigerator for 2-4 minutes to form a transparent gel to obtain a chiral helical HDGA transparent gel ;

[0035] Described L-HDGA powder, preparation method is as follows:

[0036] Dissolve 0.855 g of hexadecanedioic acid in 30 mL of petroleum ether, and after reflux begins, add 3 mL of thionyl chloride dropwise, and reflux for 8 hours to obtain a colorless oily liquid;

[0037] Add 0.475 mg L-diethyl glutamate hydrochloride to a mixed solution of 3 mL triethylamine and 10 mL dichloromethane, stir at room temperature for 30 min, then add 0.645 g colorless oily liquid in an ice-water bath, and stir at room temperature 3h;

[0038]Wash the mixed solution three times with 10 mL distilled water, once with 10 mL 2M HCl, once with 10 mL saturated sodium bicarbonate solution...

Embodiment 2

[0042] Example 2 A preparation method of a chiral MOF supramolecular composite material

[0043] Dissolve 2.0 g of cobalt nitrate in 10 mL of water, and ultrasonically obtain a red transparent solution of cobalt nitrate;

[0044] Dissolve 2.2 g of dimethylimidazole in 10 mL of water, and ultrasonically obtain a colorless and transparent solution of dimethylimidazole;

[0045] Take 80 μL of cobalt nitrate solution and add it to the chiral helical L-HDGA transparent gel, sonicate for 10 minutes to make it uniformly dispersed, then add 80 μL of dimethylimidazole solution, sonicate for 10 minutes, and suction filter to obtain ZIF-67 nanocrystal loading The composite material L-HDGA@ZIF-67 on the surface of L-HDGA helix, that is, the chiral MOF supramolecular composite material.

Embodiment 3

[0046] Example 3 Preparation method of a chiral MOF supramolecular composite material

[0047] Dissolve 2.0-2.4 g of cobalt nitrate in 10-20 mL of water, and ultrasonically obtain a red transparent solution of cobalt nitrate;

[0048] Dissolve 2.2-2.6 g of dimethylimidazole in 10-20 mL of water, and ultrasonically obtain a colorless and transparent solution of dimethylimidazole;

[0049] Add 80-120 μL of cobalt nitrate solution to the chiral helical L-HDGA transparent gel, and disperse it evenly by ultrasonication for 10 minutes, then add 80-120 μL of dimethylimidazole solution, ultrasonication for 10 minutes, and suction filtration to obtain ZIF- The composite material L-HDGA@ZIF-67 with 67 nanocrystals loaded on the surface of L-HDGA helix, that is, chiral MOF supramolecular composite material.

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Abstract

The invention discloses a preparation method of a chiral MOF supermolecule composite material and an application of such material in efficient electrochemical identification of a penicillamine enantiomer and belongs to the technical field of nanomaterials, electrochemical chiral recognition and metal organic frame materials. The method mainly comprises the following steps: synthesizing a chiral L-glutamic acid bolaamphiphile L-HDGA by using hexadecyl diacid and diethyl glutamate, and then, preparing a spirally-arranged L-HDGA template with ethanol and water as solvents; and through a self-assembly method, preparing the composite material with ZIF 67 nanoparticles loaded on the surface of the L HDGA spiral structure. The application of the material in efficient electrochemical identification of the penicillamine enantiomer has the advantages of simple process, fast response and wide electrochemical identification; and the material has an application prospect.

Description

technical field [0001] The invention relates to a preparation method of a chiral MOF supramolecular composite material and the application of the material for electrochemical recognition of penicillamine enantiomers, belonging to nanomaterials, electrochemical chiral sensing, and metal organic framework material technologies field. Background technique [0002] Chirality is one of the most fundamental and attractive properties in all living organisms, and chirality is also commonly found in the pharmaceutical and chemical industries. Often, a pair of enantiomers with a mirror-image structure, one exhibits the desired biochemical activity, transport mechanism, and metabolic behavior, while the other may cause side effects or even severe toxicity. Therefore, it is of great interest to develop efficient methods capable of determining individual enantiomers in a sample, which depend on very small interactions between the enantiomers and the applied chiral selector. Therefore, ...

Claims

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Application Information

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IPC IPC(8): G01N27/30G01N27/327G01N27/48
CPCG01N27/308G01N27/3275G01N27/48
Inventor 赵璐王志玲
Owner UNIV OF JINAN
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