Preparation method of sucrose-6-ester

Abstract

The invention provides a preparation method of sucrose 6 ester. The preparation method comprises the following steps: preparing a reaction solution of sucrose and an organic tin compound; atomizing the reaction solution to form small liquid drops; fully mixing and contacting the droplets with a gasified dehydration medium, and carrying out dehydration reaction on the droplets so as to generate anintermediate mixture containing the sucrose organic tin ester droplets; separating the intermediate mixture to obtain a sucrose organic tin ester solution and a dehydrated gas-liquid mixture; recovering the sucrose organic tin ester solution obtained in the separation step and circulating the sucrose organic tin ester solution to the atomization step and the dehydration step for multiple times; and carrying out acylation reaction on the sucrose organic tin ester solution and organic anhydride to generate sucrose 6 ester. According to the method, rapid and efficient dehydration of the esterification reaction can be realized in an extremely short time, the sucrose organic tin ester intermediate is efficiently prepared, decomposition of carbohydrates and side reactions in the system are reduced to a great extent, the energy consumption is low, the product yield is high, the selectivity is high, and the sucrose reaction degree is more thorough.

Description

technical field

[0001] The invention belongs to the technical field of chemical manufacturing, and in particular relates to a preparation method of sucrose-6-ester. Background technique

[0002] Sucrose-6-ester is an important chemical product and intermediate, such as sucrose-6-acetate is an important intermediate for the synthesis of sucralose (Wu Hongying, School of Chemical Engineering and Biological Engineering, Zhejiang University, Wu Hongying, etc. Sweetener The latest progress in the synthesis of sucralose[J].Chemical Progress, 2016,35(1):227-238.), many sucrose-6-fatty acid esters are important food additives and chemicals.

[0003] At present, the industry usually adopts the single-group protection method to synthesize sucrose-6-ester. The synthesis process is generally to dissolve the organotin compound and sucrose in a polar solvent, and azeotropically dehydrate through a non-polar solvent (Chinese patent CN1210286) or a single The polar solvent is directly dist...

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