115 results about "Succinchlorimide" patented technology

The invention discloses a preparation method of a cell inflammatory factor adsorbent, which comprises the following steps: mixing styrene, divinyl benzene and hydroxyethyl acrylate, and adding a pore-foaming agent and mesoporous SiO2 nano powder to prepare a porous microsphere carrier; the preparation method comprises the following steps: mixing chitosan and poly (N-isopropylacrylamide) in an acetic acid solution to obtain a temperature-sensitive chitosan hydrogel precursor solution; the preparation method comprises the following steps: activating the surface of a porous microsphere carrier by using 1-ethyl-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide, mixing the activated porous microsphere carrier and a temperature-sensitive chitosan hydrogel precursor solution to obtain a water phase, and assembling, washing and drying in an oil phase to obtain the cell inflammatory factor adsorbent. Through the design of the core-shell structure and the addition of the mesoporous SiO2 nano powder, the temperature response characteristic and the recyclable characteristic are given to the cell inflammatory factor adsorbent, the adsorption capacity of cell factors is also improved, and a new solution is provided for physical adsorption of the cell inflammatory factors.

The invention relates to the technical field of protective films, in particular to a high-light-transmittance label protective film and a preparation method thereof.A multi-layer protective film formed by compounding a release film layer, an adhesive layer, a PET film and a protective layer is constructed; composite vinyl ester resin constructed by taking epoxy resin and acrylic acid as raw materials is subjected to toughening modification, and then a linear reactive diluent is compounded to construct a high-toughness protective layer which is resistant to high temperature and aging and can be photo-cured; long-chain alkane modified nano silicon dioxide is introduced into the protective coating, nano silicon dioxide is aminated by 3-aminopropyltriethoxysilane, and then 17-carbon monoisocyanate prepared by taking acetone, stearic acid, triphenylphosphine, sodium azide and N-chlorosuccinimide as raw materials is grafted to form the long-chain alkane modified nano silicon dioxide. Vinyl butadiene styrene rubber, composite vinyl ester resin, tackifying resin, a softening agent and a photoinitiator are mixed to prepare the adhesive layer.

The invention discloses a functional hydrogel microsphere and a preparation method and application thereof, and relates to the technical field of medicines.The preparation method comprises the steps that a hyaluronic acid methacrylic acid precursor solution and an IL-1beta shRNA adenovirus stock solution are mixed to obtain an Ad-atHAMA precursor solution; preparing the Ad (at) HAMA precursor solution through an oil-in-water micro-fluidic technology to obtain an Ad (at) HAMA microsphere; and sequentially adding the Ad (at) HAMA microspheres, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide into a 2-morpholinoethanesulfonic acid buffer solution, carrying out activating treatment, adding E selectin, and incubating to obtain the functionalized hydrogel microspheres. The functionalized hydrogel microspheres can inhibit a related mechanism of acute spinal cord injury pathological progress and promote neural function repair by targeting adsorption of neutrophil to regulate Nets-triggered innate immune inflammation cascade.

The invention relates to a method for synthesizing an iodo-pyridine compound from N-propargyl enaminone, which comprises the following steps: by taking N-propargyl enaminone as a raw material, DMF (Dimethyl Formamide) as a reaction solvent and copper acetate and N-iodosuccinimide as accelerators, carrying out intramolecular coupling reaction at 60 DEG C to synthesize the iodo-pyridine compound. The method for directly synthesizing the pyridine heterocyclic compound through the intramolecular coupling reaction of the N-propargyl enaminone under the non-alkaline condition is disclosed for the first time, reaction substrates are not limited to benzene rings on alkynyl, the application range of the reaction is greatly expanded, and the method has the advantages of being wide in substrate range, strong in functional group application range, mild in reaction condition, easy to operate, safe, high in yield and the like. And raw materials are cheap.

The application relates to the technical field of organic synthesis, and discloses a synthesis method of a benzoyl modified nucleoside, which comprises the following steps: dissolving or suspending a substrate in a solvent, adding N-chlorosuccinimide, reacting at a certain temperature, generating a corresponding N-chloroamine intermediate, then adding a certain equivalent of benzaldehyde, and generating a final product under the joint action of an oxidant and a catalyst. According to the method, the hydroxyl group on the sugar ring does not need to be protected, and is directly reacted with the amino group on the base, so that the side reaction is less, the obtained product is high in purity, and the yield is high.

This invention belongs to the field of coolant technology, specifically relating to a coolant and its application in an immersion liquid-cooled energy storage system. The coolant, by weight, comprises 80-95 parts base oil, 1-5 parts thermally conductive nanoparticles, 0.5-2 parts composite dispersant, 0.3-1 part composite corrosion inhibitor, 0.1-0.5 parts antioxidant, 0.2-0.5 parts pour point depressant, and 0.01-0.05 parts defoamer. The base oil is a mixture of polyalphaolefin and synthetic ester, and the composite dispersant is a compound of polyisobutylene succinimide and Mannich base dispersant. Aging tests show that this coolant exhibits high thermal conductivity retention, low acid value increase, and low corrosion rate. The coolant of this invention can effectively maintain the dispersion stability of nanoparticles in the environment of precipitates from sealing materials, extending the fluid change cycle.

The application belongs to the technical field of biological medicine, and discloses a synthesis method of aryl F-18 labeled sulfuryl chloride and application of the aryl F-18 labeled sulfuryl chloride in amine compound labeling. The method takes thiophenol derivative as a labeling precursor, obtains F-18 labeled thiophenol intermediate through photocatalytic aryl F-18 fluorination reaction, and then obtains aryl F-18 labeled sulfuryl chloride through N-chlorosuccinimide oxidation chlorination. The obtained aryl F-18 labeled sulfuryl chloride (4-[ 18 F] fluorobenzenesulfonyl chloride) can occur sulfurylization reaction with various amine compounds at room temperature, and the radiochemical conversion rate is as high as 98%. The application is successfully applied to novel synthesis of AMPA receptor PET imaging agent[ 18 F]2 (the conversion rate is 96%, which is much higher than 13% reported in the literature). The application has the advantages of mild reaction condition, high conversion rate and wide substrate application range, and provides an efficient method for innovative preparation of F-18 labeled PET probes.

The invention belongs to the field of Velciguat synthesis, and particularly relates to a preparation method of Velciguat and an intermediate product thereof. The preparation method of the Velciguat comprises the following steps: (1) reacting aminomalononitrile with methyl chloroformate to generate an intermediate product I; (2) carrying out ring closing on the intermediate product I and formamidine under an alkaline condition to obtain an intermediate product II; (3) carrying out bromination reaction on the intermediate product II and N-bromosuccinimide to obtain an intermediate product III; (4) reacting the intermediate product III with bis (pinacolato) diboron under the action of a catalyst to obtain an intermediate product IV; and (5) carrying out a reaction on the intermediate product IV and 5-fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo [3, 4-b] pyridine to prepare the viriciguat. The method is simple to operate, low in cost and safe in production. The invention also provides the intermediate product obtained by the preparation method.

The invention relates to the technical field of compound synthesis, in particular to a method for directly reducing carboxylic acid into aldehyde. The preparation method comprises the following steps: mixing triphenylphosphine, dichloromethane, carboxylic acid and N-chlorosuccinimide, and reacting to obtain a reactant; mixing with pinacol borane and 4-dimethyl pyridine, and continuously reacting to obtain a continuous reactant; and separating and purifying to obtain aldehyde. The synthesis of the substrate carboxylic acid provided by the invention and the rapid deoxidation of the carboxylic acid are carried out to obtain an aldehyde product, especially the following compounds 2aa, 2ab, 2ae, 2bc, 2be, 2bf, 2bg, 2bh, 2bi, 2bj, 2bk and 2bl have catalytic hydrolysis effects on hypophosphamide; the compound 2bl has a particularly excellent effect on hydrolysis of hypophosphamide.

The invention belongs to the technical field of deuterated organic chemical synthesis, and particularly relates to a synthesis method of deuterated 9-phenyl anthraceneboronic acid-D8, which comprises the following steps of: 1, halogenation reaction: reacting 9-phenyl anthracene-D9, bromo-succinimide (NBS) and triethylamine (TEA) in dichloromethane at low temperature to generate an intermediate 9-phenyl-10-bromoanthracene-D8; step 2, carrying out nucleophilic reaction of forming carbon negative by pulling out bromine with strong in a low-temperature environment of-65 DEG C to-70 DEG C, reacting n-butyllithium with the intermediate 9-phenyl-10-bromoanthracene-D8 in 2-methyltetrahydrofuran to generate 9-phenyl anthracene lithium; then triisopropyl borate is added for a boronation reaction, and the 9-phenyl anthracene boric acid-D8 is obtained after hydrochloric acid hydrolysis and purification. The purity of the deuterated 9-phenyl anthracene boric acid-D8 is greater than or equal to 99.8%, the deuteration rate is greater than or equal to 98%, and the deuterated 9-phenyl anthracene boric acid-D8 is suitable for being used as

The present invention discloses a method for preparing N-hydroxysuccinimide. The method uses a weakly acidic cation exchange resin as a catalyst. By reducing the acidity of the reaction system, product decomposition can be avoided, thereby improving product yield and quality. The method also reduces the reaction temperature, lowers equipment anti-corrosion requirements, extends equipment service life, reduces energy consumption, and is more conducive to industrial implementation. Furthermore, the catalyst is recyclable and does not require the addition of a stabilizer, making it more environmentally friendly.

The method for manufacturing an intermediate compound for shikonin synthesis of the present invention comprises the steps of: reacting 1,5-dihydroxynaphthalene with dimethyl sulfate to prepare 1,5-dimethoxynaphthalene; reacting 1,5-dimethoxynaphthalene with N-bromosuccinimide (NBS) to prepare 1,5-dibromo -4,8-dimethoxynaphthalene; introducing a methoxy group into 1,5-dibromo-4,8-dimethoxynaphthalene using copper iodide (CuI) and 1,10-phenanthroline as a catalyst to prepare 1,4,5,8-tetramethoxynaphthalene; performing formylation of 1,4,5,8-tetramethoxynaphthalene using phosphoryl chloride (POCl3) to prepare 2-formyl-1,4,5,8-tetramethoxynaphthalene; and forming a boron complex using pinacolborane (HBpin) and 3,3-dimethylallyl bromide and reacting the boron complex with 2-formyl -1,4,5,8-tetramethoxynaphthalene to prepare a prenylated shikonin intermediate. Compared to conventional synthetic methods, the method of the present invention offers milder reaction conditions, shorter reaction time, and improved yield, thereby greatly enhancing the economic feasibility of shikonin synthesis.

The application belongs to the technical field of organic synthesis, and provides a star structure carbazole derivative, a preparation method thereof and a carbazole conductive polymer. The application obtains an intermediate by mixing 10-phenyl-10H-phenothiazine, N-bromosuccinimide and a first organic solvent for reaction; obtains the star structure carbazole derivative by mixing the intermediate, 9H-carbazole-2-boronic acid pinacol ester, tetrakis(triphenylphosphine)palladium, an accelerator and a second organic solvent for reaction; and obtains the carbazole conductive polymer by mixing the star structure carbazole derivative and an electrolyte solution for cyclic voltammetry electrochemical polymerization. The method is simple, has few by-products, and the star structure carbazole derivative obtained by the method is a non-coplanar star structure, which is beneficial to the embedding and discharging of electrolyte ions, so that the carbazole conductive polymer has excellent electrochemical performance and energy storage properties, and the conductive polymer also has excellent electrochromic performance.

The invention discloses a preparation process of 5-bromonicotinic acid, which comprises the following steps: sequentially adding ethyl nicotinate and pinacol borane into a reaction kettle, heating to react, adding N-bromosuccinimide into the reaction kettle, maintaining the reaction temperature, and filtering to remove a byproduct succinimide after the reaction is finished. And carrying out reduced pressure distillation to recover the solvent to obtain the ethyl 5-bromonicotinate. Adding ethyl 5-bromonicotinate into another reaction kettle, adding an alkali solution, heating, stirring for reaction, cooling reaction liquid after the reaction is finished, dropwise adding hydrochloric acid to adjust the pH value, cooling, crystallizing, filtering, washing a filter cake, and drying to obtain a 5-bromonicotinic acid finished product. The total yield gt of the preparation process of the 5-bromonicotinic acid; the HPLC purity is gt; 99%. The process is simple and convenient to operate and easy to implement, raw materials are cheap and easy to obtain, reaction conditions are mild, high-temperature and high-pressure reaction is not needed, and requirements on equipment are reduced. The whole process is safer to the environment, and green and pollution-free production can be realized.

This invention discloses a two-photon fluorescent dye, prepared as follows: 6-hydroxy-2-naphthaldehyde reacts with a dihaloalkane under alkaline conditions to obtain a monohaloalkane-based aryl ether, which is then reacted with an aqueous trimethylamine solution to prepare S1; diethyl 4-(4-tolyl)pyridine-2,6-dicarboxylate reacts with N-bromosuccinimide to obtain a brominated product, which is then reacted with triphenylphosphine to prepare S2. After intermediates S1 and S2 react under strongly alkaline conditions, the product is then hydrolyzed to prepare the target product. This dye exhibits good cell membrane permeability, good dispersion in the cytoplasm, preferentially targets organelles in the cytoplasm, is water-soluble, has very low toxicity, and a high two-photon absorption interface, making it suitable for two-photon fluorescence confocal microscopy imaging.

The invention relates to the field of drug synthesis, in particular to an amine compound for fungi drugs and a preparation method of the amine compound. Comprising the following steps: 1) adding N-bromosuccinimide (NBS) into 4-iodobenzene serving as an initial raw material in an acetonitrile solvent in the presence of benzoyl peroxide serving as a catalyst, and reacting to obtain a 1-bromomethyl-4-iodobenzene compound II; 2) adding N-methylacetamide into the compound II in a tetrahydrofuran solvent by using potassium carbonate as alkali, and reacting to obtain an N-(4-iodobenzyl)-N-methylacetamide compound III; and 3) heating the compound III in a sodium hydroxide solution for deacetylation to obtain the compound IN-methyl-1-(4-iodophenyl) methylamine. The invention aims to provide a preparation process of the N-methyl-1-(4-iodophenyl) methylamine compound I, which is simple, convenient, green, environment-friendly and suitable for industrial production.

This invention provides a method for synthesizing 1,5-diazabicyclo[3.1.0]hexane compounds, their preparation, and their applications, belonging to the fields of organic synthesis and liquid propellant technology. 1,3-Propanediamine is dispersed in a suitable amount of chlorinated hydrocarbon solvent, and the corresponding aldehyde or ketone, a suitable amount of trifluoromethane sulfonate, and diisopropylethylamine are added sequentially. After half an hour, N-chlorosuccinimide is slowly added, and the reaction continues for 6-48 hours. The reaction is quenched with a suitable amount of water, and the mixture is extracted with dichloromethane. After concentrating the filtrate, column chromatography is used to obtain the corresponding 1,5-diazabicyclo[3.1.0]hexane compounds. Experiments have confirmed that 1,5-diazabicyclo[3.1.0]hexane compounds can rapidly and spontaneously ignite with fuming nitric acid and dinitrogen tetroxide, showing promising application prospects as a green fuel to replace methylhydrazine in the field of bicomponent liquid propellants.

The invention discloses a preparation method and application of a liquid reaction type bromine flame retardant, and belongs to the technical field of flame retardant preparation, and the preparation method comprises the following steps: mixing polypropylene glycol, tetrahydrofuran, N-bromosuccinimide, azodiisobutyronitrile and tetrahydrofuran for reaction, and performing post-treatment to obtain a brominated polyether polyol flame retardant; according to the invention, the prepared brominated polyether polyol flame retardant is also used in thermosetting resin to prepare a flame-retardant resin composition; according to the brominated polyether polyol flame retardant, the balance of high bromine content, high reaction activity and excellent synergism is realized; as a reactive flame retardant, the flame retardant not only can improve the flame retardant property of thermosetting resins such as polyurethane, but also can better retain the inherent physical and mechanical properties of a resin matrix.

The invention discloses a method for synthesizing 3-bromine-9-ethyl carbazole through reactive extrusion. The method comprises the following reaction steps: (1) adding uniformly mixed 9-ethyl carbazole, N-bromosuccinimide and a solid diluent into a solid feeding bin of a double-screw extruder; (2) adjusting the feeding speed and the screw rotating speed of the double-screw extruder, and dropwise adding auxiliary liquid through a peristaltic pump; and (3) collecting the product, dissolving, filtering, evaporating to remove the solvent and the like to obtain the 3-bromine-9-ethyl carbazole. According to the present invention, the double-screw extruder is adopted to efficiently prepare the 3-bromo-9-ethyl carbazole through the reaction extrusion, such that the use amount of the toxic and harmful solvent is substantially reduced, the product yield is improved, and the good application prospect is provided.

This invention relates to the field of pharmaceutical and food flavoring synthesis technology, specifically disclosing a method for preparing 4-ethoxy-3-methoxybenzaldehyde. This method uses... N Using 4-ethoxy-3-methoxybenzyl)methanesulfonamide as a raw material, in an organic solvent, under light conditions, at 30°C, it reacts with... N Chlorosuccinimide (NCS) reacts with deionized water to produce 4-ethoxy-3-methoxybenzaldehyde. This method features mild reaction conditions, requires no expensive reagents or catalysts, does not require the use of hazardous oxidants such as peroxides or oxygen, and is safe and simple to operate.

The application belongs to the technical field of pesticide intermediate preparation, and discloses a preparation method and application of 4-chloro-2,6-dimethylbromobenzene. The method uses 3,5-dimethylphenol as a starting material, and first reacts with p-toluenesulfonyl chloride under alkaline conditions to obtain 3,5-dimethylphenyl p-toluenesulfonate, then performs selective bromination with N-bromosuccinimide in the presence of a free radical initiator to obtain 4-bromo-3,5-dimethylphenyl p-toluenesulfonate, and finally performs a substitution reaction with a chlorine source such as concentrated hydrochloric acid or lithium chloride to obtain the target product 4-chloro-2,6-dimethylbromobenzene; the product can be used for synthesizing pesticides such as methoxypiperidine acetate and dispiro. The method realizes high-selectivity halogenation by regulating the electron cloud distribution of the benzene ring through functional group transformation, has mild reaction conditions, simple operation, avoids high-risk reagents and processes, has high yield, less waste, low cost, and is suitable for industrial production.

The application belongs to the field of vixepiromide synthesis, and particularly relates to a preparation method of vixepiromide and intermediate products thereof. The preparation method of vixepiromide comprises the following steps: (1) reacting aminopropandinitrile with methyl chloroformate to generate an intermediate product one; (2) ring closing the intermediate product one with formamidine under alkaline conditions to generate an intermediate product two; (3) performing bromination on the intermediate product two with N-bromosuccinimide to generate an intermediate product three; (4) reacting the intermediate product three with pinacol diboron under the action of a catalyst to generate an intermediate product four; and (5) reacting the intermediate product four with 5-fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine to generate vixepiromide. The application has the advantages of simple operation, low cost and safe production. The application further provides the intermediate products generated in the above preparation method.

The invention provides an ionic liquid-containing lubricating oil composition for a piston type aero-engine, and relates to the technical field of lubricating oil. The composition is prepared from the following components in percentage by weight: 1 to 2 percent of ionic liquid, 0.5 to 2.0 percent of an antioxidant mixture, 0.5 to 1.0 percent of tricresyl phosphate, 0.01 to 0.2 percent of a benzotriazole metal deactivator, 6.0 to 9.0 percent of an ethylene-propylene copolymer viscosity index improver, 3.0 to 6.0 percent of a succinimide ashless dispersant, 10 to 100 ppm of an anti-foaming agent and the balance of base oil, wherein the antioxidant mixture is prepared from the following components in percentage by weight: 0.4 to 1.0 percent of p-diisooctyl diphenylamine and 0.4 to 1.0 percent of lipid antioxidant. According to the piston type aviation lubricating oil composition containing the ionic liquid, the wear resistance, the thermal stability, the low-temperature fluidity and the oxidation resistance of lubricating oil are improved.

The application discloses a chiral thioimine lipid compound and a preparation method and application thereof, and the preparation method comprises the following steps: stirring sulfenamide, isobutyl alcohol, MS, a metal center chiral cobalt (III) complex anion and super-dry tetrahydrofuran at-40 DEG C for 30 minutes, then adding N-iodosuccinimide, and reacting at the same temperature for 36 hours; after the reaction is completed, the reaction is quenched by using an aqueous Na2S2O3 solution, and the chiral thioimine lipid compound is obtained through separation and purification; the chiral thioimine lipid compound prepared by the application provides a robust and practical method for solving the challenging asymmetric problem in sulfur stereochemistry, and opens up a road for a new type of chiral sulfur-containing compound which has a wide application in the fields of medicine and pesticides.

This invention discloses a highly dispersible lubricating oil composition, its preparation method, and a diesel engine oil, belonging to the field of lubricating oil technology. The lubricating oil composition, by mass percentage, comprises: detergent, 1%–6%; dispersant, 1%–8%; corrosion inhibitor, 0.1%–5%; antioxidant, 0.1%–6%; viscosity index improver, 0.1%–4%; base oil, balance; wherein the dispersant is selected from succinimidyl-succinate polymers. The highly dispersible lubricating oil composition and diesel engine oil provided by this invention exhibit excellent dispersing and detergency properties.

The application discloses a succinimide triptycyl compound organic solvent composite nanofiltration membrane and a preparation method thereof, and belongs to the technical field of separation membranes. The application is characterized in that, polyacrylonitrile or polyimide ultrafiltration membrane is used as a base film, after a surface pore preserving agent is removed, the base film is first soaked in an aqueous solution containing a succinimide triptycyl compound, then is soaked in an organic solution containing a polybasic acid chloride to perform an interfacial polymerization reaction, and finally is dried through heat crosslinking to obtain a composite nanofiltration membrane. The composite nanofiltration membrane prepared by the application has high stability in various polar organic solvents, has good selectivity to organic small molecules, and has high solvent permeability, and has high economic value in separation of organic solvent systems in industry.

This invention discloses a eutectic solvent and its preparation, a metal leaching agent, and a metal leaching method. The eutectic solvent is prepared by mixing choline chloride and a sulfonamide compound in a specific ratio; the sulfonamide compound is sulfonamide, 4-amino-N-(aminoiminomethyl)benzenesulfonic acid, or p-aminobenzenesulfonamide. This invention provides a metal leaching agent containing the aforementioned eutectic solvent, which is a transparent liquid prepared from the eutectic solvent and an auxiliary agent. The auxiliary agent is at least one selected from 1,3-dibromo-5,5-dimethylhydantoin, 1,3-dichloro-5,5-dimethylhydantoin, N-chlorosuccinimide, N-bromosuccinimide, chloramine T, and sodium hypochlorite. The eutectic solvent of this invention is an environmentally friendly compound, and the metal leaching agent system containing this eutectic solvent possesses both good oxidizing and coordinating abilities, enabling the leaching of gold and palladium with rapid leaching speed and high extraction rate.

The invention discloses a preparation method of deflazacort, which is characterized in that 3-(hydrazinoformyl) hydrazone-16beta, 17beta-epoxy imino-1, 4-pregnadiene-11, 20-diketone is used as a raw material, high-selectivity synthesis of 11beta-hydroxyl is realized at-10 + / -2 DEG C through photocatalysis and steric hindrance-directed reduction of diisopinopinyl borane, and ee (enantiomeric excess) value is greater than or equal to 95%. The preparation method comprises the following steps: after iodinating with N-iodosuccinimide, quenching with sodium thiosulfate, carrying out ring-opening esterification with potassium acetate, and recrystallizing to obtain the product, the total yield is 57%, the impurity content is low, and the preparation method is suitable for industrialization.

The present invention relates to the technical field of organic synthesis, and in particular to a method for rapidly preparing N-methylbenzisothiazolinone-1-oxide. At present, using p-benzisothiazolinone as a reaction raw material, benzisothiazolinone-1-oxide is synthesized by a non-direct oxidation method, and product yield is difficult to reach more than 80%. In view of the above problems, the present invention provides a method for rapidly preparing N-methylbenzisothiazolinone-1-oxide: at room temperature, 2-mercapto-N-methylbenzamide and N-chlorosuccinimide (NCS) are vigorously stirred in an organic solvent. After the reaction is completed, N-methylbenzisothiazolinone-1-oxide is obtained by concentration, extraction, and vacuum distillation. The inventive method has mild reaction conditions, short reaction time, high yield, and good application prospect.

The invention relates to the technical field of compound synthesis, in particular to a preparation method of N, N '-bis (2, 4, 6-trimethoxyphenyl) oxamide. The preparation method comprises the following steps: S1, bromination reaction: mixing dichloromethane, 1, 3, 5-trimethoxybenzene and triethylene diamine, adding NBS (N-bromosuccinimide) or dibromohydantoin, and reacting to obtain 1-bromo-2, 4, 6-trimethoxybenzene; s2, amination reaction: mixing an organic solvent, an acid binding agent, 1-bromo-2, 4, 6-trimethoxybenzene, a cuprous compound and a catalyst, and reacting to obtain 2, 4, 6-trimethoxyaniline hydrochloride; and S3, condensation reaction: mixing the 2, 4, 6-trimethoxyaniline hydrochloride with dichloromethane, adding triethylamine, and dropwise adding oxalyl chloride to obtain the N, N '-bis (2, 4, 6-trimethoxyphenyl) oxamide. The invention provides a preparation method of N, N '-bis (2, 4, 6-trimethoxyphenyl) oxamide, and aims to solve the problems of relatively slow reaction speed, incomplete reaction conversion, generation of impurities, poor product purity and low yield in a synthetic method in related technologies.