85 results about "Sodium dithionite" patented technology

The invention relates to a sodium hydrosulfite production risk assessment method and system based on multi-source data fusion. The system comprises a production process data acquisition module, a key variable linkage analysis module, a real-time risk detection module, a dynamic risk trigger analysis module and a comprehensive risk score calculation module. The method not only improves the risk assessment precision in the sodium hydrosulfite production process, but also realizes effective risk early warning and control through real-time and dynamic monitoring and regulation means. Meanwhile, the method fully combines the particularity of the sodium hydrosulfite production process, has significant value in safety guarantee, production efficiency improvement and management optimization, and establishes a new risk assessment normal form with scientificity and practicability for the chemical industry.

The invention relates to the technical field of industrial wastewater pollution treatment, in particular to a graded recovery method for copper and arsenic in wastewater. According to the method, the copper ions and the trivalent arsenic ions in the wastewater are respectively recovered by adopting sodium hydrosulfite under the condition of different pH values, so that the elementary substance copper and the elementary substance arsenic are obtained. According to the method, efficient graded recovery of copper and arsenic can be realized without introducing excessive substances; the treated wastewater can also reach the discharge standard, so that the effective treatment of the wastewater is realized; the method is simple to operate, high in efficiency, low in cost and wide in applicability.

The invention discloses an iron-based layered silicate material for efficiently removing variable-valence heavy metals and water treatment application of the iron-based layered silicate material, and belongs to the technical field of water treatment.The preparation method of iron-containing layered silicate minerals comprises the following steps that ferrous sulfate heptahydrate is dissolved in water, sodium dithionite and sodium orthosilicate are sequentially added, stirring is conducted, and a mixture is obtained; stirring, homogenizing and aging for two hours; the hydrothermal reaction kettle is used for reacting in a high-temperature and high-pressure environment; according to the iron-containing layered silicate mineral material, a unique layered structure similar to natural iron-containing layered silicate minerals and high adsorption performance are reserved, variable-valence heavy metal arsenic in a wastewater solution is synergistically and efficiently removed by means of the oxidation-reduction activity of the iron-containing layered silicate mineral material and induction of generation of Fenton-like reaction, and the iron-containing layered silicate mineral material is obtained. The method disclosed by the invention shows high treatment efficiency, environmental friendliness and remarkable economic benefits, and is expected to exert remarkable environmental benefits in the field of water treatment.

The invention discloses a method for removing thiocyanate radicals in cyanide-containing wastewater, and belongs to the technical field of metal refining. The method comprises the following steps: adding concentrated sulfuric acid to adjust the pH value of cyanogen-containing wastewater to 2-3, carrying out a stirring reaction, filtering, adding sodium hydrosulfite into a filtrate, simultaneously adding concentrated sulfuric acid to maintain the pH value to 3-5, carrying out a stirring reaction, firstly introducing a sodium sulfite acidic solution into overflowed H2S and HCN gas to absorb H2S gas, and then introducing a sodium hydroxide strong alkaline solution to absorb HCN gas. Aiming at cyanide-containing wastewater subjected to acidification treatment, firstly, a strong reducing agent sodium hydrosulfite is added to reduce SCN <-> into H2S and HCN with recycling value, then H2S is absorbed, elemental sulfur is recovered, finally HCN is absorbed, CN <-> is recovered, and the method is used for cyaniding gold extraction of a gold leaching system. The absorption and separation of H2S and HCN gas are realized, the recovery of elemental sulfur and CN <-> is further realized, and other ions are not introduced into a water supply system.

The invention provides a method for treating discharge wastewater of a waste lithium battery, which comprises the following steps: S1, pulping a lithium cobalt oxide material by using discharge wastewater, and adding a first oxidant for reaction to obtain primary oxidized slurry; s2, mixing the primary oxidized slurry with high-grade matte nickel, and adding a second oxidizing agent for reaction to obtain secondary oxidized slurry; s3, the secondary oxidation slurry and an iron circulation activating agent are mixed for acid leaching, a liquid phase is taken after solid-liquid separation, and metal leaching liquid containing nickel and cobalt is obtained; wherein the first oxidizing agent comprises persulfate, the second oxidizing agent is selected from hydrogen peroxide, and the iron circulation activating agent is at least one of sodium hydrosulfite or sodium pyrosulfite. According to the method, short-range efficient selective recovery of valuable metals is realized through cooperation of lithium cobalt oxide and high nickel matte, the influence on the environment is greatly reduced, and the economic cost of the process is reduced.

The invention relates to the technical field of nicotinic acid synthesis, and particularly discloses an efficient nicotinic acid synthesis method based on step-by-step feeding dynamic control, which comprises the following specific steps: step 1, uniformly dividing potassium permanganate into 3 parts, adding the potassium permanganate into an aqueous solution containing 3-methylpyridine every 15 + / -5 minutes, and supplementing 5-8mL of water after each addition; 2, reacting at 70-90 DEG C for 2-4 hours, and filtering while the solution is hot; 3, adding sodium dithionite into the filtrate, wherein the mass of the sodium dithionite is 0.4-0.6 time that of the potassium permanganate; and 4, concentrating the filtrate to 30-50% of the original volume, adjusting the pH value to 3.0-3.5 with acid, and crystallizing to obtain the nicotinic acid. The method has the following effects: the yield is up to 89.52% at most; the cost is reduced: the consumption of hydrochloric acid is reduced by 77%, and the consumption of potassium permanganate is optimized by 16.7%; the efficiency is improved; the reaction time is shortened by 50%; the large fluctuation of the reaction temperature is controlled through step-by-step feeding, the problem that the reaction liquid which is not completely reacted is too alkaline is solved by filtering and adding sodium dithionite, and the false yield is eliminated through the purification and concentration step while the yield is further improved.

The invention discloses a high-yield method for reducing dinitro and retaining sensitive protecting groups, which comprises the following steps: adding water, sodium dithionite and sodium carbonate into a container, stirring and clarifying, and dropwise adding a mixed solution containing raw materials; after the reaction is finished, extracting, separating liquid, concentrating, and purifying by silica gel column chromatography to obtain a product and a byproduct; the raw material is a compound containing a carbon-carbon double bond, a p-methoxybenzyl protecting group, a t-butyloxycarboryl protecting group and dinitro. Adding a byproduct into a phosphoric acid mixed solution for reaction; and after the reaction is finished, adding dichloromethane and water, dropwise adding triethylamine to adjust the pH value, extracting, separating liquid, drying, concentrating, and purifying by silica gel column chromatography to obtain the product. According to the method, a sodium hydrosulfite / sodium carbonate system and phosphoric acid step-by-step treatment strategy is adopted, reduction of dinitro is achieved under mild conditions, meanwhile, PMB protecting groups, Boc protecting groups and C-C double bonds are reserved, and the problem that stability and high yield of the protecting groups cannot be considered at the same time in an existing method is solved.

This invention belongs to the field of epoxy resin synthesis technology, specifically relating to epoxy resin and an anhydrous epoxy resin synthesis process. The anhydrous epoxy resin synthesis process of this invention includes the following steps: dissolving bisphenol A in an organic solvent, adding sodium dithionite and mixing thoroughly, then adding solid sodium hydroxide, reacting under negative pressure and heating conditions, filtering after the reaction, adding the sodium bisphenol A solution to epichlorohydrin containing solid sodium hydroxide, and heating to carry out the resin synthesis reaction; after the reaction, performing solid-liquid separation, collecting the liquid phase and performing vacuum distillation to remove the solvent and unreacted epichlorohydrin, obtaining the epoxy resin. The anhydrous epoxy resin synthesis process provided by this invention avoids epichlorohydrin hydrolysis and is a novel epoxy resin synthesis process that is low-cost, highly efficient, and ensures excellent product color. The epoxy resin prepared by this invention guarantees product quality, with low color and low epoxy equivalent.

The present invention relates to the technical field of dispersants, and discloses a polymer-based dispersant and a preparation process and application. The present invention reacts polyethylene glycol and 5-nitroisophthalic acid to obtain a dispersant precursor; then reduces the nitro group through sodium dithionite to obtain a polymer-based dispersant, which contains polyethylene glycol molecular chains, has good complexing and stabilizing effects on silver ions, plays the role of a dispersant, is conducive to suppressing the agglomeration of nano silver, and reduces particle size. The polymer-based dispersant contains a terminal hydroxyl reducing group of polyethylene glycol, and the molecular chain side chain contains a large amount of reducing aniline groups, which plays the role of a reducing agent. It can effectively achieve the reduction of silver ions at low temperatures, significantly improving the output of nano silver.

This invention belongs to the field of soil manganese extraction technology, and discloses a stepwise extraction method and application for manganese species in soil. First, exchangeable manganese is extracted using magnesium chloride; then, manganese carbonate and sulfides are extracted using hydrochloric acid; next, active Mn(III) bound to organic matter is extracted using pyrophosphate solution under alkaline pH; then, manganese oxides are dissolved using hydroxylamine hydrochloride; and finally, manganese bound to crystalline iron and manganese oxides is extracted using sodium dithionite solution. This stepwise extraction scheme accurately quantifies the concentration of active Mn(III) species bound to organic matter in the soil. Experimental results show that the extraction method of this invention can effectively separate different forms of manganese in soil. In particular, PP extraction successfully distinguishes Mn(III) bound to organic matter without introducing interfering substances such as iron minerals that may interfere with dissolution.

The present application relates to the technical field of mineral processing and metallurgy, and particularly relates to a processing technology for full combustion of sulfur ore in a fluidized bed furnace, which comprises the following steps: after the pyrite is crushed, the pyrite is screened and then compounded, and then the pyrite is floated with a high-efficiency inhibitor to obtain pretreated pyrite powder; the pretreated pyrite powder is then added into the fluidized bed furnace, is leveled and then is fully combusted to obtain furnace gas and furnace slag; the high-efficiency inhibitor is obtained by mixing sodium hyposulfite, sodium mercaptoacetate, sodium humate and a buffer; wherein the furnace temperature during the full combustion is 910-930 DEG C, the combustion duration is 4-5 h, and the oxygen concentration at the outlet of the fluidized bed furnace is 2.5%-3.0%. The specific particle size and high-quality combination roasting process of the pretreated pyrite powder make the present application have higher burning-out rate, higher iron grade of the furnace slag and longer service life of the circulating pump compared with the prior art, and the application prospect is also wider.

The invention relates to the technical field of natural rubber processing, and particularly discloses a natural rubber latex preservative and a preparation method thereof. The preservative is prepared from modified nano titanium dioxide, ethylparaben, enzymolysis chitosan, immobilized lysozyme, pentaerythritol ester, sodium hydrosulfite, rosmarinic acid, potassium ferrocyanide, an acrylic acid-chitosan copolymer and the balance of deionized water. The preparation method comprises the steps of enzymolysis chitosan solution preparation and enzyme compounding, organic phase emulsification, nano component ultrasonic dispersion and vacuum defoaming aging, wherein the intermittent ultrasonic temperature control process guarantees the biological activity. The preservative can replace traditional ammonia water to be used for natural latex preservation, and has the advantages of being high in bacteriostasis and oxidation resistance synergism, high in colloid stability, environmentally friendly, safe and free of residues; according to the preparation method, through low-temperature enzyme protection and nano interface engineering innovation, the problems of biological inactivation and particle agglomeration in a traditional process are solved, and efficient and green production is achieved.

The invention belongs to the technical field of tail gas recovery treatment, and discloses a selenium-containing tail gas absorption liquid treatment method, which comprises: 1, adding sodium dithionite to a selenium-containing tail gas absorption liquid, and completely reacting to obtain a solution A; and 2, adding sulfuric acid or hydrochloric acid into the solution A, maintaining the pH value of the solution to be 0.1-1, carrying out a stirring reaction for 1-2 h, and carrying out solid-liquid separation to obtain solid crude selenium. According to the treatment method of the selenium-containing tail gas absorption liquid, nitrite of the selenium-containing tail gas absorption liquid is reduced through sodium dithionite, nitrous acid is prevented from being decomposed to generate nitric oxide, meanwhile, selenium can be reduced into elemental selenium through residual liquid in a specific pH environment, pollution is reduced, meanwhile, selenium in the tail gas absorption liquid is efficiently recycled, and the selenium-containing tail gas absorption liquid is obtained. The method has the advantages of short process and low cost.

The invention relates to the technical field of mineral separation and metallurgy, in particular to a processing technology for sufficient combustion of sulfur ore in a fluidized bed roaster, which comprises the following steps: crushing pyrite, screening, compounding, and carrying out flotation by using an efficient inhibitor to obtain pretreated pyrite powder; the pretreated pyrite powder is added into a fluidized bed furnace, and sufficient combustion treatment is carried out after the pretreated pyrite powder is spread flatly, so that furnace gas and furnace slag are obtained; the efficient inhibitor is obtained by mixing sodium hydrosulfite, sodium thioglycollate, sodium humate and a buffering agent; wherein the furnace temperature during sufficient combustion treatment is 910-930 DEG C, the combustion time is 4-5 h, and the oxygen concentration of an outlet of the fluidized bed furnace is 2.5%-3.0%. The specific particle size and high quality of the pretreated pyrite powder are combined with a roasting process, so that compared with the prior art, the method has the advantages that the firing rate is higher, the iron grade of slag is higher, the service life of a circulating pump is longer, and the application prospect is wider.

Various embodiments provide an electrolyte solution, a secondary battery, a battery module, a battery pack and an electric device. In those embodiments, the electrolyte solution includes an electrolyte, a solvent and an additive, the additive including sodium hydrosulfite. Various embodiments improve an overall performance of the secondary battery, for example, initial DCR, storage gas production, a rate performance, or the like.

The present application relates to the technical field of industrial wastewater treatment, and specifically discloses a sodium hydrosulfite production wastewater recycling treatment method, comprising the following steps: step 1: introducing sodium hydrosulfite production wastewater into a hydrolysis unit for treatment with a degradation catalyst, so that abundant hydroxyl radicals are generated by the chelation of ferrous ions and water molecules to degrade organic matter; step 2: introducing the hydrolyzed wastewater into an oxidative degradation unit for secondary degradation treatment, so that active oxygen is generated by electrolysis and the degradation effect of hydroxyl radicals is promoted to degrade organic matter; step 3: adding the treated wastewater into a light reaction unit for degradation by microbial reaction materials, so that crude clean water is obtained through the synergistic effect of nitrifying bacteria, flocculating bacteria and modified adsorption resins; and clean water is obtained after the crude clean water is filtered. The present application performs multiple degradation on production wastewater, and the concentration of organic matter is reduced to meet the discharge standard.

The invention belongs to the technical field of soldering paste preparation, and particularly discloses nano soldering paste and a preparation method thereof.The nano soldering paste comprises modified nano silver-copper soldering powder, scaling powder and surface modified nano Ni particles; a preparation method of the modified nano-silver-copper solder powder comprises the steps that solder powder is added into a 0.01 M dilute nitric acid solution with the volume being 5 times of the weight of the solder powder, stirring is conducted for 5 min, a mixture aqueous solution containing 0.02 mol / L sodium hydroxide and 0.01 mol / L sodium hydrosulfite with the volume being 1 / 2 of that of the dilute nitric acid solution is dropwise added, stirring is conducted for 30 min at the room temperature, filtering is conducted, vacuum drying is conducted at the temperature of 70 DEG C, and the modified nano-silver-copper solder powder is obtained. The soldering flux comprises the following raw materials in parts by weight: 35-50 parts of esterified modified rosin, 10-15 parts of a self-made mixed activator, 1-2 parts of a surfactant, 3-5 parts of a thixotropic agent, 4-6 parts of a corrosion inhibitor, 2-3 parts of an antioxidant and 25-40 parts of an organic solvent. The prepared high-stability environment-friendly soldering paste has excellent chemical stability and corrosion resistance and has the potential of being widely applied and stored for a long time.

The invention discloses a hexavalent chromium polluted underground water green remediation system and application. The hexavalent chromium polluted underground water green remediation system comprises a remediation well body and a non-contact sustainable electron injection system arranged in the remediation well body. The repair well main body comprises a shaft and a through hole formed in the wall of the shaft; the non-contact sustainable electron injection system comprises a medicament chamber and a graphite cathode plate; the medicament chamber is a closed space enclosed by a proton exchange membrane and a sealing plug, and a graphite anode plate and a sodium dithionite solution are accommodated in the medicament chamber; the graphite cathode plate is electrically connected with the graphite anode plate; according to the non-contact sustainable electron injection hexavalent chromium polluted underground water green remediation method, a reducing agent does not need to be added into a water-containing layer, the secondary pollution risk caused by the reducing agent and a product thereof is avoided, and green and efficient hexavalent chromium underground water remediation is achieved.

The application provides a high-concentration superfine anthraquinone cooking aid, which comprises the following components in parts by weight: 10-15 parts of sulfonated anthraquinone, 15-25 parts of anthraquinone, 2-8 parts of sodium hyposulfite, 1.0-2.0 parts of wetting agent, 0.5-2.0 parts of dispersing agent, 0.2-0.8 parts of defoaming agent, 0.5-2.0 parts of NaOH, 0.5-1.5 parts of xanthan gum, 0.5-1.0 parts of ethyl hydroxyethyl cellulose, 0.1-0.3 parts of preservative and 50-65 parts of water. The application further provides a preparation method of the high-concentration superfine anthraquinone cooking aid, which specifically comprises the following steps: S1, pre-dispersion and alkalization reaction; S2, emulsification and dispersion; S3, suspension agent compounding; S4, fine grinding; S5, suspension stabilization; and the like. The high-concentration superfine anthraquinone cooking aid prepared by the application has the advantages of excellent suspension stability in a high-concentration state and smaller particle size to realize efficient penetration and catalysis.

The utility model discloses a box for mixing detection reagents, which is characterized in that the box comprises a box body provided with a colorimetric card coating area, an alkaline liquid cavity, a sodium dithionite cavity and a urine cavity are arranged in the box body, the alkaline liquid cavity, the sodium dithionite cavity and the urine cavity are sequentially arranged, and the colorimetric card coating area is arranged in the box body. A connecting channel I is arranged between the alkaline liquid cavity and the sodium dithionite cavity, and a switch valve I and a corresponding control switch I are arranged on the connecting channel I; a second connecting channel is arranged between the sodium hydrosulfite cavity and the urine cavity, a second switch valve and a corresponding second control switch are arranged on the second connecting channel, and a urine injection hole is formed in the side wall of the urine cavity. The rapid detection kit is good in stability, simple and convenient to operate, beneficial for improving the rescue success rate of rescuing diquat and paraquat poisoning patients by primary medical workers, and meanwhile capable of being used for daily rapid detection in farmer markets and families.

The present application relates to a preparation method of 2-hydroxy-5-aminobenzoic acid, comprising the steps of: putting raw material 5-ASA into a reactor, adding hydrochloric acid solution to mix and then cooling, then adding sodium nitrite solution, realizing the aminodiazotization reaction of 5-ASA, and obtaining diazo salicylic acid hydrochloride; after cooling, adding sodium hydroxide solution and salicylic acid alkaline solution into the reactor, realizing the coupling reaction of diazo salicylic acid hydrochloride, and filtering by pressure after adding acetic acid to obtain the azo compound Olsalazine solid; sodium hydroxide solution and Olsalazine solid are added into the reduction reactor, slowly adding sodium dithionite solid after heating, passing nitrogen, cooling after reaction, then adding hydrochloric acid solution into the system, vacuum filtration after stirring to obtain crude product 5-ASA. This preparation method has simple circuit, low cost and can reduce the three wastes produced, and is suitable for large-scale industrial production.

The invention belongs to the technical field of fabrics, and discloses an antibacterial breathable fabric and a preparation process thereof; 3-chloro-2-hydroxypropionic acid; a blocked polyether polyurethane and 5-nitroisophenylene (N-dimethylaminoethylformamide) undergo quaternization polymerization reaction, and finally the nitro group is reduced by sodium dithionite to obtain a novel amino quaternary ammonium salt polyurethane finishing agent. The amino quaternary ammonium salt polyurethane finishing agent contains a large number of amino groups, which can react with the aldehyde group of the oxidized cotton fabric to produce a Schiff base reaction, so that the quaternary ammonium salt polyurethane finishing agent is chemically grafted to the surface of the cotton fabric, so that the cotton fabric maintains excellent hydrophilic moisture permeability; the amino quaternary ammonium salt polyurethane finishing agent contains a large number of quaternary ammonium salt antibacterial groups in the main chain, and the cotton fabric exhibits strong bactericidal performance after finishing. After washing, the quaternary ammonium salt polyurethane finishing layer is not easy to fall off, and still maintains excellent bactericidal effect.

The invention discloses a bio-based degradable plastic preparation method, which comprises: adding polylactic acid into dichloromethane, stirring until the system is in a transparent state, dropwise adding into an activated cellulose dispersion liquid, stirring, adding graphene oxide and a glyoxal solution, continuously stirring, adjusting the system to be acidic, stirring in an ice-water bath, heating to 100-110 DEG C, vigorously stirring, and cooling to the room temperature, thereby obtaining the bio-based degradable plastic. Performing vacuum freeze drying and crushing to obtain activated polylactic acid; the preparation method comprises the following steps: adding montmorillonite into hydrochloric acid, adding sodium dithionite, stirring, filtering, washing, adding butyl titanate, carrying out ball milling, adding water, continuously grinding, dehydrating, drying, cooling and crushing to obtain activated montmorillonite; polystyrene, polyamide, a compatilizer, an antioxidant and activated polylactic acid are stirred, activated montmorillonite is added, stirring is performed, and a premix is obtained; and carrying out extrusion granulation on the premix, carrying out hot pressing and deflation on granules, and then maintaining the pressure at 5-10MPa for 1-5 minutes to obtain the bio-based degradable plastic.

The invention discloses a bone marrow mesenchymal stem cell osteogenesis induction enhancing solution, which is prepared from the following components: 6.5 to 9.5 mg / ml of sodium hydrosulfite, 8.5 to 13.5 mg / ml of nicotinamide ribose, 1.5 to 2.1 mg / ml of deoxycholic acid, 45.0 to 55.0 mu g / ml of estradiol, 0.2 to 0.6 mg / ml of calcitriol, and 90.0 to 110.0 mu g / ml of rrBMP-2. Traditional osteogenic induction and 1% osteogenic induction enhancing liquid have high cell activity on BMSC cell proliferation, and compared with traditional osteogenic induction (containing 0.2 mmol / L of ascorbic acid, 10 mmol / L of beta-sodium glycerophosphate and 100 nmol / L of dexamethasone), the alkaline phosphatase staining color is deeper, the positive area is larger, the alkaline phosphatase activity is higher, more calcium nodules are formed, and the BMSC cell proliferation effect is better. It is shown that the osteogenic induction enhancing liquid provided by the invention enhances the osteogenic ability of the rat BMSC.

This invention relates to the field of filtration and dust removal technology, specifically disclosing a high-efficiency dust removal device and method for a sealed silo. The device includes a dust collection box fixedly installed on the outside of the top of the silo body. An air inlet pipe communicating with the silo body is fixedly installed on the lower side of the dust collection box, and a first pump body is installed outside the air inlet pipe. A horizontally arranged mounting plate is fixedly installed in the middle of the silo body, and a filter cylinder for filtering large particles is installed below it. A filter plate for filtering small particles is installed on the inner side of the middle position of the mounting plate. This high-efficiency dust removal device and method for a sealed silo employs a novel structural design. The air filtered by the filter plate enters the interior of a limiting cover. Sodium dithionite particles inside the limiting cover react with oxygen in the air (a strong reducing agent that reacts rapidly with oxygen), achieving the purpose of removing oxygen and reducing the possibility of subsequent dust explosions.

The invention relates to the technical field of building materials, and discloses a method for producing calcined talc powder for high-whiteness building materials by using black talc. The method comprises the following steps: pickling the black talc ore powder in a hydrochloric acid or nitric acid system, rinsing the black talc ore powder with sodium dithionite, flotation purification in a flotation system of fatty alcohol polyoxyethylene ether sulfonate, fatty alcohol ether phosphate MOA-3P, etc., and finally calcining the talc powder to obtain a talc powder with a whiteness of 90.3-95.2% and a talc content of 86.4-93.5%. The scheme of the invention is used in building materials, so as to realize resource utilization of the black talc ore and significantly improve the quality of the talc powder.

The invention discloses an ammonia leaching process of copper oxide ore, which comprises the following steps: crushing and grinding the copper oxide ore, adding an activating agent into the obtained ore pulp for activating treatment, sequentially adding ammonia liquor and sulfide for leaching treatment and precipitation reaction, and filtering, and copper sulfide concentrate and filtrate are obtained. Compared with a conventional ammonia leaching process, the ammonia leaching process of the copper oxide ore has the advantages that the copper oxide ore is sequentially subjected to crushing, ore grinding, activating treatment, leaching treatment and precipitation reaction, the copper leaching rate of the copper oxide ore can be remarkably increased, meanwhile, agent consumption and environmental pollution are reduced, and the ammonia leaching process is suitable for efficient recovery of complex and difficult-to-treat copper oxide ore; the method has the advantages of simplicity in operation, low cost, high leaching efficiency, good leaching effect, environmental friendliness and the like, and is high in use value and good in application prospect.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of trimethyl phloroglucinol. The invention provides a preparation method of trimethyl phloroglucinol, which comprises the following steps: preparing a crude product: mixing 1, 3, 5-tribromobenzene, sodium methoxide, methanol, N, N-dimethylformamide and cuprous chloride, uniformly stirring, reacting for 6-12 hours, after the reaction is finished, transferring a reaction solution into a sulfuric acid solution, crystallizing, and filtering to obtain the trimethyl phloroglucinol crude product; and crude product purification: adding the trimethyl phloroglucinol crude product and sodium dithionite into a recrystallization solvent, heating and stirring to dissolve the trimethyl phloroglucinol crude product and sodium dithionite, dropwise adding into water to crystallize, and filtering and drying to obtain trimethyl phloroglucinol. The preparation method provided by the invention has the advantages that the steps are simple, the preparation process is safe and controllable, the yield of the obtained trimethylphloroglucinol is more than 90%, the liquid phase purity is higher than 99.9%, the color meets the pharmacopoeia standard requirement, and the industrial batch production is more favorably realized.

The invention discloses a synthesis method of 3-hydroxyazetidine hydrochloride, and belongs to the technical field of organic synthesis. According to the method, tert-butylamine and epichlorohydrin are used as starting raw materials, and a target product is prepared through three-step reaction of cyclization, acetylation and deacetylation in sequence. The method is characterized in that in the acetylation reaction step, a step-by-step strategy that hydroxyl is subjected to monoacetylation at low temperature, and then tert-butyl acetylation is carried out by heating under the conditions that Lewis acid is used for catalysis and sodium hydrosulfite is used as a binding agent is adopted; the binding agent can effectively capture fallen tert-butyl, and side reaction between the fallen tert-butyl and the intermediate is avoided. By optimizing the synthesis route and the purification process, the problems of high raw material cost, high hydrogenation deprotection safety risk, more side reactions, difficulty in intermediate purification, poor product crystallization effect and the like in the prior art are solved. The obtained product is high in purity (greater than or equal to 98%) and good in crystal form, and the whole process is good in safety, simple and convenient to operate and more suitable for industrial production.

The invention belongs to the technical field of biological nano-medicines, and discloses a low-inflammation immune ionizable liposome and a preparation method and application thereof.The preparation method comprises the steps that 1, cholesterol, nicotinamide adenine dinucleotide and potassium carbonate are added into a solvent A for a reaction, and a precipitate is filtered and collected; (2) adding the precipitate into water, dissolving, then adding a sodium dithionite solution, stirring at room temperature in a dark place for reaction, filtering and collecting filtrate; (3) adding a solvent B and hydrochloric acid into the filtrate, fully and uniformly mixing, centrifuging, and collecting supernate to obtain NAD < + >-CHol; and (4) adding ionizable lipid, DSPE-PEG, DSPC, NAD < + >-CHol and cholesterol into absolute ethyl alcohol, uniformly mixing to obtain a lipid solution, and carrying out freeze-drying treatment on the lipid solution to obtain the low-inflammation immune ionizable liposome. The liposome disclosed by the invention is uniform in size and negatively charged, can cause the increase of neutrophil and macrophage in immune cells while delivering genes, and can effectively reduce immunogenicity.