Vaccines comprising truncated HBC core protein plus saponin-based adjuvants

An adjuvant and saponin technology, applied in the field of vaccines containing truncated HBC core protein and saponin-based adjuvants, can solve problems such as weak immune responses
CN101309931BInactive Publication Date: 2013-03-13RAJN BIOTEKH GEZELLSHAFT FJUR NOJE BIOTEKHNOLOGISHE PROTSESSE & PROD MBKH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
RAJN BIOTEKH GEZELLSHAFT FJUR NOJE BIOTEKHNOLOGISHE PROTSESSE & PROD MBKH
Publication Date
2013-03-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

Composition (A) comprises (i) one or more hepatitis B core antigens (HBcAg) containing amino acids 1 to x (x = 100-160),their fragments, variants of fragment variants; (ii) an adjuvant containing a saponin and / or saponin derivative; and (iii) optionally, one or more hepatitis B surface antigens (HBsAg), or their fragments, variants or variant fragments. - ACTIVITY : Virucide; Hepatotropic; Antiinflammatory. Mice were immunized with a composition containing 5 mu g AbISCO-200 (RTM for a saponin composition) and 10 mu g HBcAg1-144+1 in 0.1 ml phosphate-buffered saline. The number of CD8+> cells that expressed gamma -interferon was just over 100 per 105> such cells; compared with zero when the same antigen was administered without saponin. When the composition also contained 5 mu g HBsAg, the number of such cells was 170 / 105>. The composition also resulted in high levels of immunoglobulins G1 and G2b, indicating a Th1 / Th2 response. - MECHANISM OF ACTION : Vaccine.
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Description

technical field

[0001] The present invention relates to a composition, a method for producing the composition, a composition obtainable by the method, a pharmaceutical preparation, the composition or the pharmaceutical preparation in the treatment and / or prevention of hepatitis B virus (HBV) infection and HBV-mediated The use of the composition or the pharmaceutical preparation in the production of medicines for the treatment and / or prevention of HBV infection and HBV-mediated diseases, and the treatment and / or prevention of HBV infection and HBV-mediated diseases method. Background of the invention

[0002] According to World Health Organization (WHO) estimates, more than 2 billion people are infected or have been infected with hepatitis B virus (HBV) today. Thus, HBV belongs to the most important human pathogens with enormous impact on human health.

[0003] HBV infection can occur via blood, contaminated blood products, and through sexual intercourse, wherein the infect...

Claims

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