92results about How to "Large response" patented technology

A biosensor comprising an electrically insulating base plate, an electrode system containing a working electrode and a counter electrode disposed on the base plate, and a reagent system comprising at least an oxidoreductase, a hydrophilic polymer and an electron mediator, wherein the reagent system further comprises a substance having a function to convert an organic product generated by direct reaction of a substrate to be measured with the oxidoreductase to another compound.

The present invention provides compositions that comprise a phospholipid component (that contains one or more phospholipids) and a pharmaceutically acceptable fluid carrier, where the phospholipid component is in the range from about 10% to about 90% of the total weight. Optionally, the compositions may further comprise non-phospholipid filler materials, where the amount of the non-phospholipid filler materials is in the range from about 5% to about 50% of the total weight. In certain embodiments, the compositions may be injectable, non-liposomal, and/or in form of a gel or a paste. The compositions of the present invention are useful for repairing and augmenting soft and/or hard tissues or for sustained local drug delivery.

A probe instrument using room-temperature sensor(s) that can measure variations in magnetic susceptibilities. The instrument has sufficient resolution to monitor paramagnetic materials in a human body, such as iron in a human liver, by noninvasively examining patients with iron-overload diseases. The instrument includes room temperature magnetic sensors, and detects the sample, that is, the tissue response to an alternating current field applied by an applied field coil. The applied field coil dimensions are chosen so that the applied field is optimized for maximum response from the liver while minimizing the effects due to the overlying abdominal tissue and at the same time not unduly increasing the sensitivity of the instrument to the lung. To overcome variations in the sensor output due to fluctuations in the applied field, change in the ambient temperature and mechanical relaxation of the instrument, the sensor-sample distance is modulated. The detector assembly is oscillated while the examined patient remains stationary. An improved water-bag technique is employed to eliminate background tissue response. The detector assembly forms part of a probe instrument for performing noninvasively the paramagnetic concentration of a patient.

A system, a method, and a programmed device for measurement of translocational activity among cellular compartments process magnified images of cellular material exposed to an agent by segmenting and compartmentalizing the images and then measuring fractional localized intensity of two or more components in the segmented, compartmentalized image. The measured fractional localized intensities are compared to determine translocation of cellular material among the measured components caused by the agent.

The present invention is directed to the use of bcl-2 antisense oligomers to treat and prevent bcl-2 related disorders. These disorders include cancers, tumors, carcinomas and cell-proliferative related disorders. In one embodiment of the invention, a bcl-2 antisense oligomer is administered at high doses. The present invention is also directed to a method of preventing or treating a bcl-2 related disorder, in particular cancer, comprising administering a bcl-2 antisense oligomer for short periods of time. The present invention is further drawn to the use of bcl-2 antisense oligomers to increase the sensitivity of a subject to cancer therapeutics. The present invention also relates to pharmaceutical compositions comprising one or more bcl-2 antisense oligomers, which may comprise one or more cancer therapeutic agents.

A heterodyne detection technique for highly localized IR spectroscopy based on an AFM. A pulsed IR source illuminates a sample and causes contact resonance of an AFM probe, which is a function of localized absorption. The probe is operated in intermittent contact mode and is therefore oscillated at a resonance frequency. A secondary oscillation is mixed in to the probe oscillation such that the sum of the secondary oscillation and the IR source pulse frequency is near another harmonic of the probe. A mixing effect causes measurable probe response at the other harmonic allowing data to be taken away from the pulse frequency, resulting in background effect rejection and improved spatial resolution.

A catheter for human or animal vascular engagement is provided. The catheter has at least one interior lumen defined by a sidewall having an exterior circumferential. A titanium surface area is positioned along the circumferential surface entirely or at one or both ends to enhance lubricity. Additionally included may be an anti pathogenic and/or anti microbial surface area positioned adjacent to the titanium surface area of the circumferential surface.

A steering controller for an electric power steering device 110 includes a base signal computing part 51 for computing a base signal D_T in accordance with at least the steering torque; a damper compensation signal computing part 52 for computing a damper compensation signal in accordance with an angular velocity of an electric motor 4 or a speed of steering wheel turn; and an inertia compensation signal computing part 53 for compensating inertia and viscosity in the steering unit. The electric motor is driven by a target signal IM₁ obtained by compensating the base signal with a damper compensation signal and an inertia compensation signal, to provide a steering auxiliary force. The target signal of the auxiliary torque is compensated so that a difference between a reference self-aligning torque of front wheel in a front wheel steering vehicle and a self-aligning torque of front wheel in an all-wheel steering vehicle is provided to a driver as a responsive feeling from the steering torque.

The invention relates to a bioabsorbable surgical osteosynthesis plate, operable to be secured by at least one fastener through at least one fastener opening formed in the plate to a bone. The osteosynthesis plate has first and second surfaces, and it is formed to one piece from a bioabsorbable polymer material that is oriented multiaxially and is substantially rigid and substantially deformable at a first thermochemical state. The plate comprises an oblique (diagonal) orientation gradient in relation to the direction of a reference axis of the plate.

The invention provides a self-plugging releasing temperature resistant temporary plugging agent used for water-based drilling fluid, the self-plugging releasing temperature resistant temporary plugging agent comprises nano calcium carbonate and a product which is obtained by reacting starch, alkali metal hydroxide, halogenated organic acid, carbonate, a hydrophobic modification agent and alcohol with water. The invention also provides a preparation method of the self-plugging releasing temperature resistant temporary plugging agent used for the water-based drilling fluid, and the self-plugging releasing temperature resistant temporary plugging agent used for the water-based drilling fluid can be obtained by proportionally adding components into a kneading machine for kneading. The self-plugging releasing temperature resistant temporary plugging agent has strong high temperature resistance, and can resist the temperature up to 140 DEG C; and the self-plugging releasing temperature resistant temporary plugging agent has good temporary plugging effect and significant reservoir protection effect, and the water-based drilling fluid added with the temporary plugging agent has high temporary plugging rate and oil phase permeability recovery rate; at the same time, the temporary plugging agent has self-plugging releasing ability. During the late flowback, the self-plugging releasing can be realized by formation of a hydrophobic channel without acid washing for mud cake removal and other processes, and secondary damage to a reservoir can be avoided.

A recombinant DNA containing a sequence (1) coding for a polypeptide heterologous to a filamentous haemagglutinin of Bordetella (Fha) fused within the reading frame to a sequence (2) located upstream from the first sequence. Sequence (2) codes for at least part of the Fha precursor, which part comprises at least the N-terminal region of a truncated mature Fha protein, which contains the interaction site of Fha and heparin and the secretion domain. This Fha protein is under the control of a promoter recognized by the cell polymerases of B. pertussis and is inserted into a B. pertussis cell culture, is expressed in the culture and excreted into the cell culture medium. The invention uses both the abilities of Bordetella and particularly B. pertussis to secrete or surface expose the heterologous polypeptide fused to the Fha portion corresponding to sequence (2), which does not appear to produce extracellular proteases, and the ease with which filamentous haemagglutinins can be isolated from other Bordetella proteins.

Disclosed is a biological molecule-immobilized carbon membrane which comprises a porous carbon membrane and a biological molecule (e.g., an enzyme) immobilized on the carbon membrane, wherein the porous carbon membrane has three-dimensional cancellous pores through which fluid can permeate. The carbon membrane can have a large amount of a biological molecule (e.g., an enzyme) immobilized thereon and can also have a higher level of enzymatic activity or the like compared to a conventional one. Therefore, the carbon membrane is useful as an electrode for a bio-sensor or a bio-fuel cell.

A light emitting diode (LED) based luminaire driving arrangement constituted of: a switched driver; a plurality of LED based luminaires arranged to receive power from the switched driver; at least one electronically controlled switch in series with at least one of the plurality of LED based luminaires and arranged to alternatively pass current through the at least one LED based luminaire when closed and prevent the flow of current through the at least one LED based luminaire when opened; and at least one synchronous driver in communication with the at least one electronically controlled switch, the at least one synchronous driver arranged to close the at least one electronically controlled switch only when the switched driver is actively supplying power.

An ultrasonic device is provided for training a dog to cease from certain undesirable behaviors using a short ultrasonic burst that sweeps across multiple frequencies in one of several user-selected ranges. The user can program the device to a particular range by stepping through the available frequency ranges and noting the animal's response to ultrasonic bursts at each frequency range. Once the frequency range most disturbing to the animal has been identified, the user can set the device to operate in that range. In response to bark detection in an automatic mode or to a manual trigger in either an automatic or manual mode of operation, the device administers a short ultrasonic burst in the programmed frequency range for a fixed time duration. When triggered manually, the length of the burst is the same regardless of how long the manual trigger remains activated.

An artificial tendon, ligament, bone and skin panel are provided, made of biocompatible materials and capable of being seeded and eventually coated with selected cell types. Seeded or coated artificial tendon, ligament, bone or skin panels can be shaped and implanted in mammals. Implantable cell growth cages may be seeded with selected cell types and used to produce desired gene expression products within a mammal. Gene expression products may be harvested from transfected animal cells cultured in a cell growth chamber.

A preparation method of graphene comprises the steps of: dispersing the graphite in an ionic liquid to form a mixture of graphite and ionic liquid; placing the mixture of graphite and ionic liquid in a ball-milling container, adding milling balls to carry out ball-milling, so as to obtain a slurry; taking the slurry out of the ball-milling container, separating the milling balls and conducting centrifugation and separation to obtain a graphene solution; and carrying out filtering, washing and drying treatment on the graphene solution to obtain the graphene. The ball milling method uses the ion liquid as a solvent to prepare the graphene with good dispersion, effectively prevents re-agglomeration of the graphite, and realizes large reaction amount, high yield and high specific surface area of the obtained graphene.

A therapeutic composition comprising (i) at least one antigen or at least one in vivo generator of a compound comprising an amino acid sequence and (ii) at least one adjuvant comprising at least one pharmaceutically acceptable and water-soluble salt of an organic anion and a metal cation.

Methods, combinations and compositions for relieving or preventing the effects of stress are provided. In particular, combinations and compositions comprising cis-3-hexen-1-ol, trans-2-hexenal and α-pinene, articles of manufacture impregnated with the combination or composition and methods of relieving stress by exposure to the combination or composition are described.

A method for removing a ceramic core of a hollow blade of a turbine of an aircraft engine comprises the four steps of primary core removing, secondary core removing, third core removing and ultrasonic cleaning. The concentration of KOH alkali liquor used in primary core removing is 40%, the concentration of KOH alkali liquor used in secondary core removing is 30%, and the concentration of KOH alkali liquor used in third core removing is 40%. Every time core removing is conducted, the temperature of the alkali liquor ranges from 160 DEG C to 200 DEG C, the pressure of the alkali liquor fluctuates between 0.4 MPa and 0.5 MPa, water is added every six hours, and soaking time is 48 hours. According to the method, the concentration of the alkali liquor is reduced, the water is added every six hours, and it is guaranteed that salt generated due to reactions is sufficiently dissolved; the alkali liquor is replaced every 48 hours, the concentration of the alkali liquor changes in a stepped mode, and it can be guaranteed that the chemical reactions are conducted effectively; the pressure of the alkali liquor fluctuates in a pulse mode, core cracking can be facilitated, the reaction interface between the alkali liquor and the core is enlarged, and the reacting dose is increased. Through the method, the ceramic core removing period can be shortened to six days from over twenty days, and the first pass yield of core removing can be higher than 90%.

An apparatus for deriving a directional information from a plurality of microphone signals or from a plurality of components of a microphone signal, wherein different effective microphone look directions are associated with the microphone signals or components, has a combiner configured to obtain a magnitude value from a microphone signal or a component of the microphone signal. The combiner is further configured to combine direction information items describing the effective microphone look directions, such that a direction information item describing a given effective microphone look direction is weighted in dependence on the magnitude value of the microphone signal, or of the component of the microphone signal, associated with the given effective microphone look direction, to derive the directional information.

Embodiments of the present invention relate to a biodegradable scaffold for replacing tissue or inducing tissue regeneration and a preparation method thereof, wherein the scaffold comprises at least one woven silk tube layer and a collagen layer inside the tube layer. The scaffold is excellent in terms of tissue regeneration and mechanical properties and causes little or no immune response after implantation. Thus, the scaffold can be effectively used as a matrix for the regeneration of ligaments and tendons and the repair of injured muscles.

The present application discloses a microfluidic chip, a production method and an in-situ catalysis and detection method thereof, wherein a periodic peak microstructure is processed inside a silicon-based Y type channel. According to the present invention, after the black silicon surface is subjected to hydrogenation treatment with hydrofluoric acid, the in-situ chemical growth of silver nanoparticles on the peak microstructure surface can be achieved, such that the catalytic reaction efficiency and the reaction activity of the reduction of p-nitrophenol into p-aminophenol are improved by using the large specific surface area and the roughness of the Ag-black silicon composite structure (Ag-BS); the surface plasma resonance motif is easily formed with the Ag-BS composite structure so as to be used for surface-enhanced Raman scattering (SERS) detection; and the Ag-BS micro-nano-structure composite device has wide application prospects in highly integrated chemical synthesis, analysis, biosensing, diagnosis and other fields.