Neural crest cell culture fluid, preparation method of neural crest mesenchymal stem cells and application of neural crest mesenchymal stem cells

A technology of stem cells and cell culture, applied in the field of stem cells and regenerative medicine, can solve the problems of long-term cell survival, heterogeneity and functional instability, and limit the wide application of MSCs in clinical practice
CN110241084APending Publication Date: 2019-09-17SHENZHEN RES INST THE CHINESE UNIV OF HONG KONG
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHENZHEN RES INST THE CHINESE UNIV OF HONG KONG
Publication Date
2019-09-17

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Abstract

The invention relates to the field of stem cells and regenerative medicine, and particularly relates to neural crest cell culture fluid, a preparation method of neural crest mesenchymal stem cells and an application of the neural crest mesenchymal stem cells. Experimental results of the invention show that mesenchymal stem cells of the neural crest stem cell lineage, induced and differentiated by human totipotent stem cells, can obviously improve neurological dysfunctions, reduce an area of an ischemic region, inhibit immune reactions and promote endogenous repairs of brain tissues in a neonatal rat hypoxic-ischemic model, thereby proving that human neural crest-derived mesenchymal stem cells have effects of significantly improving the inflammatory reaction of neonates with ischemic and anoxic encephalopathy and effectively promoting the neural function recovery. The invention also provides a test index for identifying the activity of the neural crest mesenchymal stem cells.
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Description

technical field

[0001] The invention relates to the field of stem cells and regenerative medicine, in particular to a neural crest cell culture medium, a preparation method of neural crest mesenchymal stem cells and an application of neural crest mesenchymal stem cells. Background technique

[0002] Neonatal hypoxic-ischemic encephalopathy (Hypoxic-ischemic Encephalopathy, HIE) is the brain damage caused by hypoxia and ischemia caused by various perinatal factors, and is the most common cause of neurological disability in children. In the past 20 years, due to the advancement of obstetrics and newborn care technology, on the one hand, the survival rate of newborns has increased due to successful rescue, and on the other hand, the incidence of HIE and its sequelae has increased significantly. There are 18 million to 20 million live births in my country every year, and the incidence rate of suffocation is 13.6%, of which 15.6% are disabled. As a result, about 300,000 disabled ...

Claims

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