Oryzanol containing soft capsule preparation method

A technology of oryzanol and soft capsules, which is applied in the field of preparation of oryzanol-containing soft capsules, can solve the problems of low bioavailability, inconvenient use, and insignificant curative effect of tablets, and achieve the goal of improving endocrine balance disorders, improving sleep, reducing Painful effects of medication

Inactive Publication Date: 2006-02-22
石家庄开发区达为医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the low bioavailability of the tablet, it is not easy to be absorbed by the body, and the curative effect is not significant, while the injection needs to be injected deep into the muscle, which is inconvenient to use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take by weighing 5 grams of oryzanol, dissolve in acetone, and freeze-dry quickly to obtain fluffy oryzanol micropowder. Another 200 grams of edible oil is weighed and placed in a batching device, and an appropriate amount of surfactant is added and stirred. Add the pretreated oryzanol micropowder into the batching device under stirring, pass through the colloid mill, and let it stand for defoaming. Put the prepared liquid on the soft capsules machine-packed into capsules, and after drying, 1000 finished oryzanol soft capsules are obtained.

[0018] The oryzanol micropowder can also be prepared by dissolving it in acetone, spray drying, or pulverizing oryzanol with a jet mill. The medicine also adds other pharmacological substances Panax notoginseng or the extract of safflower or Chuanxiong or the effective parts or active ingredients in the extract. The edible oil can be rice sugar oil, soybean oil, peanut oil, corn oil, rapeseed oil, safflower oil, sesame oil, olive...

Embodiment 2

[0020] Take by weighing 20 grams of oryzanol, dissolve in acetone, and freeze-dry quickly to obtain fluffy oryzanol micropowder. In addition, take 500 grams of edible oil and place it in a batching device, add an appropriate amount of surfactant, and stir. Add the pretreated oryzanol micropowder into the batching device under stirring, pass through the colloid mill, and let it stand for defoaming. Put the prepared liquid on the soft capsules machine-packed into capsules, and after drying, 1000 finished oryzanol soft capsules are obtained.

[0021] The oryzanol micropowder can also be prepared by dissolving it in acetone, spray drying, or pulverizing oryzanol with a jet mill. The medicine also adds other pharmacological substances Panax notoginseng or the extract of safflower or Chuanxiong or the effective parts or active ingredients in the extract. The edible oil can be rice sugar oil, soybean oil, peanut oil, corn oil, rapeseed oil, safflower oil, sesame oil, olive oil, fis...

Embodiment 3

[0023] Take by weighing 40 grams of oryzanol, dissolve in acetone, and freeze-dry quickly to get fluffy oryzanol micropowder. In addition, take 600 grams of edible oil and place it in a batching device, add an appropriate amount of surfactant, and stir. Add the pretreated oryzanol micropowder into the batching device under stirring, pass through the colloid mill, and let it stand for defoaming. Put the prepared liquid on the soft capsules machine-packed into capsules, and after drying, 1000 finished oryzanol soft capsules are obtained.

[0024] The oryzanol micropowder can also be prepared by dissolving it in acetone, spray drying, or pulverizing oryzanol with a jet mill. The medicine also adds other pharmacological substances Panax notoginseng or the extract of safflower or Chuanxiong or the effective parts or active ingredients in the extract. The edible oil can be rice sugar oil, soybean oil, peanut oil, corn oil, rapeseed oil, safflower oil, sesame oil, olive oil, fish o...

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PUM

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Abstract

The present invention is preparation process of soft medicine capsule containing oryzanol. The preparation process includes the following steps: preparing fine powder with oryzanol in 5-40 or 100-300 weight portions; mixing edible oil in 200-1200 weight portions and proper amount of surfactant inside the mixer via stirring; mixing the fine oryzanol powder and the edible oil; milling in colloid mill and letting stand to eliminate bubble; capsulizing the compounded liquid, and drying to obtain the soft oryzanol capsule. The present invention may be absorbed by human body and has high bioavailability.

Description

technical field [0001] The invention relates to a preparation method of soft capsule medicine containing oryzanol. Background technique [0002] Oryzanol is a mixture of ferulic acid esters with cycloartenol as the main body, also known as ferulic acid esters, the English name is r-oryzanol, and it mainly exists in rice bran oil. Oryzanol is white or off-white crystalline powder, odorless; soluble in chloroform and acetone, slightly soluble in ethanol or n-heptane, insoluble in water. Because oryzanol acts on the human body to treat many diseases, its clinical application is extremely extensive. However, the dosage form of oryzanol widely used clinically is tablet, each tablet contains 10 mg of oryzanol, and the usage and dosage are as follows: 10-20 mg orally each time, 3 times a day. Another clinically available oryzanol dosage form is injection, a light yellow clear oily liquid with a specification of 2ml: 40mg. The clinical indications include primary dysmenorrhea in a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/215A61K31/56A61K36/258A61K36/286A61K36/23A61K9/48A61P25/00A61P15/12A61P15/00
Inventor 马志梅
Owner 石家庄开发区达为医药科技有限公司
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