Application of tristilbeside in the preparation of drugs for improving microcirculation disorder

Abstract

The invention discloses an application of tristilbene in the preparation of a drug for improving microcirculation disorder, using tristilbene as an effective active ingredient, and its structural formula is: adding one or more pharmaceutically acceptable auxiliary agents, In particular gastrodin and / or water soluble cyclodextrin derivatives as well as PEG400 and mannitol. Using trizaperine as an effective active ingredient, it is used to improve the disorder caused by cerebral microvascular injury and / or the disorder caused by ischemia-reperfusion injury and / or the disorder caused by leukocyte adhesion damage and / or the disorder caused by peroxide. The application of the drug causing the disorder. The present invention uses normal mice of Kunming species and artificially induced microcirculation disorder model mice, injects administration through tail vein, and observes contraction of arterioles and venules and capillary network under a microcirculation microscope and shows that: all blood vessels of normal mice have The obvious expansion effect can obviously resist the contraction of arterioles and venules and the reduction of the opening number of capillary network in the model mice of microcirculation disorder, and can obviously resist the slowing down of blood flow velocity.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and in particular relates to an application of tristilbene in the preparation of medicines for improving blood microcirculation disorders. Background technique [0002] Microcirculation refers to the circulation of blood between arterioles and venules. The basic function of microcirculation is to exchange substances between blood and interstitial fluid. Under normal circumstances, the blood flow of the microcirculation adapts to the metabolic level of tissues and organs, ensuring the blood perfusion of various tissues and organs and regulating the amount of blood returned to the heart. If the microcirculation is disturbed, it will directly affect the physiological functions of various organs. The walls of arterioles, posterior arterioles, capillary anterior sphincters, and venules mainly contain smooth muscles, and their diastolic and contractile activities directly affect the blood flow in t...

AI Technical Summary

Problems solved by technology

[0007] In view of the shortcomings of the current drugs for the treatment of microcirculation disorders, such as single function, poor curative effect, and large toxic and side effects, people pay more attention to finding, researching and developing ideal drugs for treating microcirculation disorders from traditional medicine herbal medicines

Although polydatin or its salt, Panax notoginseng saponins, and ginsenoside monomer Rb have also been developed successively in recent years. 2 , calcium dobesilate and kudzu root flavonoid composition, ginsenoside and breviscapine composition, etc. are used in the treatment of microcirculation disorders, but there are still some aspects such as insignificant clinical effect, large side effects, and difficulty in controlling addiction lack of

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