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Pharmaceutical formula with functions of tonifying kidney and reducing phlegm as well as promoting blood circulation and inducing resuscitation

A technology for promoting blood circulation, invigorating kidney and resolving phlegm, which can be used in drug combinations, pharmaceutical formulations, active ingredients of hydroxyl compounds, etc., and can solve problems such as no breakthrough progress.

Inactive Publication Date: 2018-05-04
YANKUANG GRP CO LTD GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In terms of treatment methods, they are still limited to the prevention and treatment of VD risk factors and the application of some neurotransmitter-related drugs, neurotrophic drugs, cerebral vasodilators, and smart drugs. Most of these treatment strategies for a single target are only symptomatic. , from the perspective of treatment effect, there is no breakthrough progress, and its curative effect and long-term toxic and side effects still need further research

Method used

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  • Pharmaceutical formula with functions of tonifying kidney and reducing phlegm as well as promoting blood circulation and inducing resuscitation
  • Pharmaceutical formula with functions of tonifying kidney and reducing phlegm as well as promoting blood circulation and inducing resuscitation
  • Pharmaceutical formula with functions of tonifying kidney and reducing phlegm as well as promoting blood circulation and inducing resuscitation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A medicinal prescription for invigorating the kidney, resolving phlegm, promoting blood circulation and resuscitating one's senses, in parts by weight, comprising 15 parts of rehmannia glutinosa, 15 parts of sealwort, 12 parts of cornus, 6 parts of notoginseng, 12 parts of Chuanxiong, 15 parts of salvia miltiorrhiza, and 15 parts of gastrodia elata , 15 parts of Poria cocos, 12 parts of Shichangpu, 12 parts of ginger Pinellia, 15 parts of Ganoderma lucidum, 24 parts of Astragalus, 20 parts of Cistanche, 0.1 part of borneol.

[0020] The above-mentioned medicines are prepared according to the traditional Chinese medicine decoction method, and the solid content of the soup is 10wt%.

Embodiment 2

[0021] Embodiment 2: animal experiments

[0022] Selected objects: 20 15-month-old Wistar male rats were used to establish the IBO dementia rat model group.

[0023] The above-mentioned dementia rats were divided into 2 groups, respectively a model group and a drug group, 10 in each group, wherein, the model group was intraperitoneally injected with 2ml of ultrapure water every day, and the drug group was injected with 2ml of the drug decoction prepared in Example 1 every day , after 10 weeks of feeding and injection, each animal was subjected to 5 Y-maze experiments.

[0024] Experimental results: the rats in the drug group performed the Y-maze correctly for a total of 38 times, while the rats in the model group performed the Y-maze correctly for a total of 12 times. It can be seen that the prescription of nourishing the kidney, activating blood and resuscitation can significantly improve the correct number of Y-maze in demented rats.

Embodiment 3

[0025] Embodiment 3: clinical trial

[0026] 1. Case selection:

[0027]1.1 Diagnostic criteria:

[0028] 1.1.1 Western medicine diagnostic criteria for vascular dementia: The diagnostic criteria for VD in the American "Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition)" (DSM-IV) were adopted. There is a causal relationship between dementia and stroke, and dementia appears within 3 months after a definite stroke; sudden onset or fluctuating, step-like development of the disease course; through imaging examinations, including CT, MRI, etc. Related cerebrovascular disease basis.

[0029] 1.1.2 Diagnostic criteria for the degree of dementia: using the revised 1975 Folstein et al Mini-Mental State Examination (MMSE-R) (Table 2) and the 1993 Morris-revised Clinical Dementia Rating Scale (CDR), the degree of dementia (mild, moderate , heavy) judgment. CDR=0 means no dementia, CDR=0.5 means suspicious dementia, CDR=1.0 means mild dementia, CDR=2.0 means modera...

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Abstract

The invention relates to a pharmaceutical formula with functions of tonifying kidney and reducing phlegm as well as promoting blood circulation and inducing resuscitation. The pharmaceutical formula comprises the following raw materials in parts by weight: 10-20 parts of radix rehmanniae preparata, 10-21 parts of rhizoma polygonati, 8-16 parts of fructus corni, 2-8 parts of radix notoginseng, 8-14parts of rhizoma chuanxiong, 10-20 parts of radix salviae miltiorrhizae, 10-20 parts of rhizoma gastrodiae, 9-20 parts of poria cocos, 8-16 parts of rhizoma acori graminei, 8-17 parts of rhizoma pinelliae, 10-20 parts of lucid ganoderma, 20-30 parts of radix astragali seu hedysari, 15-30 parts of herba cistanche and 0.1-0.2 part of borneol. Due to the compatibility of medicines, the pharmaceutical formula has the function of nourishing kidney and strengthening essence, tranquilizing mind and promoting intelligence, reducing phlegm and inducing resuscitation, activating blood to dredge vesselsas well as removing blood stasis and promoting fresh blood production. The pharmacological action of the pharmaceutical formula is consistent with modern medical treatment principle of vascular dementia, and comprises increment of blood flow in the ischemic regions, improvement of brain metabolism and free radical metabolism, and the like; therefore, the pharmaceutical formula provides a theoretical basis for the treatment of the vascular dementia.

Description

technical field [0001] The invention relates to a medicinal prescription, in particular to a traditional Chinese medicine prescription which is effective in treating vascular dementia by invigorating the kidney and resolving phlegm, promoting blood circulation and resuscitating one's mind. Background technique [0002] Vascular dementia (VD) refers to dementia caused by brain damage caused by ischemic and hemorrhagic cerebrovascular diseases. With the aging of the population and the rising incidence of cerebrovascular diseases, the number of VD patients is increasing day by day. Severe VD patients have obvious personality disorders and cannot take care of themselves, which brings a great burden to the family and society. [0003] Although there is no name for the disease "vascular dementia" in Chinese medicine, the main clinical symptoms are forgetfulness, dullness, stupidity, ignorance, and stupidity. Dementia" and other categories. Ancient TCM literature has long record...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61P25/00A61P7/00A61K31/045
CPCA61K31/045A61K36/074A61K36/076A61K36/236A61K36/258A61K36/40A61K36/481A61K36/537A61K36/64A61K36/804A61K36/888A61K36/8888A61K36/8969A61K36/8988A61K2300/00
Inventor 许兰兰李召燕刘玉
Owner YANKUANG GRP CO LTD GENERAL HOSPITAL
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