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Pharmaceutical composition for treating stroke and preparation method thereof

A composition and stroke technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of activation, differentiation, and proliferation of neural stem cells that have not been reported in the literature, so as to improve brain blood supply, Increase the effect of new blood vessels and promote the recovery of nerve function

Inactive Publication Date: 2015-03-04
孟萍萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern pharmacological studies have shown that Wortia chinensis has a better effect on the anti-proliferation of human colon cancer cells, but there is no literature reporting that it has the biological activity of activating, differentiating, and proliferating neural stem cells

Method used

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  • Pharmaceutical composition for treating stroke and preparation method thereof
  • Pharmaceutical composition for treating stroke and preparation method thereof
  • Pharmaceutical composition for treating stroke and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of embodiment 1 Coriander flower extract

[0026]0.825 kg of dried sage flower raw materials, crushed to about 60 mesh, first leached with hot water ultrasonically, the extraction conditions are: solid-liquid ratio 1:15 (kg / L), temperature 65 ° C, ultrasonic frequency 40 Hz, repeated extraction 2 times; filter, discard the filtrate, filter residue with dichloromethane / methanol (volume ratio 2:1) ultrasonic assisted leaching, extraction conditions: solid-liquid ratio 1:12 (kg / L), water bath temperature 68 ℃, The ultrasonic frequency was 35Hz, and the extraction was repeated 3 times; the filtrate was collected by filtration, evaporated under reduced pressure and concentrated to dryness to obtain an extract, freeze-dried, pulverized into fine powder, and passed through a 100-mesh sieve to obtain the extract of the sage flower.

Embodiment 2

[0027] The preparation of embodiment 2 Orangis flower extract

[0028] 1.5kg of dry scallop flower raw materials were crushed, passed through a 60-mesh sieve, and leached with hot water ultrasonically. The leaching conditions were: solid-liquid ratio 1:10 (kg / L), temperature 62°C, ultrasonic frequency 40Hz, repeated Extract 2 times; filter, discard the filtrate, filter residue with dichloromethane / methanol (volume ratio 2:1) ultrasonic assisted leaching, leaching conditions: solid-liquid ratio 1:9 (kg / L), water bath temperature 68°C , ultrasonic frequency 35Hz, repeated extraction 3 times; filtrate was collected by filtration, evaporated under reduced pressure and concentrated to dryness to obtain extract, freeze-dried, pulverized into fine powder, and passed through a 100-mesh sieve to obtain the extract of Wingweed flower.

Embodiment 3

[0029] The preparation of embodiment 3 granules

[0030]

[0031] Preparation process: Pass the extract of Orangis chinensis flower prepared in Example 2 through a 100-mesh sieve, and pass through a sieve of 80 mesh for lactose, microcrystalline cellulose and low-substituted hydroxypropyl cellulose, and weigh the prescription amount of Orangis chinensis flower extract and lactose, Mix low-substituted hydroxypropyl cellulose and microcrystalline cellulose evenly, add an appropriate amount of 8% hydroxypropyl methylcellulose solution to granulate, dry at 60°C, granulate with a 16-mesh sieve, and add stearic acid in the prescribed amount to the dry granules Magnesium mix well, pack.

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Abstract

The invention discloses a pharmaceutical composition for treating stroke and a preparation method thereof. The pharmaceutical composition for treating stroke is prepared from polygonum oriental flower extract and pharmaceutically available auxiliary materials, wherein the polygonum oriental flower extract is obtained by extracting herb residue (obtained after water extraction is carried out on polygonum oriental flowers) in a dichloromethane-methyl alcohol mixed solution, can be used for activating endogenous neural stem cells, increasing new vessels in an ischemic region, improving blood supply in the ischemic region and promoting neural functional recovery and can be developed into a medicinal preparation for treating ischemic stroke.

Description

technical field [0001] The invention belongs to the technical field of plant extraction, and in particular relates to a pharmaceutical composition for treating cerebral apoplexy and a preparation method thereof. Background technique [0002] Stroke is the fourth leading cause of death in the world, second only to cardiovascular diseases, tumors and chronic lower respiratory diseases, and it is also one of the most important causes of lifelong disability. Among them, about 80% of the patients are ischemic strokes, the main cause of which is insufficient blood supply and oxygen supply to brain tissue caused by cerebral vascular obstruction or cerebral hemorrhage. It is predicted that the cost of stroke treatment in the United States from 2005 to 2050 will be about 152 billion U.S. dollars based on the purchasing power in 2005, which has caused a huge burden on the economy and health. In China, with economic development, changes in people's lifestyles and population aging, the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61P9/10
CPCA61K36/704A61K9/1652A61K2236/331A61K2236/333A61K2236/39
Inventor 孟萍萍张树超王强刘淑芹柏广涛
Owner 孟萍萍
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