1168 results about "Heart atrium" patented technology

Interatrial shunts are described herein that are designed to benefit both the left side of the heart and the right side of the heart. The interatrial shunt is anchored in the atrial septum to permit blood to flow between atrial heart chambers across the atrial septum. In accordance with some aspects, the lumen of the shunt has an effective orifice area selected to permit blood flow across the atrial septum to unload the patient's left ventricle with beneficial effects on the patient's right ventricle. The shunts are structured to be suitably anchored at the atrial septum for long-term implantation. Further, the shunts preferably have insignificant late lumen loss. The interatrial shunts are expected to treat pathologies such as heart failure and pulmonary hypertension.

The invention discloses a test system and method for an artificial heart valve implant, and relates to the technical field of medical instrument detection. The system comprises a ventricle simulator, an atrium simulator, a circulation loop, a high-speed camera and a laser generator, wherein an artificial heart valve is arranged in the high-transparency compliance valve testing cavity, and the circulation loop is composed of a blood vessel compliance simulator and a blood vessel damping simulator. The circulation loop simulates a blood flowing environment for the artificial heart valve, and a flowing medium is added with tracer particle turbid liquid; the ventricle simulator, the atrium simulator, the vascular damper and the vascular compliance simulator respectively provide power, storage space, resistance and pulse pressure for the flowing medium; and the laser generator and the high-speed camera act together to obtain a particle image behind the artificial heart valve. The particle image is uploaded to a computer for heart valve pulsating flow field visualization analysis based on the digital particle image velocity measurement technology, and therefore quantitative analysis of the risk after the heart valve is implanted into the expected position is achieved.

The present invention provides a prosthetic heart valve device with improved fit and / or apposition between the device frame and left atrial tissue and / or the device base and the annular tissue of the left atrium to improve shifting of the implanted device and / or mitigate paravalvular leakage. The improved fit and / or apposition arises in various embodiments by providing or allowing an asymmetrical frame and / or frame base and / or providing a lower lip to aid in conforming to the asymmetrical shape of the atrium and / or ensure firm positioning therein. An additional benefit of these arrangement(s) is mitigation of paravalvular leakage as a result of improved fit and seal. In certain embodiments, the asymmetry of the frame assists with delivery of the device into the atrium.

To provide a device assembly and a method for treating heart failure by normalizing an elevated blood pressure in the left atrium of the heart of a mammal.SOLUTION: Disclosed herein is a transcatheter interatrial septum excision device assembly configured to create a sized interatrial aperture between right and left atria of a heart for relief of an elevated left atrial pressure. The device assembly comprises a delivery catheter, a tissue stabilizer attached to a first catheter having a central lumen and a penetrating tip that permits passage of a guidewire, and a cutter attached to a second catheter having a central lumen that permits passage of the first catheter. Alternative configurations comprise a (third) catheter having a central lumen that permits passage of the components to and from the right atrium, a tissue retention mechanism, and an optional coaxial alignment mechanism.SELECTED DRAWING: Figure 1

Systems for delivering a device for regulating blood pressure across a patients atrial septum are provided. The delivery apparatus may include a first catheter, a hub having one or more engagers disposed thereon, the one or more engagers configured to releasably engage with a first expandable end of the shunt in a contracted delivery state within a lumen of a sheath, and an second catheter extending through a center lumen of the first catheter and the hub, wherein the first catheter, the hub, and the second catheter are independently moveable relative to the sheath. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits. The inventive devices also may be used to treat subjects having heart failure, pulmonary congestion, or myocardial infarction, among other pathologies.

Implants, implant systems, and methods for treatment of mitral valve regurgitation and other valve diseases generally include a coaptation assist body which remains within the blood flow path as the leaflets of the valve move, the valve bodies often being relatively thin, elongate (along the blood flow path), and / or conformable structures which extend laterally from commissure to commissure, allowing the native leaflets to engage and seal against the large, opposed surfaces on either side of the valve body during the heart cycle phase when the ventricle contracts to empty that chamber of blood, and allows blood to pass around the valve body so that blood flows from the atrium to the ventricle during the filling phase of the heart cycle. Separate deployment of independent anchors near each of the commissures may facilitate positioning and support of an exemplary triangular valve body, with a third anchor being deployed in the ventricle. An outer surface of the valve body may accommodate tissue ingrowth or endothelialization, while a fluid-absorbing matrix can swell after introduction into the heart. The valve body shape may be selected after an anchor has been deployed, and catheter-based deployment systems may have a desirable low profile.

A normothermic perfusion circuit can be used to perfuse a donor heart after transportation and before transplantation. The circuit can drain the organ storage container of cold preservation solution, perfuse the aorta of the heart with warm fluid to initiate heart activity, and then perfuse the left atrium of the heart with warm fluid to bolster heart activity and evaluate heart viability. Heart viability can be determined using parameters measured by sensors in the circuit.

A normothermic perfusion circuit can be used to perfuse a donor heart after transportation and before transplantation. The circuit can drain the organ storage container of cold preservation solution, perfuse the aorta of the heart with warm fluid to initiate heart activity, and then perfuse the left atrium of the heart with warm fluid to bolster heart activity and evaluate heart viability. Heart viability can be determined using parameters measured by sensors in the circuit.

Devices are provided with an internal dimension that can be reduced and increased in vivo. In one example, an interatrial shunt for placement at an atrial septum of a patient's heart includes a body. The body includes first and second regions coupled in fluid communication by a neck region. The body includes a shape-memory material. The body defines a passageway through the neck region for blood to flow between a first atrium and a second atrium. The first and second regions are superelastic at body temperature, and the neck region is malleable at body temperature. A flow area of the passageway through the neck region may be adjusted in vivo.

An asymmetric device for regulating blood volume distribution across a patient's atrial septum having a first expandable end region and a second expandable end region. The first expandable end region is transitionable from a contracted delivery state to an expanded deployed state in which the first expandable end region extends into the patient's left atrium and an inlet end of the first expandable end region is in a first plane. The second expandable end region is transitionable from a contracted delivery state to an expanded deployed state in which the second expandable end region extends into the patient's right atrium and an outlet end of the second expandable end region is in a second plane, such that the first plane intersects the second plane. The device further includes a neck region joining the first expandable end region to the second expandable end region, wherein the neck region is sized and shaped for placement in the patient's atrial septum.

Systems, methods, and devices allow intravascular or percutaneous mapping, orientation and / or ablation, in bodily cavities or lumens. A device includes elongate members, moveable between an unexpanded configuration and an expanded or fanned configuration. The elongate members form a stack in the unexpanded configuration to fit through a catheter sheath. The elongate members follow respective arcuate or curvilinear paths as advanced from the sheath into the bent or coiled stack configuration, adopting volute, scroll or rho shapes, and may be nested. The elongated members are fanned or radially spaced circumferentially with respect to one another into the expanded or fanned configuration. Transducer elements carried by elongate members sense various physiological characteristics of or proximate tissue, and / or may apply energy to or proximate tissue. The elongate members are rotatable in groups or as a group in the expanded configuration. The device is retractable.

Methods and systems for automated electrocardiogram (ECG) analysis using neural networks, enhancing the accuracy of beat-by-beat cardiac monitoring. The system utilizes a Generative Adversarial Network (GAN) and beat classifiers to analyze ECG data and detect conditions various beast properties of an ECG at a discrete level. Additional neural networks may be trained to detect beat based conditions such as premature atrial contractions (PACs) and premature ventricular contractions (PVCs). The GAN generates realistic ECG beats, while classifiers detect abnormalities. Additional transformers may be trained to detect rhythm based conditions such as AFib and Aflutter. Methods and Systems support real-time cardiac health insights and integrates with ECG devices for continuous monitoring, offering a robust solution for improving diagnostic accuracy.

To provide a system for transmitting blood pressure reduction electrical stimulation to the heart of a patient capable of determining a desirable AV delay.SOLUTION: The atrium is paced and the ventricle is paced with a given (arbitrary) delay to obtain a desired blood pressure change. Then, the atrium is sensed, the ventricle is paced, the blood pressure change is observed, and the resulting blood pressure change is compared with the paced-atrium-paced-ventricle desired blood pressure change. In the case where the blood pressure changes are not substantially equal, the timing of the sensed-atrium-paced-ventricle stimulation is adjusted on the basis of the comparison. The new modified resulting blood pressure change is observed, and the modified blood pressure change is compared with the paced-atrium-paced-ventricle desired blood pressure change. Adjustment and observation may be repeated until the timing of the sensed-atrium-paced-ventricle stimulation achieves the same blood pressure change as the desired blood pressure change of the paced-atrium-paced-ventricle stimulation.SELECTED DRAWING: Figure 9

Coaptation assist device for repairing cardiac valves and associated systems and methods are disclosed herein. A coaptation assist device configured in accordance with embodiments of the present technology can include, for example, a fixation member configured to press against cardiac tissue proximate to a native valve annulus, and a stationary coaptation structure extending away from the fixation member. The coaptation structure can include an anterior surface configured to coapt with a first native leaflet during systole and a posterior surface configured to displace at least a portion of a second native leaflet. The device also includes at least one sensor configured to detect parameters associated with at least one of cardiac function and device functionality. The sensors can be pressure sensors configured to detect left atrial pressure and / or left ventricular pressure.

Systems and methods for controlling blood pressure by controlling atrial pressure and atrial stretch are disclosed. In some embodiments, a stimulation circuit may be configured to deliver a stimulation pulse to at least one cardiac chamber of a heart of a patient, and at least one controller may be configured to execute delivery of one or more stimulation patterns of stimulation pulses to the at least one cardiac chamber, wherein at least one of the stimulation pulses stimulates the heart such that an atrial pressure resulting from atrial contraction of an atrium overlaps in time a passive pressure build-up of the atrium, such that an atrial pressure of the atrium resulting from the stimulation is a combination of the atrial pressure resulting from atrial contraction and the passive pressure build-up and is higher than an atrial pressure of the atrium would be without the stimulation, and such that the blood pressure of the patient is reduced.

For repairing a valve situated between an atrium and a ventricle of a heart of a subject, and having a first leaflet and a second leaflet, apparatus is provided that includes an implant and a delivery tool. The implant includes a flexible patch defining slots along an edge of the patch; a first anchor; and a second anchor. The delivery tool is adapted to transluminally deliver the implant to the heart; and implant the implant in the ventricle by securing the patch against a ventricular surface of the first leaflet by anchoring the first anchor to the first leaflet, and against a ventricular surface of the second leaflet by anchoring the second anchor to the second leaflet, such that (i) chordae of the valve extend through the slots, and (ii) the patch bridges a gap between the first leaflet and the second leaflet. Other embodiments are also disclosed.

Interatrial shunts having incorporated physiologic sensors are provided for monitoring and treating cardiovascular syndromes, including heart failure and pulmonary hypertension, in which the one or more sensors are affixed to the shunt to measure a physiologic parameter within the interatrial shunt. The one or more sensors may be directly affixed to or within a lumenal surface of the shunt or may be disposed on a support structure in a spaced relation to the shunt lumen, the one or more sensors disposed at locations subject to little or no pannus formation or cardiac wall motion artifact.

A method and system for performing transseptal extracorporeal membrane oxygenation is disclosed. The method may include puncturing a septum between the right atrium and the left atrium and advancing a catheter system through the puncture and into the aorta. A first portion of the catheter system can remove blood from the patient, in some examples near the inferior vena cava. A second portion can return oxygenated blood to the patient, through the transseptal puncture and into the aorta.

The present application relates to the field of medical devices, and specifically to a repair device for preventing valve regurgitation, comprising a mounting bracket, a single anti-reflux prosthesis for replacing the function of a single native valve leaflet, and a fixing member, wherein one end of the single anti-reflux prosthesis is fixed on the mounting bracket, and an atrial segment is provided at the distal end of the mounting bracket, and the atrial segment is configured to adapt to the morphology of the native valve ring tissue, and the atrial segment includes a leak-proof portion, and the proximal end portion of the mounting bracket is anchored in the ventricle by the fixing member, wherein, after the mounting bracket is installed in place, the leak-proof portion abuts against or fits the native valve ring tissue, and when the native valve opens and closes so that the morphology of the native valve ring changes, the leak-proof portion follows the morphological change of the native valve ring and produces adaptive deformation, so that the leak-proof portion always abuts against or fits the native valve ring tissue.

Devices, systems and methods deliver implantable medical devices for atrioventricular (VfA) cardiac treatment. The VfA device can be implanted in the right atrium (RA), where electrodes extend from the right atrium into the left ventricular myocardium. A flexible lead or other probe can be advanced to a potential implantation site and used to identify the precise location of an implanted medical device, such as an electrode, a small lead, a lead, or an intracardiac device. Some methods may include locating a potential implantation site in the Koch triangle in the right atrium of the patient's heart; attaching a retaining sheath to the right atrial endocardium of the potential implantation site; and implanting the medical device via a guidewire at the potential implantation site. An implantable medical device may include an intracardiac housing and a small lead that can be delivered by these methods.

The invention discloses a method for quantitatively analyzing a left auricle occlusion effect based on a CT image. The method comprises the following steps: step 1, acquiring a heart CTA image; 2, performing three-dimensional reconstruction to obtain a heart three-dimensional image, and obtaining a left atrium three-dimensional image by using the left atrium segmentation model; 3, obtaining a left auricle occluder area by using the left auricle occluder segmentation model; 4, constructing a three-dimensional model of the left auricle occluder on the basis of the segmented left auricle occluder area so as to obtain a three-dimensional image of the left auricle occluder; 5, obtaining a three-dimensional plane of the left auricle plugging device, a front view of the plugging device and a left auricle opening plane; 6, left auricle occlusion postoperative evaluation parameters are extracted, wherein the parameters at least comprise the size, position and classification of residual shunt, the position of an occluder, the shoulder exposing position and height, the endothelialization degree of the occluder and the position of instrument-related thrombus; and 7, evaluating the left auricle occlusion effect according to the obtained evaluation parameters after the left auricle occlusion operation.

A method and apparatus for treatment of hypertension and heart failure by increasing secretion of endogenous atrial hormones by pacing of the heart. Pacing is done during the ventricular refractory period resulting in premature atrial contraction that does not result in ventricular contraction. Pacing results in the atrial wall stress, peripheral vasodilation, ANP secretion. Concomitant reduction of the heart rate is monitored and controlled as needed with backup pacing.

A prosthetic heart valve includes a collapsible and expandable outer frame, a collapsible and expandable inner frame, and a prosthetic valve assembly. The outer frame may be configured to engage tissue of a native heart valve, and may have (i) an atrial portion adapted to be positioned on an atrial side of the native heart valve; (ii) a ventricle portion adapted to be positioned on a ventricle side of the native heart valve; and (iii) a narrowed waist portion between the atrial portion and the ventricle portion. The inner frame may be positioned radially inward of the outer frame and may be coupled to the outer frame. A constraining band may extend around a circumference of the inner frame. The prosthetic valve assembly may be coupled to, and positioned radially inward of, the inner frame.

Systems and methods for controlling blood pressure by controlling atrial pressure and atrial stretch are disclosed. In some embodiments, a stimulation circuit may be configured to deliver a stimulation pulse to at least one cardiac chamber of a heart of a patient, and at least one controller may be configured to execute delivery of one or more stimulation patterns of stimulation pulses to the at least one cardiac chamber, wherein at least one of the stimulation pulses stimulates the heart such that an atrial pressure resulting from atrial contraction of an atrium overlaps in time a passive pressure build-up of the atrium, such that an atrial pressure of the atrium resulting from the stimulation is a combination of the atrial pressure resulting from atrial contraction and the passive pressure build-up and is higher than an atrial pressure of the atrium would be without the stimulation, and such that the blood pressure of the patient is reduced.

The invention discloses a heart AI system based on deep learning, and relates to the technical field of medical image processing, and the heart AI system comprises a two-dimensional fully-supervised left atrium segmentation algorithm module, a three-dimensional semi-supervised left atrium segmentation algorithm module, and a whole heart segmentation algorithm module. Meanwhile, through combination of Transform and a residual network, semantic information in the image is captured in a larger visual field, so that the segmentation precision of the network is improved; a two-dimensional fully-supervised left atrium segmentation algorithm module based on axial attention is provided from a two-dimensional angle by taking UNet as a basic model, the algorithm module firstly constructs a double-layer residual error convolution module, gradient information is transmitted through a plurality of paths, then a task-driven feature enhancement module is introduced to optimize feature representation, and finally, a task-driven left atrium segmentation algorithm is constructed. A multivariate feature fusion module is designed to integrate features, and finally a feature coupling module is designed, so that the limitation of traditional convolution operation is overcome.

The invention provides a left heart data analysis method and system based on image segmentation, and relates to the technical field of medical image processing. Comprising the following steps: acquiring cardiac ultrasound image data and preprocessing; performing image segmentation on the preprocessed image data to obtain a segmentation result including a left ventricle, a left ventricular wall and a left atrium; searching a boundary line of the left ventricle and the left atrium, selecting two boundary points corresponding to the minimum and maximum abscissas in the boundary line as left and right mitral valve ring points respectively, and establishing a long axis based on the mitral valve ring midpoint and the cardiac apex point; modeling the ventricle into a structure formed by superposing a plurality of discs along the long axis direction, and obtaining the diameter of the corresponding disc; based on the obtained diameters of the corresponding discs, the left ventricular volumes in the diastolic period and the systolic period are calculated respectively, and the left ventricular ejection fraction is calculated. According to the method, image segmentation and geometric modeling are fused to achieve accurate calculation of the cardiac ejection fraction, meanwhile, the accuracy of cardiac structure image segmentation is improved, and an interpretable ejection fraction estimation process is achieved.

Devices are provided with an internal dimension that can be reduced and increased in vivo. In one example, an interatrial shunt for placement at an atrial septum of a patient's heart includes a body. The body includes first and second regions coupled in fluid communication by a neck region. The body includes a shape-memory material. The body defines a passageway through the neck region for blood to flow between a first atrium and a second atrium. The first and second regions are superelastic at body temperature, and the neck region is malleable at body temperature. A flow area of the passageway through the neck region may be adjusted in vivo.

Systems and methods for delivering a device for regulating blood pressure across a patient's atrial septum are provided. The delivery apparatus may include a first catheter, a hub having one or more engagers disposed thereon, the one or more engagers configured to releasably engage with a first expandable end of the shunt in a contracted delivery state within a lumen of a sheath, and an second catheter extending through a center lumen of the first catheter and the hub, wherein the first catheter, the hub, and the second catheter are independently moveable relative to the sheath. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits. The inventive devices also may be used to treat subjects having heart failure, pulmonary congestion, or myocardial infarction, among other pathologies.

A method includes, in a processor, receiving example representations of geometrical shapes of a given type of organ. In a training phase, a neural network model is trained using the example representations. In a modeling phase, the trained neural network model is applied to a set of location measurements acquired in an organ of the given type, to produce a three-dimensional model of the organ.

The invention provides a multi-bend mapping catheter. The multi-bend mapping catheter comprises a handle; the catheter sequentially comprises a catheter main body, a second bending section and a first bending section from the near end to the far end, and the shear moduli of the catheter main body, the second bending section and the first bending section are sequentially reduced; the electrode is arranged on one side of the far end of the catheter; the first bending adjusting assembly can control the bending degree of the first bending adjusting section on the first plane; and the second bending adjusting assembly can control the bending degree of the second bending adjusting section on a second plane, and the first plane and the second plane are different planes. By means of the scheme, bending adjustment can be conducted on the first bending adjustment section and the second bending adjustment section in different planes and directions, so that the catheter can smoothly enter the atrium through CSO and vena cava, then stimulation of the catheter to the heart can be reduced by adjusting the first bending adjustment section and the second bending adjustment section, and therefore the catheter can enter the atrium smoothly. And the electrodes on the catheter are tightly attached to improve the mapping accuracy and stability.