594 results about "Heart atrium" patented technology

A normothermic perfusion circuit can be used to perfuse a donor heart after transportation and before transplantation. The circuit can drain the organ storage container of cold preservation solution, perfuse the aorta of the heart with warm fluid to initiate heart activity, and then perfuse the left atrium of the heart with warm fluid to bolster heart activity and evaluate heart viability. Heart viability can be determined using parameters measured by sensors in the circuit.

A normothermic perfusion circuit can be used to perfuse a donor heart after transportation and before transplantation. The circuit can drain the organ storage container of cold preservation solution, perfuse the aorta of the heart with warm fluid to initiate heart activity, and then perfuse the left atrium of the heart with warm fluid to bolster heart activity and evaluate heart viability. Heart viability can be determined using parameters measured by sensors in the circuit.

To provide a system for transmitting blood pressure reduction electrical stimulation to the heart of a patient capable of determining a desirable AV delay.SOLUTION: The atrium is paced and the ventricle is paced with a given (arbitrary) delay to obtain a desired blood pressure change. Then, the atrium is sensed, the ventricle is paced, the blood pressure change is observed, and the resulting blood pressure change is compared with the paced-atrium-paced-ventricle desired blood pressure change. In the case where the blood pressure changes are not substantially equal, the timing of the sensed-atrium-paced-ventricle stimulation is adjusted on the basis of the comparison. The new modified resulting blood pressure change is observed, and the modified blood pressure change is compared with the paced-atrium-paced-ventricle desired blood pressure change. Adjustment and observation may be repeated until the timing of the sensed-atrium-paced-ventricle stimulation achieves the same blood pressure change as the desired blood pressure change of the paced-atrium-paced-ventricle stimulation.SELECTED DRAWING: Figure 9

Coaptation assist device for repairing cardiac valves and associated systems and methods are disclosed herein. A coaptation assist device configured in accordance with embodiments of the present technology can include, for example, a fixation member configured to press against cardiac tissue proximate to a native valve annulus, and a stationary coaptation structure extending away from the fixation member. The coaptation structure can include an anterior surface configured to coapt with a first native leaflet during systole and a posterior surface configured to displace at least a portion of a second native leaflet. The device also includes at least one sensor configured to detect parameters associated with at least one of cardiac function and device functionality. The sensors can be pressure sensors configured to detect left atrial pressure and / or left ventricular pressure.

Interatrial shunts having incorporated physiologic sensors are provided for monitoring and treating cardiovascular syndromes, including heart failure and pulmonary hypertension, in which the one or more sensors are affixed to the shunt to measure a physiologic parameter within the interatrial shunt. The one or more sensors may be directly affixed to or within a lumenal surface of the shunt or may be disposed on a support structure in a spaced relation to the shunt lumen, the one or more sensors disposed at locations subject to little or no pannus formation or cardiac wall motion artifact.

The present application relates to the field of medical devices, and specifically to a repair device for preventing valve regurgitation, comprising a mounting bracket, a single anti-reflux prosthesis for replacing the function of a single native valve leaflet, and a fixing member, wherein one end of the single anti-reflux prosthesis is fixed on the mounting bracket, and an atrial segment is provided at the distal end of the mounting bracket, and the atrial segment is configured to adapt to the morphology of the native valve ring tissue, and the atrial segment includes a leak-proof portion, and the proximal end portion of the mounting bracket is anchored in the ventricle by the fixing member, wherein, after the mounting bracket is installed in place, the leak-proof portion abuts against or fits the native valve ring tissue, and when the native valve opens and closes so that the morphology of the native valve ring changes, the leak-proof portion follows the morphological change of the native valve ring and produces adaptive deformation, so that the leak-proof portion always abuts against or fits the native valve ring tissue.

The invention provides a left heart data analysis method and system based on image segmentation, and relates to the technical field of medical image processing. Comprising the following steps: acquiring cardiac ultrasound image data and preprocessing; performing image segmentation on the preprocessed image data to obtain a segmentation result including a left ventricle, a left ventricular wall and a left atrium; searching a boundary line of the left ventricle and the left atrium, selecting two boundary points corresponding to the minimum and maximum abscissas in the boundary line as left and right mitral valve ring points respectively, and establishing a long axis based on the mitral valve ring midpoint and the cardiac apex point; modeling the ventricle into a structure formed by superposing a plurality of discs along the long axis direction, and obtaining the diameter of the corresponding disc; based on the obtained diameters of the corresponding discs, the left ventricular volumes in the diastolic period and the systolic period are calculated respectively, and the left ventricular ejection fraction is calculated. According to the method, image segmentation and geometric modeling are fused to achieve accurate calculation of the cardiac ejection fraction, meanwhile, the accuracy of cardiac structure image segmentation is improved, and an interpretable ejection fraction estimation process is achieved.

Devices are provided with an internal dimension that can be reduced and increased in vivo. In one example, an interatrial shunt for placement at an atrial septum of a patient's heart includes a body. The body includes first and second regions coupled in fluid communication by a neck region. The body includes a shape-memory material. The body defines a passageway through the neck region for blood to flow between a first atrium and a second atrium. The first and second regions are superelastic at body temperature, and the neck region is malleable at body temperature. A flow area of the passageway through the neck region may be adjusted in vivo.

A valve frame includes a tubular portion defining a plurality of valve-frame coupling elements disposed circumferentially around a longitudinal axis of the valve frame, and a plurality of arms, extending radially outward from an upstream portion of the tubular portion to define an arm span, and configured to engage tissue in the atrium. An outer frame is coupled to the valve frame, and includes a ring circumscribing the tubular portion, and a plurality of flanges that extend radially outward from the ring to define a flange span, and are configured to engage ventricular tissue. Each arm defines a rigid portion and a flexible portion that is disposed radially outward from the rigid portion, and is more flexible than the rigid portion. The majority of the flexible portion is disposed further radially outward than the flange span. Other embodiments are also described.

An implant for implantation at a native atrioventricular valve of a subject, includes a frame assembly, including a valve frame and an outer frame coupled to each other. The valve frame includes a tubular portion that circumscribes a longitudinal axis of the valve frame so as to define a lumen along the axis, and an upstream support portion including a plurality of arms. Each arm extends radially outward from the tubular portion to engage tissue in the atrium. The outer frame includes a ring that circumscribes the tubular portion, and a plurality of ventricular anchors that extend radially outward from the ring and are configured to anchor the implant to tissue of the ventricle. In an expanded state of the frame assembly, the implant defines a toroidal space between the plurality of ventricular anchors and the upstream support portion. Other embodiments are also described.

An asymmetric device for regulating blood volume distribution across a patient's atrial septum having a first expandable end region and a second expandable end region. The first expandable end region is transitionable from a contracted delivery state to an expanded deployed state in which the first expandable end region extends into the patient's left atrium and an inlet end of the first expandable end region is in a first plane. The second expandable end region is transitionable from a contracted delivery state to an expanded deployed state in which the second expandable end region extends into the patient's right atrium and an outlet end of the second expandable end region is in a second plane, such that the first plane intersects the second plane. The device further includes a neck region joining the first expandable end region to the second expandable end region, wherein the neck region is sized and shaped for placement in the patient's atrial septum.

Devices, systems, and methods for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium are disclosed. Devices and methods include a method for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium, the method comprising: implanting a variable occluder in a coronary sinus region proximate a left atrium, wherein the variable occluder is configured to gradually increase a level of blood flow restriction over a period of days to enable a venous system of the myocardium to compensate for increased pressure caused by the gradual increase in the level of blood flow restriction; and following venous system compensation, shunting oxygenated blood flow into the coronary sinus to cause retrograde flow of oxygenated blood in at least a portion of the venous system of the myocardium to thereby enable revascularization of the myocardium.

Apparatus and methods are described including a valve frame configured to support a prosthetic valve within a native atrio-ventricular valve. The valve frame includes an atrial part comprising a disc-shaped portion configured to be deployed on an atrial side of the valve annulus, and a frustoconical portion, and a cylindrical part to which the prosthetic valve leaflets are coupled. The cylindrical part configured to be deployed such that a ventricular end of the cylindrical part is disposed within the ventricle. A plurality of protruding struts are configured to protrude from outside the cylindrical part, the frustoconical portion of the atrial part being coupled to the cylindrical part via the protruding struts. Other applications are also described.

The invention relates to the technical field of medical instruments, in particular to a valve stent for mitral valve replacement, which comprises an integrally formed stent, the stent is formed by a plurality of folding parts along the circumferential direction and the axial direction, each folding part comprises two folding arms which are connected in a V shape, and two ends of each folding arm are respectively a first connecting end and a second connecting end; the first connecting end of each folding arm is connected with the first connecting end of the adjacent folding arm in the circumferential direction, and the second connecting end of the same folding arm is connected with the second connecting end of the other adjacent folding arm in the circumferential direction; and a wave-shaped connecting rod is arranged between each folding arm and the adjacent folding arm in the axial direction. The stent has the beneficial effects that the shortening rate of the stent is effectively reduced, and implantation is more convenient through the left atrium.

The invention provides an atrial defect and ventricular defect image model reconstruction method, and relates to the technical field of medical image processing. The method comprises the following steps: acquiring two-dimensional medical image data of a heart area; based on the two-dimensional medical image data, utilizing an image segmentation technology to identify atrial defect and ventricular defect areas and extracting feature points; constructing a preliminary three-dimensional model of the atrial defect and the ventricular defect according to the feature points by using a three-dimensional reconstruction algorithm; and the preliminary three-dimensional model is refined through a model optimization technology, so that the accuracy and definition of the preliminary three-dimensional model are improved. By means of the scheme, the accuracy and definition of the three-dimensional model can be improved in atrial defect and ventricular defect image model reconstruction.

Cardiac pacemaker for a patient's heart including a processing unit with a data memory, further including a first detector, and a second detector, a pacing signal generator, which are all electrically connected to the processing unit, wherein the first detector is configured to detect time-dependent electrical signals of the heart, wherein the second detector is configured to detect time-dependent bodily signals of the patient different from the signals detected by the first detector, wherein the first detector and the second detector are configured to transmit the detected and, if applicable, pre-processed signals to the processing unit, wherein the processing unit is configured to process the signals received from the first detector and the signals from the second detector and to detect from the received signals of the first detector intrinsic atrial events, intrinsic ventricular events and pacing events and to determine an actual cardiac rate.

Systems and methods for implanting a shunt for regulating blood pressure between a patient's left and right atria are provided. The shunt comprises an anchor having a neck region, first and second end regions, and a conduit affixed with the anchor formed of a biocompatible material that is resistant to transmural and translation tissue ingrowth and that reduces a risk of paradoxical embolism. The shunt may be advanced through the sheath until the first region protrudes from the sheath and self-expands within the left atrium. The shunt and the sheath may then be retracted until the first region contacts the left side of the atrial septum. The sheath may further be retracted until the counterforce exerted by shunt tension on the atrial septum overcomes the friction of the retained portions of the shunt such that the second region is exposed from the sheath and self-expands within the second atrium.

Methods and devices for reducing ventricle filling volume are disclosed. In some embodiments, an electrical stimulator may be used to stimulate a patient's heart to reduce ventricle filling volume or even blood pressure. When the heart is stimulated in a consistent way to reduce blood pressure, the cardiovascular system may over time adapt to the stimulation and revert back to the higher blood pressure. In some embodiments, the stimulation pattern may be configured to be inconsistent such that the adaptation response of the heart is reduced or even prevented. In some embodiments, an electrical stimulator may be used to stimulate a patient's heart to cause at least a portion of an atrial contraction to occur while the atrioventricular valve is closed. Such an atrial contraction may deposit less blood into the corresponding ventricle than when the atrioventricular valve is opened throughout an atrial contraction.

A method and apparatus for treatment of heart failure by increasing secretion of endogenous naturetic hormones ANP and BNP such as by stimulation of the heart atria. Heart pacing is done at an atrial contraction rate that is increased and can be higher than the ventricular contraction rate. Pacing may include mechanical distension of the right atrial appendage. An implantable device is used to periodically cyclically stretch the walls of the appendage with an implanted balloon.

The invention discloses a heart semi-supervised segmentation method fusing a double-teacher model and weighted label fusion, and belongs to the technical field of medical image processing, and the method comprises the steps: obtaining a heart or left atrium MRI image set of a unified size, carrying out the label processing, and carrying out the data set division operation; constructing a student network; constructing a double-teacher network; the double-teacher network comprises a teacher model A and a teacher model B which run independently; the network structures of the teacher model A and the teacher model B are the same as the student network; designing a heart segmentation network model according to the student model and the double-teacher model; and training the heart segmentation network model by using a data set division operation result, and verifying the model. According to the method, the network segmentation performance can be effectively improved in a limited annotation data situation, and the method is particularly suitable for complex medical scenes such as heart or left atrium MRI and has wide clinical application value and good development prospects.

A method of reducing left atrial pressure is provided for treating diastolic heart failure. A puncture catheter is advanced into a coronary sinus for creating an opening in a wall between the coronary sinus and a left atrium of a heart. A cauterizing tool may be used to create a controlled scarring pattern in the tissue along the opening. After the opening is created, a blood flow path is provided from the left atrium to the coronary sinus for reducing blood pressure in the left atrium and thereby alleviating symptoms of heart failure. If necessary, a shunt device may be implanted within the opening to ensure that the blood flow path remains open.

The utility model provides a rapid non-exchange puncturing and conveying system for heart patent foramen ovale plugging. The rapid non-exchange puncturing and conveying system comprises a conveying sheath body and an expansion inner core. The conveying sheath body comprises a sheath head section, a bending adjusting section, a pipe body section and a connector section which are sequentially arranged. The total length of the sheath head section and the bending adjusting section is 2-3 cm, the length of the bending adjusting section is 0.5-1 cm, and the bending degree of the bending adjusting section is adjustable. The expansion inner core is arranged in the conveying sheath body in a penetrating mode. The conveying sheath body, the expansion core and the plugging device assembly system can smoothly complete the conveying sheath to enter the left atrium through the patent foramen ovale and complete the plugging device release operation, particularly, the bending adjusting section is designed to be adjustable in bending, the conveying sheath is more suitable for right atrium operation of different forms, the instrument exchange step in the existing operation process is reduced, and the operation efficiency is improved. The risk that an atrium and an atrial appendage are damaged by an existing material is reduced, the operation time can be remarkably shortened, and a very simple patent foramen ovale plugging operation is achieved.

Systems, devices and methods are provided for supporting cardiac function. A device comprises an elongate housing configured for implantation into a patient exterior to the chest cavity. The housing includes a first inlet and an outlet that define a primary blood flow path from the left atrium through at least a portion of the housing within the right atrium, and to the aorta. The housing comprises a motor disposed within the housing and an impeller coupled to the motor for pumping blood from the first inlet to the outlet of the housing through the primary blood flow path. The device bypasses the left ventricle by drawing freshly oxygenated blood from the left atrium and propelling this blood directly into the aorta. Implanting the pump exterior to the chest cavity is less invasive and allows the pump to be quickly and easily repaired, cleaned, repositioned and or replaced without removing or replacing the tubes that are anchored to sensitive tissue structures within the thoracic cavity.

The invention provides an automatic counting method and system for ultrasonic microbubbles in right heart acoustic radiography. The method comprises the following steps: acquiring a cardiac radiography image of a patient through high-resolution ultrasonic equipment; extracting a region of interest of the cardiac angiography image based on the cardiac vascular structure, and performing image registration operation on the cardiac angiography image by taking the region of interest as a reference point to obtain a registered image; carrying out pixel-by-pixel addition on two frames of pulse images with opposite phases in the registered image to obtain an enhanced image; determining the high-echo bright spots in the enhanced image as suspected microbubbles, and performing denoising processing according to the feature similarity to obtain real microbubbles; judging pathological conditions according to whether real microbubbles exist in the left atrium or not; if the real microbubbles exist in the left atrium, grading the abnormal blood flow according to the change data of the microbubbles in the left atrium and the right atrium. According to the method, through high-precision image registration, multi-modal feature analysis and dynamic parameter fusion technologies, the microbubble detection accuracy is improved, and quantitative grading of pathological conditions is achieved.

The present invention is directed to a system for monitoring and evaluating electrogram signals representing electric activities of a heart chamber by computing the entropy of the electrogram signals, said system comprising a signal input that is connected to a mapping catheter comprising at least one electrode pole for picking up electric potentials and generating electrogram signals from the picked up electric potentials, along with the 3D location of the catheter at the time of recording and a signal processing and evaluation unit for processing and evaluating electrogram signals received at the signal input. The invention is further to a non-transitory computer readable medium for use in a system for monitoring and evaluating electrogram signals representing electric activities of a heart.

A device for regulating blood pressure between a patient's left atrium and right atrium comprises an hourglass-shaped stent comprising a neck region and first and second flared end regions, the neck region disposed between the first and second end regions and configured to engage the fossa ovalis of the patient's atrial septum, and a drug-eluting biodegradable material that biodegrades over time to release a drug that limits tissue overgrowth. The inventive device also may include a biodegradable material that biodegrades to offset flow changes caused by tissue overgrowth. The inventive device may reduce left atrial pressure and left ventricular end diastolic pressure, and may increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits.

The invention relates to the technical field of medical image processing and three-dimensional reconstruction, and particularly discloses a reconstruction and analogue simulation method based on a cardiac image. The method comprises the following steps: firstly, preprocessing an input CT or MRI medical image, and automatically segmenting a heart multi-tissue structure by using an nnUNetv2 model, including a plurality of anatomical regions such as atrium, ventricle, myocardial tissue and blood pool; and then performing topology repair, smoothing processing and label resampling on the segmentation result to obtain a three-dimensional label body with a continuous structure and a complete boundary. And based on the optimized tag body, constructing a heart three-dimensional surface model by adopting a Marching Cubes algorithm, and generating a multi-material volume grid suitable for finite element analysis. According to an electrode position and a radio frequency parameter set by a user, a radio frequency ablation simulation model based on a Pennes biological heat conduction equation and an Arrhenius model is established, a temperature field and a tissue thermal damage range are calculated, and a simulation result is displayed in a three-dimensional mode in an overlapping mode. According to the method, the integrated process from medical image automatic segmentation to heart three-dimensional reconstruction and thermal simulation is realized, the segmentation precision, the modeling efficiency and the simulation reliability are improved, and the method can be applied to application scenes such as surgical planning, preoperative evaluation and medical teaching.

A prosthetic mitral valve includes an anchor assembly, a strut frame, and a plurality of replacement leaflets secured to the annular strut frame. The anchor assembly includes a ventricular anchor, an atrial anchor, and a central portion therebetween. The ventricular anchor and the atrial anchor are configured to flare radially outwards relative to the central portion. The annular strut frame is disposed radially within the anchor assembly and is attached to the anchor assembly. The central portion is configured to align with a native valve orifice and the ventricular anchor and the atrial anchor are configured to compress native cardiac tissue therebetween.

A device for regulating blood pressure between a patient's left atrium and right atrium comprises an hourglass-shaped stent comprising a neck region and first and second flared end regions, the neck region disposed between the first and second end regions and configured to engage the fossa ovalis of the patient's atrial septum; and a one-way tissue valve coupled to the first flared end region and configured to shunt blood from the left atrium to the right atrium when blood pressure in the left atrium exceeds blood pressure in the right atrium. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, and may increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits. The inventive devices may be used, for example, to treat subjects having heart failure, pulmonary congestion, or myocardial infarction, among other pathologies.

A method and system for performing transseptal extracorporeal membrane oxygenation is disclosed. The method may include puncturing a septum between the right atrium and the left atrium and advancing a catheter system through the puncture and into the aorta. A first portion of the catheter system can remove blood from the patient, in some examples near the inferior vena cava. A second portion can return oxygenated blood to the patient, through the transseptal puncture and into the aorta.