721 results about "Heart atrium" patented technology

A normothermic perfusion circuit can be used to perfuse a donor heart after transportation and before transplantation. The circuit can drain the organ storage container of cold preservation solution, perfuse the aorta of the heart with warm fluid to initiate heart activity, and then perfuse the left atrium of the heart with warm fluid to bolster heart activity and evaluate heart viability. Heart viability can be determined using parameters measured by sensors in the circuit.

A normothermic perfusion circuit can be used to perfuse a donor heart after transportation and before transplantation. The circuit can drain the organ storage container of cold preservation solution, perfuse the aorta of the heart with warm fluid to initiate heart activity, and then perfuse the left atrium of the heart with warm fluid to bolster heart activity and evaluate heart viability. Heart viability can be determined using parameters measured by sensors in the circuit.

Devices are provided with an internal dimension that can be reduced and increased in vivo. In one example, an interatrial shunt for placement at an atrial septum of a patient's heart includes a body. The body includes first and second regions coupled in fluid communication by a neck region. The body includes a shape-memory material. The body defines a passageway through the neck region for blood to flow between a first atrium and a second atrium. The first and second regions are superelastic at body temperature, and the neck region is malleable at body temperature. A flow area of the passageway through the neck region may be adjusted in vivo.

An asymmetric device for regulating blood volume distribution across a patient's atrial septum having a first expandable end region and a second expandable end region. The first expandable end region is transitionable from a contracted delivery state to an expanded deployed state in which the first expandable end region extends into the patient's left atrium and an inlet end of the first expandable end region is in a first plane. The second expandable end region is transitionable from a contracted delivery state to an expanded deployed state in which the second expandable end region extends into the patient's right atrium and an outlet end of the second expandable end region is in a second plane, such that the first plane intersects the second plane. The device further includes a neck region joining the first expandable end region to the second expandable end region, wherein the neck region is sized and shaped for placement in the patient's atrial septum.

To provide a system for transmitting blood pressure reduction electrical stimulation to the heart of a patient capable of determining a desirable AV delay.SOLUTION: The atrium is paced and the ventricle is paced with a given (arbitrary) delay to obtain a desired blood pressure change. Then, the atrium is sensed, the ventricle is paced, the blood pressure change is observed, and the resulting blood pressure change is compared with the paced-atrium-paced-ventricle desired blood pressure change. In the case where the blood pressure changes are not substantially equal, the timing of the sensed-atrium-paced-ventricle stimulation is adjusted on the basis of the comparison. The new modified resulting blood pressure change is observed, and the modified blood pressure change is compared with the paced-atrium-paced-ventricle desired blood pressure change. Adjustment and observation may be repeated until the timing of the sensed-atrium-paced-ventricle stimulation achieves the same blood pressure change as the desired blood pressure change of the paced-atrium-paced-ventricle stimulation.SELECTED DRAWING: Figure 9

Coaptation assist device for repairing cardiac valves and associated systems and methods are disclosed herein. A coaptation assist device configured in accordance with embodiments of the present technology can include, for example, a fixation member configured to press against cardiac tissue proximate to a native valve annulus, and a stationary coaptation structure extending away from the fixation member. The coaptation structure can include an anterior surface configured to coapt with a first native leaflet during systole and a posterior surface configured to displace at least a portion of a second native leaflet. The device also includes at least one sensor configured to detect parameters associated with at least one of cardiac function and device functionality. The sensors can be pressure sensors configured to detect left atrial pressure and / or left ventricular pressure.

Interatrial shunts having incorporated physiologic sensors are provided for monitoring and treating cardiovascular syndromes, including heart failure and pulmonary hypertension, in which the one or more sensors are affixed to the shunt to measure a physiologic parameter within the interatrial shunt. The one or more sensors may be directly affixed to or within a lumenal surface of the shunt or may be disposed on a support structure in a spaced relation to the shunt lumen, the one or more sensors disposed at locations subject to little or no pannus formation or cardiac wall motion artifact.

The present application relates to the field of medical devices, and specifically to a repair device for preventing valve regurgitation, comprising a mounting bracket, a single anti-reflux prosthesis for replacing the function of a single native valve leaflet, and a fixing member, wherein one end of the single anti-reflux prosthesis is fixed on the mounting bracket, and an atrial segment is provided at the distal end of the mounting bracket, and the atrial segment is configured to adapt to the morphology of the native valve ring tissue, and the atrial segment includes a leak-proof portion, and the proximal end portion of the mounting bracket is anchored in the ventricle by the fixing member, wherein, after the mounting bracket is installed in place, the leak-proof portion abuts against or fits the native valve ring tissue, and when the native valve opens and closes so that the morphology of the native valve ring changes, the leak-proof portion follows the morphological change of the native valve ring and produces adaptive deformation, so that the leak-proof portion always abuts against or fits the native valve ring tissue.

The invention discloses a method for quantitatively analyzing a left auricle occlusion effect based on a CT image. The method comprises the following steps: step 1, acquiring a heart CTA image; 2, performing three-dimensional reconstruction to obtain a heart three-dimensional image, and obtaining a left atrium three-dimensional image by using the left atrium segmentation model; 3, obtaining a left auricle occluder area by using the left auricle occluder segmentation model; 4, constructing a three-dimensional model of the left auricle occluder on the basis of the segmented left auricle occluder area so as to obtain a three-dimensional image of the left auricle occluder; 5, obtaining a three-dimensional plane of the left auricle plugging device, a front view of the plugging device and a left auricle opening plane; 6, left auricle occlusion postoperative evaluation parameters are extracted, wherein the parameters at least comprise the size, position and classification of residual shunt, the position of an occluder, the shoulder exposing position and height, the endothelialization degree of the occluder and the position of instrument-related thrombus; and 7, evaluating the left auricle occlusion effect according to the obtained evaluation parameters after the left auricle occlusion operation.

A method and apparatus for treatment of hypertension and heart failure by increasing secretion of endogenous atrial hormones by pacing of the heart. Pacing is done during the ventricular refractory period resulting in premature atrial contraction that does not result in ventricular contraction. Pacing results in the atrial wall stress, peripheral vasodilation, ANP secretion. Concomitant reduction of the heart rate is monitored and controlled as needed with backup pacing.

A prosthetic heart valve includes a collapsible and expandable outer frame, a collapsible and expandable inner frame, and a prosthetic valve assembly. The outer frame may be configured to engage tissue of a native heart valve, and may have (i) an atrial portion adapted to be positioned on an atrial side of the native heart valve; (ii) a ventricle portion adapted to be positioned on a ventricle side of the native heart valve; and (iii) a narrowed waist portion between the atrial portion and the ventricle portion. The inner frame may be positioned radially inward of the outer frame and may be coupled to the outer frame. A constraining band may extend around a circumference of the inner frame. The prosthetic valve assembly may be coupled to, and positioned radially inward of, the inner frame.

Systems and methods for controlling blood pressure by controlling atrial pressure and atrial stretch are disclosed. In some embodiments, a stimulation circuit may be configured to deliver a stimulation pulse to at least one cardiac chamber of a heart of a patient, and at least one controller may be configured to execute delivery of one or more stimulation patterns of stimulation pulses to the at least one cardiac chamber, wherein at least one of the stimulation pulses stimulates the heart such that an atrial pressure resulting from atrial contraction of an atrium overlaps in time a passive pressure build-up of the atrium, such that an atrial pressure of the atrium resulting from the stimulation is a combination of the atrial pressure resulting from atrial contraction and the passive pressure build-up and is higher than an atrial pressure of the atrium would be without the stimulation, and such that the blood pressure of the patient is reduced.

The invention provides a left heart data analysis method and system based on image segmentation, and relates to the technical field of medical image processing. Comprising the following steps: acquiring cardiac ultrasound image data and preprocessing; performing image segmentation on the preprocessed image data to obtain a segmentation result including a left ventricle, a left ventricular wall and a left atrium; searching a boundary line of the left ventricle and the left atrium, selecting two boundary points corresponding to the minimum and maximum abscissas in the boundary line as left and right mitral valve ring points respectively, and establishing a long axis based on the mitral valve ring midpoint and the cardiac apex point; modeling the ventricle into a structure formed by superposing a plurality of discs along the long axis direction, and obtaining the diameter of the corresponding disc; based on the obtained diameters of the corresponding discs, the left ventricular volumes in the diastolic period and the systolic period are calculated respectively, and the left ventricular ejection fraction is calculated. According to the method, image segmentation and geometric modeling are fused to achieve accurate calculation of the cardiac ejection fraction, meanwhile, the accuracy of cardiac structure image segmentation is improved, and an interpretable ejection fraction estimation process is achieved.

Devices are provided with an internal dimension that can be reduced and increased in vivo. In one example, an interatrial shunt for placement at an atrial septum of a patient's heart includes a body. The body includes first and second regions coupled in fluid communication by a neck region. The body includes a shape-memory material. The body defines a passageway through the neck region for blood to flow between a first atrium and a second atrium. The first and second regions are superelastic at body temperature, and the neck region is malleable at body temperature. A flow area of the passageway through the neck region may be adjusted in vivo.

Systems and methods for delivering a device for regulating blood pressure across a patient's atrial septum are provided. The delivery apparatus may include a first catheter, a hub having one or more engagers disposed thereon, the one or more engagers configured to releasably engage with a first expandable end of the shunt in a contracted delivery state within a lumen of a sheath, and an second catheter extending through a center lumen of the first catheter and the hub, wherein the first catheter, the hub, and the second catheter are independently moveable relative to the sheath. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits. The inventive devices also may be used to treat subjects having heart failure, pulmonary congestion, or myocardial infarction, among other pathologies.

A method includes, in a processor, receiving example representations of geometrical shapes of a given type of organ. In a training phase, a neural network model is trained using the example representations. In a modeling phase, the trained neural network model is applied to a set of location measurements acquired in an organ of the given type, to produce a three-dimensional model of the organ.

The invention provides a multi-bend mapping catheter. The multi-bend mapping catheter comprises a handle; the catheter sequentially comprises a catheter main body, a second bending section and a first bending section from the near end to the far end, and the shear moduli of the catheter main body, the second bending section and the first bending section are sequentially reduced; the electrode is arranged on one side of the far end of the catheter; the first bending adjusting assembly can control the bending degree of the first bending adjusting section on the first plane; and the second bending adjusting assembly can control the bending degree of the second bending adjusting section on a second plane, and the first plane and the second plane are different planes. By means of the scheme, bending adjustment can be conducted on the first bending adjustment section and the second bending adjustment section in different planes and directions, so that the catheter can smoothly enter the atrium through CSO and vena cava, then stimulation of the catheter to the heart can be reduced by adjusting the first bending adjustment section and the second bending adjustment section, and therefore the catheter can enter the atrium smoothly. And the electrodes on the catheter are tightly attached to improve the mapping accuracy and stability.

A valve frame includes a tubular portion defining a plurality of valve-frame coupling elements disposed circumferentially around a longitudinal axis of the valve frame, and a plurality of arms, extending radially outward from an upstream portion of the tubular portion to define an arm span, and configured to engage tissue in the atrium. An outer frame is coupled to the valve frame, and includes a ring circumscribing the tubular portion, and a plurality of flanges that extend radially outward from the ring to define a flange span, and are configured to engage ventricular tissue. Each arm defines a rigid portion and a flexible portion that is disposed radially outward from the rigid portion, and is more flexible than the rigid portion. The majority of the flexible portion is disposed further radially outward than the flange span. Other embodiments are also described.

An implant for implantation at a native atrioventricular valve of a subject, includes a frame assembly, including a valve frame and an outer frame coupled to each other. The valve frame includes a tubular portion that circumscribes a longitudinal axis of the valve frame so as to define a lumen along the axis, and an upstream support portion including a plurality of arms. Each arm extends radially outward from the tubular portion to engage tissue in the atrium. The outer frame includes a ring that circumscribes the tubular portion, and a plurality of ventricular anchors that extend radially outward from the ring and are configured to anchor the implant to tissue of the ventricle. In an expanded state of the frame assembly, the implant defines a toroidal space between the plurality of ventricular anchors and the upstream support portion. Other embodiments are also described.

The invention discloses a lantern-shaped variable-diameter transcatheter artificial mitral valve stent, and belongs to the technical field of medical instruments. Comprising a lantern-shaped outer stent body and an outer stent covering film, the outer stent covering film is arranged close to an aorta side semi-open window, and the outer stent covering film is arranged close to the aorta side semi-open window. The grid lantern-shaped support body comprises an atrial side umbrella disc, a ventricular side variable diameter structure and a negative pressure suction cup which is connected with the atrial side umbrella disc and the ventricular side variable diameter structure and used for strengthening anchoring. The valve inner frame comprises a grid barrel-shaped inner frame body and an inner frame covering film, and the inner side of the inner frame body is connected with an artificial valve leaflet. By means of the lantern-shaped design of the outer stent and the valve ring suction cup for assisting anchoring, the problem that an artificial mitral valve replaced through a catheter is difficult to anchor is solved, and the problem that a left ventricular outflow tract is prone to being blocked after a covered stent is implanted is solved through the design that the single side of the dynamically-changeable valve outer stent is not covered with a film.

An asymmetric device for regulating blood volume distribution across a patient's atrial septum having a first expandable end region and a second expandable end region. The first expandable end region is transitionable from a contracted delivery state to an expanded deployed state in which the first expandable end region extends into the patient's left atrium and an inlet end of the first expandable end region is in a first plane. The second expandable end region is transitionable from a contracted delivery state to an expanded deployed state in which the second expandable end region extends into the patient's right atrium and an outlet end of the second expandable end region is in a second plane, such that the first plane intersects the second plane. The device further includes a neck region joining the first expandable end region to the second expandable end region, wherein the neck region is sized and shaped for placement in the patient's atrial septum.

A method, for use at a mitral valve of a heart of a subject, is provided which includes advancing a transluminal sheath into a femoral vein of the subject, through an inferior vena cava of the subject, into a right atrium of the subject, and transseptally into a left atrium of the subject. A surrounding-sheath is advanced out of a distal end of the transluminal sheath, into the left atrium, and toward a commissure of the mitral valve. An anchor is implanted by advancing the anchor out of the surrounding-sheath into a left ventricle of the subject, such that the anchor helically wraps around left ventricular mitral valve tissue. The surrounding-sheath is then extracted from the heart and then, a guide wire is advanced through the transluminal sheath. Other embodiments are also described.

Devices, systems, and methods for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium are disclosed. Devices and methods include a method for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium, the method comprising: implanting a variable occluder in a coronary sinus region proximate a left atrium, wherein the variable occluder is configured to gradually increase a level of blood flow restriction over a period of days to enable a venous system of the myocardium to compensate for increased pressure caused by the gradual increase in the level of blood flow restriction; and following venous system compensation, shunting oxygenated blood flow into the coronary sinus to cause retrograde flow of oxygenated blood in at least a portion of the venous system of the myocardium to thereby enable revascularization of the myocardium.

Apparatus and methods are described including a valve frame configured to support a prosthetic valve within a native atrio-ventricular valve. The valve frame includes an atrial part comprising a disc-shaped portion configured to be deployed on an atrial side of the valve annulus, and a frustoconical portion, and a cylindrical part to which the prosthetic valve leaflets are coupled. The cylindrical part configured to be deployed such that a ventricular end of the cylindrical part is disposed within the ventricle. A plurality of protruding struts are configured to protrude from outside the cylindrical part, the frustoconical portion of the atrial part being coupled to the cylindrical part via the protruding struts. Other applications are also described.

The invention relates to the technical field of artificial blood vessels, and discloses an artificial blood vessel for coronary artery bypass grafting and a preparation method thereof. The artificial blood vessel is prepared from the following raw materials: collagen and a solvent, the solid-to-liquid ratio of the collagen to the solvent is (3-5) g: 100mL. The artificial blood vessel provided by the invention takes collagen as a raw material, the raw material composition is simple, the inner caliber of the artificial blood vessel is 1.61 + / -0.1 mm, the length is greater than or equal to 13mm, the wall thickness is 298 + / -35 microns, and the suture retention strength is 2.1 + / -0.2 N; compared with coronary arteries of a left atrial anterior branch, a left atrial rotary branch, a sinus atrial node branch and a right atrial anterior branch, the coronary artery has no obvious difference in inner caliber, wall thickness and suture retention strength, has equivalent mechanical properties, and is suitable for being used as a substitute material of autologous blood vessels of the parts.

The invention relates to a heart valve regurgitation drum and optional closure disk and / or tubular stent to manage and provide levels of intentional regurgitation within an orthogonally delivered transcatheter prosthetic heart valve having a first inner flow control component / valve, a second inner regurgitation control component, and an outer annular support frame having compressible wire cells that facilitate folding flat along the z-axis and compressing the valve vertically along the y-axis, or orthogonally to the central axis of the flow control component, allowing a very large diameter valve to be delivered and deployed to the tricuspid valve from the inferior vena cava or superior vena cava, or trans-atrially to the mitral valve, the valve having a height of about 5-60 mm and a diameter of about 25-80 mm, without requiring an oversized diameter catheter and without requiring delivery and deployment from a catheter at an acute angle of approach.

Apparatuses and methods for performing transseptal extracorporeal membrane oxygenation are disclosed. The method may include puncturing a septum between the right atrium and the left atrium and advancing a catheter system through the puncture and into the aorta. The catheter system may include coaxially arranged and independently moveable venus and arterial sheaths having independently positionable openings for removing blood from the patient and for returning oxygenated blood to the patient, e.g., within the aorta.

The invention relates to the technical field of medical instruments, in particular to a valve stent for mitral valve replacement, which comprises an integrally formed stent, the stent is formed by a plurality of folding parts along the circumferential direction and the axial direction, each folding part comprises two folding arms which are connected in a V shape, and two ends of each folding arm are respectively a first connecting end and a second connecting end; the first connecting end of each folding arm is connected with the first connecting end of the adjacent folding arm in the circumferential direction, and the second connecting end of the same folding arm is connected with the second connecting end of the other adjacent folding arm in the circumferential direction; and a wave-shaped connecting rod is arranged between each folding arm and the adjacent folding arm in the axial direction. The stent has the beneficial effects that the shortening rate of the stent is effectively reduced, and implantation is more convenient through the left atrium.

The invention provides an atrial defect and ventricular defect image model reconstruction method, and relates to the technical field of medical image processing. The method comprises the following steps: acquiring two-dimensional medical image data of a heart area; based on the two-dimensional medical image data, utilizing an image segmentation technology to identify atrial defect and ventricular defect areas and extracting feature points; constructing a preliminary three-dimensional model of the atrial defect and the ventricular defect according to the feature points by using a three-dimensional reconstruction algorithm; and the preliminary three-dimensional model is refined through a model optimization technology, so that the accuracy and definition of the preliminary three-dimensional model are improved. By means of the scheme, the accuracy and definition of the three-dimensional model can be improved in atrial defect and ventricular defect image model reconstruction.

Cardiac pacemaker for a patient's heart including a processing unit with a data memory, further including a first detector, and a second detector, a pacing signal generator, which are all electrically connected to the processing unit, wherein the first detector is configured to detect time-dependent electrical signals of the heart, wherein the second detector is configured to detect time-dependent bodily signals of the patient different from the signals detected by the first detector, wherein the first detector and the second detector are configured to transmit the detected and, if applicable, pre-processed signals to the processing unit, wherein the processing unit is configured to process the signals received from the first detector and the signals from the second detector and to detect from the received signals of the first detector intrinsic atrial events, intrinsic ventricular events and pacing events and to determine an actual cardiac rate.