418 results about "Heart atrium" patented technology

A normothermic perfusion circuit can be used to perfuse a donor heart after transportation and before transplantation. The circuit can drain the organ storage container of cold preservation solution, perfuse the aorta of the heart with warm fluid to initiate heart activity, and then perfuse the left atrium of the heart with warm fluid to bolster heart activity and evaluate heart viability. Heart viability can be determined using parameters measured by sensors in the circuit.

A normothermic perfusion circuit can be used to perfuse a donor heart after transportation and before transplantation. The circuit can drain the organ storage container of cold preservation solution, perfuse the aorta of the heart with warm fluid to initiate heart activity, and then perfuse the left atrium of the heart with warm fluid to bolster heart activity and evaluate heart viability. Heart viability can be determined using parameters measured by sensors in the circuit.

The invention provides a left heart data analysis method and system based on image segmentation, and relates to the technical field of medical image processing. Comprising the following steps: acquiring cardiac ultrasound image data and preprocessing; performing image segmentation on the preprocessed image data to obtain a segmentation result including a left ventricle, a left ventricular wall and a left atrium; searching a boundary line of the left ventricle and the left atrium, selecting two boundary points corresponding to the minimum and maximum abscissas in the boundary line as left and right mitral valve ring points respectively, and establishing a long axis based on the mitral valve ring midpoint and the cardiac apex point; modeling the ventricle into a structure formed by superposing a plurality of discs along the long axis direction, and obtaining the diameter of the corresponding disc; based on the obtained diameters of the corresponding discs, the left ventricular volumes in the diastolic period and the systolic period are calculated respectively, and the left ventricular ejection fraction is calculated. According to the method, image segmentation and geometric modeling are fused to achieve accurate calculation of the cardiac ejection fraction, meanwhile, the accuracy of cardiac structure image segmentation is improved, and an interpretable ejection fraction estimation process is achieved.

Devices, systems, and methods for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium are disclosed. Devices and methods include a method for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium, the method comprising: implanting a variable occluder in a coronary sinus region proximate a left atrium, wherein the variable occluder is configured to gradually increase a level of blood flow restriction over a period of days to enable a venous system of the myocardium to compensate for increased pressure caused by the gradual increase in the level of blood flow restriction; and following venous system compensation, shunting oxygenated blood flow into the coronary sinus to cause retrograde flow of oxygenated blood in at least a portion of the venous system of the myocardium to thereby enable revascularization of the myocardium.

Systems and methods for implanting a shunt for regulating blood pressure between a patient's left and right atria are provided. The shunt comprises an anchor having a neck region, first and second end regions, and a conduit affixed with the anchor formed of a biocompatible material that is resistant to transmural and translation tissue ingrowth and that reduces a risk of paradoxical embolism. The shunt may be advanced through the sheath until the first region protrudes from the sheath and self-expands within the left atrium. The shunt and the sheath may then be retracted until the first region contacts the left side of the atrial septum. The sheath may further be retracted until the counterforce exerted by shunt tension on the atrial septum overcomes the friction of the retained portions of the shunt such that the second region is exposed from the sheath and self-expands within the second atrium.

Methods and devices for reducing ventricle filling volume are disclosed. In some embodiments, an electrical stimulator may be used to stimulate a patient's heart to reduce ventricle filling volume or even blood pressure. When the heart is stimulated in a consistent way to reduce blood pressure, the cardiovascular system may over time adapt to the stimulation and revert back to the higher blood pressure. In some embodiments, the stimulation pattern may be configured to be inconsistent such that the adaptation response of the heart is reduced or even prevented. In some embodiments, an electrical stimulator may be used to stimulate a patient's heart to cause at least a portion of an atrial contraction to occur while the atrioventricular valve is closed. Such an atrial contraction may deposit less blood into the corresponding ventricle than when the atrioventricular valve is opened throughout an atrial contraction.

The invention provides an automatic counting method and system for ultrasonic microbubbles in right heart acoustic radiography. The method comprises the following steps: acquiring a cardiac radiography image of a patient through high-resolution ultrasonic equipment; extracting a region of interest of the cardiac angiography image based on the cardiac vascular structure, and performing image registration operation on the cardiac angiography image by taking the region of interest as a reference point to obtain a registered image; carrying out pixel-by-pixel addition on two frames of pulse images with opposite phases in the registered image to obtain an enhanced image; determining the high-echo bright spots in the enhanced image as suspected microbubbles, and performing denoising processing according to the feature similarity to obtain real microbubbles; judging pathological conditions according to whether real microbubbles exist in the left atrium or not; if the real microbubbles exist in the left atrium, grading the abnormal blood flow according to the change data of the microbubbles in the left atrium and the right atrium. According to the method, through high-precision image registration, multi-modal feature analysis and dynamic parameter fusion technologies, the microbubble detection accuracy is improved, and quantitative grading of pathological conditions is achieved.

The present invention is directed to a system for monitoring and evaluating electrogram signals representing electric activities of a heart chamber by computing the entropy of the electrogram signals, said system comprising a signal input that is connected to a mapping catheter comprising at least one electrode pole for picking up electric potentials and generating electrogram signals from the picked up electric potentials, along with the 3D location of the catheter at the time of recording and a signal processing and evaluation unit for processing and evaluating electrogram signals received at the signal input. The invention is further to a non-transitory computer readable medium for use in a system for monitoring and evaluating electrogram signals representing electric activities of a heart.

A device for regulating blood pressure between a patient's left atrium and right atrium comprises an hourglass-shaped stent comprising a neck region and first and second flared end regions, the neck region disposed between the first and second end regions and configured to engage the fossa ovalis of the patient's atrial septum, and a drug-eluting biodegradable material that biodegrades over time to release a drug that limits tissue overgrowth. The inventive device also may include a biodegradable material that biodegrades to offset flow changes caused by tissue overgrowth. The inventive device may reduce left atrial pressure and left ventricular end diastolic pressure, and may increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits.

The invention relates to the technical field of medical image processing and three-dimensional reconstruction, and particularly discloses a reconstruction and analogue simulation method based on a cardiac image. The method comprises the following steps: firstly, preprocessing an input CT or MRI medical image, and automatically segmenting a heart multi-tissue structure by using an nnUNetv2 model, including a plurality of anatomical regions such as atrium, ventricle, myocardial tissue and blood pool; and then performing topology repair, smoothing processing and label resampling on the segmentation result to obtain a three-dimensional label body with a continuous structure and a complete boundary. And based on the optimized tag body, constructing a heart three-dimensional surface model by adopting a Marching Cubes algorithm, and generating a multi-material volume grid suitable for finite element analysis. According to an electrode position and a radio frequency parameter set by a user, a radio frequency ablation simulation model based on a Pennes biological heat conduction equation and an Arrhenius model is established, a temperature field and a tissue thermal damage range are calculated, and a simulation result is displayed in a three-dimensional mode in an overlapping mode. According to the method, the integrated process from medical image automatic segmentation to heart three-dimensional reconstruction and thermal simulation is realized, the segmentation precision, the modeling efficiency and the simulation reliability are improved, and the method can be applied to application scenes such as surgical planning, preoperative evaluation and medical teaching.

A device for regulating blood pressure between a patient's left atrium and right atrium comprises an hourglass-shaped stent comprising a neck region and first and second flared end regions, the neck region disposed between the first and second end regions and configured to engage the fossa ovalis of the patient's atrial septum; and a one-way tissue valve coupled to the first flared end region and configured to shunt blood from the left atrium to the right atrium when blood pressure in the left atrium exceeds blood pressure in the right atrium. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, and may increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits. The inventive devices may be used, for example, to treat subjects having heart failure, pulmonary congestion, or myocardial infarction, among other pathologies.

The invention relates to a multifunctional heart pulsation simulation system, which comprises a ventricle simulation mechanism, an atrium simulation mechanism, an artery simulation mechanism and a backwater mechanism, and is characterized in that the ventricle simulation mechanism comprises a ventricle cavity and a pulsation pump; the atrial simulation mechanism comprises an atrial cavity connected with the ventricular cavity and an atrial compliance cavity connected with the atrial cavity, and a first valve carrier is detachably mounted at the joint of the ventricular cavity and the atrial cavity; the artery simulation mechanism comprises an artery water inlet cavity connected with the ventricular cavity, an artery water outlet cavity connected with the artery water inlet cavity, an artery compliance cavity arranged at the top of the artery water outlet cavity and an artery root compliance cavity arranged at the bottom of the artery water outlet cavity; a second valve carrier is detachably mounted at the joint of the artery water inlet cavity and the artery water outlet cavity; the water return mechanism is connected between the atrial compliance cavity and the artery compliance cavity. According to the invention, two types of valves are simultaneously placed in the system for testing, so that the accuracy of a test result is effectively improved.

A plurality of catheter-based ablation apparatus embodiments are provided that address several areas of atrial target tissue and which feature firm and consistent ablation element to tissue contact enabling the creation of effective continuous lesions.

A blood flow pathway is formed between a left atrium and a coronary sinus for relieving elevated left atrial pressure. The treatment method includes providing first and second delivery catheters, wherein a medical device is carried by the second delivery catheter. A side outlet opening of the first delivery catheter is positioned within the coronary sinus and oriented toward a left atrium. An anchor on the first delivery catheter contacts an inner surface of the coronary sinus for stabilization. A distal portion of the second delivery catheter is advanced through the side outlet opening. A puncture component is then passed through a target wall portion for creating the blood flow pathway. The medical device is positioned in the opening.

Docking devices for securing a prosthetic valve at a native valve are provided. The docking device can include a coil and a guard member. The coil includes a plurality of helical turns when in a deployed orientation. The guard member may be attached to the coil by being coupled to at least a portion of a helical turn thereof. The docking devices include a atrial functional turn configured to enhance the transient stage stability of the docking device in the left atrium of the heart.

The invention provides an automatic identification method and device for a pulmonary vein orifice, relates to the field of medical image processing, and solves the technical problem of low identification accuracy of the pulmonary vein orifice in a complex scene in the prior art. The method comprises the following steps: acquiring a vertex set and a triangular patch set of a left atrium three-dimensional grid model; calculating a three-dimensional space parameter of each vertex based on the vertex set and the triangular patch set, and generating a feature vector of the corresponding vertex according to the three-dimensional space parameter; and clustering the feature vector of each vertex through a clustering algorithm, and identifying the pulmonary vein orifice based on a clustering result. The method and device are used in the pulmonary vein mouth recognition process.

Implantable medical device for stimulating a heart includes a proximal electrode pole, and first and second distal electrode poles. During operation, the device performs: a) detecting an intrinsic atrial contraction of the heart; b) detecting an intrinsic ventricular contraction of the heart; c) determining a first intrinsic atrioventricular conduction time between i) the intrinsic atrial contraction or the stimulation of the atrium and ii) the intrinsic ventricular contraction detected with the first distal electrode pole; and determining a second intrinsic atrioventricular conduction time between i) the intrinsic atrial contraction or the stimulation of the atrium and iii) the intrinsic ventricular contraction detected with the second distal electrode pole; d) setting a stimulated atrioventricular conduction time for stimulating the ventricle of the heart with the first and / or second distal electrode poles, the stimulated atrioventricular conduction time being shorter than the shorter of the first and second intrinsic atrioventricular conduction times.

An implantable lead for use with an implantable medical device (IMD) includes a tubular lead body having a proximal portion including a proximal end, a distal portion including a distal end opposite the proximal end, and an intermediate portion between the proximal portion and the distal portion. A helical electrode extends distally from the distal end of the tubular lead body. At least one atrial electrode is disposed in the intermediate portion of the tubular lead body. At least one electrical conductor extends through the tubular lead body and is mechanically and electrically coupled to the helical electrode and the at least one atrial electrode. The intermediate portion may have a pre-formed bend configured to urge the at least one atrial electrode against a surface of the right atrium when the lead is implanted. A distal pre-formed bend located in the distal portion of the tubular lead body may be configured to bias a plurality of pacing / sensing electrodes towards a surface of a right ventricle. A distal pre-formed bend located in the distal portion of the tubular lead body may be configured to bias the helical electrode and at least one pacing / sensing against a surface of a right ventricle.

An introductory lead system can include a first implantable lead having a first electrode and a second implantable lead having a second electrode guided to an implant site by the first implantable lead. The second electrode can be implanted in a patient's heart at the same implant site as the first electrode or at a second implant site. The introductory lead system can be delivered to one or more implant sites using various methods, including at the Koch triangle for ventricular free wall to atrium (VfA) therapy, at the right ventricular septal wall for dual bundle branch pacing, or in the coronary vasculature for left-sided sensing and pacing.

The invention discloses a medical instrument, which comprises a control device, and is configured to execute the following steps in an operation period: determining a ventricular excitation source of a heartbeat according to a difference value between a first specific time and a second specific time. The ventricular excitation source of the heartbeat is determined according to the difference value between the first specific time and the second specific time, time information of an atrium does not need to be used, it is not needed to wait for complete ventricular excitation of the heart, a morphological algorithm does not need to be used, the classification mode is simple, and energy consumption generated by medical instruments cannot be affected.

The application relates to the technical field of medical devices, in particular to a valve support for mitral valve replacement, which comprises an annular support formed integrally, one end of the support is provided with an anchoring part, and the other end is provided with a connecting part; the connecting part comprises a connecting arm, the connecting arm comprises a bending section and a connecting section which are connected to each other, the bending section is integrally extended from the support, and the connecting section is provided with a flexible section used for abutting against the atrial wall; the anchoring part comprises a bendable anchoring arm, one end of the anchoring arm away from the support is provided with a clamping part used for anchoring the valve, and a fixing part used for preventing the valve from rotating. The valve support has the beneficial effects that the anchoring performance of the valve support is enhanced, and the risk of paravalvular leakage is reduced.

Methods of administering an anti-arrhythmic, such as dofetilide, to a patient in an amount effective for treating a cardiovascular condition are described. The drug can be administered intravenously for at least one hour. A loading dose of 0.1 to 12 μg / kg bodyweight over a duration of up to 60 minutes can be administered and / or a maintenance dose of 0.1 to 10 μg / kg / hr can be administered intravenously over a duration of at least 1 hour, optionally alternatively or in addition wherein the amount of the loading dose and / or the IV maintenance dose is in the range of about ±50% of a maintenance dofetilide dose. The cardiovascular condition can include atrial fibrillation or flutter, ventricular tachycardia, hemodynamically stable or unstable ventricular tachycardia, paroxysmal atrial fibrillation, ventricular fibrillation, paroxysmal supraventricular tachycardia, heart failure, coronary artery disease, or pulmonary artery hypertension. A patient's QT interval and / or a creatinine clearance can be measured, and the effective amount can be selected based on either or both of the QT interval or the creatinine clearance measurements.

The application provides an atrial stent and relates to the technical field of medical devices.The atrial stent comprises a ball cage, a cylindrical stent, a sealing membrane and an artificial valve; the ball cage is supported in an atrium, and a ball cage opening is formed in the bottom end of the ball cage; the cylindrical stent extends from the ball cage opening to the inside of the ball cage; the sealing membrane covers the bottom of the ball cage and the cylinder wall of the cylindrical stent; and the artificial valve is located in the cylindrical stent.In the application, the ball cage is supported in the atrium after surgery, and the structure is stable, so that relative displacement of the ball cage and the original valve cannot be caused by the beating of the heart or the flushing of blood; and the blood in the atrium can flow into the ventricle through the cylindrical stent; the original valve still maintains the original function; the artificial valve and the original valve form a double-valve structure; and the regurgitation caused by the incomplete closure of the original valve during the output of the blood in the ventricle is blocked by the artificial valve, so that the functional defects of the original valve are complemented, and an ideal interventional treatment effect can be achieved.

The application relates to the field of medical devices, in particular to an implant capable of avoiding interlayer reflux, which comprises an anchoring device, a closing aid, and an adjusting mechanism, the closing aid is fixed on atrial tissue through the anchoring device, one end of the adjusting mechanism is connected with the closing aid, and the other end of the adjusting mechanism is fixed on ventricular tissue or apical tissue, the closing aid comprises a first patch and a second patch, one side of the first patch close to the anchoring device is a root, and the other side of the first patch away from the anchoring device is a head, wherein the first patch is arranged above the second patch, and the first patch and the second patch cooperate to form a pocket structure with an opening direction towards the head direction; the application can effectively avoid the existence of a gap between the closing aid and the autologous valve leaflet, so that blood flowing into the gap can be prevented from being accumulated into thrombus, calcified and other adverse conditions, and the application has good clinical significance.

Ventricle-from-atrium (VfA) devices, systems, and methods may be configured to detect a tachyarrhythmia. For in-stance, an atrial event rate may be compared to a ventricular rate to determine whether a patient's heart is undergoing a tachyarrhythmia. Further, it may be determined whether the tachyarrhythmia is a supraventricular tachycardia or ventricular tachycardia prior to delivering therapy to treat the tachyarrhythmia.

Implantable medical device comprising a sensing unit, a control unit, a memory, a communication unit, wherein - the sensor unit is set up to detect an atrial heart signal over a predefined period of time, wherein the heart signal has a multitude of successive atrial events which form a multitude of successive heart intervals, - the control unit is set up to determine the length of each heart interval and, if the intervention length falls below a certain threshold, to increment a mode switch counter, - the control unit is set up to record a cumulative mode-switch time over the predefined period, - the control unit is set up to determine, after the predefined time period has elapsed, a percentage of the cumulative mode-switch time normalized to the predefined time period and to store it in memory together with a value of the mode-switch counter, and - and the communication unit is set up to send the stored value of the mode switch counter and the stored percentage of the cumulative mode switch time or an alarm signal based thereon to an external device.

The present disclosure relates to a device assembly and a method for treating heart failure by normalizing elevated blood pressure in the left atrium of a heart of a mammal. Disclosed herein is a transcatheter interatrial septum excision device assembly configured to create a sized interatrial aperture between the right and left atria of a heart for the relief of elevated left atrial pressure. The device assembly comprises a delivery catheter, a tissue stabilizer attached to a first catheter having a central lumen and a penetrating tip that permits passage of a guidewire, and a cutter attached to a second catheter having a central lumen that permits passage of the first catheter. Alternative configurations comprise a (third) catheter having a central lumen that permits passage of the aforementioned components to and from the right atrium, a tissue retention mechanism and an optional coaxial alignment mechanism.

The present application relates to the technical field of heart valve testing, and specifically relates to a multifunctional combined heart valve testing experiment device, which comprises a base, a base body, a pressure regulating assembly, a pacing assembly and a circulation assembly. The base body, the pressure regulating assembly, the pacing assembly and the circulation assembly are fixedly installed above the base. The base body comprises an atrium simulation area, a ventricle simulation area and an artery simulation area. An atrium simulation area is formed in the upper part of the base body. The ventricle simulation area is fixedly and communicatively connected below the atrium simulation area. The artery simulation area is fixedly and communicatively connected below the ventricle simulation area. A communication pipe is in communication with the atrium simulation area. The ventricle simulation area is in communication with the pacing assembly. The artery simulation area is in communication with the circulation assembly. Thus, the contraction and relaxation of the heart can be simulated while testing whether the multifunctional combined heart valve leaks under dynamic pressure, and the transvalvular pressure difference of the multifunctional combined heart valve can be monitored in real time, thereby solving the problems that it is difficult to accurately test the transvalvular pressure difference of the multifunctional combined heart valve under dynamic pressure and whether the multifunctional combined heart valve leaks.

This invention discloses a method for preparing a simulated heart model and the simulated heart model itself. The method for preparing the simulated heart model includes: dividing a digital heart model into two parts along its coronal plane; preparing corresponding molding molds according to the structural characteristics of the two parts, each molding mold including an outer molding mold and an inner cavity molding mold; applying silicone to the molding surfaces of the outer molding mold and the inner cavity molding mold to form the endocardium and epicardium; applying silicone to the portion of the inner cavity molding mold used for molding the valve to form the valve; assembling the outer molding mold and the inner cavity molding mold to form a cavity; sequentially injecting silicone of corresponding hardness into the regions of the cavity used for molding the atrial myocardium, interatrial septal myocardium, ventricular myocardium, and interventricular septal myocardium to form heart model halves; and bonding the heart model halves corresponding to the two molding molds together to obtain the simulated heart model.

An arrhythmia type inference device includes: an obtaining section that obtains a target signal waveform indicating a time-series change in the area of a region, which is at least one of a left atrium, a left ventricle, a right atrium, and a right ventricle, the target signal waveform being generated by analyzing an image of a heart of a target subject; and an inference section that infers the type of tachyarrhythmia suffered by the target subject based on the shape of the target signal waveform having a frequency in a frequency band higher than a reference frequency band predetermined as a normal range. This allows the arrhythmia type inference device to accurately infer the type of tachyarrhythmia from the image obtained by image-capturing of the heart.