53 results about "Heart Valve Leaflet" patented technology

The disclosure relates to a device that is configured to be implanted on the native leaflet of a heart valve to increase its length and / or thickness and thereby to improve the valve function and reduce regurgitation. The device may include a leaflet section. The leaflet section may include a central member. The central member may include a first portion, a second portion that opposes the first portion, and a base portion disposed between the first portion and the second portion. The first section may extend from the first portion and the second section may extend from the second portion. The device may include one or more engaging members extending from the central member at an angle with respect to the first section and the second section. The second section may be larger than the first section. The leaflet section may define a three-dimensional region or a bulge.

The disclosure relates to a device that is configured to be implanted on the native leaflet of a heart valve to increase its length and / or thickness and thereby to improve the valve function and reduce regurgitation. The device may include a leaflet section. The leaflet section may include a central member. The central member may include a first portion, a second portion that opposes the first portion, and a base portion disposed between the first portion and the second portion. The first section may extend from the first portion and the second section may extend from the second portion. The device may include one or more engaging members extending from the central member at an angle with respect to the first section and the second section. The second section may be larger than the first section. The leaflet section may define a three-dimensional region or a bulge.

A prosthetic heart valve for treatment of a diseased heart valve having native anterior and posterior leaflets that move between an open configuration and a closed position to regulate blood flow through the heart valve during a cardiac cycle of a heart. The prosthetic heart valve having a crescent shaped stent, at least one prosthetic leaflet mounted on an inner surface of the stent, and at least one prong structure coupling a portion of the at least one prosthetic leaflet to a lower ventricular portion of the stent frame. The prosthetic heart valve further having systems for anchoring the upper flared portion of the stent to a posterior portion of the native valve annulus.

A fixation device for securing together leaflets of a heart valve is provided. The fixation device may comprise two plates that are disposed on either side of the tricuspid valve. The plates may be secured to one another by a locking clip, thereby securing the valve leaflets between the plates.

To provide methods and apparatuses for bisection of heart valve leaflets using a catheter having a cutting element.SOLUTION: The invention is a device, system, and method for repairing the heart valve function, which may include bisecting native valve leaflets for improved deployment of a prosthetic heart valve in the native valve annulus. The invention may include a catheter having a cutting element shaft with a cutting element configured to puncture a valve leaflet and / or make a controlled cut through the leaflet. The device may have an extendable foot configured to be positioned on an opposite side of the valve leaflet from the cutting element shaft. The device may include magnets to guide the cutting element and / or cutting element shaft in proper alignment with the extendable foot and to hold the elements in place during leaflet bisection.SELECTED DRAWING: Figure 7

To provide a heart valve repair device.SOLUTION: An implantable device or implant includes an anchor portion including one or more anchors coupled to an actuating element. An anchor is configured to attach to one or more leaflets of a native heart valve. An anchor is configured to move between an open position and a closed position. A device or implant includes an indication feature that is movable between an acceptable tension position and an exceeded tension position. When the anchor is attached to a native heart valve leaflet, the indicating feature indicates to a user when an amount of force applied to the anchor portion by the native heart valve leaflet exceeds a preset or predetermined amount of force.SELECTED DRAWING: Figure 69

A method of forming an implantable biomaterial comprising the steps of providing a polyether-diisocyanate prepolymer, reacting the prepolymer with one or more chain extender molecules typically including benzene 1,4-diol to form a mouldable polymer selected from a polyurethane or polyurethane-urea polymer or a polyurethane-urea block copolymer; placing the mouldable polymer into an implantable biomaterial shaped mould, and shaping and curing the mouldable polymer in the implantable biomaterial shaped mould to form the implantable biomaterial. An implantable biomaterial such as a heart valve leaflet is also disclosed.

A system for cutting at least one valve leaflet of a heart valve having multiple valve leaflets includes an elongate shaft, an expandable balloon coupled to the elongate shaft, an expandable framework disposed radially outward of the expandable balloon, and at least one electrode disposed on the expandable framework. The expandable balloon is configured to shift between a deflated configuration and an inflated configuration, and the expandable framework is configured to shift between a collapsed configuration and an expanded configuration. When the expandable framework is in the expanded configuration, the at least one electrode is configured to cut the at least one valve leaflet.

An annuloplasty device is disclosed comprising first and second support rings having a coiled configuration, and respective first and second retention units, the first support ring transitions to the second support ring over a transition section, the transition section is adapted to be arranged at a commissure of the heart valve leaflets, the first and second support rings extend in respective first and second coil planes being essentially perpendicular to the central axis, the transition section bends at least partly along the central axis so that the first coil plane is separated a distance from the second coil plane along the central axis at the transition section.

A system (100) for use with a valve (10) of a heart of a subject includes an anchor (30) and an implant (200) including a wing (220) having a contact surface (222) and an opposite surface (223) opposite the contact surface. The wings define a tip portion (232), a root portion (230), and a flexible element (280q) coupling the tip portion to the root portion. The implant includes an interface (250) at a root portion of the wing. The system includes a delivery tool (150) including a catheter (140) transluminally advanceable to the heart and a shaft (160) disposed within the catheter and engaged with an interface of the implant. Other embodiments are also described.

Systems, apparatuses, and methods disclosed herein are provided for medical treatment, including transcatheter medical treatments and / or for treatment of dilated hearts (e.g., dilated left ventricle) or functional mitral valve regurgitation within a human heart. The systems, apparatuses, and methods disclosed herein may include applying one or more heart splints to the patient's heart to apply pressure to the heart to reshape the heart. Anchors disclosed herein may be utilized in plugs for treating openings in a septum between two chambers of a heart, e.g., ventricular septal defects (VSD), atrial septal defects (ASD), and patent foramen ovale (PFO). In addition, the anchors disclosed herein may be utilized to reshape an annulus of a patient's heart valve, including a tricuspid valve of a patient's heart. The anchors disclosed herein may also be utilized to reposition a heart valve leaflet to reduce heart valve leaflet prolapse.

A system for lacerating heart valve leaflets (20) includes a coronary guidewire (110) and a laceration device including an ablative cutting element (122). A system may include a first guidewire for insertion into a left ventricle and a guide catheter configured to translate along the first guidewire. The guide catheter may include a steering element configured to direct the coronary guidewire toward the coronary artery. The laceration device cooperates with the coronary guidewire to align the ablative cutting element with a nadir of a heart valve leaflet. A method of lacerating heart valve leaflets includes advancing the coronary guidewire into a coronary artery, translating the laceration device along the coronary guidewire to a position adjacent a heart valve leaflet, positioning the ablative cutting element in contact with a nadir of the heart valve leaflet, and lacerating the heart valve leaflet from the nadir to a free edge of the heart valve leaflet.

A suture construction for adjustable fixation of a heart valve leaflet relative to a papillary muscle or other supporting heart tissue is defined by a central body portion having a plurality of longitudinally spaced indexing openings or loops, an anchor structure at a first end of the body portion, and a suturing structure at a second end of the body portion. The anchor structure is secured or coupled to the papillary muscle or supporting heart tissue and the suturing structure is passed through the heart valve leaflet where one of the indexing loops is selectively fixed to the heart valve leaflet to adjustably fix the heart valve leaflet in a desired functional position relative to the supporting heart tissue. The indexing loops of the suture construction prevent unwanted movement of the heart valve leaflet in both directions and are securable in very small incremental positions for proper functional spacing.

A fixation device for securing together leaflets of a heart valve is provided. The fixation device may comprise two plates that are disposed on either side of the tricuspid valve. The plates may be secured to one another by a locking clip, thereby securing the valve leaflets between the plates.

A system (100) for use with a subject heart valve (10) includes an anchor (30) and an implant (200) including wings (220) having a contact surface (222) and an opposing surface (223) opposite the contact surface. The wings define a tip portion (232), a root portion (230), and a bending element (280q) connecting the tip portion to the root portion. The implant includes an interface (250) at the root portion of the wing. The system includes a delivery tool (150) including a catheter (140) transluminally advanceable into the heart and a shaft (160) disposed within the catheter and engaging the interface of the implant. Other embodiments are also described.

This application relates to prosthetic heart valve leaflet coaptation assemblies and methods. Disclosed are prosthetic heart valves and related methods for assembling a prosthetic heart valve including an annular frame and a plurality of leaflets. As one example, the valve includes a plurality of coaptations, each coaptation including an attachment member having a protruding portion, a first coaptation tab of a first leaflet of the plurality of leaflets being disposed adjacent a first side of the protruding portion and directly secured to the attachment member. Each coaptation also includes a second coaptation tab of a second leaflet of the plurality of leaflets being disposed adjacent an opposite second side of the protruding portion and directly secured to the attachment member.

A system comprises an anchor, having an anchor head that defines a forward-torque face and a reverse-torque face. A delivery tool comprises a transluminally advanceable driver, comprising a driveshaft, and a distal drive head. The drive head is shaped to engage the anchor head such that while the driveshaft presses the drive head distally into engagement with the anchor head, forward rotation of the drive head screws the anchor into the tissue. Reverse rotation of the drive head hooks the drive head onto the anchor head. While the drive head remains hooked onto the anchor head, reverse rotation of the drive head, and pulling the anchor head by tensioning of the driveshaft, unscrews the anchor from the tissue. Tensioning the driveshaft while the drive head is not hooked onto the anchor head pulls the drive head away from the anchor head. Other embodiments are also disclosed.

A medical assembly includes a guide catheter having a lumen extending therethrough and an electrocautery member slidingly disposed within the lumen. The electrocautery member has an elongate shaft having a proximal shaft segment and a distal shaft segment adapted to be movable between a puncture position and an incise position. In some cases, a hinge segment is disposed between the proximal shaft segment and the distal shaft segment and includes a leading edge adapted to form a puncture within a heart valve leaflet when the distal shaft segment is in its puncture position and a trailing edge adapted to incise the heart valve leaflet when the distal shaft segment is in its incise position. In some cases, the electrocautery member includes electrically isolated puncture and incise electrodes.

The invention belongs to the technical field of medical instruments and discloses a valve leaflet clamping device which comprises a catheter component, a driving mechanism, a first clamping arm, a second clamping arm and an auxiliary clamping component, the driving mechanism comprises a handle assembly and a driving assembly, the driving assembly is connected to the handle assembly and penetrates through the catheter component, the first clamping arm is arranged at the far end of the catheter component, and the second clamping arm is arranged at the far end of the catheter component. The second clamping arm is connected to the first clamping arm, the driving assembly drives the second clamping arm to be opened or closed, the second clamping face of the second clamping arm can make contact with the first clamping face of the first clamping arm, the auxiliary clamping component is assembled on the first clamping arm, and when the second clamping arm is opened, the driving assembly drives the auxiliary clamping component to move towards the second clamping arm. The auxiliary clamping part of the auxiliary clamping component can abut against the second clamping face. By applying the technical scheme, the problems that in the heart valve leaflet repairing operation, when a native valve leaflet is clamped, due to the fact that the native valve leaflet is prone to slipping, clamping is difficult, operation is repeated, the operation time is prolonged, and the operation risk is increased are solved.

An annuloplasty device comprises first and second support rings having a coiled configuration in which the first and second support rings are arranged as a coil around a central axis, wherein the first and second support rings are configured to be arranged on opposite sides of native heart valve leaflets of a heart valve, a stent arranged around at least a portion of the first and / or second support ring, and wherein the stent comprises retention units. A related method of repairing a defective heart valve is also disclosed.

The invention relates to a prosthetic heart valve leaflet assembly and a method of assembly. A leaflet assembly for a prosthetic heart valve is disclosed. As one example, a method includes forming a plurality of leaflet assemblies, each including a leaflet and a skirt and formed by arranging the skirt on one side of the leaflet such that the skirt extends along a curvilinear apex edge portion of the leaflet and two commissure lugs, folding two ends of the skirt around the respective commissure lugs, each folded end is sewed to a respective commissure lug to form a corresponding half commissure portion, and the skirt is sewed to the tip edge portion, and forming the leaflet assembly by pairing each half-commissure portion of each leaflet assembly with a half-commissure portion of another leaflet assembly to form a plurality of pairs of adjacent half-commissure portions and stitching the adjacent half-commissure portions to each other for each pair to form a commissure.

A valve fixation device may include a unitary elongated member biased toward a closed configuration in which at least a pair of tissue engaging surfaces of the elongated member are held in a position proximal to one another by a biasing force. The biasing force is at least equal to a leaflet grasping force, thereby enabling the fixation device to grasp and retain the leaflets as part of a cardiac treatment. A delivery tool including an expander can independently translate the tissue engaging surfaces to enable the heart valve leaflets to be captured and retained between the tissue engaging surfaces. The valve fixation device may include at least two arms, each arm being independently controllable to grasp and capture opposing leaflets of a valve, such as an anterior and posterior leaflet of a mitral valve, to reduce the size of the valve opening and improve cardiac function.

Devices and methods for removing a valve clip which is pre-positioned on a heart leaflet, the valve clip including a delivery catheter having a distal end portion configured to be positioned near a heart valve; a grasping tool deployable from the distal end portion of the delivery catheter, the grasping tool configured to grasp and manipulate a valve clip from an implanted condition to an elongated condition, wherein the valve clip in the elongated condition has an elongated width less than an implanted width of the valve clip in the implanted condition; and a removal tool extendable relative to the distal end portion of the delivery catheter, the removal tool configured to at least partially surround the valve clip in the elongated condition and to remove the valve clip from the heart valve leaflet.

In one example, an implantable prosthetic device comprises a spacer body portion configured to be disposed between native leaflets of a heart, and an anchor portion configured to secure the native leaflets against the spacer body portion. The prosthetic device can be movable between multiple configurations. A size of the spacer body is configured to be adjusted after the spacer body is placed between the native valve leaflets and the pair of anchors are placed against the ventricular surfaces of the native heart valve leaflets. A delivery apparatus can have a first shaft and a second shaft, wherein movement of the first shaft relative to the second shaft moves the anchor portion relative to the spacer body.

The present disclosure describes a replacement valve that can remove or lacerate the anterior mitral leaflet (or other portion of the heart) to reduce the obstruction of the left ventricular outflow tract (LVOT). The replacement valve can include integrated cutting features to lacerate a leaflet of a heart valve. For example, the cutting features can include blades or electrosurgical features that can cut the leaflets to reduce obstruction of the LVOT. As the cutting features are integrated components of the replacement valve, the laceration of the leaflet can follow implantation of the replacement valve and enables for clinical decisions to be made based on the degree of obstruction to the LVOT following the implantation procedure.

A system for implanting two or more implants into a heart of a patient may include a multi-device steerable guide catheter ("MDSGC"), a transcatheter edge-to-edge repair ("TEER") implant delivery device, and an additional implant delivery device for implanting an additional medical device. The additional medical device may be a collapsible and expandable prosthetic transcatheter aortic valve repair ("TAVR") device or a collapsible and expandable left atrial appendage ("LAA") occluder device. The MDSGC may have a first handle and may be steerable, the TEER delivery device may have a second handle, and the additional delivery device may have an additional handle. The system may include a fixation device to capture native heart valve leaflets therebetween as part of a TEER procedure. The TEER delivery device and the additional delivery device may each have a catheter sized and shaped to pass through an interior of a catheter of the MDSGC.

A medical system includes a catheter that can be navigated through a patient's vasculature to introduce a valve clip configured to engage an edge of a heart valve leaflet. The valve clip includes a deformable wire configured to engage the valve leaflet, the wire extending from a first wire portion to a second wire portion. The catheter includes a handle having a control member, an elongated body defining a cavity extending from the handle to a distal opening, and first and second delivery devices operably coupled to the control member and extending through the cavity to the distal opening. Each delivery device is configured to releasably couple to a portion of the wire and be movable relative to the distal opening. The delivery devices are controllable at the handle to move the valve clip between an extended configuration and a contracted configuration to engage the valve leaflet.

A method of repairing a defective heart valve involves positioning first and second support rings of an annuloplasty device in a first configuration on opposite sides of native heart valve leaflets and activating a contracted state of the annuloplasty device so that a first pitch distance between the first and second support rings in the first configuration is reduced to a second pitch distance that is shorter than the first pitch distance to move the first and second support rings toward each other to pinch the native heart valve leaflets.

The equipment (100) for preparation of leaflets (L) for bioprosthetic heart valves (10) comprises a station (200) for digitization of patches (P) of animal tissue including 2D optical sensors (225, 235) for imaging the patch (P) with at least one of bright-field epi- illumination and transillumination means (220, 230) for at least one of detection defects and assessing a collagen density in the patch (P), 3D optical sensors (240) for obtaining a thickness map (250) of patch (P), and a small-angle light scattering (SALS) system (300) for obtaining a through thickness orientation and dispersion map (255) of collagen fibers in patch (P). A station (400) for automatic selection of optimal regions of patch (P) to form accepted leaflets (L) based on a leaflet model (L'), a leaflet cutting station (500), a station (600) for final inspection, acceptance, and certification of cut leaflets (L) and a grouping station (700) are also provided.

A transcatheter heart valve leaflet replacement system includes a valve prosthesis and a multi-stage, multi-lumen (MSML) heart valve delivery and implantation system for guiding and implanting the prosthesis to a native annulus. The prosthesis includes a stent frame including an upper atrial flared portion and a lower ventricular portion, a plurality of prosthetic leaflets, and at least one lining skirt. The prosthesis is configurable or otherwise sizable to fit in the MSML delivery and implantation system and to subsequently be selectively expanded to an operative size and position once deployed within the annulus. A portion of the prosthesis can be configured to couple with dual guiding and fixation (DGF) members to guide and fix the prosthesis to the annulus. In one aspect, the MSML delivery and implantation system includes a main docking system, a DGF member delivery system, and a valve housing, positioning, and locking system.