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Crosslinked bioprosthesis valve processing method

A technology of biological valves and treatment methods, applied in the field of biomedical materials and medical devices, can solve the problems of inability to eliminate inflammatory reactions, toxicity, calcification, etc., achieve good blood compatibility, good mechanical properties, and reduce inflammatory reactions.

Pending Publication Date: 2019-05-31
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, glutaraldehyde crosslinking also has some inherent disadvantages, such as susceptibility to calcification, toxicity, insufficient stability, and inability to eliminate inflammatory reactions, which can shorten the service life of the valve
Currently, some other cross-linking agents have been reported, such as carboimides, epoxy compounds, etc., but the tissue stability obtained by these methods is not good

Method used

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  • Crosslinked bioprosthesis valve processing method
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  • Crosslinked bioprosthesis valve processing method

Examples

Experimental program
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Effect test

Embodiment 1

[0027] A method for processing a cross-linked artificial biological valve. The biological valve is obtained through a three-step process. The first step is to modify the heterogeneous biological tissue and an unsaturated group compound to react with an unsaturated group, and the second step is to obtain a cross-linked biological valve through free radical polymerization. Linked biological valve tissue, the third step is to process the residual unsaturated groups in the cross-linked tissue to eliminate unreacted unsaturated groups. The xenogeneic biological tissue includes decellularized or non-decellularized porcine arterial valve, porcine pericardium or bovine pericardium. The unsaturated groups are (meth)acrylamide, (meth)acrylate, allyl. The free radical polymerization method is thermal polymerization or photopolymerization, wherein the thermal polymerization initiator is an organic peroxide initiator, an inorganic peroxide initiator, an azo initiator, a redox initiator, pr...

Embodiment 2

[0041] In this example, the porcine pericardium prepared in Example 1 was soaked in 5 mM ammonium persulfate / sodium bisulfite solution for thermal polymerization, placed at 37 degrees for 24 hours, and the cross-linked valve was treated with ethanol and Rinse thoroughly with deionized water.

Embodiment 3

[0043] In this implementation, the porcine pericardium prepared in Example 1 was soaked in 0.5% initiator Igcure2959 solution overnight at 37 degrees centigrade for the photopolymerized porcine pericardium, and the valve was taken out and irradiated with ultraviolet light for 10 minutes to complete cross-linking. The crosslinked valves were rinsed thoroughly with ethanol and deionized water.

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Abstract

The invention discloses a biovalve crosslinking method. The method includes introducing an unsaturated group to heterogeneous biological tissues such as porcine active valves, pig pericardia and bovine pericardia into through active groups on the biological tissues such as a carboxyl group, a hydroxyl group, an amino group and a sulfhydryl group reacting with an unsaturated group-containing compound to obtain an unsaturated group-modified biological tissue, and then obtaining a crosslinked biological tissue by radical polymerization. The biological tissue obtained by the crosslinking method has excellent collagen and elastin stability, blood compatibility, no cytotoxicity, good mechanical properties, anti-calcification capability and low inflammatory response.

Description

technical field [0001] The invention relates to the technical field of biomedical materials and medical devices, in particular to a cross-linked artificial biological valve processing method and biological materials thereof. Background technique [0002] Valve diseases such as valve stenosis and prolapse can affect the normal blood circulation of the body and even be life-threatening. For more severe valve disease, valve replacement is the best treatment. At present, there are two types of valves used clinically: mechanical valves and biological valves. The biological valves are superior to mechanical valves in most performance indicators, but the lifespan of biological valves is much lower than that of mechanical valves, especially in young and middle-aged patients. The median life expectancy is only about 5 years, so bioprosthetic valves are not currently recommended for patients under the age of 50. Patients with mechanical valves must take anticoagulants for life, and ...

Claims

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Application Information

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IPC IPC(8): A61F2/24
Inventor 王云兵郭高阳雷洋金林赫
Owner SICHUAN UNIV
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