32 results about "Tetramic acid" patented technology

The present invention relates to findings that reducing the activity of Plasminogen Activator Inhibitor-1 (PAI-1) suppresses an excessive deposition of collagen which is known as a cause for the formation of abnormal scars. These abnormal scars include but are not limited to keloids, adhesions, hypertrophic scars, skin disfiguring conditions, fibrosis, fibrocystic conditions, contractures, and scleroderma, all of which are associated with or caused by an excessive deposit of collagen in a wound healing process. Accordingly, aspects of the present invention are directed to the reduction of PAI-1 activity to decrease an excessive accumulation of collagen, prevent the formation of an abnormal scar, and/or treat abnormal scars that result from an excessive accumulation of collagen. The PAI-1 activity can be reduced by PAI-1 inhibitors which include but are not limited to PAI-1 neutralizing antibodies, diketopiperazine based compounds, tetramic acid based compounds, hydroxyquinolinone based compounds, Enalapril, Eprosartan, Troglitazone, Vitamin C, Vitamin E, Mifepristone (RU486), and Spironolactone to name a few. Another aspect of the present invention is directed to methods of measuring PAI-1 activity in a wound healing process and determining the propensity of the formation of an abnormal scar.

The present invention relates to the preparation process and use of fluoro aromatic organic tetraacid dianhydride and its derivative. The present invention prepares fluoro aromatic organic tetrahydric dianhydride and its derivative through the Grignard reaction between metal trifluoroacetate and substituted halogeno benzene to produce alpha, alpha, alpha-trifluoromethyl phenyil ketone; the condensation reaction of the alpha, alpha, alpha-trifluoromethyl phenyil ketone and one-xylene under the action of strong acid to obtain fluoro aromatic tetramethyl compound; the high temperature nitric acid oxidation or KMnO4 oxidation of the fluoro aromatic tetramethyl compound to obtain fluoro aromatic organic tetracid; and the final dewatering. Fluoro aromatic organic tetrahydric dianhydride and its derivative may be prepared into fluoro aromatic polyimide with excellent comprehensive performance through condensation with aromatic organic diamine and subsequent imination.

Novel tetramic acid-type compounds isolated from a CCR-5 active complex produced by fermentation under controlled conditions of a biologically pure culture of the microorganism, Chaetomium globosum Kunze SCH 1705, ATCC 74489., pharmaceutical compositions containing the compounds and the use of the CCR-5 antagonist compounds and compositions to treat HIV-1 infections in humans are disclosed.

The invention belongs to the field of pesticides, and discloses an insecticidal acaricidal composition containing an active component A and an active component B, wherein the active component A is selected from the following compounds disclosed in the specification; the active component B is selected from tetronic acid (tetronic acid/tetramic acid derivative) insecticides and acaricides; the tetronic acid insecticides and acaricides comprise spirodiclofen, spiromesifen, spirotetramat or the like; and the weight ratio of the active component A to the active component B is 1:99-99:1. The composition has obvious synergistic action, widens the insecticidal spectrum, and reduces the pesticide consumption; and the pests can not easily generate drug resistance, and thus, the composition can be used for preventing and treating multiple pests and acarids on multiple crops.

The invention discloses a preparation method of aromatic diether dianhydride, which comprises the following steps of: by using isobutene or tert-butyl alcohol as a protecting group of carboxyl of chlorinated or nitrophthalic acid, carrying out etherification reaction with disodium bisphenol salt to obtain an intermediate, removing the tert-butyl ester protecting group in the intermediate by usinga small amount of acid without strong alkali treatment to obtain diether tetracarboxylic acid, and finally, enabling the solid tetracarboxylic acid to directly form anhydride at a proper temperature,wherein acetic anhydride dehydration is not needed, and the reaction time of the whole process is only about 21 hours. The preparation method of the aromatic diether dianhydride is short in reaction period, simple and safe in process, high in production efficiency and low in production cost.

The invention relates to novel 2.4-dihalogen-6-(C2-C3-alkyl)-phenyl substituted tetramic acid derivatives of formula (I), wherein A, B, D, G, X, Y and Z have the above mentioned meaning. The invention also relates to several methods and intermediate products for the production and use thereof as pesticides and/or herbicides, in addition to selective herbicidal agents which contain 2.4-dihalogen-6-(C2-C3-alkyl)-phenyl substituted tetramic acid derivatives and at least one compound which improves the compatibility of cultivated plants.

Compounds for the treatment of bacterial and parasitic infections which are hybrid compounds of compounds having antibacterial or antiparasitic activity and compounds that decrease the absorption of the hybrid compound from the gastrointestinal tract. The compounds are preferably for use against C. difficile infections and comprise a hybrid molecule of an anti-C. difficile compound such as a nitroimidazole and a tetramic acid derivative.

The invention relates to a silver metal complex constructed by furantetracarboxylic acid and a preparation method of the silver metal complex. The chemical composition of the complex contains a furantetracarboxylic acid (H4fa) ligand and a bpy ligand. The synthesis scheme comprises the following steps: dissolving potassium salt of furantetracarboxylic acid and AgNO3 in distilled water according to a stoichiometric ratio, dissolving a bpy ligand in acetonitrile, mixing, and adding 1d HCl; and putting the obtained solution into a polytetrafluoroethylene lining, then putting the polytetrafluoroethylene lining into a reaction kettle, putting the reaction kettle into a drying oven, and carrying out heating reaction for 3 days to obtain a target product. The mass ratio of the potassium salt of furantetracarboxylic acid to AgNO3 to bpy is 1: 0.85: 0.39.

A method for purification of a biphenol tetraacid composition includes contacting the biphenol tetraacid composition with a solvent including a C1-6 alcohol to form a slurry and isolating the purified biphenol tetraacid from the slurry. The biphenol tetraacid composition includes a biphenol tetraacid and a biphenol. A purified biphenol tetraacid composition is also described.

The present invention relates to novel trifluoromethoxyphenyl-substituted tetramic acid derivatives of the formula (I) shown in the description, in which J, X, Y, A, B, D and G are each as defined above, to several processes for their preparation and to their use as pesticides and/or herbicides. The invention also provides selectively herbicidal compositions which comprise firstly trifluoromethoxyphenyl-substituted tetramic acid derivatives and secondly a compound which improves the crop plant tolerability. The invention further relates to the enhancement of the action of crop protection compositions comprising compounds of the formula (I) by the additions of ammonium or phosphonium salts and if appropriate penetration enhancers.