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Alginate-based hydrogel dressing and preparation method thereof

A technology of alginate and hydrogel, applied in] The present invention relates to the technical field of medical supplies, and can solve the problems of poor transparency, poor water retention performance, poor water content, and poor mechanical properties.

Active Publication Date: 2017-03-15
QINGDAO CHENLAND MARINE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, alginic acid hydrogel dressings are commonly used in light and ion cross-linking methods, but there are disadvantages such as poor transparency, poor mechanical properties, and poor water retention and moisture content.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1. Preparation of Alginate-Based Hydrogel Aqueous Solution

[0023] Dissolve 1g of sodium alginate in 100ml of deionized water and stir at room temperature. After it swells completely, add 2g of polyvinyl alcohol, 1g of carbomer, and 2g of glycerol in sequence, and keep stirring until completely dissolved, then overnight Let stand to defoam;

[0024] 2. Preparation of cross-linking agent

[0025] Dissolve 0.2 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 0.1 g of N-hydroxysuccinimide dopamine in 100 ml of deionized water, and dissolve completely Linking agent A; 1g of calcium chloride solution was dissolved in 100ml of deionized water to obtain crosslinking agent B;

[0026] 3. pre-crosslinked

[0027] Add 5ml of cross-linking agent A to the solution in step 1, and after stirring for 1h, continue to add 5ml of cross-linking agent B, and stir for 0.5h;

[0028] 4. Coating

[0029] Use a film applicator to coat the film, and the backing is ...

Embodiment 2

[0035] 1. Preparation of Alginate-Based Hydrogel Aqueous Solution

[0036] Dissolve 2g of sodium alginate in 100ml of deionized water and stir at room temperature. After it swells completely, add 1g of polyvinyl alcohol, 2g of carbomer, and 1g of glycerol in sequence, and keep stirring until it is completely dissolved, then overnight Let stand to defoam;

[0037] 2. Preparation of cross-linking agent

[0038] Dissolve 0.5 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 0.2 g of N-hydroxysuccinimide dopamine in 100 ml of deionized water, and dissolve completely Linking agent A; 2g calcium chloride solution was dissolved in 100ml deionized water to obtain crosslinking agent B;

[0039] 3. pre-crosslinked

[0040] Add 3ml of crosslinking agent A to the solution in step 1, stir for 1 hour, then continue to add 2ml of crosslinking agent B, and stir for 0.5h;

[0041] 4. Coating

[0042] Use a film applicator to coat the film, and the backing is medical...

Embodiment 3

[0048] 1. Preparation of Alginate-Based Hydrogel Aqueous Solution

[0049]Dissolve 3g of sodium alginate in 100ml of deionized water and stir at room temperature. After it swells completely, add 3g of polyvinyl alcohol, 1g of carbomer, and 5g of glycerol in sequence, and keep stirring until it is completely dissolved, then overnight Let stand to defoam;

[0050] 2. Preparation of cross-linking agent

[0051] Dissolve 0.1 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 0.8 g of N-hydroxysuccinimide dopamine in 100 ml of deionized water, and dissolve completely Linking agent A; 2.5g calcium chloride solution was dissolved in 100ml deionized water to obtain crosslinking agent B;

[0052] 3. pre-crosslinked

[0053] Add 6ml of crosslinking agent A to the solution in step 1, stir for 1 hour, then continue to add 6ml of crosslinking agent B, and stir for 0.5h;

[0054] 4. Coating

[0055] Use a film applicator to coat the film, and the backing is medica...

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Abstract

The invention relates to an alginate-based hydrogel dressing and a preparation method thereof, and belongs to the technical field of medical supplies. Raw materials of the invention are a compound of sodium alginate or other alginates and a thickener, a moisturizer and other functional matters, are subjected to swelling dosing, pre-crosslinking, film coating, spray crosslinking, constant-temperature crosslinking plasticizing and film-covering shear forming, and are then prepared into a three-dimensional water-containing grid structure through covalent cross-linking and ion cross-linking. The medical hydrogel dressing is a topical gel dressing, has good moisturizing performance, toughness and adhesion, is mainly suitable for superficial skin damage, such as cut wound, lacerated wound, scratch, burns, suture wounds and the like, protects skin wound healing of a patient, has effects of easing pain, inhibiting bacteria, resisting inflammation, keeping the wound moist, promoting wound healing, and improving the wound repairing quality, is more suitable for treating bedsore wounds, ulcer wounds and other sites hard to be bound after a surgery, can also be used for non-wound sites, and plays a role of moisturizing.

Description

technical field [0001] The invention relates to the technical field of medical supplies. The alginate hydrogel dressing can provide a good moist environment for wound healing, and has a certain liquid absorption performance, creating a good healing environment and the basis of a drug delivery system, which is better than traditional colloid dressings. Excellent mechanical properties and moisturizing properties, its own liquid content reaches more than 60%, and its liquid absorption is more than 2 times its own weight. It is suitable for various important periods of wound healing, and can also enter the clinical operating room to treat wounds from the earliest stage. Effective care can prevent wound infection and adhesion during use, and will not cause secondary damage to the wound when changing the dressing, reducing patient pain, reducing the burden of medical workers, reducing medical expenses, and has good air permeability and transparent appearance during the nursing proces...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/24A61L15/20A61L15/18A61L15/42
CPCA61L15/18A61L15/20A61L15/24A61L15/28A61L15/42C08L5/04C08L29/04C08L33/02
Inventor 邹仁利杨毅李乘风
Owner QINGDAO CHENLAND MARINE BIOTECH CO LTD
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