Thermosensitive gel containing matrine alkaloid and preparation method of thermosensitive gel

Abstract

The invention discloses thermosensitive gel containing matrine alkaloid. The thermosensitive gel containing the matrine alkaloid is prepared from the following raw and supplemental materials in percentage by mass: 1% to 5% of the matrine alkaloid, 15% to 25% of poloxamer 407, 0.1% to 1.5% of a biological adhesion agent, and 0% to 2% of a gel temperature regulator, wherein the biological adhesion agent is selected from one or a mixture of two or more of methyl cellulose, sodium carboxymethyl cellulose and sodium alginate. The thermosensitive gel disclosed by the invention is reasonable in preparation formula and gelatinized when being close to the body temperature, and has no leakage after being administrated, convenient use, and further wide clinical application prospects in aspects of preventing and / or treating colitis, vaginitis, prostatitis and a pelvic inflammatory disease and the like.

Description

technical field [0001] The invention relates to a thermosensitive gel containing matrine alkaloids and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Matrine alkaloids are a class of alkaloids with the chemical structure characteristics of matrine-15-one. They are mainly natural products isolated and extracted from plants Sophora flavescens and Sophora flavescens, including the total alkaloid parts (referred to as flavescens for short). total alkaloids) and monomeric compounds purified from matrine total alkaloids, such as matrine, oxymatrine, sophoridine, aloperine, sophocarpine, sophoramine, sophoryl, oxidized sophocarp alkali. Most matrine alkaloids have antibacterial, anti-inflammatory, antiviral, analgesic, antipruritic, insecticidal and other effects, and are widely used clinically in diseases such as skin diseases, gynecology and sexually transmitted diseases of men and women. However, the current external preparation...

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Problems solved by technology

However, the inventors of the present invention have found through experiments that the thermosensitive gel provided by the above-mentioned patent still has obvious disadvantages: (1) the thermosensitive gel uses hypromellose as a bioadhesive agent, which will cause a problem in the animal retention experiment. Leakage occurs, and the stability of the preparation solution is not good, and the gelation and stratification of the solution will occur during the placement process; (2) Poloxamer 407 is used as the heat-sensitive material alone, and the gelation temperature is relatively low. It is easy to gel at a lower temperature, and it is inconvenient to administer; (3) The preparation process requires stricter requirements, and there is a specific order of addition. For example, it is necessary to dissolve matrine before adding poloxamer 407

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