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Olive bitter glycoside suppository

A technology of oleuropein suppository and oleuropein, which is applied in the directions of suppository delivery, anti-inflammatory agent, non-central analgesic, etc., can solve the problems of no oleuropein suppository, bacterial resistance, difficult to control inflammation, etc. Good lubricating effect, comfortable medication, prolonged action time

Active Publication Date: 2017-01-04
CHENGDU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, vaginitis, pelvic inflammatory disease and cervical erosion are all prone to relapse, and relapse is related to unclean personal hygiene, unclean sex life or vaginal and pelvic environmental flora imbalance. Improve the curative effect by increasing the dose. When the dose reaches the maximum, the inflammation will be difficult to control, which will bring pain and mental burden to the patient.
There are no reports of oleuropein suppositories

Method used

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  • Olive bitter glycoside suppository
  • Olive bitter glycoside suppository
  • Olive bitter glycoside suppository

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Immediate Release Oleuropein Suppository

[0019] (1) Get carbomer 0.3g, add water 29.7g, leave standstill 4h, make the carbomer solution that concentration is 1%, namely hydrogel;

[0020] (2) Take oleuropein, grind it finely, weigh 3g after passing through a 100-mesh sieve, add 3g of oleuropein to the hydrogel several times, and stir evenly;

[0021] (3) Weigh 198g of PEG4000, heat and melt it at 80°C, and then keep it at 60°C;

[0022] (4) Weigh 22 g of the hydrogel mixed with oleuropein prepared in step (2), add it to the melted PEG4000, heat and stir for 20 minutes, and mix it evenly;

[0023] (5) Pour the matrix containing oleuropein obtained in step (4) into the suppository mold while it is hot, and make 100 quick-release oleuropein suppositories, each weighing 2.2 g, each containing 20 mg of oleuropein, It contains 2.18g of matrix, in which PEG4000 accounts for 90.83%, and hydrogel accounts for 9.17%.

[0024] Get 6 prepared oleuropein suppositories...

Embodiment 2

[0025] Example 2 Immediate Release Oleuropein Suppository

[0026] (1) Take 109g of PEG400, add 2g of oleuropein, ultrasonically or slightly heat to dissolve the oleuropein;

[0027] (2) Weigh 99g of PEG4000, heat and melt it at 80°C, and then keep it at 60°C;

[0028] (3) Add the oleuropein-containing PEG400 obtained in step (1) into the melted PEG4000 several times, stir while adding, and continue stirring for 30 minutes after adding;

[0029] (4) The matrix containing oleuropein obtained in step (3) was poured into the suppository mold while it was hot, and 100 quick-release oleuropein suppositories were obtained, each weighing 2.1 g, each containing 20 mg of oleuropein, It contains 2.08g of matrix, in which PEG4000 accounts for 47.60%, and PEG400 accounts for 52.4%.

[0030] Get 6 prepared oleuropein suppositories to measure the hardness, the average hardness is 1.70 ± 0.22kg; according to the second method of the dissolution and release determination method of the 2015 ...

Embodiment 3

[0031] Example 3 Oleuropein Suppository with Moderate Release Rate

[0032] (1) Get 0.3 g of sodium carboxymethyl cellulose, add 29.7 g of water, let it stand for 4 hours, and obtain a sodium carboxymethyl cellulose solution with a concentration of 1%, namely hydrogel;

[0033] (2) Take oleuropein, grind it finely, weigh 3g after passing through a 100-mesh sieve, add 3g of oleuropein to the hydrogel several times, and stir evenly;

[0034] (3) Weigh 176g of PEG4000 and 22g of glyceryl monostearate, heat and melt them at 80°C, and then keep them warm at 60°C;

[0035] (4) Weigh 22 g of the hydrogel mixed with oleuropein prepared in step (2), add it to molten PEG4000 and glyceryl monostearate, heat and stir for 20 minutes, and mix it evenly;

[0036] (5) Pour the oleuropein-containing matrix obtained in step (4) into the suppository mold while it is hot to prepare 100 medium-release oleuropein suppositories, each weighing 2.2g, and each containing oleuropein 20mg , containing ...

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PUM

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Abstract

The invention discloses an olive bitter glycoside suppository. Medicine components of the suppository are bitter glycosides, components and proportions of substrates of the suppository are adjusted, and quick release suppositories and suppositories with medium release rate can be obtained. The suppository is supplied through a vagina and can be used for treating gynecological diseases such as vaginitis, pelvic infection and cervical erosion, the suppository is supplied through a rectum can be used for treating rectitis and rectal cancer, and the suppository can enter general blood circulation through a rectal mucosal lower vessel and has the functions of generalized inflammation resistance and osteoporosis improvement and the like.

Description

technical field [0001] The invention relates to a suppository, in particular to an oleuropein suppository. Background technique [0002] Vaginitis, pelvic inflammatory disease, and cervical erosion are common and frequently-occurring diseases in gynecology. The microorganisms that infect the vagina and pelvis include bacteria, candida, and trichomonas. The commonly used clinical treatment methods are oral anti-anaerobic drugs such as metronidazole and tinidazole. And clindamycin combined with local suppository treatment, commonly used suppositories include metronidazole suppositories, miconazole suppositories, nystatin suppositories and clotrimazole suppositories. However, vaginitis, pelvic inflammatory disease and cervical erosion are all prone to relapse, and relapse is related to unclean personal hygiene, unclean sex life or vaginal and pelvic environmental flora imbalance. The curative effect can be improved by increasing the dosage. When the dosage reaches the maximum ...

Claims

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Application Information

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IPC IPC(8): A61K9/02A61K31/7048A61P1/00A61P15/00A61P15/02A61P19/10A61P29/00A61P35/00
CPCA61K9/0031A61K9/0034A61K9/02A61K31/7048A61K47/10A61K47/32A61K47/38
Inventor 刘嵬姚倩苟小军郭晓强颜军梁立
Owner CHENGDU UNIV
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