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56results about How to "Improve intestinal barrier function" patented technology
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Composition comprising HMSs/HMOs and use thereof
InactiveUS20160243139A1Increase abundanceImprove intestinal barrier functionOrganic active ingredientsMedicineVisceral pain
The application relates to synthetic compositions containing one or more human milk mono- or oligosaccharides for treating visceral pain.
Owner:GLYCOM AS
Nutrition with lipids and non-digestible saccharides
ActiveUS20120129935A1Sufficient availabilityGrowth inhibitionAntibacterial agentsBiocideDiseaseMedicine
The invention relates to a liquid nutrition comprising short chain fatty acyl chains and a non-digestible, fermentable saccharide. The composition is particular suitable for use as an infant nutrition. The composition is also suitable for treatment and / or prevention of gut barrier related disorders.
Owner:NV NUTRICIA
Probiotic bifidobacterium adolescentis strains
ActiveUS20170252382A1Inhibit disease severityAlleviated colitis symptomNervous disorderAntipyreticAutoimmune conditionDendritic cell
The present invention relates to novel isolated strains of Bifidobacterium adolescentis which are capable of i) increasing the trans-epithelial electrical resistance (TER) of a Caco-2 cell monolayer after 10 h treatment to more than 120% of TER at treatment start, ii) inducing secretion of >200 pg / ml of IL-10, and / or iii) inducing an IL-10:IL-12 ratio>1 when co-incubated with human PBMC derived dendritic cells. The strains may have one, two or all three of these capabilities. The present invention relates to the use of these novel strains for the in prevention, alleviation of symptoms, and treatment of diseases or conditions with an underlying impaired intestinal barrier function and pro-inflammatory activation of the mucosa. More specifically, the present invention relates to se of an isolated strain according to the invention for the prevention, alleviation of symptoms, or treatment of intestinal inflammatory conditions such as IBD and IBS, liver diseases such as NAFLD, NASH, cirrhosis, and alcohol-related liver disease, metabolic disorders such as metabolic syndrome, insulin resistance, type 2 diabetes, obesity, cardiovascular atherosclerosis, autoimmune diseases, such as celiac disease, type 1 diabetes, multiple sclerosis and rheumatoid arthritis, and mental conditions such as major depressive disorders, a mood disorder, a cognitive chronic fatigue syndrome, and anxiety.
Owner:CHR HANSEN AS
Probiotic bifidobacterium longum
The invention relates to novel, probiotic, anti-inflammatory strains of Bifidobacterium longum, their use for treatment of diseases, and for preparation of human or pet food or pharmaceutical compositions. The strains produce high amounts of exopolysaccharides with a high content of mannose- and glucose residues. Accordingly, the invention also relates to a bacterial polysaccharide composition obtained from the strains, their use for treatment of diseases, and pharmaceutical compositions comprising such polysaccharides.
Owner:CHR HANSEN AS
Lactobacillus plantarum S58 and application thereof in preparation of products for relieving obesity
The invention discloses a preservation number of CCTCC NO: M 2019595 Lactobacillus plantarumS58 and application thereof in preparation of products such as health care products, foods and medicines forrelieving obesity. The invention not only expands the application range of the Lactobacillus plantarumS58 and improves the utilization value of the Lactobacillus plantarumS58, but also brings new hope for treating obesity.
Owner:SOUTHWEST UNIVERSITY
Lactic acid bacteria formula for preventing acute and chronic alcoholic liver injury and application thereof
ActiveCN111437294AGood simulated gastrointestinal fluid toleranceInhibit inflammationDigestive systemUnknown materialsLactobacillus acidophilusFatty acid
The invention discloses a lactic acid bacteria formula for preventing acute and chronic alcoholic liver injury and application thereof. Lactobacillus plantarum KLDS1.0344 and lactobacillus acidophilusKLDS1.0901 have good gastrointestinal fluid tolerance simulating capacity, have certain adhesion capacity to HT-29 cells and have basic probiotic characteristics; the lactobacillus plantarum KLDS1.0344 and the lactobacillus acidophilus KLDS1.0901 can prevent acute alcoholic liver injury; and the lactobacillus plantarum KLDS1.0344 and the lactobacillus acidophilus KLDS1.0901 can prevent chronic alcoholic liver injury. Specifically, the lactobacillus plantarum KLDS1.0344 and the lactobacillus acidophilus KLDS1.0901 have the functions of reducing the liver index, improving the intestinal barrier, improving the liver function, reducing the inflammation level in the liver, increasing the content of short-chain fatty acid in the intestinal tract, reducing protein expression of CYP2E1 in the liver and the like.
Owner:NORTHEAST AGRICULTURAL UNIVERSITY
A method of preparing a nutriment from a plurality of Chinese herbal medicines capable of being adopted as foods and medicines
InactiveCN104137972AImprove solubilityEasy to spreadFood ingredient functionsFood preparationDiseaseFood flavor
The invention relates to a functional food prepared from fresh juice of a plurality of Chinese herbal medicines capable of being adopted as food and medicines, and particularly relates to a method of preparing tea preparations, granules, tablets, capsules and beverages from the fresh juice of a plurality of Chinese herbal medicines capable of being adopted as food and medicines. The functional food is mainly used for nutrition supplementary for weak people susceptible to diseases, post-operation nutrition supplementary, nutrition supplementary after delivery, nutrition supplementary for vital organ functional failure of malignant tumor patients, and nutrition supplementary after radiotherapy and chemotherapy, and belongs to the technical field of healthcare food processing. Aiming at disadvantages of short fresh-keeping time, unstable quality, easy loss of effective components, taking inconvenience, and the like of "five-juice drink" in Item Differentiation of Warm Febrile Diseases wrote by Wu Jutong in the Qing dynasty, a modern preparation product, which maintains the flavor of the normal juice of the juice of the medicines capable of being adopted as food and medicines and has characteristics of long fresh-keeping time, stable quality, well maintained effective components and taking convenience, is developed.
Owner:李亦武
Nutrition with lipids and non-digestible saccharides
ActiveUS20090136615A1Stimulates barrier reinforcementSimple compositionAntibacterial agentsAntipyreticVegetable oilFermentable sugar
The invention relates to a liquid nutrition comprising short chain fatty acyl chains, polyunsaturated fatty acyl chains, vegetable oil and a non-digestible, fermentable saccharide. The composition is particular suitable for use as an infant nutrition. The composition is also suitable for treatment and / or prevention of gut barrier related disorders.
Owner:NV NUTRICIA
Application of litchi pulp polyphenol QRR and composition thereof in preparation of intestinal microecological preparation
InactiveCN111494398AGood varietyProportional balanceOrganic active ingredientsDigestive systemBiotechnologyIntestinal microorganisms
The invention discloses application of litchi pulp polyphenol QRR and a composition thereof in preparation of an intestinal microecological preparation. According to the litchi pulp polyphenol QRR andthe composition thereof, intestinal microbial flora disturbance can be improved, the diversity and richness of intestinal microorganisms can be improved, the flora composition structure can be optimized, the intestinal barrier function can be enhanced, and the intestinal tract can be protected.
Owner:GUANGZHOU UNIVERSITY
Medicine and food for preventing or treating COVID-19 and application thereof
ActiveCN112135625AAvoid damageReduce infection rateOrganic active ingredientsPeptide/protein ingredientsInflammatory factorsDisease
The invention discloses application of lysozyme or a combination comprising the lysozyme to preparation of a medicine for preventing or treating COVID-19 and application to preparation of food for assisting in preventing or treatment COVID-19. The lysozyme or the combination thereof provided by the invention can effectively inhibit cell damage caused by novel coronavirus virus, inhibit inflammatory factor expression induced by novel coronavirus virus, improve airway obstruction and expiratory volume reduction caused by pulmonary lesions, and improve intestinal barrier dysfunction. The composition has a good effect on high virus load, respiratory distress, intestinal function impairment and the like of patients, and can reduce the infection rate of novel coronavirus virus and reduce the novel coronavirus rate of pneumonia severe case. In addition, because the lysozyme is extremely high in safety, the lysozyme also has a very important value for preventing novel coronavirus disease of undiagnosed novel coronavirus virus high-risk infected people.
Owner:GUANGZHOU CENTURY CLINICAL RES CO LTD +4
Composition comprising HMSs/HMOs and use thereof
ActiveUS11040050B2Safe and effective and convenient to administerIncrease abundanceOrganic active ingredientsDigestive systemMast cellVisceral pain
Owner:GLYCOM AS
Nutrition for prevention of infections
InactiveUS20160206658A1Reduce translocationImprove intestinal barrier functionMilk preparationOrganic active ingredientsPhysiologyBacterial translocation
Owner:NV NUTRICIA
Nutrition for prevention of infections
InactiveUS20140335073A1Decreased bacterial translocationImprove intestinal barrier functionOrganic active ingredientsMilk preparationPhysiologyNutrition
A nutritional composition comprising a combination of non-digestible oligosaccharides and a product obtained by incubating an aqueous substrate by bifidobacteria and optionally a product obtained by incubating an aqueous substrate by S. thermophilus. Said combination reduces bacterial translocation and improves the intestinal barrier function.
Owner:NUTRICIA
Composition comprising hmss/hmos and use thereof
ActiveUS20180185398A1Increase abundanceImprove intestinal barrier functionOrganic active ingredientsDigestive systemMast cellVisceral pain
This invention relates generally to compositions and methods for preventing or treating mast cell mediated visceral pain.
Owner:GLYCOM AS
Formula feed for improving intestinal barrier function of early weaned piglet and feeding method of formula feed
ActiveCN106721270AIncrease average daily feed intakeReduce weight ratioFood processingAnimal feeding stuffAgricultural scienceEarly weaning
The invention relates to the technical field of pig feed preparation and particularly discloses a formula feed for improving an intestinal barrier function of an early weaned piglet and a feeding method of the formula feed. The formula feed comprises basal diet and a feed additive; the feed additive comprises MOS occupying 0.10-0.20 percent of the mass percentage of the basal diet and Ala-Gln occupying 0.15-0.30 percent of the mass percentage of the basal diet. When the formula feed disclosed by the invention is used for feeding the early weaned piglet, the average daily feed intake of the weaned stress piglet can be significantly improved, so that the feed-weight ratio of the weaned stress piglet is significantly reduced, the villus height / crypt depth of each of duodenum and ileum is significantly improved, the jejunum crypt depth is significantly reduced, and the diarrhea rate of the weaned stress piglet is significantly reduced; after the weaned piglet is fed for 28 days, an interaction effect on the villus height of the duodenum and the villus height / crypt depth is realized. The formula feed disclosed by the invention is easy for raw material obtaining, simple in preparation method and convenient to use.
Owner:JIANGXI AGRICULTURAL UNIVERSITY +1
Application of atractylodes macrocephala polysaccharide and pachymaran as feed additive for improving intestinal health of piglets
InactiveCN109527250AImprove intestinal barrier functionImprove performanceAccessory food factorsEarly weaningWeaned piglets
The invention discloses an application of atractylodes macrocephala polysaccharide and pachymaran as a feed additive for improving intestinal health of piglets, which belongs to the field of the feedadditive. The application of atractylodes macrocephala polysaccharide and pachymaran as feed additive for improving intestinal health of piglets is characterized in that the appropriate addition amount accounts for 0.02%-0.08% of mass of a basic feed, the overhigh addition amount affect the growth performance, immunity and feed-to-weight ratio of the piglets, and the excessive low addition amountcannot achieve the effect; the atractylodes macrocephala polysaccharide and pachymaran is composed of atractylodes macrocephala polysaccharide and pachymaran according to a mass ratio of 1-2:1-2, thecontent of polysaccharides in atractylodes macrocephala polysaccharide and pachymaran is 37.5%; and the application of atractylodes macrocephala polysaccharide and pachymaran as the feed additive forimproving intestinal health of the piglets can effectively improve the intestinal barrier function of the early weaned piglets, improves the intestinal health of piglets, and can replace the antibiotics in promoting the growth performance of the piglets.
Owner:JIANGXI AGRICULTURAL UNIVERSITY
Inflammatory bowel disease therapies
ActiveUS8962530B2Reduce intestinal permeabilityImprove intestinal barrier functionBiocideAntipyreticBowels diseasesBarrier function
Owner:UNIV OF COLORADO THE REGENTS OF +1
Probiotic Bifidobacterium adolescentis strains
ActiveUS10022408B2Induce regulating elementImprove intestinal barrier functionBiocideNervous disorderAutoimmune conditionDendritic cell
Owner:CHR HANSEN AS
Composition and methods of treating inflammatory and autoimmune diseases
PendingUS20220008533A1Improve compoundFunction increasePeptide/protein ingredientsHydroxy compound active ingredientsAutoimmune conditionAntiendomysial antibodies
This invention relates to methods of treating disorders such as celiac disease by administrating anti-CD3 antibodies alone or in combination with additional agents.
Owner:TIZIANA LIFE SCI PLC
Intestinal barrier function-enhancing composition
PendingCN111526735AImprove intestinal barrier functionHydroxy compound active ingredientsMetabolism disorderGallic acid esterBiochemistry
The purpose of the present invention is to provide: an intestinal barrier function-enhancing composition capable of enhancing intestinal barrier function; and an agent for enhancing the intestinal barrier function of gallic acid. The present invention pertains to an intestinal barrier function-enhancing composition containing gallic acid as an active ingredient.
Owner:SUNTORY HLDG LTD
Application of rutin as growth promoting agent in poultry feed
ActiveCN112913983AImprove immunityImprove intestinal barrier functionFood processingAccessory food factorsBiotechnologyImmunity
The invention discloses application of rutin as a growth promoting agent in poultry feed. It is found for the first time that when 200-1500 mg / kg of rutin is added into a feed for white feather broilers, the immunity of the broilers can be effectively enhanced, the intestinal barrier function is improved, ingestion of the broilers is promoted, and the daily gain and the feed utilization efficiency are improved. The rutin disclosed by the invention has the advantages of being green, environment-friendly, wide in source, low in cost and the like, and is a safe and efficient green feed growth promoting additive.
Owner:NANJING AGRICULTURAL UNIVERSITY
Glp-2 fusion polypeptides and uses for treating and preventing gastrointestinal conditions
InactiveUS20200199192A1Promote absorptionIncrease concentrationPolypeptide with localisation/targeting motifPeptide/protein ingredientsRadiation injuryImmunoglobulin region
Described are fusion proteins of GLP-2 with an Fc region of immunoglobulin. The GLP-2 and Fc regions are separated by a linker comprised of amino acids. The fusion proteins persist and remain active in the body for longer periods of time than GLP-2 itself. Methods are disclosed of using the fusion proteins to treat and prevent enterocutaneous fistulae, radiation damage to the gastrointestinal tract, obstructive jaundice, and short bowel syndrome.
Owner:SHIRE NPS PHARM INC
Lactobacillus plantarum s58 and its application in the preparation of products for alleviating obesity
The invention discloses Lactobacillus plantarum S58 (Lactobacillus plantarumS58) with a preservation number of CCTCC NO: M 2019595 and its application in the preparation of health care products, food and medicine for alleviating obesity, which not only expands the application range of Lactobacillus plantarum S58 , improve its utilization value, and bring new hope to the treatment of obesity.
Owner:SOUTHWEST UNIV
Nutrition with lipids and non-digestible saccharides
ActiveUS8119155B2Sufficient availabilityGrowth inhibitionAntibacterial agentsBiocideBiotechnologyVegetable oil
Owner:NV NUTRICIA
Parenteral Nutrition Formulation
ActiveUS20210378998A1Improve Gut HealthMaintaining or amelioratingAntipyreticAnalgesicsPediatric patientLocal immunity
The present disclosure relates to parenteral nutrition formulations, including ready-to-use parenteral nutrition formulations which are reconstituted from multi-chamber containers and amino acid formulations. More particularly, the present disclosure is directed to formulations comprising butyrate derivatives, specifically arginine butyrate, for use with adult or pediatric patients. The disclosure further provides for methods of reducing or preventing systemic and local inflammation of patients receiving parenteral nutrition, and methods of maintaining or ameliorating their systemic immunity and local immunity, as well as the patients' gut barrier functions.
Owner:BAXTER INT INC +1
Application of dendrobium officinale in preparation of product for preventing or treating endoxemia
InactiveCN109876093AInhibition of secretionReduce inward movementAntibacterial agentsBlood disorderBarrier functionDendrobium officinale
The invention relates to a new purpose of dendrobium officinale, in particular to application of dendrobium officinale in preparation of a product for preventing or treating endoxemia. The dendrobiumofficinale can inhibit a body inflammatory reaction mediated by endotoxin, and relieve mucosal injuries and intestinal barrier functions caused by the endotoxin. Genesis and development of endoxemia can be interdicted from the links of inhibiting inflammatory injuries mediated by the endotoxin and reducing endotoxin displacement. By means of the modern preparation technology, the dendrobium officinale can be further used for preparing medicine or healthcare food or special medical purpose formula food or common food for treating endoxemia.
Owner:ZHEJIANG CHINESE MEDICAL UNIVERSITY
Intestinal barrier function enhancer containing lactic acid bacteria
InactiveUS20160279181A1Increase heightEasy to useMetabolism disorderDigestive systemDiseaseLactobacillus crustorum
Provided are an intestinal barrier function enhancer capable of enhancing intestinal barrier function and thereby capable of preventing or treating metabolic syndrome, and a drug and a food or drink containing the same. An intestinal barrier function enhancer containing cells or a treated cell product of Lactobacillus crustorum. This intestinal barrier function enhancer functions effectively to enhance intestinal barrier function and to prevent or treat conditions or diseases caused by impaired intestinal barrier function such as metabolic syndrome and the like.
Owner:SUNTORY HLDG LTD
Mixture of hmos
PendingUS20200260771A1Improve cognitive functionImprove intestinal barrier functionAntibacterial agentsOrganic active ingredientsBiotechnologyMicrobiology
Owner:SOC DES PROD NESTLE SA
Bacillus cereus and application thereof
InactiveCN113502252AInhibition of growth and reproductionImprove diarrheaBacteriaDigestive systemBiotechnologyUlcerative colitis
The invention relates to bacillus cereus, the scientific name of the bacillus cereus is Bacillus cereus HMPM18123, the preservation date is July 30, 2021, the preservation unit is Guangdong Microbial Culture Collection Center, the preservation place is the 5th floor, No.59, No.100 Courtyard, Xianlie Middle Road, Guangzhou, and the preservation code is GDMCC61838. The invention discloses application of bacillus cereus in preparation of functional microbial agents, food and / or medicines for improving ulcerative colitis, reducing pathological injury of enteritis intestinal tissues, inhibiting inflammation, improving the barrier function of intestinal tracts and improving intestinal flora composition. The traditional Chinese medicine composition has the advantages of high practical application value and small toxic and side effects, and has a very obvious effect on treating ulcerative colitis.
Owner:ANHUI UNIVERSITY
Nutritional composition comprising 2'fucosyllactose and 3'galactosyllactose
PendingUS20220110985A1Improve intestinal barrier functionImprove the intestinal barrierDigestive systemUnknown materialsNutritionLactose
The invention pertains to a nutritional composition for infants or young children comprising 2′fucosyllactose, and 3′galactosyllactose, and preferably dietary butyric acid.
Owner:NV NUTRICIA
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