Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Intestinal barrier function-enhancing composition

A technology of intestinal barrier function and composition, applied to the application of improving intestinal barrier function, improving intestinal barrier function, and the field of intestinal barrier function improving enhancer of gallic acid, which can solve the problem of unfavorable economy or safety and other problems, to achieve the effect of improving intestinal barrier function and enhancing the effect of improving intestinal barrier function

Pending Publication Date: 2020-08-11
SUNTORY HLDG LTD
View PDF8 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since EGF, which is a cytokine, exists only in a small amount in the living body, it is not preferable to use it as a material for improving the intestinal barrier function in terms of economy or safety.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Intestinal barrier function-enhancing composition
  • Intestinal barrier function-enhancing composition
  • Intestinal barrier function-enhancing composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0113] Using gallic acid as a sample, the effect of improving intestinal barrier function in Caco-2 cells was evaluated by the above evaluation method. Gallic acid (Nacalai Tesque Co., Ltd.) was added so that the concentration in the test solution would be 100 μM (μmol / L).

[0114] As a reference, 100 μM quercetin (Funakoshi Co., Ltd.) was added to the test solution instead of gallic acid, and the intestinal barrier function improving effect was similarly evaluated. For quercetin, a tight junction barrier function improving action has been reported (Non-Patent Document 1).

[0115] As a result, the TEER reduction inhibition rate was 86.5% for gallic acid and 75.0% for quercetin. It has been confirmed that gallic acid at 100 μM has a 1.15-fold higher inhibition rate of TEER reduction than quercetin at the same concentration.

Embodiment 2

[0117] In evaluations 1 to 4, gallic acid and the following phenolic compounds were used as samples.

[0118] Evaluation 1: Catechin (CA) (Wako Pure Chemical Industries, Ltd.)

[0119] Evaluation 2: Epicatechin (EC) (Wako Pure Chemical Industries, Ltd.)

[0120] Evaluation 3: Gallocatechin (GC) (Wako Pure Chemical Industries, Ltd.)

[0121] Evaluation 4: Epigallocatechin (EGC) (Wako Pure Chemical Industries, Ltd.)

[0122] The phenolic compounds used in Example 2 are flavanols.

[0123] In evaluations 1 to 4, for the samples shown in (i) to (iii) in each evaluation system, the TEER decrease inhibition rate (%) in Caco-2 cells was evaluated by the evaluation method described above.

[0124] (i) Phenolic compounds (CA, EC, GC or EGC) (1 μM)

[0125] (ii) Gallic acid (GA) (1 μM)

[0126] (iii) Combined use of phenolic compound (1 μM) and gallic acid (1 μM) (phenolic compound + GA)

[0127] The sample was added to the test liquid so that the concentration in the test liquid ...

Embodiment 3

[0138] Using the above-mentioned evaluation method using Caco-2 cells, gallic acid and the phenolic compounds shown in Tables 2 to 3 were used as samples to evaluate intestinal barrier function improvement effects (Evaluations 5 to 43).

[0139] In the same manner as in Example 2, the following (i) to (iii) were used as samples in each evaluation system, and the TEER decrease inhibition rate (%) was evaluated.

[0140] (i) Phenolic compounds (10 μM for compounds shown in Table 2; 1 μM for compounds shown in Table 3)

[0141] (ii) Gallic acid (10 μM in the evaluation system of the compounds shown in Table 2; 1 μM in the evaluation system of the compounds shown in Table 3)

[0142] (iii) Combined use of phenolic compound and gallic acid (10 μM in the evaluation system of the compounds shown in Table 2; 1 μM in the evaluation system of the compounds shown in Table 3)

[0143] The sample was added to the test liquid so that the concentration in the test liquid became the above-me...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The purpose of the present invention is to provide: an intestinal barrier function-enhancing composition capable of enhancing intestinal barrier function; and an agent for enhancing the intestinal barrier function of gallic acid. The present invention pertains to an intestinal barrier function-enhancing composition containing gallic acid as an active ingredient.

Description

technical field [0001] The present invention relates to a composition for improving intestinal barrier function. Furthermore, the present invention relates to an enhancer of gallic acid's effect of improving intestinal barrier function. The invention also relates to a method for improving intestinal barrier function and the application of gallic acid for improving intestinal barrier function and the like. Background technique [0002] In recent years, awareness about gut health has grown, and gut-related functional foods are also being sold in large numbers. Intestinal functions are mainly nutrient absorption function and barrier function (intestinal barrier function) to prevent intrusion (permeation) of harmful substances. Among them, intestinal barrier function is known to be closely related to chronic inflammatory diseases that increase with age. [0003] There are many immune system cells such as macrophages, dendritic cells, T cells, and B cells under the intestinal ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/10A61K31/05A61K31/12A61K31/192A61K31/353A61K31/7024A61K31/7034A61K31/7048A61P1/00A61P3/00A61P9/10A61P37/02A61P43/00
CPCA23L33/10A61K31/05A61K31/12A61K31/192A61K31/353A61K31/7024A61K31/7034A61K31/7048A61P1/00A61P3/00A61P9/10A61P37/02A61P43/00A61K9/0053
Inventor 船木亜由太笠岛直树有江秀行
Owner SUNTORY HLDG LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com