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42results about How to "Reduce translocation" patented technology

Apparatus and methods for performing optical nanopore detection or sequencing

InactiveUS20140087474A1Reducing translocation speedReduced translocation speedMicrobiological testing/measurementMaterial analysis by optical meansProtein translocationNanopore
Methods and systems for detecting or sequencing a biological molecule or polymer, e.g., a nucleic acid, are provided. Optical sequencing of a molecule may be performed utilizing an optical or photon detector operated in time delayed integration mode. In certain variations, the translocation rate of molecules through a, pore, nanopore or channel may be controlled or reduced by increasing the diameter of the molecules to allow for molecule detection or sequencing by optical or electrical detection. In certain variations, a plurality or an array of, pores, nanopores, or channels may be utilized to optically detect a plurality of molecules.
Owner:QUANTAPORE

Remedy for diseases associated with immunoglobulin gene translocation

A medicament comprising a compound having an inhibitory action on Hsp90 or a pharmaceutically acceptable salt thereof as an active ingredient is used as a therapeutic agent for diseases associated with immunoglobulin gene translocations. In diseases associated with immunoglobulin gene translocations, abnormal enhancement of the expression of a partner gene in immunoglobulin gene translocation participates in the development of the diseases and the progress of the symptoms. By administering the compound having an inhibitory action on Hsp90 or a pharmaceutically acceptable salt thereof, degradation of protein encoded by the partner gene is promoted and the diseases can be treated.
Owner:KYOWA HAKKO KIRIN CO LTD

Composite feed additive for restoring baby pig intestine mucosal injury

The invention relates to a composite feed additive for restoring baby pig intestine mucosal injury, belonging to the technical field of feed additives for baby pigs. The feed additive comprises 0.1-0.2 part of glutamine, 0.01-0.1 part of butyrin, 0.01-0.1 part of yeast nucleic acid, 0.02-0.2 part of threonine, 0.03-0.3 part of origanum oil, 0.03-0.3 part of chitooligosaccharide, 0.1-0.5 part of active dry yeast, 0.1-0.5 part of Bacillus subtilis, 0.11-0.3 part of vitamin and 5-7.5 parts of carrier. On the basis of the basic principles of baby pig intestinal tract nutrition, intestinal tract immunity and intestinal tract microecology, the invention can effectively restore baby pig intestine mucosal injury, accelerate the growth of baby pigs, and promote the health and immunity of the baby pig intestinal tract, thereby enhancing the survival rate and growth rate of the baby pigs.
Owner:巨星农牧有限公司

Compounds and methods for the treatment and prevention of bacterial infection

InactiveUS7037503B2Reduced ability to form poreInhibit pore-forming abilityAntibacterial agentsBacterial antigen ingredientsDominant-Negative MutantDominant negative
The invention provides mutant forms of pore-forming toxins. These mutant toxins may be used in vaccines for the prevention of bacterial infection. Additionally, dominant negative mutants may be administered as therapeutics for the treatment of bacterial infection.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE

Nutrition for prevention of infections

InactiveUS20110097437A1Decreased bacterial translocationImprove intestinal barrier functionOrganic active ingredientsPeptide/protein ingredientsPhysiologyBacterial translocation
A nutritional composition comprising a combination of non-digestible oligosaccharides and a product obtained by incubating an aqueous substrate by bifidobacteria and optionally a product obtained by incubating an aqueous substrate by S. thermophilus. Said combination reduces bacterial translocation and improves the intestinal barrier function.
Owner:NUTRICIA

Pediococcus pentosaceus and application thereof

The invention discloses pediococcus pentosaceus and application thereof. The Latin name of the pediococcus pentosaceus is Pediococcus pentosaceus LI05, and the pediococcus pentosaceus is preserved in the China General Microbiological Culture Collection Center and has a preservation number of CGMCC No.7049. The pediococcus pentosaceus disclosed by the invention has the morphological characteristics that the thallus is rod-shaped, dose not generate spores, does not have motility, and has masculine Gram staining. The whole-cell fatty acid of the pediococcus pentosaceus disclosed by the invention comprises the following main components in percentage by weight: about 1.45% of 14:0, about 3.26% of 16:1w7c / 16:1w6c, about 31.25% of 16:0, about 6.31% of 18:1w9c, about 38.59% of 18:1w7c, about 1.37% of 18:0 and about 14.59% of un18.846 / 19:1w6c. The invention also discloses a complete sequence of 16S ribosome DNA (16SrDNA) of the pediococcus pentosaceus. The pediococcus pentosaceus and a preparation thereof disclosed by the invention can be used for adjusting the micro-ecological balance of intestinal tracts of human or animals, promoting digestive absorption and slowing down the happening and development of liver failure of experimental animals.
Owner:ZHEJIANG UNIV

Immune type protein powder solid beverage and preparation method thereof

The invention discloses an immune type protein powder solid beverage and a preparation method thereof and belongs to the field of nutritional foods. The solid beverage comprises the following components: 70-85 percent of concentrated whey protein powder, 3-8 percent of pea protein, 5-15 percent of wheat protolysate, 2-4 percent of phospholipid, 1-3 percent of an acerola cherry extract, 1-5 percent of edible essence, 0.5-1.5 percent of a yeast extract, 0.5-1.5 percent of gamma-aminobutyric acid, 0.5-1.5 percent of coconut milk powder, 0.3-0.8 percent of silicon dioxide and 0.1-0.3 percent of stevioside. The invention also discloses the preparation method of the solid beverage. The solid beverage disclosed by the invention fully meets the demands of the human body, is scientific in prescription design, reasonable in nutrition arrangement and different in taste according to different customers, and can meet the special demands of different people on taste; the solid beverage is mellow in taste, convenient to use, stable in quality, simple in preparation method, easy to operate, suitable for large-scale industrial production, free of sugar in the prescription and suitable for diabetics to eat.
Owner:JIANGSU ALAND NOURISHMENT

Lactobacillus plantarum strains as hypocholesterolemic agents

The invention relates to a composition comprising an effective amount of at least one of the strains selected from the group consisting of Lactobacillus plantarum CECT 7527,Lactobacillus plantarum CECT 7528, and Lactobacillus plantarum CECT 7529, These new strains have good probiotic features and are useful for the prevention and / or the treatment of cardiovascular disorders.
Owner:BIOTICS

Antioxidant, Anti-Inflammatory, Anti-Radiation, Metal Chelating Compounds And Uses Thereof

The present invention relates to potent compounds having combined antioxidant, anti-inflammatory, anti-radiation and metal chelating properties. Specifically, the present invention relates to short peptides having these properties, and to methods and uses of such short peptides in clinical and cosmetic applications.
Owner:YISSUM RES DEV CO OF THE HEBREWUNIVERSITY OF JERUSALEM LTD +1

Compositions for management of disorders of the gastrointestinal tract

PendingUS20220047646A1Reduce translocationReduce pathogen-induced intestinal epithelial barrier dysregulationHydroxy compound active ingredientsInorganic phosphorous active ingredientsIntestinal tract diseasesDisease
Effective and economical compositions and methods are disclosed for the treatment, and prevention of diseases and disorders associated with inflammation and / or damage to the gastrointestinal tract, including environmental enteric dysfunction. Compositions are provided comprising a synergistic combination of colostrum, immune egg, and optionally one or more additional active agents.
Owner:PANTHERYX

Strain of lactobacillus pentosus as probiotic

Provided is the new strain Lactobacillus pentosus CECT 7504 and compositions and products comprising said strain and uses in the prevention and / or treatment of candidiasis (oral, intestinal and vaginal) and of bacterial vaginosis.
Owner:GYNEA LAB

Nutrition for prevention of infections

A nutritional composition comprising a combination of non-digestible oligosaccharides and a product obtained by incubating an aqueous substrate by bifidobacteria and optionally a product obtained by incubating an aqueous substrate by S. thermophilus. Said combination reduces bacterial translocation and improves the intestinal barrier function.
Owner:NUTRICIA

Traditional Chinese medicine composite glutamine special meal food and making method thereof

The invention belongs to the technical field of a formula of a special meal food, and the food is suitable for promotion of rehabilitation of postoperative stomach and intestine functions, increment of cell volume and promotion of muscle growth. The food is prepared from the following raw material components in parts by mass of 30-70g of glutamine, 1-30g of fish collagen peptide, 20-60g of isomaltooligosacharide and 1-20g of a composite traditional Chinese medicine extract, wherein the effective components of the composite traditional Chinese medicines comprise the following raw materials in percentage by weight of 5-30% of Chinese wolfberry fruits, 15-40% of poria cocos, 15-30% of red jujubes, 1-20% of radish seeds, 1-20% of haws, and 10-40% of licorice roots. Through pretreatment, mixingand packing, the food is made. The food of a special meal formula is reasonable in formula and safe to eat, after being scientifically taken, the food of a special meal formula can effectively promote the rehabilitation of postoperative stomach and intestine functions, and growth of the muscle of movement crowds.
Owner:陕西三正医用营养有限公司

Method to identify regulators of cellular activation using Bcl10

InactiveUS7169570B2Reducing signal transductionEnhance signal transductionMicrobiological testing/measurementTissue cultureCell activationBCL10
Disclosed are methods for evaluating the activation of Bcl10 in a cell in response to a putative stimulus, as well as methods for evaluating or identifying a regulatory compound which regulates activation of Bcl10-mediated signal transduction. These methods utilize the discovery of the activation-dependent formation in a cell of Bcl10 aggregates in a cell.
Owner:NAT JEWISH MEDICAL & RES CENT +1

Systems and methods for separating, detecting, and quantifying a target polynucleotide

Systems and methods for controlling molecular translocation in solid-state nanopores by edge field leakage. The system dramatically reduces (by orders of magnitude) and controls the fast electrophoretic velocity of molecules to realize sensitive and selective solid-state nanopore sensors for polynucleotides and sequencing platforms.
Owner:UNIV OF NOTRE DAME DU LAC

Preparation process of glutamine enteric microcapsules

The invention belongs to the technology of microcapsule coating and concretely relates to a process capable of protecting the effective component activity of glutamine. According to the process, enteric coating materials are dissolved in mixed solvents according to the proportion that 0.3g of enteric coating materials are dissolved in the 6.0ml of mixed solvents, the stirring is carried out through a magnetic stirrer, glutamine and antiadherents are added after the uniform dispersion, the stirring is carried out again, then, emulsifying agents are added for filtering after the uniform dispersion, obtained microcapsules are cleanly flushed by normal hexane, and the drying is carried out for 0.5 hour. Glutamine enteric microcapsules prepared by the process have the advantages that the intestinal mucosa atrophy can be effectively prevented, the weight, the structure and the protein content of the normal intestinal mucosa are ensured, the intestinal cell activity is enhanced, the intestinal immunologic function is improved, and the translocation of intestinal bacteria and endotoxin is reduced. The process has the advantages that required materials are easy to obtain, and products have safety, inertia and high dissolving speed.
Owner:王老七 +2

Substituted polyamines as inhibitors of bacterial efflux pumps

Disclosed are methods of treating bacterial infections including those caused by multidrug resistant bacteria using polyamine efflux pump inhibiting compounds, including for example N-benzylated polyazaalkanes, N-benzylated polyaminoalkanes, or mixed N-benzylated poly(aza / amino)alkanes, optionally in combination with other drugs such as antibiotics, as well as pharmaceutical compositions thereof.
Owner:PARATEK PHARM INC

Breast cancer conditioning convenience food

The present invention provides a breast cancer conditioning convenience food, which uses L- glutamine as the main raw material, is based on the physical characteristics of breast cancer patients, is directed by essence of traditional Chinese medicine theory and has targeted reasonable compatibility: extract of dendrobium, semen coicis, oysters, dandelion, hawthorn, fructus perillae, honeysuckle flower, dates, tangerine red epicarp, longan, date seed, cinnamon, licorice, winter collybia, dried tangerine peel, Poria, siberian solomonseal rhizome, ginseng, gardenia, common selfheal spike, peppermint, appendiculate cremastra pseudobulb and other medicinal and edible herbs. Then vitamins and minerals are added to obtain the food. The food produced according to the formula in the present invention is easy to dissolve, fast to absorb and utilize, and improves the nutritional status of the breast cancer patients. The bioactive components in the medicinal and edible herb extract have assistance effects of improving immunity of human body, thereby playing a role of suppressing cancer and anti-cancer. The food is suitable for breast cancer patients, especially for the cancer patients received radiotherapy or chemotherapy to eat. Therefore, the food has unique advantages of combining triple effects of diet cure, prevention and conditioning.
Owner:胡安然

Composition for pediatric cancer patients to eat

The invention belongs to the field of food, and particularly relates to a composition for pediatric cancer patients to eat. The composition comprises protein, fat, carbohydrate, multi-vitamins, mineral elements and glutamine. In the composition, the fat serves as a main ingredient and provides calories, energy generated by cancer cells through a glucose anaerobic glycolysis path and essential groups of cancer cell DNA replication are blocked, and the aims of starving cancer cells and inhibiting cancer cell growth are achieved. According to the composition for pediatric cancer patients to eat,medium chain triglyceride contained in the composition can intensify the in-vivo ketogenic effect of patients, and child cancer cells are specificity starved. Intestinal-mucosa damage caused by chemotherapy drugs can be prevented and repaired through the added glutamine, an intestinal micro-ecosystem can be adjusted through added bifidobacterium triple viable bacteria, and an antitumor immunity mechanism of the body is activated; meanwhile, the composition has the high-energy density and the suitable osmotic pressure, malnutrition can be effectively improved, and the composition also has the intestinal-receptivity advantage, and is particularly suitable for child patients.
Owner:吕麟亚 +1

Compositions and methods for treating and preventing hyperlipidemia, fatty liver, atherosclerosis and other disorders associated with metabolic syndrome

The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject. Compositions and methods including a Nuclear Transport Modifier may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease in cholesterol and triglyceride levels in the blood and liver, a decrease in atherosclerotic lesion size, a decrease in body weight and in hyperglycemia, a reduction of fatty liver inflammation, and an improvement in liver function.
Owner:VANDERBILT UNIV

Special clinical nutrition formula for bone cancer and preparation method thereof

The invention discloses a special clinical nutrition formula for bone cancer and a preparation method thereof. The formula comprises the following components in parts by weight: 40-60 parts of a solvent and 1-5 parts of an additive, carbohydrate 2-28 parts, 10-45 parts of protein, 0.1 to 3 parts of arginine; 1 to 5 parts of glutamine; 0.2 to 0.5 part of beta-hydroxy-beta-methyl calcium butyrate, 0.1 to 2 parts of unsaturated fatty acid, 0.008 to 0.3 part of compound vitamin, 2.5 to 4 parts of selenium, 0.02 to 1 part of L-carnitine, 8 to 12 parts of yellow or green vegetables, 6 to 10 parts ofdietary fiber, 0.03 to 3.5 parts of new resource food and 1 to 15 parts of medicinal and edible components. According to the special clinical nutrition formula, with the reasonable diet blending, thenutrition status of the bone cancer patient is improved, the adverse reaction during the chemotherapy is reduced, the prognosis of the patient is improved, the subsequent reasonable nutrition supportis provided while the abnormal metabolism of the tumor is regulated, the growth of the tumor is inhibited, and the survival time of the patient is finally prolonged.
Owner:SHANGHAI FUDAN AOYI MEDICAL TECH

Compositions and methods for treating and preventing hyperlipidemia, fatty liver, atherosclerosis and other disorders associated with metabolic syndrome

The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject. Compositions and methods including a Nuclear Transport Modifier may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease in cholesterol and triglyceride levels in the blood and liver, a decrease in atherosclerotic lesion size, a decrease in body weight and in hyperglycemia, a reduction of fatty liver inflammation, and an improvement in liver function.
Owner:VANDERBILT UNIV

Weaning health-care agent for fur-bearing animals

The invention belongs to the technical field of feeds, and particularly relates to a weaning health-care agent for fur-bearing animals. The weaning health-care agent is prepared from the following raw materials in parts by weight: 5-10 parts of egg microcapsule powder, 30-40 parts of fermented soybean meal, 13-20 parts of glucose, 2 parts of probiotics, 20-30 parts of puffing corn powder and 10-20 parts of wheat hydrolyzed protein. The weaning health-care agent for fur-bearing animals, disclosed by the invention, is particularly suitable for young fur-bearing animals which are weaned and separated into broods and eat foods, and the occurrence of diseases of digestive tracts, such as diarrhoea, of the fur-bearing animals, can be effectively avoided; besides, the growth and the development of the fur-bearing animals are promoted, particularly the balance of microorganisms in intestinal tracts of the fur-bearing animals and the health of the intestinal tracts are promoted, the organism immunity of the fur-bearing animals is strengthened, the survival rate of the young fur-bearing animals is increased, the economic benefits are increased, and the breeding cost is reduced.
Owner:山东贝瑞康生物科技有限公司
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