42results about How to "Reduce translocation" patented technology

Methods and systems for detecting or sequencing a biological molecule or polymer, e.g., a nucleic acid, are provided. Optical sequencing of a molecule may be performed utilizing an optical or photon detector operated in time delayed integration mode. In certain variations, the translocation rate of molecules through a, pore, nanopore or channel may be controlled or reduced by increasing the diameter of the molecules to allow for molecule detection or sequencing by optical or electrical detection. In certain variations, a plurality or an array of, pores, nanopores, or channels may be utilized to optically detect a plurality of molecules.

A medicament comprising a compound having an inhibitory action on Hsp90 or a pharmaceutically acceptable salt thereof as an active ingredient is used as a therapeutic agent for diseases associated with immunoglobulin gene translocations. In diseases associated with immunoglobulin gene translocations, abnormal enhancement of the expression of a partner gene in immunoglobulin gene translocation participates in the development of the diseases and the progress of the symptoms. By administering the compound having an inhibitory action on Hsp90 or a pharmaceutically acceptable salt thereof, degradation of protein encoded by the partner gene is promoted and the diseases can be treated.

The invention provides mutant forms of pore-forming toxins. These mutant toxins may be used in vaccines for the prevention of bacterial infection. Additionally, dominant negative mutants may be administered as therapeutics for the treatment of bacterial infection.

A nutritional composition comprising a combination of non-digestible oligosaccharides and a product obtained by incubating an aqueous substrate by bifidobacteria and optionally a product obtained by incubating an aqueous substrate by S. thermophilus. Said combination reduces bacterial translocation and improves the intestinal barrier function.

The invention discloses pediococcus pentosaceus and application thereof. The Latin name of the pediococcus pentosaceus is Pediococcus pentosaceus LI05, and the pediococcus pentosaceus is preserved in the China General Microbiological Culture Collection Center and has a preservation number of CGMCC No.7049. The pediococcus pentosaceus disclosed by the invention has the morphological characteristics that the thallus is rod-shaped, dose not generate spores, does not have motility, and has masculine Gram staining. The whole-cell fatty acid of the pediococcus pentosaceus disclosed by the invention comprises the following main components in percentage by weight: about 1.45% of 14:0, about 3.26% of 16:1w7c/16:1w6c, about 31.25% of 16:0, about 6.31% of 18:1w9c, about 38.59% of 18:1w7c, about 1.37% of 18:0 and about 14.59% of un18.846/19:1w6c. The invention also discloses a complete sequence of 16S ribosome DNA (16SrDNA) of the pediococcus pentosaceus. The pediococcus pentosaceus and a preparation thereof disclosed by the invention can be used for adjusting the micro-ecological balance of intestinal tracts of human or animals, promoting digestive absorption and slowing down the happening and development of liver failure of experimental animals.

The invention discloses an immune type protein powder solid beverage and a preparation method thereof and belongs to the field of nutritional foods. The solid beverage comprises the following components: 70-85 percent of concentrated whey protein powder, 3-8 percent of pea protein, 5-15 percent of wheat protolysate, 2-4 percent of phospholipid, 1-3 percent of an acerola cherry extract, 1-5 percent of edible essence, 0.5-1.5 percent of a yeast extract, 0.5-1.5 percent of gamma-aminobutyric acid, 0.5-1.5 percent of coconut milk powder, 0.3-0.8 percent of silicon dioxide and 0.1-0.3 percent of stevioside. The invention also discloses the preparation method of the solid beverage. The solid beverage disclosed by the invention fully meets the demands of the human body, is scientific in prescription design, reasonable in nutrition arrangement and different in taste according to different customers, and can meet the special demands of different people on taste; the solid beverage is mellow in taste, convenient to use, stable in quality, simple in preparation method, easy to operate, suitable for large-scale industrial production, free of sugar in the prescription and suitable for diabetics to eat.

The invention relates to a composition comprising an effective amount of at least one of the strains selected from the group consisting of Lactobacillus plantarum CECT 7527,Lactobacillus plantarum CECT 7528, and Lactobacillus plantarum CECT 7529, These new strains have good probiotic features and are useful for the prevention and/or the treatment of cardiovascular disorders.

The present invention relates to potent compounds having combined antioxidant, anti-inflammatory, anti-radiation and metal chelating properties. Specifically, the present invention relates to short peptides having these properties, and to methods and uses of such short peptides in clinical and cosmetic applications.

Effective and economical compositions and methods are disclosed for the treatment, and prevention of diseases and disorders associated with inflammation and/or damage to the gastrointestinal tract, including environmental enteric dysfunction. Compositions are provided comprising a synergistic combination of colostrum, immune egg, and optionally one or more additional active agents.

Provided is the new strain Lactobacillus pentosus CECT 7504 and compositions and products comprising said strain and uses in the prevention and/or treatment of candidiasis (oral, intestinal and vaginal) and of bacterial vaginosis.

A nutritional composition comprising a combination of non-digestible oligosaccharides and a product obtained by incubating an aqueous substrate by bifidobacteria and optionally a product obtained by incubating an aqueous substrate by S. thermophilus. Said combination reduces bacterial translocation and improves the intestinal barrier function.

The invention belongs to the technical field of a formula of a special meal food, and the food is suitable for promotion of rehabilitation of postoperative stomach and intestine functions, increment of cell volume and promotion of muscle growth. The food is prepared from the following raw material components in parts by mass of 30-70g of glutamine, 1-30g of fish collagen peptide, 20-60g of isomaltooligosacharide and 1-20g of a composite traditional Chinese medicine extract, wherein the effective components of the composite traditional Chinese medicines comprise the following raw materials in percentage by weight of 5-30% of Chinese wolfberry fruits, 15-40% of poria cocos, 15-30% of red jujubes, 1-20% of radish seeds, 1-20% of haws, and 10-40% of licorice roots. Through pretreatment, mixingand packing, the food is made. The food of a special meal formula is reasonable in formula and safe to eat, after being scientifically taken, the food of a special meal formula can effectively promote the rehabilitation of postoperative stomach and intestine functions, and growth of the muscle of movement crowds.

Disclosed are methods for evaluating the activation of Bcl10 in a cell in response to a putative stimulus, as well as methods for evaluating or identifying a regulatory compound which regulates activation of Bcl10-mediated signal transduction. These methods utilize the discovery of the activation-dependent formation in a cell of Bcl10 aggregates in a cell.

Systems and methods for controlling molecular translocation in solid-state nanopores by edge field leakage. The system dramatically reduces (by orders of magnitude) and controls the fast electrophoretic velocity of molecules to realize sensitive and selective solid-state nanopore sensors for polynucleotides and sequencing platforms.

The invention belongs to the field of food, and particularly relates to a composition for pediatric cancer patients to eat. The composition comprises protein, fat, carbohydrate, multi-vitamins, mineral elements and glutamine. In the composition, the fat serves as a main ingredient and provides calories, energy generated by cancer cells through a glucose anaerobic glycolysis path and essential groups of cancer cell DNA replication are blocked, and the aims of starving cancer cells and inhibiting cancer cell growth are achieved. According to the composition for pediatric cancer patients to eat,medium chain triglyceride contained in the composition can intensify the in-vivo ketogenic effect of patients, and child cancer cells are specificity starved. Intestinal-mucosa damage caused by chemotherapy drugs can be prevented and repaired through the added glutamine, an intestinal micro-ecosystem can be adjusted through added bifidobacterium triple viable bacteria, and an antitumor immunity mechanism of the body is activated; meanwhile, the composition has the high-energy density and the suitable osmotic pressure, malnutrition can be effectively improved, and the composition also has the intestinal-receptivity advantage, and is particularly suitable for child patients.

The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject. Compositions and methods including a Nuclear Transport Modifier may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease in cholesterol and triglyceride levels in the blood and liver, a decrease in atherosclerotic lesion size, a decrease in body weight and in hyperglycemia, a reduction of fatty liver inflammation, and an improvement in liver function.

The invention discloses a special clinical nutrition formula for bone cancer and a preparation method thereof. The formula comprises the following components in parts by weight: 40-60 parts of a solvent and 1-5 parts of an additive, carbohydrate 2-28 parts, 10-45 parts of protein, 0.1 to 3 parts of arginine; 1 to 5 parts of glutamine; 0.2 to 0.5 part of beta-hydroxy-beta-methyl calcium butyrate, 0.1 to 2 parts of unsaturated fatty acid, 0.008 to 0.3 part of compound vitamin, 2.5 to 4 parts of selenium, 0.02 to 1 part of L-carnitine, 8 to 12 parts of yellow or green vegetables, 6 to 10 parts ofdietary fiber, 0.03 to 3.5 parts of new resource food and 1 to 15 parts of medicinal and edible components. According to the special clinical nutrition formula, with the reasonable diet blending, thenutrition status of the bone cancer patient is improved, the adverse reaction during the chemotherapy is reduced, the prognosis of the patient is improved, the subsequent reasonable nutrition supportis provided while the abnormal metabolism of the tumor is regulated, the growth of the tumor is inhibited, and the survival time of the patient is finally prolonged.

The invention belongs to the technical field of feeds, and particularly relates to a weaning health-care agent for fur-bearing animals. The weaning health-care agent is prepared from the following raw materials in parts by weight: 5-10 parts of egg microcapsule powder, 30-40 parts of fermented soybean meal, 13-20 parts of glucose, 2 parts of probiotics, 20-30 parts of puffing corn powder and 10-20 parts of wheat hydrolyzed protein. The weaning health-care agent for fur-bearing animals, disclosed by the invention, is particularly suitable for young fur-bearing animals which are weaned and separated into broods and eat foods, and the occurrence of diseases of digestive tracts, such as diarrhoea, of the fur-bearing animals, can be effectively avoided; besides, the growth and the development of the fur-bearing animals are promoted, particularly the balance of microorganisms in intestinal tracts of the fur-bearing animals and the health of the intestinal tracts are promoted, the organism immunity of the fur-bearing animals is strengthened, the survival rate of the young fur-bearing animals is increased, the economic benefits are increased, and the breeding cost is reduced.

The invention discloses a functional food for assisting in repairing digestive tract mucous membranes after chemotherapy. The functional food comprises galactooligosaccharide, stachyose, mannan oligosaccharide, glutamine, vitamin A, vitamin D3, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, nicotinic acid, folic acid, pantothenic acid, biotin, choline, inositol, calcium, potassium, magnesium, iron, zinc, iodine, selenium, copper, manganese, DHA, EPA, omega-3 and phosphatidylserine. The functional food can effectively repair digestive tract barriers, improve the immunityof tumor patients and effectively reduce the side effects of chemotherapeutic drugs on digestive tracts after chemotherapy.