Preparation process of glutamine enteric microcapsules

A glutamine sausage preparation technology, which is applied in the direction of microcapsules, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of patients taking inconvenience and adverse reactions, and achieve easy-to-obtain, Fast dissolution to reduce translocation effects

Inactive Publication Date: 2012-07-04
王老七 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Glutamine itself has a peculiar smell, which brings inconvenience to patients; and has some adverse reactions

Method used

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  • Preparation process of glutamine enteric microcapsules
  • Preparation process of glutamine enteric microcapsules
  • Preparation process of glutamine enteric microcapsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] Hereinafter, the present invention will be described in one step in combination with specific embodiments.

[0012] 1. Choose suitable materials and optimize the coating prescription.

[0013] A. Determination of the solubility of excipients

[0014] Under the condition of 37℃, dissolve polyacrylic resin in 50ml of methanol and acetone. The volume ratio of methanol and acetone is 1:5. After the dissolution is completed, add a certain amount of polyacrylic resin until it is no longer Until it dissolves. It was measured that 0.3 g of polyacrylic resin was dissolved in 6.0 ml of mixed solvent.

[0015] B. Choice of anti-adhesive

[0016] When preparing the microcapsules, the addition of a binder can keep the dispersed droplets in a stable form. Different anti-adhesive aluminum stearate and magnesium stearate are selected to prepare microcapsules and different dosages and compare them. See Table 1 below.

[0017] Table 1 The influence of choosing different anti-adhesive types on ca...

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Abstract

The invention belongs to the technology of microcapsule coating and concretely relates to a process capable of protecting the effective component activity of glutamine. According to the process, enteric coating materials are dissolved in mixed solvents according to the proportion that 0.3g of enteric coating materials are dissolved in the 6.0ml of mixed solvents, the stirring is carried out through a magnetic stirrer, glutamine and antiadherents are added after the uniform dispersion, the stirring is carried out again, then, emulsifying agents are added for filtering after the uniform dispersion, obtained microcapsules are cleanly flushed by normal hexane, and the drying is carried out for 0.5 hour. Glutamine enteric microcapsules prepared by the process have the advantages that the intestinal mucosa atrophy can be effectively prevented, the weight, the structure and the protein content of the normal intestinal mucosa are ensured, the intestinal cell activity is enhanced, the intestinal immunologic function is improved, and the translocation of intestinal bacteria and endotoxin is reduced. The process has the advantages that required materials are easy to obtain, and products have safety, inertia and high dissolving speed.

Description

Technical field [0001] The invention belongs to the microcapsule coating technology, and specifically relates to a process capable of protecting the activity of the effective component of glutamine. Background technique [0002] Glutamine is an essential nutrient for the metabolism of intestinal mucosal cells and plays a very important role in maintaining the integrity of the intestinal mucosal epithelial structure. Glutamine itself has a peculiar smell, which brings inconvenience to patients; and has some adverse reactions. It affects the clinic, so the development of new dosage forms is particularly important. [0003] After the drug is microencapsulated, it can prolong the action time, improve the stability, cover up the bad smell, and reduce the irritation to the stomach. There are many factors that affect the preparation of microcapsules, such as coating material, anti-adhesive content, stirring rate, emulsification time, temperature, drug dosage, solvent selection and dosag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/198A61K47/32A61P1/04
Inventor 王老七陶海静郑鸣
Owner 王老七
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