13 results about "Corneal nerve" patented technology

The invention provides a nerve growth factor functionalized exosome as well as a preparation method and application thereof. The functionalized exosome can activate a Wnt / beta-catenin signal channel to maintain dryness of corneal limbal stem cells (LSCs) so as to promote corneal epithelium repair, can activate a cAMP signal channel to relieve inflammatory response and promote corneal nerve regeneration, and can be used for treating or relieving corneal chemical burns, including relieving inflammatory response, reducing stromal scar formation and inhibiting corneal neovascularization. Corneal epithelium repair and nerve regeneration are promoted.

The present application relates to the technical field of medical image processing, in particular to an image intelligent analysis system for corneal nerve fibers of dry eye patients, which comprises an image acquisition module, an image preprocessing module, a nerve fiber segmentation module, a nerve morphological analysis module based on differential geometry, a nerve regeneration monitoring module, a data management module and a clinical auxiliary decision module. The nerve morphological analysis module based on differential geometry is the core innovation, which contains a nerve fiber curvature analysis unit, a multi-scale differential invariant extraction unit and a nerve network topology structure quantification unit. The system introduces the theory of differential geometry, represents the nerve fiber through a parameterized curve and calculates the local curvature characteristics. A Gaussian scale space is constructed to extract multi-scale differential invariants. The graph structure representation of the nerve network is established to analyze the topological characteristics. The morphological characteristics of the corneal nerve fibers can be quantified comprehensively from the local curvature to the global topological structure, and the accurate detection of the slight changes of the nerve fibers is realized.

The invention relates to a method for providing control data for an ophthalmic laser (12) of a treatment device (10), wherein the method comprises the following steps performed by a control unit (18): receiving anatomical data relating to the anatomy of a cornea (16) of an eye to be treated; determining the position of the corneal nerve plexus (24) in the cornea (16) based on the anatomical data of the cornea (16) to be treated; determining the depth distribution of the corneal nerve plexus (24) in the cornea (16); receiving cutting instructions for performing a cut (26) in the cornea (16) by the ophthalmic laser (12) of the treatment device (10); Determining a target depth (28) for the laser (12) to perform the cut (26) based on the cut specifications and the depth distribution of the corneal nerve plexus (24) according to a specified cut depth specification;and generating control data for controlling the ophthalmic laser (12) to perform the cut (26) in the cornea (16).;

The present application relates to the technical field of biological medicine, and particularly relates to application of a nucleic acid vector encoding a macrophage monocarboxylate transporter MCT1 in preparation of a pharmaceutical composition for promoting corneal nerve regeneration and recovery of corneal sensitivity after corneal nerve injury. The present application finds that after corneal nerve injury, increasing the level of macrophage MCT1 can drive the change of the metabolic mode of macrophages to the direction of enhanced oxidative phosphorylation and reduced glycolysis, reduce the expression of local pro-inflammatory related factors, and increase the level of pro-regeneration factors and neurotrophic factors, thereby improving the regeneration of corneal nerve structure and the recovery of sensory function. Therefore, a macrophage-targeted or macrophage-biased expression vector containing a nucleic acid sequence encoding MCT1 can be used for preparation of a pharmaceutical composition for treating corneal nerve injury.

The invention provides an anterior segment transmission interference microscopic imaging device, method and system, and relates to the technical field of medical optical imaging and ophthalmic diagnosis. The single-frame imaging field of view is not less than 2mm * 1mm and is larger than that of a common clinical confocal microscope and a corneal endothelial mirror, so that the statistical reliability and the lesion detection rate can be improved; through a transmission interference mechanism, corneal nerves, epithelial cells and crystalline lens fine structures can be displayed in a high contrast manner, and the method is particularly suitable for low-scattering transparent tissues; a common-path optical structure is adopted, a reference arm or a high-speed scanning unit is not needed, and the system is small in size, low in cost and good in stability; in the examination process, contact with the ocular surface or introduction of a contrast agent is not needed, and discomfort and risks possibly caused by traditional contact type or intrusive type examination are avoided; the method can be used for corneal nerve evaluation, endothelial disease screening, crystalline lens microstructure observation and preoperative / postoperative follow-up visit.

The invention relates to application of regulatory T cells and mesenchymal stem cells in preparation of medicines or medical instruments for repairing corneal nerve injury. The regulatory T cells are prepared from peripheral blood mononuclear cells, the adipose-derived stem cells are prepared from adipose tissues, the sources are wide, the adipose-derived stem cells are easy to obtain, the biocompatibility is good, the quantity is large and the purity is high after in-vitro extraction and amplification, the regulatory T cells and the adipose-derived stem cells are combined for use, corneal nerve repair can be promoted, and the treatment and repair effect is excellent. Further verification shows that corneal nerve repair is beneficial to corneal epithelium defect repair, corneal edema reduction and inhibition of generation of neovascularization and lymphatic vessels, and especially has a good application prospect in the aspect of corneal epithelium damage repair involving corneal limbus.

The invention belongs to the technical field of biology, and particularly relates to a corneal nerve bionic guiding support based on an electrospinning technology. The corneal nerve bionic guide stent provided by the invention is high in porosity and beneficial to cell attachment, migration and neurite extension, and during use, the stent structure can simulate the arrangement direction of corneal nerves, can effectively guide nerve axons to grow in a specific direction, and improves the nerve regeneration efficiency; according to the invention, the silk fibroin is compositely modified by adopting a plurality of growth factors such as NGF, NT-3, NT-4 / 5, NPY and VEGF, so that a multi-factor synergistic effect is realized, and related signal channels of nerve regeneration can be more comprehensively activated. After the polycaprolactone and the silk fibroin are compounded, complementary advantages are formed, the structural strength requirement of the cornea tissue engineering scaffold is met, good flexibility is kept, and the scaffold has good cell affinity and tissue integration capacity and is suitable for tissue engineering scaffolds.

The application relates to the field of biomedical technology, and discloses a Parkinson disease subtype staging inference system based on a corneal nerve image and a SuStaIn algorithm, which comprises an image data acquisition module, a health control module, an abnormality division module, a SuStaIn model construction module and an output module. The image data acquisition module acquires an original image data set, and extracts core effective features after preprocessing the original image data set. The health control module calculates the Z scores of each feature in the corresponding core effective features of Parkinson disease patients through a standardization method. The abnormality division module divides abnormality grades based on the calculation results of the Z scores, and constructs a feature event matrix. The SuStaIn model construction module constructs a disease progression model based on the feature event matrix, inputs the patient feature Z score matrix, sets related parameters, completes model training, and then determines the optimal subtype number through multi-index evaluation. The output module outputs the model prediction results. The application realizes accurate identification of Parkinson disease patient subtypes and objective inference of disease stages, and provides strong support for early diagnosis, individualized treatment and drug research and development of diseases.

Provided in the present invention is the use of KGF-2 in the treatment of dry eye diseases. By means of constructing a KGF-2 heterozygous mouse model and a dry eye disease mouse model induced by scopolamine combined with a dry environment, it is proved that KGF-2 can improve basal tear secretion, prolong the breakup time of the tear film, and reduce corneal epithelial and corneal nerve damage in dry eye disease mice in a dose-dependent manner, and can also decrease the expression level of inflammatory factors such as MMP-3, MMP-9 and TNFα in the lacrimal gland, and can further improve the tear secretion function of the lacrimal gland.

This invention discloses a corneal neural image segmentation method and system based on Transformer. The method combines local feature extraction from CNNs with global feature extraction from Transformers, and constructs a corneal neural image segmentation network based on the ResUnet framework. This network includes a multi-scale deformation attention module, an external attention module, and a depthwise separable convolutional module. The multi-scale deformation attention module and the external attention module form a new cross-attention module. This invention combines the advantages of CNNs and Transformers to extract corneal neural features more comprehensively, solving the problems of fragmentation and noise cell interference in corneal neural image segmentation.

The application provides application of KGF-2 in treatment of dry eye, and proves that KGF-2 can improve the basic tear secretion of dry eye mice in a dose-dependent manner, prolong the tear film break-up time, reduce the corneal epithelium and corneal nerve injury, and can reduce the expression levels of inflammatory factors such as tear gland MMP-3, MMP-9 and TNF alpha, and improve the tear secretion function of the tear gland.

A use of a Citrus depressa extract in preparing a composition used in repairing and / or relieving corneal nerve injury, wherein the composition includes a Citrus depressa extract in an effective amount. The Citrus depressa extract of the composition is a natural plant ingredient and does not cause side effects in a series of animal experiments. When a subject is orally administered the composition, the Citrus depressa extract is configured to provide effects of relieving and / or repairing cornea injury of the subject, including promoting corneal wound, increasing tear secretion, and promoting and / or improving regeneration of corneal nerves, thereby protecting eyes and repairing cornea injury.

This invention discloses an intelligent analysis method for diabetic corneal neuropathy based on confocal microscopy, comprising: acquiring raw images of corneal nerve tissue using a confocal microscope; performing format conversion and preliminary feature extraction via an intelligent diagnostic platform for diabetic neuropathy; calling a multi-scale neuromorphic analysis model to perform multi-dimensional analysis of nerve fiber structure and obtain a morphological parameter matrix; conducting lesion risk correlation analysis using a corneal neuropathy early warning model to generate a feature mapping map; and optimizing image quality and completing structurally defective areas using a confocal image denoising and repair algorithm. The core steps of multi-scale neuromorphic analysis, lesion early warning, and denoising and repair all include processes such as layered capture, feature fusion, risk calculation, and noise filtering. This invention achieves accurate extraction of corneal nerve morphological parameters and objective assessment of lesion risk, providing a systematic intelligent analysis solution for the early diagnosis of diabetic corneal neuropathy.