Annular microneedle for ophthalmology department

A micro-needle and ring-shaped technology, applied in the biological field, can solve the problems of decreased corneal light transmittance and corneal pain, and achieve the effects of small stimulation, small size, and improved biological safety and patient compliance.

Pending Publication Date: 2022-03-04
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to solve the problem that the existing non-invasive multi-array square microneedles can reduce the light transmittance of the cornea and easily cause corneal pain, the present inventio

Method used

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  • Annular microneedle for ophthalmology department
  • Annular microneedle for ophthalmology department
  • Annular microneedle for ophthalmology department

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1: A kind of microneedle and its preparation

[0055] This embodiment provides a kind of microneedle, and described microneedle comprises needle body 1 and base 2, and needle body 1 is fixed on base 2, and needle body 1 is the cone with height 400 μ m, bottom diameter 150 μ m, and base 2 is annular width 2mm , a ring with a thickness of 200 μm (for the overall structure of the microneedle, see figure 1 ). Name this microneedle as microneedle 1.

[0056] The preparation method of the above-mentioned microneedle 1 comprises the following steps:

[0057] Configuration of the needle solution: Weigh 50 mg each of PVP K30 (average molecular weight 58000, purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.), β-CD (molecular weight 1134.98, purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.), and Dissolve 5 mg of levofloxacin (purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.) together in 1 mL of deionized water, ultrasoni...

Embodiment 2

[0071] Embodiment 2: A kind of microneedle and its preparation

[0072] This embodiment provides a microneedle. On the basis of Example 1, the amount of PVP and CD in the preparation method is replaced by 30 mg, and the amount of PVA is replaced by 9 g. This microneedle was named microneedle 7.

Embodiment 3

[0073] Embodiment 3: A kind of microneedle and its preparation

[0074] This embodiment provides a microneedle. On the basis of Example 1, the amount of PVP and CD in the preparation method of the microneedle is replaced by 80 mg, and the amount of PVA is replaced by 24 g. Name this microneedle as microneedle 8.

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Abstract

The invention relates to an annular microneedle for ophthalmology, and belongs to the technical field of biology. The invention provides a microneedle. The microneedle comprises a needle body and a substrate, the needle body is fixed on the base; the base is annular, and the shape and the size of the base are matched with those of the sclera edge; the microneedle acts on the sclera margins of human canthus, eye diseases are treated by rapidly penetrating into the corneal stroma layer and dissolving and releasing contained drugs, the bioavailability of ocular surface drugs is remarkably improved, meanwhile, compared with a traditional non-invasive multi-array square microneedle, the microneedle is small in size, does not affect the light transmission of the center of the cornea, and can be applied to the field of ophthalmology. The stimulation to corneal nerves in a central area is smaller, the problems that a traditional non-invasive multi-array square microneedle can cause reduction of corneal translucency and is prone to causing corneal pain can be effectively solved, and the biological safety of eye microneedle administration and patient compliance are improved.

Description

technical field [0001] The invention relates to a circular microneedle for ophthalmology and belongs to the field of biotechnology. Background technique [0002] The human eye is a sensory organ with a unique anatomical structure and physiological characteristics. Studies have shown that about 80% of external information is transmitted through the eyes. Therefore, eye health is extremely important for humans to engage in normal social activities. How to prevent and treat eye health-related diseases is one of the important issues to improve and protect human health. [0003] It is extremely important to take timely intervention measures during the progression of ocular diseases. Conventional treatment strategies mainly include oral drugs, eye drops, and eye ointment formulations. Although these strategies are widely used, due to the particularity of ocular anatomy, the treatment efficiency of conventional drugs is very low. The main reasons include poor drug permeability cau...

Claims

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Application Information

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IPC IPC(8): A61M37/00A61K9/00A61K45/00A61K47/32A61K47/40A61P27/02
CPCA61M37/0015A61K9/0021A61K9/0048A61K47/32A61K47/40A61K45/00A61P27/02A61M2037/0053A61M2037/0046
Inventor 王佰亮陈浩郭一顺王璐杨建华宋冠兴邓祯女
Owner WENZHOU MEDICAL UNIV
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