Parameter adjusting method for detrusor muscle contraction stimulation and detrusor muscle contraction stimulation system

Abstract

The invention relates to a detrusor muscle contraction stimulation parameter adjusting method and a detrusor muscle contraction stimulation system, and belongs to the technical field of electrical stimulation control, the method comprises the steps that physiological parameters and a treatment period of a current user are acquired, and the physiological parameters comprise the skin electrical impedance quantity, the obesity degree and the age; current pulse parameters of a pulser are determined based on the physiological parameters, so that the pulser emits microwave pulses according to the current pulse parameters, and an electrode device in the detrusor muscle generates induction current according to the microwave pulses emitted by the pulser to stimulate the detrusor muscle; physiological feedback parameters of the current user in the detrusor muscle stimulation process are obtained, wherein the physiological parameters comprise electroencephalogram data and heart rate data; and adjusting the current pulse parameter based on the physiological feedback parameter. The method has the effect of accurately adjusting the parameters according to the condition of the patient.

Description

Technical Field

[0001] The present application relates to the technical field of electrical stimulation control, and in particular, to a method for adjusting parameters of detrusor contraction stimulation and a detrusor contraction stimulation system. Background Art

[0002] Bladder dysfunction affects the urine storage and micturition functions of patients; many bladder dysfunction diseases are combined with detrusor contraction dysfunction, which can lead to a series of clinical problems such as frequent urination, urinary retention, and hydronephrosis.

[0003] Currently, electrical stimulation is generally used to stimulate the detrusor, simulate the natural contraction of the detrusor, thereby improving muscle function, promoting nerve repair and regeneration, and thus achieving the treatment purpose.

[0004] Current electrical stimulation devices generally preset several gears, and the corresponding stimulation parameters for each gear are fixed. However, due to individual differences among patients, different patients with bladder dysfunction have different sensitivities and responses to electrical stimulation. Fixed gears and parameters may not be able to meet the treatment needs of all patients, resulting in poor treatment effects. Therefore, there is an urgent need for a method for adjusting parameters of detrusor contraction stimulation. Summary of the Invention

[0005] In order to accurately adjust parameters according to the patient's condition, the present application provides a method for adjusting parameters of detrusor contraction stimulation and a detrusor contraction stimulation system.

[0006] In the first aspect, the present application provides a method for adjusting parameters of detrusor contraction stimulation, adopting the following technical solution:

[0007] A method for adjusting parameters of detrusor contraction stimulation, applied to a detrusor contraction stimulation system, includes:

[0008] Obtaining the physiological parameters and treatment cycle of the current user, where the physiological parameters include skin impedance, obesity degree, and age;

[0009] Based on the physiological parameters, determining the current pulse parameters of the pulse generator, so that the pulse generator emits microwave pulses according to the current pulse parameters, and the electrode device in the detrusor generates an induced current according to the microwave pulses emitted by the pulse generator to stimulate the detrusor;

[0010] Obtaining the physiological feedback parameters during the detrusor stimulation process of the current user, where the physiological feedback parameters include electroencephalogram data and heart rate data;

[0011] Adjusting the current pulse parameters based on the physiological feedback parameters.

[0012] By adopting the above technical solution, the current pulse parameters of the current user are determined according to the physiological parameters of the current user, so that the pulser emits microwave pulses according to the current pulse parameters, prompting the electrode device in the detrusor muscle to generate induced current according to the microwave pulses emitted by the pulser to stimulate the detrusor muscle, and adjusting the current pulse parameters in real time through physiological feedback parameters, so that the pulse parameters during the treatment process are adapted to each current user, effectively stimulating the detrusor muscle to contract, ensuring the safety and comfort of the treatment process, and optimizing the treatment effect at the same time.

[0013] Optionally, determining the current pulse parameters of the pulser based on the physiological parameters includes:

[0014] Querying whether there is a historical user matching the current user in the parameter information database, where the parameter information database includes the historical electrical stimulation parameters of the historical user;

[0015] If there is a historical user matching the current user in the parameter information database, extract the historical electrical stimulation parameters of the historical user matching the current user, and use the extracted historical electrical stimulation parameters as the current pulse parameters.

[0016] By adopting the above technical solution, by matching the historical user matching the current user and determining the current pulse parameters through the historical electrical stimulation parameters of the historical user, since the matching process is based on the physiological parameters of the current user and the historical user, the selected historical electrical stimulation parameters are more suitable for the physical characteristics of the current user, thus avoiding the use of too high or too low stimulation parameters, reducing the discomfort and pain of the patient, improving the comfort of the treatment and the compliance of the patient, and improving the treatment effect.

[0017] Optionally, the adjustment information database includes a first matching score calculated based on the treatment cycle, obesity degree, skin impedance, and age of the historical user. Querying whether there is a historical user matching the current user in the parameter information database includes:

[0018] Determining the first calculated value corresponding to the treatment cycle;

[0019] Determining the skin impedance range corresponding to the skin impedance, and obtaining the second calculated value corresponding to the skin impedance range;

[0020] Determining the age period corresponding to the age, and obtaining the third calculated value corresponding to the age period;

[0021] Determining the obesity range corresponding to the obesity degree, and obtaining the fourth calculated value corresponding to the obesity range;

[0022] Perform a hash calculation based on the first calculated value, the second calculated value, the third calculated value, and the fourth calculated value to obtain a first screening score;

[0023] Query whether there is a first matching score in the parameter information database that matches the first screening score;

[0024] If there is a first matching score, it is determined that there is a historical user that matches the current user.

[0025] By adopting the above technical solution, through multiple physiological parameters such as the treatment cycle, skin impedance, age, and obesity level, as well as their comprehensive influence on the pulse parameter requirements, the current user and the historical user can be more accurately matched, so as to extract more appropriate pulse parameters. Moreover, the first screening score calculated by the first calculated value, the second calculated value, the third calculated value, and the fourth calculated value is used to match the corresponding first matching score, reducing the workload of one-by-one comparison and improving the search efficiency.

[0026] Optionally, determining the obesity range corresponding to the obesity level includes:

[0027] Determine the distance to be processed from the detrusor muscle to the skin based on the obesity level;

[0028] Determine the obesity range based on the distance to be processed.

[0029] By adopting the above technical solution, the distance to be processed is determined through the obesity range, and the distance to be processed is used as a factor for determining the current pulse parameters, considering the penetration of the pulse, so that the current induced by the electrode device is sufficient to stimulate the detrusor muscle, improving the treatment effect on the current user.

[0030] Optionally, adjusting the current pulse parameters based on the physiological feedback parameters includes:

[0031] Judge whether there are physiological feedback parameters that do not meet the preset conditions;

[0032] If there are physiological feedback parameters that do not meet the preset conditions, extract the physiological feedback parameters that do not meet the preset conditions and use the extracted physiological feedback parameters as the feedback data to be processed;

[0033] Determine the adjustment value for the current pulse parameters based on the feedback data to be processed;

[0034] Adjust the current pulse parameters based on the adjustment value.

[0035] By adopting the above technical solution, the pulse parameters are adjusted in a timely manner through the feedback parameter physiological parameters, avoiding potential risks that may be brought by excessive stimulation intensity or improper treatment methods, and ensuring the safety of the treatment process.

[0036] Optionally, determining the adjustment value for the current pulse parameter based on the to-be-processed feedback data includes:

[0037] Obtain the standard value corresponding to the to-be-processed feedback data;

[0038] Calculate the feedback difference between the standard value and the to-be-processed feedback data;

[0039] Construct a first scatter plot of the feedback difference of the current user and the pulse parameter;

[0040] Determine the adjustment value of the to-be-processed feedback data based on the first scatter plot.

[0041] By adopting the above technical solution, calculating the feedback difference through the to-be-processed feedback data and the standard value, and according to the first scatter plot of the feedback difference of the current user and the pulse parameter, it helps to intuitively display the relationship between the feedback difference and the pulse parameter to determine the adjustment value of the to-be-processed feedback data, so as to formulate personalized adjustment strategies for different patients and improve the adaptability to the current user.

[0042] Optionally, if there is no historical user in the adjustment information database that matches the current user, the method further includes:

[0043] Arbitrarily select three parameters from the skin impedance, obesity degree, age, and treatment cycle for combination to obtain a plurality of to-be-analyzed combined data, where the plurality of to-be-combined data includes all combination situations;

[0044] Calculate the second screening score in each of the to-be-analyzed combined data;

[0045] Query whether there is a second matching score in the parameter information database that matches the second screening score;

[0046] If so, extract the historical user information corresponding to the second matching score that matches the second screening score, where the historical user information includes the physiological parameters and treatment cycle of the historical user;

[0047] Select the historical electrical stimulation parameters of the historical user that include all the to-be-analyzed combined data;

[0048] Construct a second scatter plot of the to-be-processed parameter that is not included in the selected to-be-analyzed combined data, where the to-be-processed parameter includes one of the skin impedance, obesity degree, age, and treatment cycle;

[0049] Determine the current pulse parameter of the current user based on the second scatter plot.

[0050] By adopting the above technical solution, by optionally combining three parameters among skin impedance, obesity level, age, and treatment cycle, a variety of data combinations to be analyzed are obtained. By analyzing the data combinations to be analyzed, historical users matching the current user are preliminarily determined. The current pulse parameters of the current user are determined through a second scatter plot of the to-be-processed parameters not included in the data combinations to be analyzed, making the current pulse parameters more suitable for the current user.

[0051] Optionally, if the physiological feedback parameter meets a preset condition, the method further includes:

[0052] Obtaining the current urination data of the current user;

[0053] Judging whether the current urination data reaches the expectation;

[0054] If not, increasing the current pulse parameter.

[0055] By adopting the above technical solution, when the urination data does not reach the expectation, the pulse parameter is timely increased to ensure that the treatment always remains in the best state.

[0056] Optionally, the judging whether the current urination data reaches the expectation includes:

[0057] Calculating the data difference between the current urination data and the previous urination data;

[0058] Judging whether the data difference reaches a preset difference;

[0059] If so, determining that the urination data reaches the expectation.

[0060] By adopting the above technical solution, by calculating the data difference, the difference between the current urination data and the previous urination data is determined; if the data difference does not reach the preset difference, it indicates that the treatment effect is not good, and the pulse parameter is increased to strengthen the stimulation; on the contrary, if the data difference reaches or exceeds the preset difference, it indicates that the treatment effect is good, and the pulse parameter is maintained or appropriately adjusted to maintain the treatment effect. In the second aspect, the present application provides a detrusor contraction stimulation system, adopting the following technical solution:

[0061] A detrusor contraction stimulation system, characterized by comprising a pulse generator, an electrode device, and an electronic device;

[0062] The electronic device is used to obtain the physiological parameters and treatment cycle of the current user, and determine the current pulse parameters of the pulse generator based on the physiological parameters;

[0063] The electronic device is further used to obtain the physiological feedback parameters during the detrusor stimulation of the current user, and adjust the current pulse parameters based on the physiological feedback parameters;

[0064] The pulse generator is configured to emit microwave pulses according to the current pulse parameters determined by the electronic device;

[0065] The electrode device is disposed within the detrusor muscle and configured to generate an induced current based on the microwave pulses to stimulate the detrusor muscle.

[0066] By adopting the above technical solution, the current pulse parameters of the current user are determined according to the physiological parameters of the current user, so that the pulse generator emits microwave pulses according to the current pulse parameters, prompting the electrode device within the detrusor muscle to generate an induced current based on the microwave pulses emitted by the pulse generator to stimulate the detrusor muscle, and adjusting the current pulse parameters in real time through the physiological feedback parameters, making the pulse parameters during the treatment process adapt to each current user, effectively stimulating the detrusor muscle to contract, ensuring the safety and comfort of the treatment process, and optimizing the treatment effect at the same time. Description of the Drawings

[0067] Figure 1 is the circuit schematic diagram showing the pulse generator and the electrode device generating the induced current in the embodiment of the present application.

[0068] Figure 2 is the structural schematic diagram showing the electrode device in the embodiment of the present application.

[0069] Figure 3 is shown in the embodiment of the present application Figure 2 Partial enlarged view of part A therein.

[0070] Figure 4 is the flowchart showing a method for adjusting parameters of detrusor muscle contraction stimulation in the embodiment of the present application.

[0071] Figure 5 is the flowchart showing the specific steps of step S102 in the embodiment of the present application.

[0072] Figure 6 is the flowchart showing the specific steps of step S1032 in the embodiment of the present application.

[0073] Figure 7 is the flowchart showing the specific steps of step S104 in the embodiment of the present application.

[0074] Figure 8 is the flowchart showing the specific steps of step S1045 in the embodiment of the present application.

[0075] In the figure, 1. Electrode; 11. Front section; 111. Introduction head; 12. Middle section; 121. Electrode contact; 13. Rear section; 131. Guide post; 2. Barbed component; 21. Baffle; 22. Spring. Detailed Description of the Invention

[0076] The present application will be further described in detail below with reference to the accompanying drawings.

[0077] This specific embodiment is only an interpretation of the present application and does not limit the present application. After reading this specification, those skilled in the art can make modifications to this embodiment without creative contributions as needed, but as long as it is within the scope of the claims of the present application, it is protected by the patent law.

[0078] To make the objectives, technical solutions, and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are some, but not all, of the embodiments of the present application. All other embodiments obtained by those of ordinary skill in the art based on the embodiments in the present application without making creative efforts fall within the scope of protection of the present application.

[0079] In addition, the term "and / or" in this article is only a description of the association relationship of associated objects, indicating that there can be three relationships. For example, A and / or B can represent: A exists alone, A and B exist simultaneously, and B exists alone. In addition, the character " / " in this article generally represents an "or" relationship between the associated objects before and after, unless otherwise specified.

[0080] The embodiments of the present application will be further described in detail below with reference to the drawings in the specification.

[0081] The embodiment of the present application discloses a detrusor contraction stimulation system, including a pulse generator, an electrode device, and an electronic device. The electronic device communicates with the pulse generator; the electronic device is used to obtain the physiological parameters and treatment cycle of the current user, and determine the current pulse parameters of the pulsator based on the physiological parameters; the electronic device is also used to obtain the physiological feedback parameters during the detrusor stimulation of the current user, and adjust the current pulse parameters based on the physiological feedback parameters; the pulse generator is used to emit microwave pulses according to the current pulse parameters determined by the electronic device; the electrode device is arranged in the detrusor and used to generate an induced current according to the microwave pulses to stimulate the detrusor.

[0082] Referring to Figure 1 , the pulse generator includes a pulse power supply U1, a charging resistor R1, a discharging capacitor C1, a switch SB1, and an inductor L1. The first end of the pulse power supply U1 is connected to one end of the charging resistor R1. The other end of the charging resistor R1 is respectively connected to one end of the discharging capacitor C1 and the first end of the switch SB1. The other end of the discharging capacitor C1 is connected to the ground terminal. The other end of the switch SB1 is connected to one end of the inductor L1. The other end of the inductor L1 is grounded. The second end of the pulse power supply U1 is connected to the ground terminal.

[0083] In the case where the detrusor muscle of the bladder needs to be stimulated, first control the pulse power supply U1 to charge the discharge capacitor C1. After the discharge capacitor C1 is fully charged, disconnect the pulse power supply U1 and at the same time turn on the switch SB1 to enable the discharge capacitor C1 to start discharging, so that the inductor L1, that is, the transmitting antenna, forms a microwave pulse. At this time, the electrode L2 detects the microwave pulse emitted by the transmitting antenna, and an induced current is formed on the electrode L2, thereby stimulating the detrusor muscle of the bladder through the electrode contacts of the electrode L2.

[0084] It should be noted that Figure 1 In the shown circuit schematic diagram, the detrusor muscle of the bladder can be equivalent to an equivalent resistor R2, so as to stimulate the detrusor muscle of the bladder through the electrode contacts of the electrode L2, so as to achieve the effect of stimulating the contraction of the bladder muscle to improve urination.

[0085] The embodiment of the present application discloses an electrode device. Refer to Figure 2 and Figure 3 , the electrode device includes an electrode 1. The electrode 1 includes a front section 11, a middle section 12 and a rear section 13 that are connected to each other. One end of the front section 11 far from the middle section 12 is fixedly connected with an introduction head 111. The middle section 12 and the rear section 13 are in a cylindrical shape, and the introduction head 111 is in a semi-circular shape. The diameter of one end of the front section 11 close to the introduction head 111 is smaller than the diameter of the end close to the middle section 12. A plurality of barbed components 2 are arranged in an alternating manner on the front section 11 and the rear section 13, and one side of each barbed component 2 close to the end of the electrode 1 is separated from the electrode 1. A plurality of electrode contacts 121 are arranged on the middle section 12. In this embodiment, four electrode contacts 121 are arranged. The length of the electrode 1 is 0.4 cm and the diameter is 0.2 cm. The electrode contacts 121 are made of platinum-iridium alloy. The front section 11, the middle section 12 and the rear section 13 are all made of flexible materials. In this embodiment, the flexible material is polyurethane.

[0086] The barbed component 2 includes a baffle 21 and a spring 22. In this embodiment, the baffle 21 is rectangular and the baffle 21 is made of flexible material, so as to reduce the possibility of damaging the bladder; for the front section 11, one end of the baffle 21 close to the front section 11 is hinged to the front section 11, one end of the spring 22 is fixedly connected to the front section 11, and the other end of the spring 22 is fixedly connected to the baffle 21. When the spring 22 is in a natural elongation state, one side of the baffle 21 close to the end of the front section 11 is separated from the front section 11; for the rear section 13, one end of the baffle 21 close to the rear section 13 is hinged to the rear section 13, one end of the spring 22 is fixedly connected to the rear section 13, and the other end of the spring 22 is fixedly connected to the baffle 21. When the spring 22 is in a natural elongation state, one side of the baffle 21 close to the end of the rear section 13 is separated from the rear section 13.

[0087] In this embodiment, the baffle 21 is made of polyurethane, and the length of the baffle 21 is 0.3 cm.

[0088] After the electrode device enters the bladder wall, the spring 22 is in a natural elongation state, and the side of the baffle 21 close to the end of the electrode 1 is separated from the electrode 1. Under the action of the bladder mucosa pressure, the spring 22 is compressed. Under the action of the elastic force of the spring 22, the baffle 21 abuts tightly against the bladder wall, so that the electrode device is fixed in the bladder wall, thereby reducing the possibility of the electrode device moving in the bladder wall, so as to realize the stimulation of the detrusor contraction through the electrode device.

[0089] It should be noted that, in order to improve the treatment effect, an electrode device can be implanted in each of the left and right walls, the posterior wall, the anterior wall, and the top wall.

[0090] The embodiment of the present application provides a method for adjusting parameters of detrusor contraction stimulation. The method for adjusting parameters of detrusor contraction stimulation can be executed by an electronic device. The electronic device can be a server or a terminal device. The server can be an independent physical server, a server cluster or a distributed system composed of multiple physical servers, or a cloud server providing cloud computing services. The terminal device can be a smart phone, a tablet computer, a desktop computer, etc., but is not limited thereto.

[0091] As Figure 4 shown, a method for adjusting parameters of detrusor contraction stimulation is applied to a detrusor contraction stimulation system. The main process of the method is described as follows (Steps S101 - S104):

[0092] Step S101, obtain the physiological parameters and treatment cycle of the current user. The physiological parameters include skin impedance, obesity degree, and age.

[0093] In this embodiment, the patient or the doctor inputs the physiological parameters and treatment cycle of the patient into the electronic device through input devices such as the keyboard, mouse, and touch screen of the electronic device. The electronic device obtains the physiological parameters and treatment cycle of the patient, and takes the patient corresponding to the obtained physiological parameters and treatment cycle as the current user. Among them, the physiological parameters include but are not limited to skin impedance, obesity degree, and age. Among them, the skin impedance can be measured by a skin resistance sensor, such as the HK series. The obesity degree mentioned here is the subcutaneous fat thickness, which can be measured by ultrasonic examination or indirectly evaluated by measuring indicators such as waist circumference and hip circumference to evaluate the fat accumulation in the abdominal area.

[0094] Step S102, determine the current pulse parameters of the pulse generator based on the physiological parameters, so that the pulse generator emits microwave pulses according to the current pulse parameters, and the electrode device in the detrusor generates an induced current according to the microwave pulses emitted by the pulse generator to stimulate the detrusor.

[0095] Specifically, as Figure 5 shown, it includes the following steps (Steps S1021 - S1023):

[0096] Step S1021, query whether there is a historical user in the parameter information database that matches the current user. The parameter information database includes the historical electrostimulation parameters of the historical user. If so, execute Step S1022; otherwise, execute Step S1023.

[0097] Step S1021 specifically includes: determining a first calculated value corresponding to the treatment cycle; determining a skin impedance quantity corresponding skin impedance quantity range, and obtaining a second calculated value corresponding to the skin impedance quantity range; determining an age period corresponding to the age, and obtaining a third calculated value corresponding to the age period; determining an obesity range corresponding to the obesity degree, and obtaining a fourth calculated value corresponding to the obesity range; performing a hash calculation based on the first calculated value, the second calculated value, the third calculated value, and the fourth calculated value to obtain a first screening score; querying whether there is a first matching score in the parameter information database that matches the first screening score; if there is a first matching score, it is determined that there is a historical user that matches the current user.

[0098] In this embodiment, a skin impedance quantity range, an age period, and an obesity range are preset in the electronic device, where the skin impedance quantity range, the age period, and the obesity range are divided according to the collected treatment data or test data, and the division basis is related to the tolerance to electrostimulation, skin conductivity, and the distance from the skin to the detrusor.

[0099] In this embodiment, different calculated values are set for each treatment cycle, each skin impedance quantity range, each age period, and each obesity range, where the treatment cycle corresponds to a first calculated value, the skin impedance quantity range corresponds to a second calculated value, the age range corresponds to a third calculated value, and the obesity period corresponds to a fourth calculated value. After obtaining the first calculated data, the second calculated value, the third calculated value, and the fourth calculated data, a hash calculation is performed on the first calculated data, the second calculated value, the third calculated value, and the fourth calculated data to obtain a first screening score, where the algorithms for hash calculation include but are not limited to the MD5 algorithm and the SHA algorithm.

[0100] It should be noted that the parameter information database includes the physiological parameter information, treatment cycle, and historical electrostimulation parameters of the historical user. After storing the physiological parameter information and historical electrostimulation parameters of the historical user in the parameter information database, a hash calculation is performed on the physiological parameter information of each historical user to obtain a first matching score corresponding to each historical user, where the physiological parameters of the historical user include but are not limited to skin impedance quantity, age, and obesity degree. The skin impedance quantity range, age range, and obesity range of the historical user are consistent with the division of each range of the current user, and the first matching score is calculated using the same hash algorithm.

[0101] When the electronic device obtains the first screening score, it queries in the parameter information database whether there is a first matching score that matches the first screening score, where the first screening score matches the first matching score, that is, the first screening score is the same as the first matching score, so as to determine the current pulse parameter through the historical electrical stimulation parameters of the historical user matching the current user. In this embodiment, the binary search method can be used to find whether there is a first matching score that is the same as the first screening score in the parameter information database.

[0102] The first screening score and the first matching score are obtained through hash calculation. Through the first screening score and the first matching score, the historical user matching the current user can be quickly found, which reduces the workload of comparing each parameter one by one and improves the query speed and efficiency. At the same time, hash calculation is an encryption algorithm that can ensure the security and privacy of data.

[0103] Among them, determining the obesity interval corresponding to the obesity degree includes: determining the to-be-processed distance between the detrusor and the skin based on the obesity degree; determining the obesity interval based on the to-be-processed distance.

[0104] In this embodiment, the fat accumulation in the abdominal area is indirectly evaluated through ultrasonic examination or by measuring indicators such as waist circumference and hip circumference. The to-be-processed distance between the detrusor and the skin is calculated through the fat accumulation, and then the to-be-processed distance is compared with the values in the obesity interval to determine the obesity interval to which the to-be-processed distance belongs.

[0105] Step S1022, extract the historical electrical stimulation parameters of the historical user matching the current user, and use the extracted historical electrical stimulation parameters as the current pulse parameters.

[0106] In this embodiment, when there are historical electrical stimulation parameters of a historical user matching the current user in the parameter information database, the historical electrical stimulation parameters are directly used as the current pulse parameters. The electronic device sends the current pulse parameters to the pulser, so that the pulser emits microwave pulses according to the current pulse parameters, and the electrode device in the detrusor generates an induced current according to the microwave pulses emitted by the pulser to stimulate the detrusor.

[0107] Among them, the current pulse parameters include but are not limited to frequency, pulse width, amplitude, waveform, interval, mode, polarity, and rise / fall time. The current pulse parameters are introduced as follows:

[0108] I. Pulse frequency

[0109] Low frequency (10 - 20 Hz): Used for detrusor contraction, suitable for treating urinary retention or neurogenic bladder. Low-frequency stimulation can directly activate the contraction of the detrusor and simulate the natural urination process.

[0110] High frequency (30 - 50 Hz): Used to inhibit detrusor overactivity, suitable for treating urinary incontinence or overactive bladder. High-frequency stimulation reduces involuntary contractions of the detrusor by inhibiting nerve conduction.

[0111] II. Pulse width

[0112] Narrow pulse width (200 - 300 μs): Lower stimulation intensity, suitable for patients with mild detrusor dysfunction or those sensitive to stimulation. Narrow pulse width stimulation can activate superficial nerve fibers and reduce discomfort.

[0113] Wide pulse width (400 - 500 μs): Higher stimulation intensity, suitable for patients with severe detrusor dysfunction or those with strong tolerance to stimulation. Wide pulse width stimulation can activate deep nerve fibers and enhance detrusor contraction.

[0114] III. Pulse intensity (amplitude)

[0115] Low intensity (1 - 5 mA): Suitable for patients with mild detrusor dysfunction or those sensitive to stimulation. Low-intensity stimulation can cause mild contractions of the detrusor and reduce discomfort.

[0116] High intensity (5 - 10 mA or higher): Suitable for patients with severe detrusor dysfunction or those with strong tolerance to stimulation. High-intensity stimulation can cause strong contractions of the detrusor and enhance the therapeutic effect.

[0117] IV. Pulse waveform

[0118] Square wave: The most commonly used waveform, can effectively activate the detrusor, suitable for most patients. The square wave has steep rising and falling edges and can quickly activate nerve fibers.

[0119] Biphasic wave: Reduces tissue damage and charge accumulation, suitable for long-term treatment. The positive and negative charges of the biphasic wave cancel each other out, reducing damage to tissues.

[0120] Exponential wave: Less commonly used, suitable for specific treatment needs. The exponential wave can simulate natural nerve signals but may increase discomfort.

[0121] V. Pulse interval

[0122] Short interval (10 - 50 ms): Enhances the stimulation effect, suitable for situations requiring strong detrusor contractions. Short interval stimulation can continuously activate nerve fibers and enhance detrusor contraction.

[0123] Long interval (100 - 200 ms): Reduces detrusor fatigue, suitable for long-term treatment or patients sensitive to stimulation. Long interval stimulation can reduce nerve fiber fatigue and improve patient tolerance.

[0124] VI. Stimulation mode

[0125] Continuous mode: Continuously stimulates the detrusor muscle, suitable for situations requiring strong contractions. The continuous mode can continuously activate nerve fibers and enhance the contraction of the detrusor muscle.

[0126] Intermittent mode: Periodically stimulates the detrusor muscle, suitable for reducing fatigue and discomfort. The intermittent mode can reduce the fatigue of nerve fibers and improve the patient's tolerance.

[0127] Burst mode: Delivered in the form of a burst of pulses, suitable for specific treatment needs. The burst mode can simulate natural nerve signals and enhance the treatment effect.

[0128] VII. Pulse Polarity

[0129] Unipolar stimulation: The stimulation range is relatively large, suitable for situations where extensive activation of the detrusor muscle is required. The current flows from one electrode to another, activating a relatively large range of nerve fibers.

[0130] Bipolar stimulation: The stimulation range is relatively concentrated, suitable for situations where precise activation of the detrusor muscle is required. The current flows between two adjacent electrodes, activating a relatively small range of nerve fibers.

[0131] VIII. Pulse Rise and Fall Times

[0132] Fast rise / fall times: Enhance the stimulation effect, suitable for situations where strong detrusor muscle contractions are required. Fast rise / fall times can quickly activate nerve fibers and enhance the contraction of the detrusor muscle.

[0133] Slow rise / fall times: Improve the patient's comfort, suitable for patients who are sensitive to stimulation. Slow rise / fall times can reduce the sudden activation of nerve fibers and improve the patient's tolerance.

[0134] Among them, as Figure 6 shown, step S1023 specifically includes the following steps (steps a - g):

[0135] Step a, Select any three parameters from skin impedance, obesity level, age, and treatment cycle for combination to obtain multiple sets of combined data to be analyzed. Among them, the multiple sets of combined data to be combined include all combination situations;

[0136] In this embodiment, select any three from the four parameters of skin impedance, obesity level, age, and treatment cycle for combination until all combination situations are included, thereby obtaining multiple sets of combined data to be analyzed, such as the combined data to be analyzed including skin impedance, obesity level, age; the combined data to be analyzed including skin impedance, obesity level, treatment cycle.

[0137] Step b, Calculate the second screening score for each set of combined data;

[0138] In this embodiment, the method for calculating the second screening score is the same as that in step S1021, and details are not described herein again.

[0139] Step c: Query whether there is a second matching score in the parameter information database that matches the second screening score. If so, execute step d.

[0140] In this embodiment, the method for calculating the second matching score is the same as that in step S1021, and details are not described herein again.

[0141] When the electronic device obtains the second screening score, query in the parameter information database whether there is a second matching score that matches the second screening score. When there is a second matching score that is the same as the second screening score, it is determined that there is a second matching score that matches the second screening score.

[0142] Step d: Extract the historical user information corresponding to the second matching score that matches the second screening score. The historical user information includes the physiological parameters and treatment cycles of the historical user.

[0143] Step e: Select the historical electrical stimulation parameters of the historical user that include all the combination data to be analyzed.

[0144] In this embodiment, the historical user information herein refers to the physiological parameters and treatment cycles of the historical user. Since the current pulse parameters are determined according to the four parameters of treatment cycle, skin impedance, obesity degree, and age, and the combination data to be analyzed includes three parameters, and at this time these three parameters match the physiological parameters of the current user, it is necessary to analyze another parameter to determine the current pulse parameters. Therefore, all the historical user information corresponding to the second matching score that matches the second screening score is extracted.

[0145] Step f: Construct a second scatter plot of the parameter to be processed that is not included in the selected combination data to be analyzed. The parameter to be processed includes one of skin impedance, obesity degree, age, and treatment cycle.

[0146] In this embodiment, a scatter plot analysis is performed on the parameter to be processed that is not included in the selected combination data to be analyzed. Among them, the sum coordinate of the scatter plot is the value of another parameter, and the vertical coordinate is the historical electrical stimulation parameter. For example, if the combination data to be analyzed includes skin impedance, obesity degree, and age, then the treatment cycle is the parameter to be processed, and a third scatter plot of the parameter to be processed and the historical electrical stimulation parameter is constructed. Among them, the third scatter plot is drawn using a drawing tool (such as Matplotlib, Seaborn, etc.).

[0147] Step g: Determine the current pulse parameters of the current user based on the second scatter plot.

[0148] In this embodiment, determine the position of the parameter to be processed on the abscissa, and determine the position of the ordinate according to the position of the abscissa. The ordinate is the historical electrical stimulation parameter determined by the parameter to be processed. Among them, the linear interpolation method can be used, and the trend curve can also be obtained by connecting the points. The historical electrical stimulation parameter is determined through the trend curve, and the determined historical electrical stimulation parameter is used as the current pulse parameter.

[0149] Step S103, obtain the physiological feedback parameters during the detrusor muscle stimulation of the current user. The physiological feedback parameters include electroencephalogram data and heart rate data.

[0150] In this embodiment, the physiological feedback parameters during the detrusor muscle stimulation of the current user are collected in real time. The physiological feedback parameters include but are not limited to electroencephalogram data and heart rate data. Among them, the heart rate data can be collected by a smart bracelet, and the heart rate data can be obtained in real time through an electroencephalogram monitoring device such as an EEG headband or helmet, and the electroencephalogram data and heart rate data can be obtained by an electronic device.

[0151] Step S104, adjust the current pulse parameter based on the physiological feedback parameter.

[0152] Specifically, as Figure 7 shown, step S104 includes the following steps (steps S1041 to S1045)

[0153] Step S1041, determine whether there are physiological feedback parameters that do not meet the preset conditions; if so, execute step S1042, otherwise execute step S1045.

[0154] In this embodiment, thresholds corresponding to the electroencephalogram data and heart rate data are preset in the electronic device. When the electronic device obtains the electroencephalogram data and heart rate data, the thresholds corresponding to the electroencephalogram data and heart rate data are compared. When they do not meet the corresponding thresholds, it is determined that there are physiological feedback parameters that do not meet the preset conditions. When they meet the corresponding thresholds, it is determined that there are no physiological feedback parameters that do not meet the preset conditions.

[0155] Step S1042, extract the physiological feedback parameters that do not meet the preset conditions, and use the extracted physiological feedback parameters as the feedback data to be processed.

[0156] In this embodiment, all physiological feedback parameters that do not meet the preset conditions are extracted to analyze the physiological feedback parameters that do not meet the preset conditions.

[0157] Step S1043, determine the adjustment value of the current pulse parameter based on the feedback data to be processed.

[0158] Specifically, obtain the standard value corresponding to the feedback data to be processed; calculate the feedback difference between the standard value and the feedback data to be processed; construct a first scatter plot of the feedback difference and the pulse parameters of the current user; determine the adjustment value of the feedback data to be processed based on the first scatter plot.

[0159] In this embodiment, the standard value is the threshold value described above. Calculate the difference between the actual value of the feedback data to be processed and the standard value to obtain the feedback difference. Use a scatter plot tool (such as Excel, the Matplotlib library in Python, etc.) to construct a first scatter plot of the feedback difference and the pulse parameters of the current user, with the feedback difference as the abscissa and the pulse parameters as the ordinate, to determine the correlation or trend between the pulse parameters and the feedback difference of the current user. Determine the adjustment value through the correlation or trend to optimize the pulse parameters and make them closer to the physiological effect of reaching the standard value.

[0160] Step S1044, adjust the current pulse parameters based on the adjustment value.

[0161] In this embodiment, adjust the current pulse parameters according to the adjustment value, that is, reduce the current pulse parameters according to the adjustment value.

[0162] Specifically, as Figure 8 shown, step S1045 specifically includes the following steps (steps A to C):

[0163] Step A, obtain the current urination data of the current user;

[0164] In this embodiment, the patient or doctor inputs the current urination of the patient into the electronic device through input devices such as the keyboard, mouse, and touch screen of the electronic device. Among them, the current urination data includes but is not limited to the number of urinations and the urination time interval.

[0165] Through step B, determine whether the current urination data meets the expectation. If not, execute step C;

[0166] Among them, step B specifically includes: calculate the data difference between the current urination data and the previous urination data; determine whether the data difference reaches the preset difference; if so, determine that the urination data meets the expectation.

[0167] Step C, increase the current pulse parameters.

[0168] In this embodiment, the data difference between the current urination data and the previously recorded urination data is calculated. The increase or decrease in the urination frequency or the change in the urination time interval is determined based on the data difference. Whether the expected effect is achieved is judged by whether the data difference reaches a preset difference range. The preset difference is set as needed. When the urination data does not meet the expectation, the current pulse parameters are increased until the increased pulse parameters are the same as those in step S1043, which is not specifically limited herein. Thus, the current pulse parameters are adjusted in real time according to the physiological feedback parameters, so that the pulse parameters during the treatment process are adapted to each current user, effectively stimulating the detrusor muscle contraction, ensuring the safety and comfort of the treatment process, and optimizing the treatment effect at the same time.

[0169] In other embodiments, the current pulse parameters can also be further adjusted by using the patient's urine flow rate, urine volume, and residual urine volume in the bladder.

[0170] For the urine flow rate: If the urine flow rate is much lower than the normal range (e.g., Qmax < 5 mL / s), it is necessary to enhance the detrusor muscle contraction to make the urine flow rate tend to reach the standard.

[0171] For the residual urine volume in the bladder: If the residual urine volume in the bladder is too high (e.g., > 100 mL), it may be necessary to enhance the detrusor muscle contraction to ensure complete emptying of the bladder.

[0172] Enhancing detrusor muscle contraction: Increasing the pulse frequency: adjusting from low frequency (10 - 20 Hz) to medium frequency (20 - 30 Hz); increasing the pulse width: adjusting from narrow pulse width (200 - 300 μs) to wide pulse width (400 - 500 μs); increasing the pulse intensity: adjusting from low intensity (1 - 5 mA) to medium intensity (5 - 10 mA).

[0173] Inhibiting overactive detrusor muscle: Decreasing the pulse frequency: adjusting from high frequency (30 - 50 Hz) to medium frequency (20 - 30 Hz); decreasing the pulse width: adjusting from wide pulse width (400 - 500 μs) to narrow pulse width (200 - 300 μs); decreasing the pulse intensity: adjusting from medium intensity (5 - 10 mA) to low intensity (1 - 5 mA).

[0174] Optimizing urination efficiency: Adjusting the stimulation mode: adjusting from continuous mode to intermittent mode to reduce detrusor muscle fatigue; adjusting the pulse interval: adjusting from short interval (10 - 50 ms) to long interval (100 - 200 ms) to improve the patient's tolerance.

[0175] Among them, a urine flow rate meter, a urine volume cup, and an ultrasonic device are used to collect information on the patient's urine flow rate, urine volume, and residual urine volume in the bladder.

[0176] The term "comprising", "including" or any other variation thereof is intended to cover non-exclusive inclusion, such that a process, method, article or apparatus that comprises a series of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article or apparatus.

[0177] The above description is only a preferred embodiment of the present application and an explanation of the applied technical principles. Those skilled in the art should understand that the scope of the application involved in the present application is not limited to the technical solutions formed by the specific combination of the above technical features, but should also cover other technical solutions formed by any combination of the above technical features or their equivalent features without departing from the foregoing application concept. For example, the technical solutions formed by the mutual replacement of the above features with the technical features (but not limited to) having similar functions applied in the present application.

Claims

1. A method for adjusting parameters of detrusor contraction stimulation, applied to a detrusor contraction stimulation system, characterized in that Including: Obtaining the physiological parameters and treatment cycle of the current user, where the physiological parameters include skin impedance, obesity level, and age; Determining the current pulse parameters of the pulse generator based on the physiological parameters, so that the pulse generator emits microwave pulses according to the current pulse parameters, and the electrode device in the detrusor generates induced current based on the microwave pulses emitted by the pulse generator to stimulate the detrusor; Obtaining the physiological feedback parameters during the detrusor stimulation process of the current user, where the physiological feedback parameters include electroencephalogram data and heart rate data; Adjusting the current pulse parameters based on the physiological feedback parameters.

2. The method according to claim 1, wherein The determining the current pulse parameters of the pulse generator based on the physiological parameters includes: Querying whether there is a historical user in the parameter information database that matches the current user, where the parameter information database includes the historical electrical stimulation parameters of historical users; If there is a historical user in the parameter information database that matches the current user, extracting the historical electrical stimulation parameters of the historical user that matches the current user, and using the extracted historical electrical stimulation parameters as the current pulse parameters.

3. The method according to claim 2, wherein The adjustment information database includes a first matching score calculated based on the treatment cycle, obesity level, skin impedance, and age of the historical user. Querying whether there is a historical user in the parameter information database that matches the current user includes: Determining a first calculated value corresponding to the treatment cycle; Determining the skin impedance range corresponding to the skin impedance, and obtaining a second calculated value corresponding to the skin impedance range; Determining the age period corresponding to the age, and obtaining a third calculated value corresponding to the age period; Determining the obesity range corresponding to the obesity level, and obtaining a fourth calculated value corresponding to the obesity range; Performing a hash calculation based on the first calculated value, second calculated value, third calculated value, and fourth calculated value to obtain a first screening score; Querying whether there is a first matching score in the parameter information database that matches the first screening score; If there is a first matching score, determining that there is a historical user that matches the current user.

4. The method according to claim 1, wherein The determining the obesity range corresponding to the obesity level includes: Determining the distance to be processed between the detrusor and the skin based on the obesity level; Determining the obesity range based on the distance to be processed.

5. The method according to claim 1, wherein The adjusting the current pulse parameters based on the physiological feedback parameters includes: Judging whether there are physiological feedback parameters that do not meet the preset conditions; If there are physiological feedback parameters that do not meet the preset conditions, extracting the physiological feedback parameters that do not meet the preset conditions, and using the extracted physiological feedback parameters as the feedback data to be processed; Determining an adjustment value for the current pulse parameters based on the feedback data to be processed; Adjusting the current pulse parameters based on the adjustment value.

6. The method according to claim 5, wherein The determining an adjustment value for the current pulse parameters based on the feedback data to be processed includes: Obtaining the standard value corresponding to the feedback data to be processed; Calculating the feedback difference between the standard value and the feedback data to be processed; Constructing a first scatter plot of the feedback difference and pulse parameters of the current user; Determine the adjustment value of the feedback data to be processed based on the first scatter plot.

7. The method according to claim 2, wherein If there is no historical user in the adjustment information database that matches the current user, the method further includes: Arbitrarily select three parameters from the skin impedance, obesity level, age, and treatment cycle for combination to obtain multiple data combinations to be analyzed, where the multiple data combinations to be combined include all combination situations; Calculate the second screening score for each of the data combinations to be combined; Query whether there is a second matching score in the parameter information database that matches the second screening score; If so, extract the historical user information corresponding to the second matching score that matches the second screening score, where the historical user information includes the physiological parameters and treatment cycle of the historical user; Select the historical electrical stimulation parameters of the historical user that include all the data combinations to be analyzed; Construct a second scatter plot of the parameter to be processed that is not included in the selected data combinations to be analyzed, where the parameter to be processed includes one of the skin impedance, obesity level, age, and treatment cycle; Determine the current pulse parameters of the current user based on the second scatter plot.

8. The method according to claim 1, characterized in that, If the physiological feedback parameter meets the preset condition, the method further includes: Obtain the current urination data of the current user; Judge whether the current urination data meets the expectation; If not, increase the current pulse parameters.

9. The method according to claim 8, wherein The judging whether the current urination data meets the expectation includes: Calculate the data difference between the current urination data and the previous urination data; Judge whether the data difference reaches the preset difference; If so, determine that the urination data meets the expectation.

10. A detrusor muscle contraction stimulation system, characterized in that, It includes a pulse generator, an electrode device, and an electronic device, and the electronic device is communicatively connected to the pulse generator; The electronic device is used to obtain the physiological parameters and treatment cycle of the current user, and determine the current pulse parameters of the pulsator based on the physiological parameters; The electronic device is further used to obtain the physiological feedback parameters during the detrusor stimulation of the current user, and adjust the current pulse parameters based on the physiological feedback parameters; The pulse generator is used to emit microwave pulses according to the current pulse parameters determined by the electronic device; The electrode device is arranged in the detrusor and is used to generate an induced current according to the microwave pulses to stimulate the detrusor.

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