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Pyrazole amide compound containing diphenyl ether, and application and pesticide composition of pyrazole amide compound

A pesticide composition, pyrazole amide technology, applied in the field of pyrazole amide compounds, can solve the problems of poor control effect of diseases and insect pests, poor control effect of rice sheath blight and cucumber powdery mildew, etc.

Active Publication Date: 2015-04-29
燕化永乐(乐亭)生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, the above-mentioned pyrazole amide compounds containing diphenyl ether described in the prior art have been tested for biological activity, and have a poor effect on the control of plant diseases and insect pests, especially for rice sheath blight and cucumber powdery mildew that affect my country's food security. Poor effectiveness

Method used

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  • Pyrazole amide compound containing diphenyl ether, and application and pesticide composition of pyrazole amide compound
  • Pyrazole amide compound containing diphenyl ether, and application and pesticide composition of pyrazole amide compound
  • Pyrazole amide compound containing diphenyl ether, and application and pesticide composition of pyrazole amide compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Synthesis of diphenyl ether-containing pyrazole amide compounds shown in formula I and formula II.

[0036] Refer to synthetic route (1) and synthetic route (2) as described above.

[0037] 1. Synthesis of 2,4-dichloro-1-(2-nitrophenoxy)benzene

[0038] 2.82g (20mmol) 2-fluoronitrobenzene and 4.89g (30mmol) 2,4-dichlorophenol, 4.15g (30mmol) K 2 CO 3 Add 50ml DMF and 50ml DMF to a 100ml single-necked bottle, heat to reflux for 5h, remove DMF under reduced pressure, wash three times with 10% NaOH aqueous solution, extract with ethyl acetate, anhydrous Na 2 SO 4 After drying, it was precipitated to obtain 5.50 g of 2,4-dichloro-1-(2-nitrophenoxy)benzene, with a yield of 97%.

[0039] 2. Synthesis of 2-(2,4-dichlorophenoxy)aniline

[0040] Dissolve 5.50g (19.36mmol) of 2,4-dichloro-1-(2-nitrophenoxy)benzene in 100ml of ethanol, add 1.04g (19.36mmol) of ammonium chloride and 10ml of water, heat to reflux and add Three batches of 3.24g (58.08mmol) iron powder were reac...

preparation example 1

[0051] Compounds shown in the following formula (III) that are structurally similar to the pyrazole amide compounds shown in formula I and / or formula II were synthesized through a synthetic route similar to that of Example 1, and their numbers are shown in Table 1.

[0052]

[0053] Table 1

[0054] serial number R 6 R 2 R 3 R 4 R 5 III-1 CF 3 H Cl H H III-2 CF 3 Cl H Cl H III-3 CF 3 H H F H III-4 CF 3 H Ome Ome Ome III-5 CHF 2 H Ome Ome Ome III-6 CF 3 H H CN H III-7 CHF 2 H H CN H III-8 CF 3 Cl H H H III-9 CF 3 H H Cl H III-10 CHF 2 H H Cl H III-11 CF 3 H H CF 3 H III-12 CHF 2 H H CF 3 H III-13 CF 3 CH 3 CH 3 H H III-14 CHF 2 CH 3 CH 3 H H III-15 CF 3 H CH 3 H CH 3 III-16 CHF 2 H CH 3 H CH 3

[0055] The relevant nuclear magnetic data ...

preparation example 2

[0073] According to the methods disclosed in Examples 12 and 21 of CN 1226244A, compound 5, compound 12 and compound 21 shown in the following formula were prepared.

[0074]

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Abstract

Disclosed are a pyrazole amide compound containing diphenyl ether as represented by formula I and / or formula II, application thereof in the prevention and treatment of rice sheath blight and cucumber powdery mildew, and pesticide composition containing the compound. The pyrazole amide compound of the present invention containing diphenyl ether as represented by formula I and / or formula II, and a bactericide containing the pyrazole amide compound as an active ingredient have good prevention and treatment effects on rice sheath blight and cucumber powdery mildew.

Description

technical field [0001] The invention relates to pyrazole amide compounds containing diphenyl ether, in particular to the application of the compounds in the control of rice sheath blight and cucumber powdery mildew and the pesticide composition containing the compounds. Background technique [0002] Rice is one of the most important food crops in my country. The planting area accounts for about 30% of the food crop area, and its output is close to half of my country's total food production. Rice sheath blight is the main obstacle restricting the high and stable yield of rice, and it is the first of the three major diseases of rice in my country. In recent years, with the promotion of high-yield or super-high-yield hybrid rice varieties and the gradual increase in the amount of nitrogen fertilizer used in rice, the occurrence area of ​​rice sheath blight has increased year by year, and the degree of damage has increased year by year. In severe cases, the yield reduction of fi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D231/14A01N43/56A01P3/00
CPCA01N43/56C07D231/14C07D231/12
Inventor 杨光富熊力陈琼
Owner 燕化永乐(乐亭)生物科技有限公司
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