Method for preparing biomedical material of static self-assembly modified nano fiber

A biomedical material, electrostatic self-assembly technology, applied in the field of biomedical applications of polymer materials, can solve the problems of poor biological activity, difficulty in electrospinning and other problems, and achieve the effects of improved activity, good air permeability, and simple process

Inactive Publication Date: 2010-08-11
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a biomedical material preparation method for electrostatically self-assembled modified nanofibers to solve the above-mentioned problems such as difficulty in electrospinning and poor bioactivity of biocompatible nanofibers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] At room temperature of 25°C, 0.5g of cellulose acetate fiber was stirred and dissolved in 9.5g of acetone and N,N-dimethylacetamide mixed solvent (weight ratio: 2:1) in a stirred tank at a speed of 100rpm / min, Obtaining the cellulose acetate fiber solution that mass fraction is 5%, the electrospinning raw material that will obtain is joined in the electrospinning device, is 10 kilovolts at static voltage, and injection pump flow rate is 0.3ml / h, and spinneret is apart from receiving screen distance Electrospinning was carried out under the condition of 6 cm to obtain the cellulose acetate nanofiber template material.

[0017] The prepared nanofibrous template material was immersed in a chitosan-acetic acid aqueous solution with a concentration of 0.01 mg / ml, adsorbed for 5 minutes, washed with distilled water for 5 minutes, and dried in air; In the polysaccharide aqueous solution, the adsorption equilibrium is 5 minutes, washed with distilled water for 5 minutes, and ai...

Embodiment 2

[0020] At room temperature of 25°C, 1g of cellulose was stirred and dissolved in 13.3g of 7wt% NaOH / 12wt% urea aqueous solution in a stirred tank at a speed of 300rpm. After precooling to -12°C, the cellulose was rapidly dissolved to obtain fibers with a mass fraction of 7%. Add the obtained electrospinning raw material to the electrospinning device, and carry out electrospinning under the condition that the static voltage is 15 kV, the flow rate of the syringe pump is 0.5ml / h, and the distance between the spinneret and the receiving screen is 8cm, and the obtained Cellulose nanofiber template material.

[0021] The prepared nanofiber template material was immersed in a polyethyleneimine aqueous solution with a concentration of 1mg / ml, and the adsorption equilibrium was 10 minutes, washed with distilled water for 7 minutes, and dried in air; the dried material was immersed in a polystyrenesulfonate solution with a concentration of 1mg / ml NaCl aqueous solution, adsorption equil...

Embodiment 3

[0024] At room temperature of 25°C, 1.5g of chitosan was stirred and dissolved in 15.2g of acetic acid solvent at a speed of 500rpm in a stirred tank to obtain a chitosan acetic acid solution with a mass fraction of 9%, and the chitosan acetic acid solution was added to the electrostatic In the spinning device, electrospinning was carried out under the condition that the static voltage was 18 kV, the flow rate of the syringe pump was 0.8 ml / h, and the distance between the spinneret and the receiving screen was 8 cm to obtain the chitosan nanofiber template material.

[0025] The prepared chitosan nanofiber template material is immersed in a polyacrylic acid aqueous solution with a concentration of 2mg / ml, and the adsorption balance is 15 minutes, washed with distilled water for 9 minutes, and air-dried; the dried material is immersed in an aqueous collagen solution with a concentration of 2mg / ml. , adsorption equilibrium for 15 minutes, washed with distilled water for 9 minutes...

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Abstract

The invention relates to a method for preparing a biomedical material of a static self-assembly modified nano fiber, which is characterized by comprising the following concrete steps of: stirring and dissolving a water-insoluble macromolecular polymer for spinning in a solvent in a stirring kettle at room temperature to obtain an electric spinning raw material with the weight percentage of 5-30 percent; adding the electric spinning raw material into a static spinning device and statically spinning to obtain a nano fiber template material; soaking the nano fiber template material into a weak polymerized electrolyte aqueous solution which has the concentration of 0.01-10g / ml and an opposite charge, adsorbing for balance and drying; soaking the dried material into the weak polymerized electrolyte aqueous solution which has the concentration of 0.01-10g / ml and the opposite charge, adsorbing for balance, washing by distilled water for 5-30 minutes and drying; and obtaining the biomedical material of the static self-assembly modified nano fiber. The invention has simple molding and high bioactivity.

Description

technical field [0001] The invention relates to a biomedical material preparation method of electrostatically self-assembled modified nanofibers, belonging to the field of biomedical application of polymer materials. Background technique [0002] Electrospinning is a process in which a polymer solution or melt is sprayed under a high-voltage electric field to form nanoscale fibers. The operation process of the electrospinning process is simple, and because the obtained fibers are smaller than those obtained by conventional methods, the nanofiber membrane material has a super high specific surface area and porosity, and can produce a three-dimensional porous structure. A common approach for surface-active tissue engineering materials. Chinese patents CN1467314A and CN101172164A add antibacterial agent ultrafine particles and therapeutic drugs to the electrospun polymer solution, and then electrospin the mixed solution to obtain biocompatible nanofiber materials, but the anti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M15/03D06M15/15D06M15/61D06M15/59D06M15/356D06M15/13D06M15/233D06M15/263D01D5/40
Inventor 丁彬王先锋杨尚斌邓红兵俞建勇孙刚
Owner DONGHUA UNIV
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