The invention discloses a method for preparing a
human fibrinogen preparation. The method comprises the following step: with healthy
human plasma as
raw material, separating and purifying by a low-temperature
ethanol protein separation method, wherein a centrifugal method is replaced with a mild
filter press method; top washing is carried out on sediments by using a low-temperature
ethanol solution; a multi-stage deep
filtration is added; a freeze-dry process is improved; the freeze-dry cycle is shortened to 2-3 days from 4-8 days; and inactivation treatment is carried out on viruses by combining an S / D method, a
UVC radiation method and a
dry heat process, so that the removal effect on lipid envelop viruses and non-lipid envelope viruses, especially heat-resistant
parvovirus is ensured. The invention also discloses a
fibrinogen preparation prepared by the method. The
fibrinogen preparation produced by the method has the advantages of relatively stable quality, relatively low
impurity content, and relatively high
virus safety; the
safety risk which can be brought for a patient by the infusion of the preparation can be reduced to the maximal extent;
side reaction during clinical application is reduced; and medication is relatively safe.