Method of enhancing of binding activity of antibody composition to Fcgamma receptor IIIa

a technology of fcgamma receptor and antibody composition, which is applied in the field of enhancing the binding activity of antibody composition to fcgamma receptor iiia, can solve the problems of complex structure of sugar chains and various sugar chains
US20040259150A1Inactive Publication Date: 2004-12-23KYOWA HAKKO KIRIN CO LTD
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
KYOWA HAKKO KIRIN CO LTD
Publication Date
2004-12-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

A method for enhancing a binding activity of an antibody composition to Fcgamma receptor IIIa, which comprises modifying a complex N-glycoside-linked sugar chain which is bound to the Fc region of an antibody molecule; a method for enhancing an antibody-dependent cell-mediated cytotoxic activity of an antibody composition; a process for producing an antibody composition having an enhanced binding activity to Fcgamma receptor IIIa; a method for detecting the ratio of a sugar chain in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chain among total complex N-glycoside-linked sugar chains bound to the Fc region in an antibody composition; an Fc fusion protein composition produced by using a cell resistant to a lectin which recognizes a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through alpha-bond in a complex N-glycoside-linked sugar chain; and a process for producing the same.
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Description

BACKGROUND OF TE INVENTION

[0001] 1. Field of the Invention

[0002] The present invention relates to a method for enhancing a binding activity of an antibody composition to Fc.gamma. receptor IIIa, which comprises modifying a complex N-glycoside-linked sugar chain which is bound to the Fc region of an antibody molecule; a method for enhancing an antibody-dependent cell-mediated cytotoxic activity of an antibody composition; a process for producing an antibody composition having an enhanced binding activity to Fc.gamma. receptor IIIa; a method for detecting the ratio of a sugar chain in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chain among total complex N-glycoside-linked sugar chains bound to the Fc region in an antibody composition; an Fc fusion protein composition produced by using a cell resistant to a lectin which recognizes a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through ....

Claims

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