Viscosity-controllable and low-toxicity polysaccharide-based antibacterial detergent and preparation method thereof

Abstract

The invention provides a viscosity-controllable and low-toxicity polysaccharide-based antibacterial detergent and a preparation method thereof, and belongs to the technical field of daily chemical sterilization. The detergent comprises the following raw materials in percentage by mass: 0.5-6% of a polysaccharide thickener, 10% of a bacteriostatic agent, 10% of a glycoside nonionic surfactant and the balance of water, the polysaccharide thickening agent is a mixture of chitosan, chitosan hydrochloride and quaternized chitosan. The polysaccharide is applied to viscosity regulation and control of a surfactant system without a petroleum-based thickening agent for the first time, application of the polysaccharide in the field of daily chemical washing is expanded, and compared with other antibacterial hand sanitizer competitive products containing benzene rings and phenol bacteriostatic agents and 6501 thickening agents, the antibacterial hand sanitizer competitive products have the remarkable advantages of high biocompatibility, high antibacterial property, easiness in degradability and the like.

Description

Technical Field

[0001] The present invention relates to the technical field of daily chemical disinfection, and in particular to a polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity and a preparation method thereof. Background Art

[0002] As consumers' demand for hygiene protection increases, the disinfectant industry is showing a steady growth trend. The active ingredients of disinfectant products on the market include quaternary ammonium salts, alcohols, phenols, triclosan, chlorine-containing compounds, glycols, and biguanides. However, from the perspective of safety and bactericidal efficiency, detergents containing the above main ingredients can no longer meet the daily use needs of consumers. Although triclosan is widely used in antibacterial soaps, it is believed to be associated with problems such as antimicrobial resistance and endocrine disruption; halogenated compounds (such as chlorophenols and triclosan) and small molecule antibacterial agents such as salicylic acid can promote the development of bacterial resistance and have multiple potential toxicities. For example, they are easily ingested by children through licking after washing their hands, which is more likely to cause safety risks than adults; they can also cause skin irritation, leading to dryness, itching, redness, swelling and other discomforts, and may also interfere with the human endocrine system and affect the normal regulation of thyroid hormones. In addition, the harm of these compounds to the environment cannot be ignored. Small molecule antibacterial agents containing halogens and benzene rings are difficult to completely degrade in the natural environment, and their residues can easily enter water bodies and soil, causing persistent pollution.

[0003] In contrast, polysaccharide-based hand sanitizers offer significant advantages: their natural, non-toxic ingredients are gentle on the skin, rarely causing irritation reactions such as dryness or redness, and are suitable for long-term use. The excellent biodegradability of polysaccharides effectively prevents environmental pollution and the persistent damage posed to ecosystems by halogenated compounds. Furthermore, polysaccharides possess broad-spectrum, highly effective antimicrobial properties, effectively killing a wide range of common pathogens, thus aligning with environmental and safety trends while protecting human health. However, the preparation of polysaccharide-based antimicrobial detergents with controllable viscosity and low toxicity currently faces two scientific challenges: 1. Due to the low micelle density and simple structure of the system, surfactant systems without petroleum-based thickeners are difficult to thicken (viscosity less than 500 mPa·s). 2. Polysaccharide molecules form complex polymer networks in aqueous solutions through hydrogen bonding and electrostatic interactions. High shear forces or concentration gradients can easily disrupt this network, leading to molecular chain aggregation and precipitation, ultimately triggering phase separation. Therefore, the development of polysaccharide-based antimicrobial detergents with controllable viscosity and low toxicity has become an important and pressing issue in the field. Summary of the Invention

[0004] In view of this, the object of the present invention is to provide a polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity and a preparation method thereof.

[0005] In order to achieve the above object, the present invention provides the following technical solutions:

[0006] One of the technical solutions of the present invention is a polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity, wherein the raw materials include, by mass percentage, 0.5-6% of a polysaccharide thickener, 10% of a bacteriostatic agent, 10% of a glycoside nonionic surfactant, and the balance being water;

[0007] The polysaccharide thickener is a mixture of chitosan, chitosan hydrochloride and quaternized chitosan.

[0008] In a preferred embodiment of the present invention, the raw materials include, by mass percentage: 2-6% polysaccharide thickener, 10% antibacterial agent, 10% glycoside nonionic surfactant, and the balance water;

[0009] The polysaccharide thickener is a mixture of chitosan, chitosan hydrochloride and quaternized chitosan.

[0010] In the present invention, if the ratios of the polysaccharide thickener, the nonionic surfactant, and the antibacterial agent are not within the above ranges, the resulting detergent will be extremely unstable (phase separation will occur immediately).

[0011] Polysaccharides are composed of multiple monosaccharides and have complex polymer chain networks. They swell significantly when dissolved in water, exhibiting excellent thickening properties, but they are unstable in aqueous solutions. Surfactants, due to their dispersing, solubilizing, and stabilizing properties, can act as stabilizing dispersants for polysaccharides, improving their stability and performance. Polysaccharide thickeners of varying molecular weights can be freely selected based on the desired viscosity and system color, enabling targeted regulation and optimization. This opens new possibilities for the customized design of surfactant products.

[0012] In a preferred embodiment of the present invention, the mass ratio of chitosan, chitosan hydrochloride and quaternized chitosan is 1:1:1.

[0013] In a preferred embodiment of the present invention, the molecular weight of the chitosan, chitosan hydrochloride and quaternized chitosan is 2 million Daltons.

[0014] In a preferred embodiment of the present invention, the antibacterial agent is bletilla striata polysaccharide, tea saponin, tannic acid, gallic acid or polylysine.

[0015] In a preferred embodiment of the present invention, the glycoside nonionic surfactant is dodecyl glucoside, myristyl glucoside or glucuronide ester.

[0016] The second technical solution of the present invention is a method for preparing the above-mentioned polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity, which comprises adding a polysaccharide thickener to water, stirring for 1, then adding an antibacterial agent and a glycoside nonionic surfactant, stirring for 2, and allowing to stand to obtain the polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity.

[0017] In a preferred embodiment of the present invention, the stirring 1, stirring 2 and standing time are all 8-12 hours.

[0018] The order of adding the raw materials in the preparation method of the present invention cannot be changed arbitrarily. The polysaccharide must be added first and stirred for 8-12 hours before further mixing with the glycoside nonionic surfactant and antibacterial agent. If the order of adding the raw materials is adjusted, the resulting detergent will cause phase separation.

[0019] The present invention discloses the following technical effects:

[0020] (1) The viscosity-controllable, low-toxic polysaccharide-based antibacterial detergent of the present invention can freely control the viscosity of a surfactant system that does not contain a petroleum-based thickener by changing the molecular weight and type of the polysaccharide.

[0021] (2) Polysaccharides are unstable in aqueous solution and are prone to phase separation. The nonionic surfactant provided by the present invention can effectively enhance the stability of polysaccharides in aqueous solution, so that the polysaccharide aqueous solution has excellent high and low temperature stability.

[0022] (3) The present invention is the first to apply polysaccharides to the viscosity control of surfactant systems that do not contain petroleum-based thickeners, expanding the application of polysaccharides in daily chemical cleaning. Compared with other antibacterial hand sanitizer competitors containing benzene rings, phenolic antibacterial agents, and 6501 thickeners, the present invention has significant advantages such as high biocompatibility, strong antibacterial properties, and easy degradation. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0024] Figure 1 The results of hematoxylin-eosin staining of mice in Example 1 and Comparative Example 1 in Effect Example 2 are shown;

[0025] Figure 2 The biodegradability test results of Example 1 and Comparative Example 1 in Effect Example 4 are shown. DETAILED DESCRIPTION

[0026] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as limiting the present invention, but rather as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0027] It should be understood that the terms described herein are intended only to describe particular embodiments and are not intended to limit the present invention. In addition, for numerical ranges herein, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. The intermediate value within any stated value or stated range, and each smaller range between any other stated value or intermediate value within the stated range, is also encompassed within the present invention. The upper and lower limits of these smaller ranges may be independently included or excluded within the scope.

[0028] Unless otherwise indicated, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art. Although only preferred methods and materials are described herein, any methods and materials similar or equivalent to those described herein may also be used in the practice or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials associated with the documents. In the event of any conflict with any incorporated document, the contents of this specification shall prevail.

[0029] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments described herein without departing from the scope or spirit of the invention. Other embodiments will be apparent to those skilled in the art from the description of the invention. The description and examples are intended to be exemplary only.

[0030] The words “include,” “including,” “have,” “contain,” etc. used in this document are open-ended terms, meaning including but not limited to.

[0031] All “parts” described in the following examples are “parts by mass”.

[0032] Unless otherwise specified, the technical solutions described in the present invention are all conventional solutions in the field, and the reagents or raw materials used, unless otherwise specified, are purchased from commercial channels or have been disclosed.

[0033] In order to better understand the present invention, the content of the present invention is further illustrated below in conjunction with the examples, but the content of the present invention is not limited to the following examples.

[0034] The polysaccharide thickener used in the following examples and comparative examples of the present invention is a mixture of chitosan, chitosan hydrochloride, and quaternized chitosan (the molecular weight of chitosan, chitosan hydrochloride, and quaternized chitosan are all 2 million Daltons). The specific formula of the polysaccharide thickener is: 1 part chitosan, 1 part chitosan hydrochloride, and 1 part quaternized chitosan, calculated by mass.

[0035] In the examples, the preparation method of the detergent is as follows: a polysaccharide thickener is added to water and stirred for 12 hours to fully dissolve it, an antibacterial agent is added, and then a glycoside nonionic surfactant is added, followed by stirring for another 12 hours, and the detergent is obtained after standing for 12 hours.

[0036] Example 1

[0037] A polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity comprises 100 parts by mass of a polysaccharide thickener (2 parts), tea saponin (10 parts), dodecyl glucoside (10 parts), and the balance deionized water.

[0038] Example 2

[0039] A polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity comprises 100 parts by mass of a polysaccharide thickener (2 parts), bletilla striata polysaccharide (10 parts), dodecyl glucoside (10 parts), and the balance deionized water (100 parts).

[0040] Example 3

[0041] A polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity comprises 100 parts by mass of a polysaccharide thickener, 2 parts by mass of tannic acid, 10 parts by mass of dodecyl glucoside, and the balance by mass of deionized water.

[0042] Example 4

[0043] A polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity comprises 100 parts by mass of a polysaccharide thickener (2 parts), gallic acid (10 parts), dodecyl glucoside (10 parts), and the balance deionized water.

[0044] Example 5

[0045] A polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity comprises 100 parts by mass of a polysaccharide thickener (2 parts), polylysine (10 parts), dodecyl glucoside (10 parts), and the balance deionized water.

[0046] Example 6

[0047] A polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity comprises 100 parts by mass of a polysaccharide thickener (2 parts), tea saponin (10 parts), myristyl glucoside (10 parts), and the balance deionized water.

[0048] Example 7

[0049] A polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity comprises 100 parts by mass of a polysaccharide thickener (2 parts), bletilla striata polysaccharide (10 parts), myristyl glucoside (10 parts), and the balance deionized water.

[0050] Example 8

[0051] A polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity comprises 100 parts by mass of a polysaccharide thickener (2 parts), tannic acid (10 parts), myristyl glucoside (10 parts), and the balance deionized water.

[0052] Example 9

[0053] A polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity comprises 100 parts by mass of a polysaccharide thickener (2 parts), gallic acid (10 parts), myristyl glucoside (10 parts), and the balance deionized water.

[0054] Example 10

[0055] A polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity comprises 100 parts by mass of a polysaccharide thickener (2 parts), polylysine (10 parts), myristyl glucoside (10 parts), and the balance deionized water.

[0056] Example 11

[0057] A polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity comprises 100 parts by mass of a polysaccharide thickener (2 parts), tea saponin (10 parts), glucose alcohol ester (10 parts), and the balance deionized water.

[0058] Example 12

[0059] A polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity comprises 100 parts by mass of a polysaccharide thickener, 2 parts by mass of tannic acid, 10 parts by mass of glucosyl alcohol ester, and the balance by mass of deionized water.

[0060] Example 13

[0061] A polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity comprises 100 parts by mass of a polysaccharide thickener (2 parts), gallic acid (10 parts), glucosyl alcohol ester (10 parts), and the balance deionized water.

[0062] Example 14

[0063] A polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity comprises 100 parts by mass of a polysaccharide thickener (2 parts), bletilla striata polysaccharide (10 parts), glucose alcohol ester (10 parts) and the balance of deionized water.

[0064] Example 15

[0065] A polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity comprises 100 parts by mass of a polysaccharide thickener (2 parts), polylysine (10 parts), glucose alcohol ester (10 parts), and the balance deionized water.

[0066] Example 16

[0067] A polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity comprises 100 parts by mass of a polysaccharide thickener, 4 parts by weight of tea saponin, 10 parts by weight of dodecyl glucoside, and the balance by weight of deionized water.

[0068] Example 17

[0069] A polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity comprises 100 parts by mass of a polysaccharide thickener (6 parts), tea saponin (10 parts), dodecyl glucoside (10 parts), and the balance deionized water.

[0070] Comparative Example 1

[0071] A detergent, comprising 100 parts by mass, comprising 2 parts of 6501 thickener, 4 parts of sodium fatty alcohol polyoxyethylene ether sulfate, 10 parts of tea saponin, 10 parts of dodecyl glucoside, and the balance deionized water. (The difference from Example 1 is that the 2 parts of polysaccharide thickener are replaced with 2 parts of 6501 thickener and 4 parts of sodium fatty alcohol polyoxyethylene ether sulfate.)

[0072] Comparative Example 2

[0073] A detergent, comprising 100 parts by mass, comprising 2 parts of cocamidopropyl betaine, 3 parts of sodium fatty alcohol polyoxyethylene ether sulfate, 10 parts of tea saponin, 10 parts of lauryl glucoside, and the balance deionized water. (The difference from Example 1 is that the 2 parts of polysaccharide thickener are replaced with 2 parts of cocamidopropyl betaine and 3 parts of sodium fatty alcohol polyoxyethylene ether sulfate.)

[0074] Comparative Example 3

[0075] A detergent, comprising 100 parts by mass, comprising 2 parts of a polysaccharide thickener, 4.5 parts of cocamidopropyl betaine, 4.5 parts of sodium fatty alcohol polyoxyethylene ether sulfate, 10 parts of tea saponin, and the balance deionized water. (The difference from Example 1 is that 10 parts of lauryl glucoside are replaced with 4.5 parts of cocamidopropyl betaine and 4.5 parts of sodium fatty alcohol polyoxyethylene ether sulfate.)

[0076] Comparative Example 4

[0077] A detergent, comprising 100 parts by mass, comprising 2 parts of a polysaccharide thickener, 4.5 parts of cocamidopropyl betaine, 4.5 parts of sodium dodecylbenzenesulfonate, 10 parts of tea saponin, and the balance deionized water. (The difference from Example 1 is that 2 parts of lauryl glucoside are replaced with 4.5 parts of cocamidopropyl betaine and 4.5 parts of sodium dodecylbenzenesulfonate.)

[0078] Comparative Example 5

[0079] A detergent, calculated by weight, totaling 100 parts, comprises 5 parts of a polysaccharide thickener, 10 parts of tea saponin, 15 parts of dodecyl glucoside, and the balance of deionized water.

[0080] Comparative Example 6

[0081] The same as Example 1, the only difference is that the preparation method is: first dissolve tea saponin and dodecyl glucoside in water, and then add a polysaccharide thickener and stir for 12 hours, and then stand for 12 hours to obtain the detergent.

[0082] Effect Example 1

[0083] The detergents of Examples 1-17 and Comparative Examples 1-5 were stored at 37° C. for 90 days and then subjected to sterilization and biocompatibility tests with reference to the technical specifications for disinfection and Appendix C of GB 15979-2002 "Hygiene Standards for Disposable Sanitary Products."

[0084] Table 1 Effects of different formulations on the sterilization rate of Candida albicans and relative viscosity of detergents

[0085]

[0086]

[0087]

[0088] As shown in Table 1, the polysaccharide detergents of Examples 1-15 demonstrated significantly higher sterilization rates against Candida albicans than the petroleum-based surfactant detergents of the comparative examples (Comparative Examples 1-4). This demonstrates that the introduction of specific surfactants into the polysaccharide solution significantly improves the stability and antibacterial properties of the system. When the ratios of the polysaccharide thickener, antibacterial agent, and glycoside nonionic surfactant were outside the present invention (Comparative Example 5), the resulting detergents immediately phase separated. Furthermore, as shown in Table 1 (Examples 15-17), varying the polysaccharide content allows for flexible control of the system's viscosity. Experiments have shown that changing the order of addition or shortening the stirring time can lead to phase separation (see Comparative Example 5).

[0089] Table 2 Example 1 sterilization rate of Escherichia coli and Staphylococcus aureus

[0090]

[0091]

[0092] Effect Example 2

[0093] Example 1 and Comparative Example 1 were selected to conduct animal toxicity evaluation experiments.

[0094] Acute oral toxicity test in mice: After oral administration of the samples, the mice in Example 1 and Comparative Example 1 showed no abnormality and no death within 14 days. The median lethal concentration (LD50) of the oral toxicity in mice in Example 1 and Comparative Example 1 was 50 )>5000mg / (kg.bw), both of which are practically non-toxic substances. Further, on the 14th day, the mice of Example 1 and Comparative Example 1 were sacrificed, and the heart, liver, spleen, and kidney were pathologically analyzed by hematoxylin-eosin staining. The results showed that no abnormalities were found in the organs of the Example 1 group, but the organs of the Comparative Example 1 group all showed varying degrees of damage ( Figure 1 ).

[0095] Effect Example 3

[0096] The rabbit skin irritation test (referring to GB / T 16886.10-2017) was conducted as follows: healthy adult New Zealand white rabbits were selected. After shaving the dorsal skin, the test sample (0.5 g / mL) was evenly applied to filter paper and fixed on the rabbit skin for 4 hours. After removal, erythema and edema reactions were observed within 1, 24, 48, and 72 hours. The erythema and edema reactions were scored according to the Draize method (0 to 4 points), and the total irritation score was calculated (≤0.4 for no irritation and ≥6.0 for strong irritation). A negative control was also included. The 3R ethical principles were adhered to throughout the experiment to ensure animal welfare and operational compliance.

[0097] Table 3 Scoring criteria for rabbit skin irritation test

[0098]

[0099]

[0100] In Example 1, no skin erythema or edema was observed in the rabbits. The average skin irritation index of the polysaccharide detergent on the rabbits was 0, indicating that the disinfectant had no irritating effect on the skin. In Comparative Example 1, visible erythema appeared on the rabbits' skin, but no edema was observed. The skin irritation index was a maximum of 2, and the erythema gradually disappeared 1 hour after the sample was removed.

[0101] Acute Eye Irritation Test in Rabbits: Three healthy adult New Zealand white rabbits were selected. Prior to the experiment, both eyes were screened for intact eye damage using sodium fluorescein test paper staining combined with slit-lamp examination. In the experimental group, 0.1 mL of sample was instilled into the left conjunctival sac, and the eyelid was gently pressed to close for 1 second. The right side served as a blank control, and no rinsing was performed after the test product was instilled. Dynamic slit-lamp observations were performed 1 hour, 24 hours, 48 hours, 72 hours, and on the 4th and 7th days after treatment. If no irritation reaction (e.g., corneal opacity, conjunctival congestion, etc.) was detected for 72 consecutive hours, the experiment was terminated prematurely. Quantitative assessments were performed at each time point according to the scoring criteria in Chapter 6, "Acute Eye Irritation / Corrosion Test," of the "Safety Technical Specifications for Cosmetics" (2015 edition), to comprehensively determine the irritation level of the test substance.

[0102] The rabbits in the Example 1 group had no irritation reaction, and the average score of eye irritation was 0, indicating that the substance was non-irritating. The Comparative Example 1 group caused conjunctival congestion and mild conjunctival edema in the rabbits, which fully recovered within 72 hours, and the average score of eye irritation was 2.

[0103] Effect Example 4

[0104] Biodegradability: Determined according to the Golden Orange II spectrophotometric method specified in GB / T 15818-2018 “Test method for biodegradability of surfactants”. Figure 2 The biodegradation trends of Example 1 and Comparative Example 1 over time are shown. The results show that the primary biodegradation of Example 1 after 7 days is greater than 90% (higher than Comparative Example 1), which is much higher than the international standard requirement for readily biodegradable surfactants that the primary biodegradation after 28 days is greater than 70%.

[0105] In summary, the polysaccharide thickener of the present invention, when solubilized and dispersed in a specific surfactant system, can effectively regulate the viscosity of the surfactant-polysaccharide aqueous solution system, while avoiding the use of petroleum-based thickeners and traditional surfactants with potential environmental risks or chronic toxicity. Testing has shown that the stability and antibacterial properties of the resulting system meet the GB 15979-2002 standard. Importantly, its bactericidal rate against Escherichia coli, Staphylococcus aureus, and Candida albicans exceeds 90% within a 2-minute action time. Furthermore, the resulting detergent exhibits extremely low acute eye irritation, skin irritation, and acute oral toxicity, significantly lower than those containing petroleum-based thickeners and traditional surfactant detergents with potential environmental risks or chronic toxicity. Based on these excellent properties, low-toxicity polysaccharide-based antibacterial detergents can be widely used in medical device cleaning (such as surgical instrument surface sterilization), food processing equipment disinfection (such as slaughterhouse and assembly line cleaning), personal care products (such as hand soap and shower gel), and the development of environmentally friendly cleaners, meeting the dual needs of efficient cleaning and antibacterial while reducing potential harm to humans and the environment.

[0106] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity, characterized in that: Calculated by mass percentage, the raw materials include: polysaccharide thickener 0.5-6%, antibacterial agent 10%, glycoside nonionic surfactant 10%, and water as the balance; The polysaccharide thickener is a mixture of chitosan, chitosan hydrochloride and quaternized chitosan.

2. The viscosity-controlled, low-toxic polysaccharide-based antibacterial detergent according to claim 1, characterized in that: The mass ratio of the chitosan, chitosan hydrochloride and quaternized chitosan is 1:1:

1.

3. The viscosity-controlled, low-toxic polysaccharide-based antibacterial detergent according to claim 1, characterized in that: The antibacterial agent is bletilla striata polysaccharide, tea saponin, tannic acid, gallic acid or polylysine.

4. The viscosity-controlled, low-toxic polysaccharide-based antibacterial detergent according to claim 1, characterized in that: The glycoside nonionic surfactant is lauryl glucoside, myristyl glucoside or glucuronide ester.

5. A method for preparing the viscosity-controllable, low-toxic polysaccharide-based antibacterial detergent according to any one of claims 1 to 4, characterized in that: The polysaccharide thickener is added into water and stirred for 1, and then the antibacterial agent and the glycoside nonionic surfactant are added, stirred for 2, and allowed to stand to obtain the polysaccharide-based antibacterial detergent with controllable viscosity and low toxicity.

6. The preparation method according to claim 5, characterized in that The stirring 1, stirring 2 and standing time are all 8-12 hours.

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