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Natural glycan-based multifunctional microspheres, preparation method and application

A polysaccharide-based, multifunctional technology, which is applied in the field of natural polysaccharide-based multifunctional microspheres and its preparation, can solve problems such as poor antibacterial effect, no natural polysaccharide-based multifunctional microspheres, and no broad-spectrum antibacterial function. , to achieve good hemostatic performance, promote rapid healing, and prevent the growth of bacteria

Active Publication Date: 2018-01-19
安徽中科迈德医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, silver ions have strong cytotoxicity, and the abuse of antibiotics will also lead to poor antibacterial effects. Although cationic antibacterial agents such as quaternary ammonium salts and chitosan have certain antibacterial properties, they do not have broad-spectrum antibacterial functions.
However, dopamine, catechol, and tannic acid all come from natural extracts, which have strong antibacterial properties and can act as a hemostatic agent. At present, the above-mentioned natural extracts have not been used as cross-linking agents to prepare natural polysaccharide-based polysaccharides. Report on Functional Microspheres

Method used

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  • Natural glycan-based multifunctional microspheres, preparation method and application
  • Natural glycan-based multifunctional microspheres, preparation method and application
  • Natural glycan-based multifunctional microspheres, preparation method and application

Examples

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Effect test

Embodiment 1

[0027] A method for preparing natural polysaccharide-based multifunctional microspheres, comprising the steps of: dispersing natural polysaccharides in ultrapure water at 70° C. to form a dispersion with a mass fraction of 5%, and then adding an amount equivalent to natural polysaccharides Carboxymethyl sugars with a mass of 1% were stirred evenly to obtain a water phase; the emulsifier was dissolved in a fat-soluble solvent at 45°C, and a solution with a mass fraction of 0.03% was prepared as an oil phase. At 30°C and 500rpm, According to the volume ratio of 1:15, add the water phase to the oil phase dropwise, after the dropwise addition, continue to stir for 120min; reduce the stirring speed to 400rpm, add dropwise a cross-linking agent equivalent to 5% of the natural polysaccharide mass, After the dropwise addition, adjust the stirring speed to 500rpm and continue stirring for 5h; let it stand for 30min, wash 5 times with the first polar solvent, remove the oil phase, wash t...

Embodiment 2

[0035] A method for preparing natural polysaccharide-based multifunctional microspheres, comprising the steps of: dispersing natural polysaccharides in ultrapure water at 90° C. to form a dispersion with a mass fraction of 30%, and then adding an amount equivalent to natural polysaccharides Carboxymethyl saccharides with a mass of 6% are added with materials that are equivalent to 2% of the mass of natural polysaccharides and have a wound-healing effect, and stirred evenly to obtain an aqueous phase; the emulsifier is dissolved in a fat-soluble solvent at 75°C to form a mass The solution with a fraction of 1% is used as the oil phase. At 40°C and 1000 rpm, add the water phase to the oil phase dropwise at a volume ratio of 1:3. After the addition is complete, continue stirring for 30 minutes; reduce the stirring speed to to 600rpm, add dropwise a cross-linking agent equivalent to 30% of the mass of natural polysaccharide, after the dropwise addition, adjust the stirring speed to...

Embodiment 3

[0043] A method for preparing natural polysaccharide-based multifunctional microspheres, comprising the steps of: dispersing natural polysaccharides in ultrapure water at 80° C. to form a dispersion with a mass fraction of 15%, and then adding an amount equivalent to natural polysaccharides 3% by mass of carboxymethyl saccharides, adding 1% of the mass of natural polysaccharides with wound-healing-promoting materials, stirred evenly to obtain an aqueous phase; the emulsifier was dissolved in a fat-soluble solvent at 60°C to form a mass The solution with a fraction of 0.5% is used as the oil phase. Under the conditions of 35°C and 800rpm, the water phase is added dropwise to the oil phase at a volume ratio of 1:5. After the dropwise addition, continue to stir for 60 minutes; reduce the stirring speed to to 500rpm, add dropwise a cross-linking agent equivalent to 12% of the mass of natural polysaccharide, after the dropwise addition, adjust the stirring speed to 700rpm and contin...

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Abstract

The invention discloses natural glycan-based multifunctional microspheres, a preparation method and an application. The preparation method of the microspheres comprises steps as follows: a water dispersion liquid is prepared from natural glycan, carboxymethyl saccharides and a material with a wound healing promoting function are added, the mixture is stirred uniformly, and a water phase is obtained; an emulsifier is dissolved in a fat-soluble solvent, an oil phase is obtained, and the water phase is dropwise added to the oil phase and stirred; a crosslinking agent is dropwise added and stirred; the mixture is left to stand, a first polar solvent is used for cleaning, the oil phase is removed, a water layer is cleaned with a second polar solvent, microspheres are settled, the water layer isextracted, the microspheres are dried, and the natural glycan-based multifunctional microspheres are obtained. The microspheres can effectively block the bleeding area and promote hemostasis, do notcontain any crosslinking agent or other aids, are high in biosafety, has no hemolysis phenomenon and can be degraded and absorbed in short time. The microspheres have the efficacy of preventing breeding of bacteria and promoting rapid healing of wound while stopping bleeding of the wound.

Description

technical field [0001] The invention belongs to the technical field of hemostatic materials, relates to the field of biomedical polymer materials and compatibility modification, in particular to a degradable and absorbable natural polysaccharide-based multifunctional microsphere, a preparation method and application. Background technique [0002] Uncontrollable bleeding is an important cause of death in wars, traffic accidents and other accidental injuries, and it is also a difficult problem that is often faced in trauma first aid and surgical operations. How to effectively stop bleeding from wounds is of vital importance to save patients' lives. Therefore, the development of fast and effective hemostatic materials has become a research hotspot worldwide. [0003] Powdery hemostatic materials are widely used in the field of surgical hemostasis due to their easy operation and good wound adhesion effect. At present, powdery hemostatic materials are mainly divided into alumino...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/00
Inventor 石长灿冯亚凯李娜陈浩杨啸刘雯席光辉
Owner 安徽中科迈德医疗科技有限公司
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