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Fluorescent graft degradable block polyurethane, bone repair material and preparation method thereof

A fluorescent, polyurethane technology, applied in luminescent materials, chemical instruments and methods, pharmaceutical formulations, etc., can solve the problems of expensive LDI raw materials, difficult promotion and application, etc., and achieve the effect of convenient biodegradability and good application prospects.

Inactive Publication Date: 2015-02-18
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high price of LDI raw materials, it is difficult to popularize and apply

Method used

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  • Fluorescent graft degradable block polyurethane, bone repair material and preparation method thereof
  • Fluorescent graft degradable block polyurethane, bone repair material and preparation method thereof
  • Fluorescent graft degradable block polyurethane, bone repair material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Blend 40.0g polycaprolactone diol (PCL) (molecular weight 2000), 16.0g polyethylene glycol (PEG) (molecular weight 400) and 15.6g castor oil (CO) into a three-necked flask filled with nitrogen, then add 52.8g of isophorone diisocyanate (IPDI) (molecular weight 222.28), reacted at 70°C for 0.5h, then added 2.4g of calcein, mixed and stirred for 2h to prepare a fluorescent group-containing block polyurethane prepolymer. Then add 4 drops (about 0.2ml) of stannous octoate and continue to stir for 1 hour, then add 2ml of 1,4-butanediol and continue to react for 3 hours, then add 0.2ml of water as a foaming agent and continue to react for 0.5 hours, collect the sample and place it in an oven at 90°C Medium aging and drying for 48 hours to obtain the corresponding target product of fluorescent grafted degradable block polyurethane. The fluorescence micrographs and fluorescence spectra of the fluorescent grafted degradable block polyurethane are shown in Fig. figure 1 and f...

Embodiment 2

[0026] Blend 10.0g polycaprolactone diol (PCL) (molecular weight 1000), 12.0g polyethylene glycol (PEG) (molecular weight 600) and 15.6g castor oil (CO) into a three-necked flask filled with nitrogen, and slowly add 30wt% (about 28.5g) nano-hydroxyapatite powder, mix well, add 26.4g isophorone diisocyanate (IPDI) (molecular weight 222.28), react at 70°C for 0.5h, add 1.6g calcein and mix and stir 2h Preparation of block polyurethane prepolymers containing fluorescent groups. Then add 2 drops (about 0.1ml) of triethylenediamine and continue to stir for 1 hour, then add 2ml of 1,4-butanediol to continue the reaction for 3 hours, then add 0.2ml of water as a foaming agent to continue the reaction for 0.5 hours, and place the sample in 110 It was cured and dried in an oven at ℃ for 48 hours to obtain the target segmented polyurethane.

Embodiment 3

[0028] Blend 5.0g polycaprolactone diol (PCL) (molecular weight 500), 20.0g polyethylene glycol (PEG) (molecular weight 1000) and 20.0g castor oil (CO) into a three-necked flask filled with nitrogen, then add 26.4g of lysine diisocyanate (LDI) (molecular weight: 226.23), reacted at 70°C for 0.5h, then added 1.2g of fluorescein isothiocyanate and stirred for 2h to prepare a block polyurethane prepolymer containing fluorescent groups. Then add 2 drops (about 0.1ml) of stannous octoate and 1 drop (about 0.05ml) of triethylenediamine and continue to stir for 1h, then add 2ml of ethylene glycol and continue to react for 3h, then add 0.2ml of water as a foaming agent and continue to react for 0.5 h, the sample was collected and placed in an oven at 90°C for aging and drying for 48 hours to obtain the target block polyurethane.

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Abstract

The invention relates to a fluorescent graft degradable block polyurethane, a bone repair material and a preparation method thereof. The polyurethane is formed by grafting a pharmaceutically acceptable fluorescent component into a structure formed by polymerizing a hard segment of aliphatic diisocyanate and a soft segment of a degradable polymer chain segment of a hydroxyl-terminated polymer or block copolymer. The bone repair material is composed of the polyurethane and nano hydroxyapatite powder. The polyurethane and corresponding bone repair material have favorable biocompatibility and degradability, have the fluorescent characteristic, can be used for performing tracing evaluation on the degradation process of the block polyurethane, analyzing the mechanism of degradation and inspecting the influence of the degradation rate on the mechanical properties of the material and the tissue regeneration and reconstruction process, and provide a new visual angle and means for evaluating the biosafety of the high-polymer degradable material. The preparation technique is simple, is easy to control and operate, and has favorable application prospects in the field of biomedicine.

Description

technical field [0001] The invention relates to a fluorescent graft degradable medical block polyurethane, a bone tissue repair material using the polyurethane as a raw material, and a preparation method thereof. Background technique [0002] Polymer block nanocomposites developed from the subtle observation of natural bone tissue structure are currently one of the research hotspots in bone regenerative medicine (Lijiezhang, Thomas J. Webster, Nanotechnology and nanomaterials: promises for improved tissue regeneration, Nano Today, 2009, 4: 66-80). This block polymer that can be precisely designed and synthesized in batches can not only provide the collagen microphase environment required for cell adhesion, but also an effective solution to the bioabsorption and controllable degradation of scaffold materials. A better choice of material. Among them, block polyurethane (polyurethane, PU) with flexible and adjustable structure has gradually attracted the attention of scholar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/75C08G18/73C08G18/77C08G18/67C08G18/66C08G18/42C08G18/32C08G18/48C08J9/08C08J9/14C09K11/06A61L27/18A61L27/12A61L27/50C08G101/00
CPCA61L27/12A61L27/18A61L27/50A61L2400/00A61L2430/06A61L2430/34C08G18/12C08G18/3203C08G18/3206C08G18/4018C08G18/4244C08G18/4277C08G18/4833C08G18/6607C08G18/664C08G18/6674C08G18/6677C08G18/67C08G18/73C08G18/755C08G18/758C08G18/771C08J9/141C08J2203/14C08G2110/0083C08G18/48C08L75/04C08L75/08
Inventor 李玉宝杨博渊左奕李丽梅李吉东邹琴
Owner SICHUAN UNIV
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