The invention relates to a nucleic acid removing agent, which belongs to the field of molecular biology. The nucleic acid removing agent contains the following components in percentage by volume: 5%-10% of an oxidant, 0.1%-3% of a chlorine-containing reagent, 0.1%-3% of an acid-containing reagent, 0.1%-2% of a stabilizer, 1%-8% of a surfactant and the balance deionized water. The nucleic acid removing agent is odorless, is mild in properties, possesses no irritation effect, is simple and convenient to operate, is convenient to store and long in storage period, can be directly sprayed on the ground, wall surfaces and tabletops of laboratories, the tabletops of biosafety cabinets, the surfaces of pipettors, the outer surfacess of various instruments, the outer walls of centrifugal tubes andthe like during use, and can also be directly used for wiping the instruments, the tabletop, the tabletop and the like. By using the nucleic acid removing agent, nucleic acid fragments can be effectively degraded within several minutes, and laboratory aerosol pollution is prevented.