The invention discloses a TCTP
gene space-time specificity conditional and
tissue specific gene knock-down
animal model construction kit based on a
recombinase recognition system, a targeting vector and a construction method thereof of the targeting vector, a mouse TCTP
gene specific gene knock-down
animal model and a
sperm thereof, an
oocyte thereof, an oosperm thereof, an
embryo thereof, a filial generation thereof, a tissue thereof or a
cell thereof as well as applications of the products and methods in an
immunology research, researches of immunotoxicology, immunological rejection and andmechanisms thereof, researches of
cancer cell apoptosis mechanisms and
cancer targets, a research of targeted
cancer therapy, safety evaluation, a purpose in the pharmacodynamic evaluation aspect, making of a tumor
pathological model and a preparation of a
disease treating
medicine. By using a
homologous recombination technology and an
embryonic stem cell technology, a stably genetic TCTP
gene knockout mouse is constructed; and therefore, embryonic death caused by knockout of the gene is avoided; and important significance in researches of the TCTP gene in cancer occurrence, progression and treatment are realized.