Method for constructing and analyzing tissue-specific interaction topology network

Abstract

The invention discloses a method for constructing and analyzing a tissue-specific interaction topology network. The method comprises the following steps of: measuring similarity of integrated interaction network nodes; constructing a tissue-specific gene interaction network, a tissue-specific transcription factor interaction network and a tissue-specific encoded protein interaction network by a construction module of the tissue-specific interaction network; counting connection degree of each node in the network, counting betweenness of each node in the network, calculating closeness of each node in the network, calculating max clique in the interaction network and counting a Hub node in the interaction network by a topology analysis module of the interaction network; and acquiring related tissue-specific knowledge from a gene ontology database and a KEGG (Kyoto Encyclopedia of Genes and Genomes) biological field knowledge base by an identification module of the tissue-specific functional module. The invention provides an ideal method for constructing the interaction network from genetic information; and the method is a more ideal analysis tool for researching a tissue-specific intrinsic mechanism.

Description

technical field [0001] The invention relates to the construction and analysis of a topological network. In particular, it relates to a method for constructing and analyzing tissue-specific interaction topology networks. Background technique [0002] Tissue-specific genes refer to genes that are specifically expressed by different cell types, and their products endow various types of cells with specific morphological and structural characteristics and specific physiological functions, and are abundant in special cell types (usually ) expresses and encodes special functional products. [0003] Transcription factors are a group of protein molecules that can specifically bind to a specific sequence at the 5-end of a gene to ensure that the target gene is expressed at a specific time and space with a specific intensity. Transcription factors, also known as sequence-specific DNA-binding factors, bind to specific DNA sequences, thereby controlling the transmission of genetic info...

AI Technical Summary

Problems solved by technology

Although there are abundant data on tissue-specific genes, tissue-specific transcription factors, and encoded proteins, these data are complex and scattered, and cannot provide accurate and comprehensive information for us to study the internal mechanism of tissue-specificity.

At present, most of the work is still focused on how to obtain tissue-specific genes, transcription factors and encoded proteins more accurately, failing to take into account the multifactorial causes of biological phenomena

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