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Method for expressing corneal irregularity structure changes based on change consistency parameters of anterior segment tomography technology

A technology of tomographic imaging and structural change, applied in the field of medical detection, can solve problems such as missed diagnosis and atypical changes, and achieve the effect of reducing complexity and improving diagnostic performance

Active Publication Date: 2020-01-21
WENZHOU MEDICAL UNIV
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  • Application Information

AI Technical Summary

Problems solved by technology

The early changes of this disease are atypical, which may lead to misdiagnosis

Method used

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  • Method for expressing corneal irregularity structure changes based on change consistency parameters of anterior segment tomography technology
  • Method for expressing corneal irregularity structure changes based on change consistency parameters of anterior segment tomography technology
  • Method for expressing corneal irregularity structure changes based on change consistency parameters of anterior segment tomography technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Application of changing position consistency parameters taking Pentacam anterior segment comprehensive analyzer as an example

[0029] (a) Establish the Pentacam image database of normal subjects and subjects with early irregular keratopathy.

[0030] (b) derive each subject figure 1 Numerical matrix showing the distribution of 5 parameters, including corneal anterior surface curvature, corneal posterior surface curvature cornea, anterior surface height, corneal posterior surface height, and corneal thickness. Use the MATLAB locale to read the matrix and output the extreme values ​​and their coordinate positions (x, y, value) for each distribution.

[0031] (c) Calculate the relative distance based on the above five coordinate positions. The distance expression adopts Euclidean distance (hereinafter referred to as "Euclidean distance"), which represents the straight-line distance between two points in Euclidean space. Its expression is:

[0032]

[0033] where d ...

Embodiment 2

[0038] Application of changing position consistency parameters taking anterior segment OCT system as an example

[0039] (a) Establish the OCT image database of normal subjects and subjects with early irregular keratopathy.

[0040] (b) segment the OCT image, figure 2 Introducing the main layers of the SD-OCT anterior segment corneal image, red boundary: cornea / epithelial layer anterior surface, blue boundary: corneal epithelial basal layer / pre-bowman's membrane anterior surface, yellow boundary: pre-bowman's membrane posterior surface / corneal stromal layer anterior Surface, green border: corneal endothelium / posterior corneal surface.

[0041] (c) Using automatic segmentation software based on the MATLAB language environment ( image 3 ), automatically detect the above-mentioned corneal layers, and allow manual inspection and correction. Then surface correction is performed on the segmentation level, registration and reconstruction are performed, and the corresponding pixe...

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Abstract

The invention discloses a method for expressing corneal irregularity structure changes based on change consistency parameters of an anterior segment tomography technology. According to the method, a method for establishing objective indexes of parameter change relative positions is provided, the positions, where morphological changes may occur, of the irregular corneas are comprehensively expressed, the early diagnosis performance of irregular corneal diseases such as the conic corneas can be theoretically improved, and meanwhile the complexity of combined interpretation of a large number of parameters in clinical actual work is reduced.

Description

technical field [0001] The invention specifically relates to the technical field of medical detection, in particular to a method for expressing the structural change of corneal irregularity based on the change consistency parameter of anterior segment tomography technology. Background technique [0002] Corneal ectasia, especially keratoconus, is currently the main contraindication to corneal refractive surgery. The early changes of this disease are atypical, which may lead to misdiagnosis. According to statistics, the current annual corneal refractive surgery volume in China is about 1.5 million, and it is expected to grow at a rate of 12-15%. Keratoconus has a relatively high incidence among myopic patients who wish to undergo corneal refractive surgery, and keratoconus is the main contraindication to corneal refractive surgery. Preoperative missed diagnosis of potential keratoconus patients is an important cause of corneal ectasia after corneal refractive surgery. Ther...

Claims

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Application Information

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IPC IPC(8): G06T7/00G06T11/00G06T7/11G06T7/60G06T5/00G16H30/40G16H50/20A61B3/10A61B3/107
CPCG06T7/0012G06T11/003G06T7/60G06T7/11A61B3/107A61B3/102G16H50/20G16H30/40G06T2207/10101G06T2207/30041G06T5/80
Inventor 王梦怡沈梅晓施策周煜恒吕帆
Owner WENZHOU MEDICAL UNIV
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