49 results about "Eye anterior segment" patented technology

A system for the in vivo detection of the effects of AD in the interior of an eye. A scanning polarimeter, including a residual retardance canceling system and an improved anterior segment retardance compensator, produces an optical analysis signal representing the birefringence of the retinal nerve fiber layer (RNFL) structures of the eye. The birefringence data is more accurate because of compensation for anterior segment birefringence and residual birefringence of optical components, such as, for example, the beam splitters, lenses, scanners and retarders. An electrical analysis signal representing a large (20 by 40 degrees) retardance map is produced and evaluated by an artificial neural network to produce an analysis classification signal representing the contribution of Alzheimer's disease to the birefringence of the retinal layer corresponding to the relationship of the electrical analysis signal to an analysis signal database.

The invention discloses an eyeball tumor area real-time positioning method based on motion features of an eyeball. The eyeball tumor area real-time positioning method comprises the following steps of extracting an eye anterior-segment tissue information, conducting calibration and three-dimensional reconstruction on the eye anterior-segment tissue information to obtain shifting parameters before and after eyeball motion, establishing a three-dimensional eyeball model based on a CT image, and establishing the coordinate relation between an eye anterior segment feature structure and an intraocular tumor position. According to the eyeball tumor area real-time positioning method, an anterior-segment image obtained through real-time OCT tracking is utilized, and then the tumor is accurately positioned in a radiation area through processing technologies including image reconstruction, registering and the like. The invention further discloses an imaging device for extracting the eye anterior-segment tissue information. The imaging device for extracting the eye anterior-segment tissue information comprises an OCT light source, a beam splitter, a sample arm, a reference arm and a feedback device. A real-time positioning tracking system provides in-vitro noninvasive positioning and can achieve the purposes of improving positioning accuracy and radiation dose and local control rate of the ocular tumor, decreasing surrounding normal radiation dose and injury and the like.

The invention relates to an angiography method applied to optical coherence tomography and an OCT system. Based on the frequency division thought, OCT interference fringes are decomposed into multiple wave number bands, and noise generated when shot tissue moves is lowered. After intensity images obtained after frequency division are acquired, an improved CM method is further adopted, the change degree of the intensity, calculated through the Pearson correlation coefficient, between adjacent continuously scanned cross-sectional images is calculated, and signals of blood vessels are enhanced. In combination with information of points adjacent to detection points, sensitivity to blood vessel detection is improved, sensitivity to eye movement is reduced, and the method is suitable for angiography of biological tissue with high scattering. The method can be used for angiography of anterior segment sclera or irises or other tissue in ophthalmology and can be applied to microvascular imaging of other portions of the human body.

To determine an opening degree of a chamber angle with higher accuracy compared to that of a conventional technology, provided is an anterior ocular segment tomographic image analysis method including: a first determination step of determining an approximated line that approximates a shape of an anterior surface of an iris along the anterior surface of the iris in an anterior ocular segment tomographic image; a second determination step of determining an approximated line extended part obtained by extending the approximated line until the approximated line crosses a baseline in contact with an inner surface of a cornea and an inner surface of a sclera of an anterior ocular segment in the anterior ocular segment tomographic image; and a calculation step of calculating an opening degree of an anterior chamber angle of the anterior ocular segment through use of the approximated line and the approximated line extended part.

Provided is an ocular optical system, which permits a measuring beam scanned by two scanning units disposed close to each other to enter an anterior ocular segment of an eye to be inspected and to irradiate a fundus. The ocular optical system includes an optical unit which is disposed at a position of an intermediate image, which is optically conjugate to the fundus, and has a surface having different optical powers corresponding to scan directions of the two scanning units.

The invention discloses a multi-functional ophthalmic full-automatic measurement method and system. The multi-functional ophthalmic full-automatic measurement method comprises the steps that a three-dimensional movement control unit is adjusted to automatically adjust a probe assembly after a to-be-measured eye is monitored to be located right in front of an eye objective lens; a control device ina body module drives a first mobile control unit to control an anterior segment OCT insertion mirror to be inserted into an optical path or moved out of the optical path and adjust an optical path adjusting device; measurement light provided by the body module enters the to-be-measured eye and is focused in the anterior segment of the to-be-measured eye or the fundus of the to-be-measured eye soas to return an anterior segment optical signal or a posterior segment optical signal to be transmitted to the body module; and the body module provides reference light and can utilize the reference light to interfere with the anterior segment optical signal or the posterior segment optical signal and collect the anterior segment interference optical signal or the posterior segment interference optical signal obtained through interference so as to respectively collect an anterior segment OCT image or a posterior segment OCT image of the eye to be measured. The measurement convenience can be improved, and the measurement accuracy can be improved.

The invention discloses a frequency domain OCT based whole-eye imaging and parameter measuring method and system. The whole-eye imaging and parameter measuring system includes a ranging system and a target system; through the conversion of anterior segment-posterior segment measurement, a lens can move to change the distances to the front of the eyes; and the measuring system can measure the boundary distance of each segment in anterior segments and posterior segments, and includes the measurement calculating on ocular axial lengths and anterior and posterior mean cornea and the identificationcalculating on central corneal thicknesses, lens thicknesses, anterior chamber depths and total thicknesses of the anterior segments even on the thicknesses of retina and choroid. Compared with traditional instruments which can only perform imaging on the anterior segments or the posterior segments, the system can combine the imaging of the anterior segments and the posterior segments at a lowercost, so that the imaging and parameter measuring of whole eyes can be realized, and therefore, the measuring system and method have great advantages on the investigation of ophthalmic diseases and the location of eye diseases.

A cornea shape measurement apparatus outputs data useful for prescription as well as injection and installation of a TORIC-IOL. This apparatus includes: a projecting optical system projecting an index for measurement onto a cornea; an illuminating optical system illuminating an anterior segment on which a reference mark is placed; an imaging optical system capturing an anterior segment image containing the reference mark and an image of the index reflected from the cornea; an image processor overlaying an astigmatic axis mark indicating a direction of an astigmatic axis of the cornea, which is calculated based on the index image, on the anterior segment image; and a controller displaying the anterior segment image, which contains the astigmatic axis mark, on a display.

The invention provides an imaging device for realizing an anterior segment OCT integrated biological measuring instrument function based on a beam splitter prism. The imaging device divides referencearm light into two beams through the beam splitter prism, when a movable shielding plate is located at a first position, the first beam of reference arm light can be shielded, so that only a second plane mirror can reflect and interfere with a sample arm, and imaging of the anterior segment is realized independently; and when the movable shielding plate is located at a second position, a first plane mirror and the second plane mirror can both reflect and interfere with the sample arm, and imaging is carried out in the same image at the same time, so that the purpose that the positions of the cornea and the retina are still relatively fixed in the involuntary movement process of the eyeball is achieved, the interference of eye movement and other factors on the numerical value is reduced, the accuracy of eye axis measurement is improved, and the imaging device is particularly suitable for special crowds with poor gaze such as nystagmus and Alzheimer's disease.

An ophthalmic measurement system and method are used for detecting checked eyes. The ophthalmic measurement system includes a switching scanning element, an eye anterior segment light path assembly, an eye posterior segment light path assembly, a light splitting element and a main body module. An optical path can be switched between the eye anterior segment light path assembly and the eye posterior segment light path assembly by the switching scanning element, and an eye anterior segment and an eye posterior segment of the checked eyes are scanned. The invention provides another technical scheme which can realize the switching of scanning of the eye anterior segment and the eye posterior segment of the checked eyes to determine the axis length of the checked eyes, and the disadvantages ofcomplex structure and high cost of the prior art are overcome.

The invention provides an ophthalmic detection system, which comprises a sample arm, a side eye photographing imaging module and a main body module, the sample arm detects the anterior segment and posterior segment of an eye to-be-detected by using measuring light, the side eye photographing imaging module monitors the eye movement of the eye to-be-detected in the detection process, and the main body module is used for controlling the sample arm and the side eye photographing imaging module. The invention further provides an ophthalmic detection method. According to the ophthalmological detection system and the ophthalmological detection method, the influence of eye movement of the eye to-be-detected on the detection result can be reduced.

The invention discloses a method for expressing corneal irregularity structure changes based on change consistency parameters of an anterior segment tomography technology. According to the method, a method for establishing objective indexes of parameter change relative positions is provided, the positions, where morphological changes may occur, of the irregular corneas are comprehensively expressed, the early diagnosis performance of irregular corneal diseases such as the conic corneas can be theoretically improved, and meanwhile the complexity of combined interpretation of a large number of parameters in clinical actual work is reduced.

The invention relates to an anterior-posterior segment frequency domain optical coherence tomography system, in the anterior segment / posterior segment imaging process, an FD-OCT system adopts the sameoptical path hardware, and conversion of a scanning focus range of probe light from the fundus retina to the cornea is achieved by internally adjusting the position of a scanning conversion assemblyspecially designed in a sample arm. In the anterior segment / posterior segment imaging process of the eye, the frequency domain optical coherence tomography imaging system adopts the same optical pathhardware; by internally adjusting the position of the scanning conversion assembly specially designed in the sample arm, conversion of the scanning focus range of the probe light from the fundus retina to the cornea is achieved, and therefore the anterior segment and posterior segment frequency domain optical coherence tomography system can have the anterior segment imaging function without addingthe FD-OCT system hardware. According to the invention, an anterior segment imaging function of the posterior segment frequency domain optical coherence tomography system can be realized without adding an additional imaging objective lens, and the use and detection operation process and the system structure are simplified.

The invention discloses an ophthalmic measurement system and method. The system comprises a main body module and a probe assembly, wherein the main body module is used for providing measurement light,enabling the measurement light to pass through the probe assembly and enter a to-be-measured eye, returning an optical signal, enabling the optical signal to pass through the probe assembly, and transmitting the optical signal to the main body module. The probe assembly comprises an iris shooting module and an oblique angle anterior segment shooting module, wherein the iris shooting module is used for shooting an iris image of the to-be-measured eye, and a light path of the image shot by the iris shooting module is coaxial with a part of light path between the measurement light and the to-be-measured eye; and the oblique angle anterior segment shooting module is used for shooting an oblique angle anterior segment image of the to-be-measured eye, and a preset angle is formed between the light path of the image shot by the oblique angle anterior segment shooting module and part of the light path between the measurement light and the to-be-measured eye. According to the invention, accurate human eye parameters can be obtained.

The invention discloses an anterior segment sectional image feature extraction method based on machine vision, and the method comprises the following steps: collecting an anterior segment sectional image under low-illumination illumination; enhancing the contrast of the anterior segment sectional image by adopting a Retinex algorithm; performing Gaussian filtering to remove noise generated after the step S2; finding a potential corneal region through binarization and blob shape analysis; roughly positioning the edges of the front and rear surfaces of the cornea in the potential cornea region by using a gradient maximum method; determining sub-pixel precision boundaries of the front surface and the rear surface of the cornea through a Gaussian fitting positioning method; according to the solved sub-pixel precision boundaries of the front and rear surfaces of the cornea, finding initial points of the iris and the crystalline lens, and obtaining accurate boundary values of the front and rear surfaces of the cornea, the front surface of the crystalline lens and the front surface of the iris through tracking. The invention has the following advantages and effects that high-precision processing can be performed on the image in a low-illumination imaging mode, and the matching degree and the comfort degree of a patient can be greatly improved.

The invention discloses an image analysis system for an ophthalmological anterior chamber angle anterior segment, and belongs to the field of image analysis. The image analysis system for the ophthalmological anterior chamber angle anterior segment includes a fixing plate, an outer shell is fixedly connected to the rear side of the upper surface of the fixing plate, a rotating plate is rotatably connected to the inner side surface of the outer shell, a center lens is fixedly installed at the inner center of the rotating plate, side lenses are fixedly installed to the outer side of the outer surface of the rotating plate, and the side lenses are uniformly distributed to the outer side surface of the center lens; and connecting rods are fixedly connected to two ends of the front side surfaceof the rotating plate, the outer surfaces of the connecting rods are slidingly connected to the surfaces of the two sides of the interior of the outer shell, the other end of each connecting rod is fixedly connected with an adjustment ring, and a friction rubber ring is fixedly adhered to the inner side surface of each adjustment ring. The convenience and stability during use can be greatly improved, and the accuracy and high efficiency can be ensured.

The invention discloses a cataract and after cataract analysis system and device based on a mobile terminal. The cataract and after cataract analysis system and device judge the severity degree of cataract / after cataract based on the clarity degree of an eye fundus image, and judge the opacity degree of cataract and after cataract through an anterior segment image of the eye. The clarity degree ofthe eye fundus image and the matching degree of vision are more related and more direct, the requirement for an operator is lower, illness state evaluation is conducted through a deep learning artificial intelligence system, the grading accuracy of the opacity degree of cataract is higher, a diagnosis and treatment suggestion module is constructed, and the right to obtain the eye image is given to an intelligent terminal user rather than other medical institutions at different levels. The system and the device have the advantages that the audience range is wider and more popular to a certainextent, the problems of time and labor waste and high price of general patient examination are solved, and a portable emerging medical solution with a prospect is realized.

The invention is directed to an arrangement and a method for measuring the anterior segment of the eye using interferometric means. The eye is illuminated by a convergent beam bundle and aligned with the optical axis of the measuring device by generating directional stimuli and accommodation stimuli by means of a display which is mirrored into the beam path.

A drug support body is provided that can be used to appropriately administer a drug to the anterior segment of the eye while the production cost is reduced. A drug layer containing a drug component to be administered to an anterior segment of the eye is provided at a halfway portion in a longitudinal direction of a base plate, wherein the base plate includes a bending portion that allows the base plate to bend in a direction opposite to a surface of the base plate on which the drug layer is provided, and by bending the base plate at the bending portion, at least a portion of a surface facing the base plate of the drug layer is exposed from the base plate.

An ophthalmic imaging system including an ocular lens and an optical coherence tomography (OCT) imaging module is provided. The OCT imaging module is able to image both retina and anterior segment of eyes by switching a lens group into and out of the OCT light path. The OCT imaging module includes a retina imaging mode and an anterior segment imaging mode. In the retina imaging mode, there exists an intermediate image plane located between the ocular lens and the OCT imaging module. From the retina imaging mode, anterior segment imaging is achieved by inserting a switching lens group into the optical path inside the OCT imaging module or replacing the whole OCT imaging module of the retina mode, wherein, after the insertion, there exist a new intermediate image plane located inside the OCT imaging module and a conjugate of the entrance pupil of the OCT imaging module located between the ocular lens and the OCT imaging module.

The embodiment of the invention provides an eye movement tracking method and device for anterior segment OCTA, equipment and a storage medium, and relates to the field of eye movement tracking. The method comprises the following steps: acquiring two continuous frames of pupil images; contour extraction is carried out on the two frames of pupil images, and two pupil contours are obtained; judging whether the two pupil contours are similar to a reference contour or not; and if so, calculating the central position offset of one pupil contour relative to the other pupil contour. According to the method and the device, the problems that the current OCTA is not suitable for all patients and the OCTA image is relatively inaccurate under the condition that the patient is poor in fixation of vision or frequently blinking or moving can be solved, and the effects of improving the suitability of the current OCTA and improving the accuracy of the OCTA image under the condition that the patient is poor in fixation of vision or frequently blinking or moving are achieved.

The present invention relates to method and pharmaceutical compositions for preventing glucocorticoid-induced corneal or skin thinning. In particular, the present invention relates to a mineralocorticoid receptor antagonist for topical use in a method for preventing or reducing glucocorticoid-induced corneal or skin thinning in a subject in need thereof. The invention also relates to a topical pharmaceutical composition comprising an amount of at least one glucocorticoid and an amount of at least one mineralocorticoid receptor antagonist or inhibitor of MR expression for use in a method for treating an inflammatory skin disease or an inflammatory disease of the cornea or of the anterior segment of the eye in a subject in need thereof.

The invention discloses an ophthalmic measurement system for inspected eye detection. The system comprises a main body module, a reference plane, a switching scanning element, an anterior segment light path assembly, a posterior segment light path assembly and a light splitting element, the anterior segment light path assembly, the posterior segment light path assembly and the light splitting element are all arranged on the reference plane, and the switching scanning element can rotate around a fixed shaft, so that switching between the anterior segment light path assembly and the posterior segment light path assembly is realized, and the anterior segment and the posterior segment of a detected eye can be horizontally scanned. According to the invention, switching between anterior segmentscanning and posterior segment scanning of the detected eye can be realized based on the spectral domain OCT technology so as to determine the axial length of the detected eye, the defects of complexstructure and high cost in the prior art can be overcome, and horizontal scanning can be realized.

The invention discloses a full femtosecond laser system for eyeball spin correction. The full femtosecond laser system for eyeball spin correction comprises an eye anterior segment biological measurement unit, a spin control unit, a patient posture adjusting unit, a horizontal axial position marking unit, a negative pressure suction unit and a femtosecond laser unit, wherein the eye anterior segment biological measurement unit is used for collecting eyeball position information when a patient sits and sending the eyeball position information to the spin control unit; the spin control unit is used for collecting the eyeball position information of the patient in the supine position, comparing the eyeball position information of the patient in the supine position with the eyeball position information of the patient in the sitting position so as to obtain the eyeball spin information, and sending the eyeball spin information to the patient posture adjusting unit; the patient posture adjusting unit is used for adjusting the posture of the patient in the supine position according to the eyeball spin information, so that an absolute value of an eyeball spin angle is smaller than 1 degree; the horizontal axial position marking unit is used for completing horizontal axis marking of an operative eye in the sitting position according to a horizontal projection line; the negative pressuresuction unit is used for carrying out negative pressure suction and adjustment on the eyeball, so that a horizontal axis mark of the operative eye in the sitting position is parallel to a horizontalline of a cross mesh of an eyepiece; the femtosecond laser unit is used for carrying out femtosecond laser cutting. The full femtosecond laser system for eyeball spin correction solves the problem that an existing full femtosecond laser system fails to correct eyeball spin.

The present invention relates to an ophthalmic composition comprising pranoprofen and olopatadine and / or naphazoline. The invention also relates to a preparation method of the ophthalmic composition, which comprises the following steps: mixing the pranoprofen, the olopatadine and / or the naphazoline, the osmotic pressure regulator, the pH regulator, the metal ion chelating agent, the thickening agent, the preservative and the water for injection to obtain the ophthalmic composition. The invention also relates to an application of the ophthalmic composition in preparation of a medicine for treating ocular inflammation, and the ocular inflammation comprises external eye and / or anterior segment inflammation caused by gram-positive bacterium and / or gram-negative bacterium infection. When the ophthalmic composition provided by the invention is used as eye drops, the treatment effect on eye inflammation of a patient can be improved, and adverse effects of eye stimulation, conjunctival congestion, edema and the like after medication can be avoided, so that the medication compliance of the patient is improved, and the recovery time of the patient is shortened.

The invention provides an anterior segment OCT (optical coherence tomography) imaging system for ophthalmic examination. The imaging system comprises a pre-screening module, a main screening module, a processing module and an independent imaging module, the pre-screening module is used for acquiring an eye external image; the main screening module is used for acquiring an OCT image of an anterior segment of an eyeball; the processing module is used for processing the acquired external eye image and the OCT image of the anterior segment of the eyeball to obtain a corresponding imaging result; the independent imaging module is used for independently decomposing the OCT image of the anterior segment of the eyeball and obtaining OCT images of different parts of the anterior segment of the eyeball, the eye trauma condition can be independently analyzed, special signals in the detection process are obtained, the meticulous performance of detection analysis is improved, and the detection accuracy is improved. The problem that an existing OCT imaging analysis system is not meticulous and comprehensive enough is solved.

The invention discloses an OCT-based eye axis measurement method and device. The method comprises the following steps: performing self-inspection on an optical path of eye axis measurement by utilizing a reference position calibration method, so that a posterior segment optical path adjusting device is located at a reference position; and adjusting the eye axis measurement device to collect the OCT two-dimensional tomography results of the cornea and the retina to be measured at the same time, and then measuring the eye axis length of the eye to be measured according to the OCT two-dimensional tomography results of the cornea and the retina to be measured and the displacement of the posterior segment optical path adjusting device. The eye axis measurement device is used for implementing the eye axis measurement method, and OCT two-dimensional tomography is performed on the anterior segment and the posterior segment of the eye to be measured at the same time. According to the invention, the anterior segment and the posterior segment can be synchronously focused, synchronous and clear imaging of the anterior segment and the posterior segment can be further realized, and the reference position of the optical path of the sample arm can be quickly calibrated before each eye axis measurement by using a reference position calibration method, so that the accuracy of eye axis measurement can be improved.