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Therapeutic agent for corneal diseases

A corneal disease and therapeutic agent technology, applied in the field of corneal disease therapeutic agents, can solve the problem of no report on the proliferation promotion effect of corneal epithelial cells and corneal endothelial cells, and achieve the effect of efficient production and promotion of proliferation

Pending Publication Date: 2021-10-26
NISSAN CHEM IND LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the proliferation-promoting effect of this compound on corneal epithelial cells and corneal endothelial cells

Method used

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  • Therapeutic agent for corneal diseases
  • Therapeutic agent for corneal diseases
  • Therapeutic agent for corneal diseases

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0213] An eye ointment (in 100 g) was made containing the following ingredients.

[0214] Element

[0215] Compound 300mg shown in formula (I)

[0216] Liquid paraffin 10g

[0217] Appropriate amount of white petroleum jelly

preparation example 2

[0219] Eye drops (in 100 mL) containing the following ingredients were manufactured.

[0220] Element

[0221] Compound 500mg shown in formula (I)

[0222] Sodium Hydroxide 900mg

[0223] Appropriate amount of sterilized purified water

preparation example 3

[0225] Eye drops (in 100 mL) containing the following ingredients were manufactured.

[0226] Element

[0227]

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Abstract

The present invention pertains to a novel means for treating corneal diseases. The present invention provides a therapeutic agent for corneal diseases, which contains a compound represented by formula (I) or a salt thereof (the definition of each symbol in the formula is as described in the description).

Description

technical field [0001] The present invention relates to a novel therapeutic agent for corneal diseases and a method for treating corneal diseases using the same. Background technique [0002] The cornea is one of the transparent layers of tissue that make up the eyeball. For humans, the diameter is about 12 mm, the thickness of the central part is about 0.5 mm, and the thickness of the peripheral part is about 0.7 mm, and the corneal epithelium, Bowman's membrane, corneal stroma, corneal descemet, corneal The endothelium consists of 5 layers. Corneal epithelial cells function as a barrier to prevent the invasion of foreign matter and pathogenic bacteria. If corneal epithelial cells are damaged due to various diseases or trauma, not only pain and difficulty in seeing will continue, but also complications such as infectious diseases will occur. On the other hand, corneal endothelial cells are cells indispensable in maintaining the water content and thickness of the cornea co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P27/02C12N5/071C12N1/00A61K31/175
CPCA61P27/02A61K31/175A61K9/0048A61K9/06A61K47/06A61K47/02A61K47/44A61K9/2018A61K9/2054A61K9/2013A61K9/0019A61K47/14C07C281/14C12N5/0621
Inventor 深泽菜月西野泰斗渡边里奈
Owner NISSAN CHEM IND LTD