Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

30 results about "Cornea epithelium" patented technology

Cornea edge stem cell tissue engineering composite body and its preparation method

A tissue-engineered complex of human limbus stem cell and amnion for treating the limbus stem cell-deficiency eye diseases is disclosed. It is perpared through removing epithelium from amnion, using it as carrier, using fibroblast 3T3 as nutritive layer, culturing by cell suspension method, and promoting differentiation of cells by air-lifting technique.
Owner:天津医科大学眼科中心

Cell sheets for ectocornea formation, method of producing the same and method of using the same

The present invention has as its objective providing acorneal epithelium forming cell sheet that will adhere well to an anterior segment tissue. To attain this objective, a corneal epithelium forming cell sheet is produced by a process comprising the steps of cultivating under specified conditions corneal epithelium forming cells on a cell culture support comprising a substrate having its surface covered with a temperature responsive polymer of which the hydrating force varies in a temperature range of 0-80° C., optionally stratifying the layer of cultured cells, and thereafter, (1) adjusting the temperature of the culture solution to either above an upper critical dissolution temperature or below a lower critical dissolution temperature, (2) bringing the cultured corneal epithelium forming cells into close contact with a carrier, and (3) detaching the sheet together with the carrier under specified conditions.
Owner:DELLSEED INC +2

Low antigen hetero stroma of cornea treated by frozen, and its prepn. method

InactiveCN1692891ARetain toughnessPreserve transparencyEye implantsAntigenCollagen fibres
A frozen low-antigen matrix of foreign cornea for cornea transplantation is prepared through picking-up the fresh eyeball of animal, storing at -70 deg.C, gamma-ray irradiating, storing in -20- -70 deg.C, thawing, shearing whole cornea, and tearing out its epitheliium and endotherlium.
Owner:THE AFFILIATED SIR RUN RUN SHAW HOSPITAL OF SCHOOL OF MEDICINE ZHEJIANG UNIV

Preservative-free ophthalmic in-situ gelling agent and preparation method thereof

The invention discloses a preservative-free ophthalmic in-situ gelling agent and a preparation method thereof. The preservative-free ophthalmic in-situ gelling agent comprises Carbomer, chitosan, lubricant, stabilizer, thickener, antioxidant, acetic acid, pH regulator, osmoregulator and de-ionized water. By using the Carbomer and chitosan as base materials for the preparation of the in-situ gelling agent, the in-situ gelling agent increases the solubility of the medicament, improves the absorption and bioavailability of the medicament, reduces the frequency of use and enhances the safety and efficiency; by containing the chitosan, the in-situ gelling agent has biological adhesive action, so that the adhesion of medicament particles onto the cornea is enhanced; and the in-situ gelling agent is free of preservative, thereby having no stimulus or damage to the corneal epithelium. The preservative-free ophthalmic in-situ gelling agent can be used as artificial tear for treating xerophthalmia, and can be also used as an administration and transmission system of ophthalmic medicaments.
Owner:SOUTH CHINA UNIV OF TECH

Ophthalmic medicament composition for forming low-irritation transparent emulsion formulation for surface immune adjustment and inflammation reduction of relevant tissue of eyes or eye periphery

The invention provides an ophthalmic medicament composition for forming a low-irritation transparent emulsion formulation for the surface immune adjustment and inflammation reduction of the relevant tissue of eyes or eye periphery. The ophthalmic medicament composition is used for treating the inflammatory reaction of a serious keratoconjunctivitis sicca and cornea epithelium pathological change patient, forms an emulsion formulation, contains at least one ciclosporin, propylene glycol and polyoxyethylene castor oil derivative, such as polyoxyethylene 35 castor oil derivative, and the like, is transparent, has the characteristics of low irritation, stability and no crystallization phenomenon and is suitable for more sensitive areas, such as eye tissue, and the like.
Owner:RXVISION PHARMA CO LTD

Cornea-like epithelioid cell, tissue-engineered corneal epithelium as well as preparation and application

The invention belongs to the technical field of tissue engineering and in particular relates to a method and application for constructing tissue-engineered corneal epithelium by taking cornea-like epithelioid cells as seed cells. The invention provides a two-step method for inducing skin-derived epidermic cells to be transformed and differentiated into the cornea-like epithelioid cells, so that the cornea-like epithelioid cells obtained by induction serving as the seed cells replace the corneal limbal stem cells for constructing the tissue-engineered corneal epithelium. The prepared tissue-engineered corneal epithelium has the characteristics of being excellent in transparency, excellent in elasticity, high in operability and the like, can be applied to transplantation and repair of ocularsurfaces of animals or animals with severe vision losses or blindness due to corneal limbal stem cell deficiency, and can achieve excellent effects when applied to autotransplantation and allotransplantation of blind animal models due to the corneal limbal stem cell deficiency.
Owner:LUOYANG NORMAL UNIV

Compound dendrobium eye drops for treating xerophthalmia and preparation method thereof

The invention belongs to the traditional Chinese medicine field, relates to a traditional Chinese medicine prescription for treating xerophthalmia and a preparation method, and more specifically to a compound dendrobium eye drops for treating xerophthalmia and a preparation method thereof. The compound dendrobium eye drops are prepared from the following raw materials: 80-120g of caulis dendrobii, 80-120g of radix trichosanthis, 80-120g of folium isatidis, 50-100g of vitamin B1, and 10-20ml of honey. The eye drops are prepared by a modern advanced medicine pharmaceutical technology and have a reasonable formula which is scientific and advanced. The medicinal herb resource is abundant and the medicine cost is low. The traditional Chinese medicine prescription for treating xerophthalmia has the efficacy of improving eyesight and anti-inflammation, lubricating eye surface, and prompting cornea epithelium growth. A local drug delivery mode is employed, and the medicines directly reach the action position. The compound dendrobium eye drops for treating xerophthalmia provides a safe and effective eye medicinal preparation with convenient use for clinic treatment of the xerophthalmia. The treatment effect is reliable, and the compound dendrobium eye drops for treating xerophthalmia and the preparation method thereof can be popularized.
Owner:QINGDAO HUANGDAO HOSPITAL OF TRADITIONAL CHINESE MEDICINE

Corneal bandage lens and preparation method thereof

PendingCN111481340AClear protective effectProlonged clarityLaser surgeryProsthesisVisual field lossVitreous surgery
A corneal bandage lens prepared by the preparation method of the corneal bandage mirror provided by the embodiment of the invention has the advantages that the structure is simple; when the corneal bandage lens is applied to vitreous surgeries, in the surgery, the visual field of doctors is kept clear for a long time; generally greater than 10 minutes, if sharpness has decreased, a small amount ofbalanced salt solution is utilized; washing the surface of the corneal bandage lens; and when the sclera is pressed and the eyeball is rotated, the visual field of the doctor is not obviously deformed in the operation, and after the existing corneal bandage mirror is improved, the corneal bandage mirror is applied to the vitreous operation, so that the burden of an assistant is greatly reduced, the operation efficiency is improved, and the clinical application range of the existing corneal bandage mirror for treatment is expanded. Meanwhile, it is found that after the corneal bandage lens isremoved after the surgery is finished, the corneal epithelium integrity and the corneal epithelium edema degree of the operation eye are superior to those of a traditional balanced salt solution flushing set, and therefore the existing corneal bandage lens for treatment also has a clear protection effect on corneas in vitreous body operation.
Owner:杨晓岗

Recombinant cornea model for ocular surface irritation evaluation and preparation method thereof

PendingCN110066847ASolve non-corneal problemsSolve the problem of difficult expansionEye implantsMicrobiological testing/measurementIrritationOcular surface
The invention relates to a recombinant cornea model for ocular surface irritation evaluation and a preparation method thereof, in particular to the field of in-vitro organ culture and tissue regeneration. From the perspective of seed cells, by constructing the three-dimensional corneal epithelium model through in-vitro enrichment and corneal limbal stem cell amplification, the in-vitro in-vivo consistency of eye irritatwion evaluation is ensured with the seed cells as a cornea family, the problem about industrial large-scale production is also solved, and the promotion of ocular surface irritation in-vitro substitutive experiments is facilitated.
Owner:GUANGDONG BOXI BIO TECH CO LTD

Opthalmic compositions comprising viscosifying polymers and nucleic acids

PendingUS20220265695A1Prevents and reduces RNA toxicityPrevents and diminishes formationOrganic active ingredientsOintment deliveryDescemets MembraneCorneal disease
The invention relates to ophthalmic compositions comprising: i) a nucleic acid molecule, preferably an antisense oligonucleotide, such as an single-stranded antisense oligonucleotide that modulates splice modulation or prevention of RNA toxicity due to trinucleotide repeats in a target RNA molecule, or a gapmer that induces breakdown of a target RNA molecule after formation of a double-stranded RNA / gapmer complex; and ii) a viscosifying polymer. The ophthalmic compositions are for topical administration in the eye of a mammalian subject suffering from a corneal disease, such as a hereditary corneal dystrophy. The viscosifying polymer in the compositions of the invention allows the entry of the nucleic acid molecule to the different layers of the cornea: the corneal epithelium, Bowman's membrane, stroma, Dua's layer, the Descemet's membrane and / or the corneal endothelium.
Owner:PROQR THERAPEUTICS II BV

Nonlinear optical device for micro-machining of the corneal epithelium

A system for creating micro-channels through superficial corneal epithelium, the system including: a femtosecond laser having a pulse energy range of 1 to 20 microjoules (μJ) and a capability of generating a laser beam having a wavelength of 700-1100 nanometers (nm) and a repetition rate of 1 kilohertz to 1 megahertz, a laser delivery system comprising a beam expander, a scanning lens having a numerical aperture (NA) of 0.05 to 0.5 and a focusing objective, and control software that controls the delivery system such that the laser beam is scanned in a pattern. The system is used to noninvasively increase corneal epithelial permeability to therapeutic agents through micron-scale channels created through the corneal epithelium by the system or to induce wound healing in a cornea in a subject following creation of micron-scale channels in the cornea.
Owner:RGT UNIV OF CALIFORNIA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products