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33 results about "Sub clinical" patented technology
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Methods, compositions, devices, and kits for detecting mastitis
InactiveUS20050260695A1Bioreactor/fermenter combinationsBiological substance pretreatmentsMilk sampleMonoclonal antibody
The present invention includes compositions, kits and methods useful for the detection of mastitis in an animal. These agents and methods are primarily directed to a method of detecting the presence of mastitis, including sub-clinical mastitis, in cows, involving incubating a sample of milk from the cow with an agent that binds to lactoferrin such as, e.g., a monoclonal antibody specific for lactoferrin, and then detecting bound lactoferrin. The invention includes lateral-flow immunoassay methods and devices for assessing the presence of lactoferrin in milk samples.
Owner:GENPRIME
Prevention and treatment of sub-clinical PCVD
Owner:BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC
Livestock Anti-acid composition
ActiveUS20070065413A1Avoid accumulationAvoid dysfunctionBiocideMilk preparationSub clinicalRuminant stomach
Acid compositions for ruminants containing a plurality of acid-neutralizing salts with pKa's effective at different ruminant gastrointestinal pH ranges and an active probiotic culture capable of stimulating the growth and concentration of beneficial acid-consuming rumen microorganisms. Methods for preventing clinical and sub-clinical acidosis in ruminants with the acid-neutralizing salts and feed compositions to which the acid-neutralizing salts have been added are also disclosed.
Owner:CASTILLO ALEJANDRO R
Genotoxicity as a biomarker for inflammation
InactiveUS20100267037A1Efficacy of treatmentDecreased amount of presentMicrobiological testing/measurementMaterial analysis by electric/magnetic meansUveitisAutoimmune condition
The invention provides a method for detection of inflammatory disease in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of DNA damage. An elevated amount of marker present in the test sample compared to control sample is indicative of inflammatory disease activity, including sub-clinical inflammation. The method can be adapted for quantitatively monitoring the efficacy of treatment of inflammatory disease in a subject. Markers of DNA damage include single- and / or double-stranded breaks in leukocytes, oxidative DNA damage in leukocytes, or a marker of nitric oxide oxidative activity (protein nitrosylation in leukocytes). The inflammatory disease can be inflammatory bowel disease (ulcerative colitis or Crohn's disease). The invention may also be used for detection of other types of inflammatory disease, such as non-immune intestinal inflammatory disease (diverticulitis, pseudomembranous colitis), autoimmune diseases (rheumatoid arthritis, lupus, multiple sclerosis, psoriasis, uveitis, vasculitis), or non-immune lung diseases (asthma, chronic obstructive lung disease, and interstitial pneumonitis). This unexpected discovery of markers of genotoxicity present in circulating leukocytes enables detection of inflammation occurring at a localized site with a relatively simple and minimally invasive assay using peripheral blood.
Owner:RGT UNIV OF CALIFORNIA
Compositions and methods for detecting keratoconus
InactiveUS20070248970A1Sugar derivativesMicrobiological testing/measurementConical corneaSub clinical
The invention provides a method and assay kits for detecting keratoconus, including sub clinical keratoconus, in a specimen. The method comprises assaying a specimen of corneal epithelium for the presence of an expression product of the AQP5 gene. The invention further provides a novel gene, KC6, that exhibits cornea-specific expression, as well as KC6-related molecules.
Owner:EYE BIRTH DEFECTS RES FOUND
Device, system and method of non-invasive diagnosis of mastitis in a dairy cow
Owner:GRABEK JAMES R +1
Subclinical ketosis of milk cattle diagnose indicator paper
InactiveCN101118237AMaterial analysis by observing effect on chemical indicatorMicrobiological testing/measurementHeifer calfMilk cow's
The present invention relates to a dairy cow sub-clinical ketosis diagnosis test paper which belongs to the art of the veterinary clinical laboratory science. The present invention comprises a support cushion and a test cushion that is fixed on the support cushion; and the present invention is characterized in that the test cushion of the test paper comprises the following reagents: D-(-)-3-Hydroxybutyrate Dehydrogenase with 2270U / mg and 50mg-100mg; nicotinamide adenine dinucleotide with 300mg-500mg; diaphorase with 35U / mg-45U / mg and 500-1,000mg; NBT with 100mg-200mg; Tris Base with molecular weight 121.14 and 1.21g; oxalic acid with molecular 126 and 126mg; fucose with molecular 383 and 4-6g; and distilled water with 100ml. The dairy cow sub-clinical ketosis diagnosis test paper of the present invention is used conveniently and has the advantages of economic practicality, high sensitivity and specificity, and good stability. The test paper is used to test D-(-)-3-Hydroxybutyrate and D-(-)-3-Hydroxybutyrate sodium in the milk of the milch cow.
Owner:JILIN UNIV
Prevention and treatment of sub-clinical pcvd
ActiveUS20090010954A1Reduce in quantityReduce percentageMetabolism disorderViral antigen ingredientsSub clinicalImmunogenicity
The present invention relates to the use of an immunogenic composition comprising a porcine circovirus type 2 (PCV2) antigen for the prevention and treatment of sub-clinical PCV2 infection in animals, preferably in pigs.
Owner:BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC
Genotoxicity as a biomarker for inflammation
InactiveUS8445200B2Microbiological testing/measurementMaterial analysis by electric/magnetic meansUveitisInflammatory Bowel Diseases
The invention provides a method for detection of inflammatory disease in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of DNA damage. An elevated amount of marker present in the test sample compared to control sample is indicative of inflammatory disease activity, including sub-clinical inflammation. The method can be adapted for quantitatively monitoring the efficacy of treatment of inflammatory disease in a subject. Markers of DNA damage include single- and / or double-stranded breaks in leukocytes, oxidative DNA damage in leukocytes, or a marker of nitric oxide oxidative activity (protein nitrosylation in leukocytes). The inflammatory disease can be inflammatory bowel disease (ulcerative colitis or Crohn's disease). The invention may also be used for detection of other types of inflammatory disease, such as non-immune intestinal inflammatory disease (diverticulitis, pseudomembranous colitis), autoimmune diseases (rheumatoid arthritis, lupus, multiple sclerosis, psoriasis, uveitis, vasculitis), or non-immune lung diseases (asthma, chronic obstructive lung disease, and interstitial pneumonitis). This unexpected discovery of markers of genotoxicity present in circulating leukocytes enables detection of inflammation occurring at a localized site with a relatively simple and minimally invasive assay using peripheral blood.
Owner:RGT UNIV OF CALIFORNIA
Diagnostic and screening methods for inflammation
InactiveUS20140113306A1High expressionEnhanced phosphorylation of AktDisease diagnosisBiological testingDiabetes mellitusScreening method
This invention is directed to methods, kits and compositions for the diagnosis and treatment of conditions associated with sub-clinical inflammatory conditions such as diabetes mellitus.
Owner:RUTGERS THE STATE UNIV
Plurality of lamination for soft tissue compression support, protection and bracing; intelligent textile for equine and equestrian sports or activities
ActiveUS9398880B2Enhanced air and vapor transport and heat releaseIncrease resistanceGarment special featuresNon-adhesive dressingsFiberPolyurethane membrane
Owner:VANSCOY BARNETT KELLY ANNETTE
System and method of sub clinical detecting mastitis
Mastitis in a milking animal is detected through sensing the capacitance effects in milk. Using frequencies of greater than 60 megahertz applied by a capacitance probe to milk as it streams through otherwise conventional milking equipment during milking, yields a reliably discernable shift in the phase angle, indicating the presence of mastitis.
Owner:HOEY MICHAEL
System and method of sub clinical detecting mastitis
Mastitis in a milking animal is detected through sensing the capacitance effects in milk. Using frequencies of greater than 60 megahertz applied by a capacitance probe to milk as it streams through otherwise conventional milking equipment during milking, yields a reliably discernable shift in the phase angle, indicating the presence of mastitis.
Owner:HOEY MICHAEL
A method and a kit for diagnosing type 2 diabetes, metabolic syndrome, sub clinical atherosclerosis, myocardial infarct, stroke or clinical manifestations of diabetes.
A method and a kit for diagnosing or prognosing susceptibility to develop type 2 diabetes, the metabolic syndrome, sub clinical atherosclerosis, myocardial infarct, stroke or clinical manifestations of diabetes in a subject.
Owner:ASTRAZENECA AB
Qtls for Mastitis Resistance in Cattle
InactiveUS20100003675A1Improve the immunityAvoid economic lossMicrobiological testing/measurementQuantitative trait locusMicrosatellite
The invention relates to a method for determining mastitis resistance in bovine subjects, wherein mastitis resistance comprise resistance to both sub-clinical and clinical mastitis. In particular, the method of the invention involves identification of genetic markers and / or Quantitative Trait Locus (QTL) for the determination of mastitis resistance in a bovine subject. The determination of mastitis resistance involves resolution of the specific microsatellite status. Furthermore, the invention relates to a diagnostic kit for detection of genetic marker(s) associated with mastitis resistance. The method and kit of the present invention can be applied for selection of bovine subjects for breeding purposes. Thus, the invention provides a method of genetically selecting bovine subjects with mastitis resistance, thereby yielding cows less prone to mastitis.
Owner:MTT AGRIFOOD RES FINLAND +2
QTLs for mastitis resistance in cattle
The invention relates to a method for determining mastitis resistance in bovine subjects, wherein mastitis resistance comprise resistance to both sub-clinical and clinical mastitis. In particular, the method of the invention involves identification of genetic markers and / or Quantitative Trait Locus (QTL) for the determination of mastitis resistance in a bovine subject. The determination of mastitis resistance involves resolution of the specific microsatellite status. Furthermore, the invention relates to a diagnostic kit for detection of genetic marker(s) associated with mastitis resistance. The method and kit of the present invention can be applied for selection of bovine subjects for breeding purposes. Thus, the invention provides a method of genetically selecting bovine subjects with mastitis resistance, thereby yielding cows less prone to mastitis.
Owner:AARHUS UNIV +2
Livestock anti-acid composition
ActiveUS7597916B2Avoid accumulationAvoid dysfunctionMilk preparationAnimal feeding stuffSub clinicalAnimal husbandry
Acid compositions for ruminants containing a plurality of acid-neutralizing salts with pKa's effective at different ruminant gastrointestinal pH ranges and an active probiotic culture capable of stimulating the growth and concentration of beneficial acid-consuming rumen microorganisms. Methods for preventing clinical and sub-clinical acidosis in ruminants with the acid-neutralizing salts and feed compositions to which the acid-neutralizing salts have been added are also disclosed.
Owner:CASTILLO ALEJANDRO R
Broiler feed on basis of lactobacillus johnsonii BS15 and method for preparing broiler feed
InactiveCN105941975APrevent meat quality lossSimple structureAnimal feeding stuffGrowth promotionAntibiotic Y
The invention discloses broiler feed on the basis of lactobacillus johnsonii BS15 and a method for preparing the broiler feed. The broiler feed on the basis of the lactobacillus johnsonii BS15 contains 1*10<8>-1*10<9> cfu / kg of the lactobacillus johnsonii BS15. The service time of the boiler feed starts from one day after chicks are hatched to the broiler slaughtering time; the broiler feed and feed are mixed with each other and then are fed to broilers. The broiler feed and the method have the advantages that the problem of drug residues due to antibiotics can be solved, and gaps in the field after the antibiotics are forbidden can be filled; the intestinal tracts of the broilers can be regulated, the purpose of allowing the broilers to healthfully grow can be achieved, and growth promotion and disease prevention functions are integrated by a novel prevention and control process; the broiler feed is used for assisting in establishing healthful digestive systems of the broilers, and accordingly deterioration of the meat quality of the broilers can be prevented when sub-clinical necrotic enteritis occurs.
Owner:SICHUAN AGRI UNIV
Veterinary drug composition capable of enhancing immunity and preparation method of veterinary drug composition
InactiveCN102552379ASafe and effective treatmentWeakened immunityClimate change adaptationImmunological disordersAnti stressDisease
The invention discloses a veterinary drug composition (Guiqisu) capable of enhancing immunity, which is composed of effective component or acceptable carriers on effective component and pharmacy, wherein the effective component is prepared by astragalus membranaceus submicron powder and angelica extract. The drug composition has the effects of replenishing qi and nourishing blood and regulating double immune; the drug composition is used for treating postpartum blood deficiency weak of dam, immune system damage caused by animal virus infection, immune antibody disorder, weak anti-stress ability in laying fastigium of poultry, and weak poultry caused by diseases, and specifically the drug composition is suitable for poultry with low immunity in a sub-clinical state. The invention further discloses a preparation method of the drug composition.
Owner:韩健宝
Udder health characteristics
InactiveCN101410533AEasy to identifyMicrobiological testing/measurementQuantitative trait locusResearch Object
The invention relates to a method for determining udder health characteristics in bovine subjects, wherein udder health characteristics comprise sub-clinical and clinical mastitis. In particular, the method of the invention involves identification of genetic markers and / or Quantitative Trait Locus (QTL) for the determination of udder health characteristics in a bovine subject. The determination of udder health characteristics involves resolution of the specific microsatellite status. Furthermore, the invention relates to a diagnostic kit for detection of genetic marker(s) associated with udder health. The method and kit of the present invention can be applied for selection of bovine subjects for breeding purposes. Thus, the invention provides a method of genetically selecting bovine subjects with udder health characteristics that will yield cows less prone to mastitis.
Owner:AARHUS UNIV +1
Method device and system for monitoring sub-clinical progression and regression of heart failure
InactiveUS20170076045A1Tired easilyConvenience to workLocal control/monitoringHealth-index calculationMedicineSub clinical
A method including sensing local accelerations or changes in sensor position, including orientation and displacement, with a local acceleration sensor mounted on a chest or abdomen of a patient, and calculating energy of polyphasic motions, based on sensed information of the local acceleration sensor and classifying severity of cardiac decompensation by calculating an excessive energy index (EEi) that compares excessive energy that appears in the polyphasic motions to energy required for inspiration at a basic respiratory rate.
Owner:TECHNION RES & DEV FOUND LTD +1
Chinese herbal medicine honey tea (sugar-free particles) for improving sub-health status of perimenopause and preparation technology thereof
ActiveCN103798475AReduce inconvenienceReduce distressNervous disorderAnthropod material medical ingredientsSide effectJoint arthralgia
The invention relates to Chinese herbal medicine honey tea (sugar-free particles) for improving the sub-health status of perimenopause and a preparation technology thereof. The Chinese herbal medicine honey tea mainly contains dried rhizome of rehmannia, Chinese yam, schisandra chinensis, poria with hostwood, semen cuscutae, stir-fried fresh-water turtle shell, honey and the like. The preparation technology comprises the following steps: adding sugar-free auxiliary materials to medicine-food dual-purpose plants or Chinese herbal medicines which are disclosed by Ministry of Health and can be applied to healthcare products according to a modern preparation technology, decocting, concentrating, drying, pelleting, sterilizing and packaging, thus obtaining the Chinese herbal medicine honey tea. The formula of the Chinese herbal medicine honey tea is established mainly specific to yin-yang disharmony caused by deficiency of kidney based on the argument of spleen and kidney, and therefore, the Chinese herbal medicine honey tea is capable of making up congenital deficiency of kidney on one hand and postnatal deficiency of kidney so as to recover congenital deficiency on the other hand, so that more internal organs are simultaneously treated, the kidney essence is jointly enriched, the five internal organs are moistened and the yin and yang are balanced. The Chinese herbal medicine honey tea is capable of effectively preventing and improving sub-clinical symptoms such as fatigue, heated sweating, insomnia, vexation and arthralgia which are persistent and difficult to restore in a perimenopausal period and improving ovarian function, and has no toxic and side effects.
Owner:WUHAN AIMIN PHARMA
Traditional Chinese medicine composition for treating milk cow endometritis
ActiveCN105709035AImprove immunityWill not polluteSexual disorderMagnoliophyta medical ingredientsSide effectAngelica Sinensis Root
The invention discloses a traditional Chinese medicine composition for treating milk cow endometritis.The traditional Chinese medicine composition is prepared from, by weight, 1-10 parts of codonopsis pilosula, 1-10 parts of bighead atractylodes rhizome, 1-5 parts of radix astragali, 5-10 parts of radix angelica sinensis, 5-10 parts of white paeony roots, 1-10 parts of common yam rhizome, 3-5 parts of nutgrass galingale rhizome, 3-9 parts of cochinchinese asparagus roots, 5-10 parts of prepared radix rehmanniae, 5-10 parts of ligusticum wallichii, 5-10 parts ofsemen cuscutae, 5-10 parts of oysters, 5-15 parts of philippine flemingia roots, 5-10 parts of common andrographis herbs, 5-10 parts of honeysuckle flowers, 5-10 parts ofleatherleaf mahonia, 5-10 parts of radix sophorae flavescentis and 3-5 parts of liquorice roots.The pathogenic mechanism of cow endometritis and generated clinical symptoms are combined, composition is carried out according to the assistant and guide principle, and the medicinal materials are used together, and have the functions of tonifying qi and the spleen, warming the kidney, cultivating yuan, clearing away heat, removing dampness, activating blood, removing blood stasis, promoting qi circulation, relieving pain, resisting bacteria, diminishing inflammation and enhancing immunity of the organism.The traditional Chinese medicine composition is a pure traditional Chinese medicine preparation, does not contain antibiotics, is safe and convenient to use and has no toxic or side effects, the raw materials are wide in source, cost is low, the effect is obvious, and the traditional Chinese medicine composition is suitable for treating milk cow clinic endometritis and sub-clinical endometritis.
Owner:LUOYANG NORMAL UNIV
Nutrition complementing method for repairing cell disorder and medicine recipe for same
The invention relates to a nutrition complementing method for repairing cell disorder and medicine recipe for same. The cells are the foundation of human body texture structure. As long as the metabolism of the cells function normally, the human texture structure and function are normal, the human body can keep healthy. If disease preventive measures can be taken by applying the recipe and method, a satisfactory result can be achieved. Therefore, through the most reasonable proportioning of medicines and the control of taking time and taking amount, the sub-health and sub-clinical conditions can be prevented from the root of the cell metabolism, thus preventing and treating most chronic diseases.
Owner:肖远
Potential disease information comprehensive analysis system of modern traditional Chinese medicine
InactiveCN101596098BStrong comprehensive informationGood for long term managementSensorsMeasuring/recording heart/pulse rateDiseaseInformatization
The invention discloses a potential disease information comprehensive analysis system of the modern traditional Chinese medicine. In the invention, nine constitution identifications issued and recognized by the traditional Chinese medicine department are used as a main guide for integrating all subprogram data, a computer is fully utilized to combine with a photoelectric technology for picking upand integrating the information of the holographical embryo theories (such as an Han type microcirculation holographical observational method, an eight-detail-drawing holographical localization method of a distal blood analytical method, a pulse condition localization method, an eye blood vessel collateral localization method, a handprint contrast method and the like) of several life sciences, the sub-clinical pathological changes of a human body, i.e. the traditional Chinese medicine constitution identification standards of potential disease are emphatically contrasted, and a set of clinically feasible and visual informatization human body nonage physiological mutation prediction systems are founded, so that the purposes of early discovering and early treating momentous diseases can be achieved. The system has strong integrated information, and computer informatization is beneficial to long-term management, is convenient for the long-term tracking and self contrast and is beneficial to evidence-based medicine.
Owner:SHANGHAI INST OF LASER TECH
A kind of traditional Chinese medicinal liquid for treating condyloma acuminatum and preparation method thereof
ActiveCN104971266BNo side effectsEasy to usePharmaceutical delivery mechanismAntiviralsCnidiumAnti-inflammatory analgesics
The invention discloses a traditional Chinese medicine water preparation for treating condyloma acuminatum and a preparation method thereof. The Chinese medicine water preparation is prepared by refluxing the following raw materials in ethanol according to the proportion range shown in weight parts to obtain an extract, and then adding borneol to the extract : Sophora flavescens 10-15 parts, Hedyotis diffusa 15-18 parts, Sagittarius 8-11 parts, Coix 18-20 parts, borneol 1-5 parts, raw licorice 10-12 parts, Taoerqi 10-12 parts , 12-15 parts of hawthorn slices, 5-7 parts of quercetin, 6-8 parts of cnidium and 5-8 parts of raspberry root; Cooling blood, purging fire and detoxification, dispelling putrefaction and promoting muscle growth, expelling toxins and warts, eliminating latent warts and subclinical symptoms, and by activating cells, rejuvenating cells, completely killing skin latent viruses, so as to achieve the goal of radically curing condyloma acuminatum.
Owner:HUAIAN BENCAOTANG BIOLOGICAL TECH CO LTD
A clinical testing device and testing method for worm gear transmission accuracy
ActiveCN105598534BAvoid installation structuresEasy to measureGear-cutting machinesGear teethSub clinicalSlide plate
The invention discloses an on-machine detection device of the worm gear pair transmission precision. The detection device comprises a rotary table for installing a worm gear and a tool for installing a worm, a worm gear angular displacement sensor which detects the rotation angle of the worm gear is installed in the rotary table, a worm angular displacement sensor which detects the rotation angle of the worm is installed on the tool, the worm gear angular displacement sensor and the worm angular displacement sensor are in output connection with a worm gear detector, the tool is provided with a bracket, a sliding plate located above the bracket and a pair of fixed centers for supporting the two ends of the worm, a driving motor is arranged on the bracket and drives a gear transmission set, and a rotor of the worm angular displacement sensor and a tail end gear coaxially and synchronously rotate to measure the rotation angel of the worm; the rotary table comprises an installation table and a base which can rotate relatively, a rotor of the worm gear angular displacement sensor is coaxially installed on a protruding column of the installation table, and a stator of the worm gear angular displacement sensor is fixedly connected with the base. The invention further discloses an on-machine detection method of the worm gear pair transmission precision. By means of the on-machine detection device and detection method of the worm gear pair transmission precision, the on-machine detection problem of the worm gear pair transmission precision is solved.
Owner:CHONGQING UNIV OF TECH
Medicinal application of resveratrol
InactiveCN105267186AImproves the function of the hypothalamic-pituitary-thyroid axisImprove depression-related behaviorsNervous disorderHydroxy compound active ingredientsMental nerveSevere hypothyroidism
The invention discloses application of resveratrol to preparing medicines for treating sub-clinical hypothyroidism and neuropsychiatric syndromes due to the sub-clinical hypothyroidism. The application has the advantages that the resveratrol is applied to preparing the medicines for treating the sub-clinical hypothyroidism and the neuropsychiatric syndromes due to the sub-clinical hypothyroidism, accordingly, imbalance hypothalamus-pituitary-thyroid axis functions of sub-clinical hypothyroidism patients can be improved, the learning and memory ability of the sub-clinical hypothyroidism patients can be enhanced, and depression-related behavior of the sub-clinical hypothyroidism can be improved.
Owner:ANHUI MEDICAL UNIV
Diagnostic method for paratuberculosis
InactiveUS7731937B2Increase productionImprove responseBacterial antigen ingredientsPeptide/protein ingredientsAntigenMycobacterium Infections
The present invention is intended to provide a diagnostic method for paratuberculosis by which an animal infected with Mycobacterium avium subsp. Paratuberculosis can be diagnosed at a high sensitivity in the sub-clinical infection stage before the specific antibody level begins to increase and a large number of specimens can be treated. The present invention provides: a diagnostic method for paratuberculosis characterized by collecting the blood of a subject animal, adding an anti-IL-10 antibody and a Mycobacterium avium subsp. Paratuberculosis antigen to the collected blood followed by culture, and then measuring the amount of produced IFNγ in the blood; a diagnostic method for paratuberculosis characterized in that the amount of produced IFNγ in blood is measured by the IFNγ ELISA method; and a diagnostic method for mycobacterial infection characterized by collecting the blood of a subject animal, adding an anti-IL-10 antibody and a mycobacterial antigen to the collected blood followed by culture, and then measuring the amount of produced IFNγ in the blood.
Owner:INC ADMINISTRATIVE AGENCY NAT AGRI & BIO ORIENTED RES ORG
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