33 results about "Sub clinical" patented technology

The present invention relates to the use of an immunogenic composition comprising a porcine circovirus type 2 (PCV2) antigen for the prevention and treatment of sub-clinical PCV2 infection in animals, preferably in pigs.

The invention provides a method for detection of inflammatory disease in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of DNA damage. An elevated amount of marker present in the test sample compared to control sample is indicative of inflammatory disease activity, including sub-clinical inflammation. The method can be adapted for quantitatively monitoring the efficacy of treatment of inflammatory disease in a subject. Markers of DNA damage include single- and / or double-stranded breaks in leukocytes, oxidative DNA damage in leukocytes, or a marker of nitric oxide oxidative activity (protein nitrosylation in leukocytes). The inflammatory disease can be inflammatory bowel disease (ulcerative colitis or Crohn's disease). The invention may also be used for detection of other types of inflammatory disease, such as non-immune intestinal inflammatory disease (diverticulitis, pseudomembranous colitis), autoimmune diseases (rheumatoid arthritis, lupus, multiple sclerosis, psoriasis, uveitis, vasculitis), or non-immune lung diseases (asthma, chronic obstructive lung disease, and interstitial pneumonitis). This unexpected discovery of markers of genotoxicity present in circulating leukocytes enables detection of inflammation occurring at a localized site with a relatively simple and minimally invasive assay using peripheral blood.

A Wearable Orthopedic / Orthotic Device for diagnostics and therapy of an equine limb comprises a soft tissue compression material and a sheet of stretchable laminate material for soft tissue compression and bracing. The device includes a stretchable, porous and breathable polyurethane membrane to allow a certain degree of perspiration and heat to escape while retaining a therapeutic amount of heat. The device includes an intelligent textile layer, including fibertronics, organic electronics, other forms of e-textiles and sensors for monitoring parameters associated with tendon and ligament injuries in sub clinical time periods. The device may include an acoustic sensor for detecting the speed and frequency of sound traveling through underlying tissue onto which an acoustic signal is emitted. In a diagnostic monitoring method, parameters associated with the health tissue of the equine limb and body is wirelessly transmitted by the device to an external receiver for analysis.

Acid compositions for ruminants containing a plurality of acid-neutralizing salts with pKa's effective at different ruminant gastrointestinal pH ranges and an active probiotic culture capable of stimulating the growth and concentration of beneficial acid-consuming rumen microorganisms. Methods for preventing clinical and sub-clinical acidosis in ruminants with the acid-neutralizing salts and feed compositions to which the acid-neutralizing salts have been added are also disclosed.

The invention discloses a potential disease information comprehensive analysis system of the modern traditional Chinese medicine. In the invention, nine constitution identifications issued and recognized by the traditional Chinese medicine department are used as a main guide for integrating all subprogram data, a computer is fully utilized to combine with a photoelectric technology for picking upand integrating the information of the holographical embryo theories (such as an Han type microcirculation holographical observational method, an eight-detail-drawing holographical localization method of a distal blood analytical method, a pulse condition localization method, an eye blood vessel collateral localization method, a handprint contrast method and the like) of several life sciences, the sub-clinical pathological changes of a human body, i.e. the traditional Chinese medicine constitution identification standards of potential disease are emphatically contrasted, and a set of clinically feasible and visual informatization human body nonage physiological mutation prediction systems are founded, so that the purposes of early discovering and early treating momentous diseases can be achieved. The system has strong integrated information, and computer informatization is beneficial to long-term management, is convenient for the long-term tracking and self contrast and is beneficial to evidence-based medicine.

The present invention is intended to provide a diagnostic method for paratuberculosis by which an animal infected with Mycobacterium avium subsp. Paratuberculosis can be diagnosed at a high sensitivity in the sub-clinical infection stage before the specific antibody level begins to increase and a large number of specimens can be treated. The present invention provides: a diagnostic method for paratuberculosis characterized by collecting the blood of a subject animal, adding an anti-IL-10 antibody and a Mycobacterium avium subsp. Paratuberculosis antigen to the collected blood followed by culture, and then measuring the amount of produced IFNγ in the blood; a diagnostic method for paratuberculosis characterized in that the amount of produced IFNγ in blood is measured by the IFNγ ELISA method; and a diagnostic method for mycobacterial infection characterized by collecting the blood of a subject animal, adding an anti-IL-10 antibody and a mycobacterial antigen to the collected blood followed by culture, and then measuring the amount of produced IFNγ in the blood.

The invention discloses a traditional Chinese medicine composition for treating milk cow endometritis.The traditional Chinese medicine composition is prepared from, by weight, 1-10 parts of codonopsis pilosula, 1-10 parts of bighead atractylodes rhizome, 1-5 parts of radix astragali, 5-10 parts of radix angelica sinensis, 5-10 parts of white paeony roots, 1-10 parts of common yam rhizome, 3-5 parts of nutgrass galingale rhizome, 3-9 parts of cochinchinese asparagus roots, 5-10 parts of prepared radix rehmanniae, 5-10 parts of ligusticum wallichii, 5-10 parts ofsemen cuscutae, 5-10 parts of oysters, 5-15 parts of philippine flemingia roots, 5-10 parts of common andrographis herbs, 5-10 parts of honeysuckle flowers, 5-10 parts ofleatherleaf mahonia, 5-10 parts of radix sophorae flavescentis and 3-5 parts of liquorice roots.The pathogenic mechanism of cow endometritis and generated clinical symptoms are combined, composition is carried out according to the assistant and guide principle, and the medicinal materials are used together, and have the functions of tonifying qi and the spleen, warming the kidney, cultivating yuan, clearing away heat, removing dampness, activating blood, removing blood stasis, promoting qi circulation, relieving pain, resisting bacteria, diminishing inflammation and enhancing immunity of the organism.The traditional Chinese medicine composition is a pure traditional Chinese medicine preparation, does not contain antibiotics, is safe and convenient to use and has no toxic or side effects, the raw materials are wide in source, cost is low, the effect is obvious, and the traditional Chinese medicine composition is suitable for treating milk cow clinic endometritis and sub-clinical endometritis.