Udder health characteristics

A breast, health technology, applied in the field of genetically marked diagnostic kits, which can solve problems such as limited positioning resolution

Inactive Publication Date: 2009-04-15
AARHUS UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-range LDs may lead to limited localization resolution and associations arising from gamete associations between non-syntenic points in the absence of connectivity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0622] BTA1

[0623] Table 17 lists the regression analysis structure for BTA1. Figures 1 and 2 show the QTL plots used in the regression analysis. The variance components method was used to detect cross-family QTLs for CELL, MAS1, MAS2, MAS3, MAS4, and breast health index in single-trait analysis (including all paternal families in one analysis). No significant QTLs were detected for CELL, MAS1, MAS2, MAS3, MAS4 and breast health index in the cross-family analysis. No signal was given for pleiotropic QTLs affecting the traits CELL, MAS1, MAS2, MAS3, MAS4 and breast health index from the multitrait analysis. The results of the within-family analysis are shown in Table 17.

[0624] Table 17

[0625] Significant QTLs obtained from family analysis using regression analysis for BTA1

[0626] Chromosome

Chr

main character

Location

(Morgan)

livestock pedigree

book compilation

father's name

Childhood

state

p-value ...

Embodiment 2

[0630] BTA5

[0631] Table 18 lists the regression analysis structure for BTA5. Figures 3 and 4 show the QTL plots used in the regression analysis. The variance components method was used to detect cross-family QTLs for CELL, MAS1, MAS2, MAS3, MAS4, and breast health index in single-trait analysis (including all paternal families in one analysis). A significant QTL was detected in the cross-family analysis for CELL (likelihood ratio = 11.02 at position 0.44 mo). Three paternal families correspond to this QTL: 223803, 226201 and 232606. No significant QTLs were detected for MAS1, MAS2, MAS3, MAS4 and breast health index in the cross-family analysis. No signal was given for pleiotropic QTLs affecting the traits CELL, MAS1, MAS2, MAS3, MAS4 and breast health index from the multitrait analysis.

[0632] Table 18

[0633] Significant QTLs obtained from family analysis using regression analysis for BTA5

[0634] to dye

Body Chr

main character

Location...

Embodiment 3

[0638] BTA7

[0639] Table 19 lists the regression analysis structure for BTA7. Figure 5 and Figure 6 show the QTL plots used in the regression analysis. The variance components method was used to detect cross-family QTLs for CELL, MAS1, MAS2, MAS3, MAS4, and breast health index in single-trait analysis (including all paternal families in one analysis). A significant QTL was detected in the cross-family analysis of the breast health index (likelihood ratio = 18.9 at 0.75 mo). Four paternal families corresponded to this QTL: 236947, 226804, 230104 and 237017. No significant QTLs were detected for CELL, MAS1, MAS2, MAS3 and MAS4 in the cross-family analysis. No signal was given for pleiotropic QTLs affecting the traits CELL, MAS1, MAS2, MAS3, MAS4 and breast health index from the multitrait analysis.

[0640] Table 19

[0641] Significant QTLs obtained from family analysis using regression analysis for BTA7

[0642] Chromosome

Chr

main character

L...

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Abstract

The invention relates to a method for determining udder health characteristics in bovine subjects, wherein udder health characteristics comprise sub-clinical and clinical mastitis. In particular, the method of the invention involves identification of genetic markers and/or Quantitative Trait Locus (QTL) for the determination of udder health characteristics in a bovine subject. The determination of udder health characteristics involves resolution of the specific microsatellite status. Furthermore, the invention relates to a diagnostic kit for detection of genetic marker(s) associated with udder health. The method and kit of the present invention can be applied for selection of bovine subjects for breeding purposes. Thus, the invention provides a method of genetically selecting bovine subjects with udder health characteristics that will yield cows less prone to mastitis.

Description

technical field [0001] The present invention relates to udder health characteristics in bovine research subjects. In particular, the invention relates to genetic markers useful for characterizing udder health in bovine research subjects and diagnostic kits for detecting genetic markers associated with udder health. Background technique [0002] Mastitis is inflammation of the mammary glands or udders of cattle due to infection or trauma and is considered to be the most economically impactful disease in cattle. [0003] The disease can be caused by various factors. The main cause of mastitis is the invasion of the mammary gland by microorganisms through the end of the teat. [0004] It is known that the shape and structure of the teat is influenced by genetic factors (Hickman, 1964). The history of mastitis from two cattle families in different geographic locations revealed significant differences between cows in the presence of mastitis. From this finding, it was conclud...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
Inventor 莫根斯·桑多·隆德克里斯蒂安·本迪克森黑勒·延森博·汤姆森彼得·索伦森瑟伦·斯文森巴特·艾伯特·约翰尼斯·巴腾赫斯维维·胡尼科克·尼尔森本特·弗卢杰尔·玛格兰伯恩特·古勃兰特森乔恩·林德·托马森
Owner AARHUS UNIV
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