Detection of viruses present in cells The present invention provides 1. A method for identifying
viral DNA integrated into the
genome of at least one mammalian test
cell, comprising: (a) determining the presence or absence of
viral DNA in
a DNA sample obtained from a mammalian test
cell; (b) determining the
methylation status of at least one
CpG site in the
viral DNA of
a DNA sample obtained from a mammalian test
cell; and the presence of viral
DNA after step (a) and a hypermethylated state in step (b) indicates that the viral
DNA has been integrated into the mammalian test cell and that the
virus is inactive, respectively; the presence of viral
DNA after step (a) and a baseline
methylation state or a hypomethylated state in step (b) indicates that the viral DNA has integrated into the mammalian test cell and that the
virus is active, respectively; the absence of viral DNA after step (a) indicates that the viral DNA has not integrated into the mammalian test cell; Methods performed on arrays Regarding.