The invention relates to the technical field of medical waste treatment, in particular to waste treatment equipment for biotechnological preventive medicine, and solves the defects that a waste treatment device for preventive medicine cannot perform equipment crushing and disinfection and has risks of virus transmission and equipment recycling. The waste treatment equipment comprises a treatment box, a lining plate is welded to the inner side of the top of the treatment box, a first spring is welded in one side of the lining plate, a cover plate is clamped on the inner side of the top of the treatment box, a material guiding pipe is welded to the bottom of the lining plate, a motor base is welded to one side of the material guiding pipe, a motor is fixed to the outer side of the motor base through screws, two connecting shafts are connected to the inner side of the material guiding pipe through bearings, the surfaces of the two connecting shafts are sleeved with pressing rollers, gears are connected to the ends of the connecting shafts in a sleeving mode, and a mounting plate is welded to the inner side of the treatment box. According to the device, abandoned solid waste can be crushed, disinfectant is sprayed through a spray head before and after disposal, the interior and the exterior of the waste are effectively and preliminarily disinfected, and the waste is prevented from being recycled by lawbreakers.