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QTLs for mastitis resistance in cattle

A technology of inflammation resistance and bovine udder, which is applied in the field of determination of test bovine mastitis resistance, can solve problems such as low quality and pollution, and achieve the effect of avoiding economic losses

Inactive Publication Date: 2009-04-22
AARHUS UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this is low quality milk compared to uninfected cows and can thus contaminate the rest of the milk in the vat

Method used

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  • QTLs for mastitis resistance in cattle
  • QTLs for mastitis resistance in cattle
  • QTLs for mastitis resistance in cattle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0319] BTA9

[0320] Statistical Analysis

[0321] Several statistical methods described below were used to identify genetic markers associated with or associated with mastitis and thus mastitis resistance.

[0322] QTL analysis

[0323] Linkage analysis (LA) is used to identify QTLs by mapping genetic markers in families to chromosomal regions that are associated with disease or trait values ​​within the pedigree that are higher than probabilistically expected. Such linked regions are more likely to contain causal genetic variants. Analyze data with series models. Initially, individual trait models using a multipoint regression approach for all traits were analyzed within families. Chromosomes with significant effects within families were analyzed with the variance components method to confirm QTLs found across families and characterization of QTLs.

[0324] regression analysis

[0325] Group allele frequencies at markers were estimated using the EM algorithm. Allele f...

Embodiment 2

[0373] BTA11

[0374] Statistical Analysis

[0375] Several statistical methods described below were used to identify genetic markers associated with or associated with mastitis and thus mastitis resistance.

[0376] QTL analysis

[0377]Linkage analysis (LA) is used to identify QTLs by mapping genetic markers in families to chromosomal regions that are associated with disease or trait values ​​within the pedigree that are higher than probabilistically expected. Such linked regions are more likely to contain causal genetic variants. Analyze data with series models. Three complementary methods were used: (i) half-sib family analysis (Haley and Knott, 1992) by regression-based method with GDQTL software (B. Guldbrandsten, 2005 personal communication); (ii) variance components method Cross-family linkage analysis, and (iii) combined linkage disequilibrium linkage analysis (LDLA) with variance components method. Each family was analyzed individually with GDQTL to determine th...

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Abstract

The invention relates to a method for determining mastitis resistance in bovine subjects, wherein mastitis resistance comprise resistance to both sub-clinical and clinical mastitis. In particular, the method of the invention involves identification of genetic markers and / or Quantitative Trait Locus (QTL) for the determination of mastitis resistance in a bovine subject. The determination of mastitis resistance involves resolution of the specific microsatellite status. Furthermore, the invention relates to a diagnostic kit for detection of genetic marker(s) associated with mastitis resistance. The method and kit of the present invention can be applied for selection of bovine subjects for breeding purposes. Thus, the invention provides a method of genetically selecting bovine subjects with mastitis resistance, thereby yielding cows less prone to mastitis.

Description

field of invention [0001] The present invention relates to a method for determining resistance to mastitis in a test bovine comprising detecting at least one genetic marker located on bovine chromosomes BTA9 and BTA11. Furthermore, the invention relates to a diagnostic kit for detecting the presence or absence of at least one genetic marker associated with mastitis resistance. Background of the invention [0002] Mastitis is inflammation of the mammary glands or udders of a cow due to infection or trauma. Mastitis is considered a disease of economically important cattle. [0003] The disease can be caused by a variety of reasons. The main cause of mastitis is caused by the invasion of microorganisms into the mammary gland through the end of the nipple. [0004] Mastitis can be clinical or subclinical, with subclinical infection preceding clinical manifestations. Clinical mastitis (CM) can be detected visually by observing red and swollen mammary glands, ie, inflamed brea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
Inventor 莫根斯·桑多·隆德克里斯蒂安·本迪克森高塔姆·萨哈娜彼得·索伦森瑟伦·斯文森博·汤姆森本特·弗卢杰尔·玛格兰艾曼·马哈穆德·萨布里英格里德·莉娜·安德生-埃克伦德希勒米·约翰娜·维克基特希·卡塔林纳·伊苏-托鲁塞利亚·玛丽亚·维塔拉尼娜·弗雷德里卡·舒尔曼尼古拉·黑斯廷斯约翰·刘易斯·威廉·威廉斯约翰·亚瑟·伍尔莱姆斯艾娜-伊莎贝尔·费尔南德斯·阿维拉哈尔伽·维纳拉斯瑟杰·瓦尔维
Owner AARHUS UNIV
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